Ivermectin for onchocercal eye disease (river blindness) (Review)
Ivermectin for onchocercal eye disease (river blindness) (Review)
Ivermectin for onchocercal eye disease (river blindness) (Review)
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
<strong>Ivermectin</strong> <strong>for</strong> <strong>onchocercal</strong> <strong>eye</strong> <strong>disease</strong> (<strong>river</strong> <strong>blindness</strong>) (<strong>Review</strong>)<br />
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />
22<br />
A D D I T I O N A L S U M M A R Y O F F I N D I N G S [Explanation]<br />
ivermectintopreventandtreat<strong>onchocercal</strong><strong>eye</strong><strong>disease</strong>inpeoplelivingincommunitiesaffectedbyO.volvulus<br />
Patientorpopulation:peoplelivingincommunitiesaffectedbyO.volvulus<br />
Settings:community<br />
Intervention:ivermectin<br />
Outcomes Illustrativecomparativerisks*(95%CI) Relativeeffect<br />
(95%CI)<br />
Visualimpairment<br />
Follow-up:24months<br />
Visualfieldloss<br />
Follow-up: mean 24<br />
months<br />
Punctatekeratitis<br />
Follow-up:24months<br />
Sclerosingkeratitis<br />
Follow-up:24months<br />
Iridocyclitis<br />
Follow-up:24months<br />
Chorioretinitis<br />
Follow-up:24months<br />
Opticnerve<strong>disease</strong><br />
Follow-up:24months<br />
Assumedrisk Correspondingrisk<br />
Control ivermectin<br />
22per1000 24per1000<br />
(7to77)<br />
180per1000 108per1000<br />
(74to160)<br />
285per1000 94per1000<br />
(63to140)<br />
348per1000 258per1000<br />
(181to369)<br />
217per1000 135per1000<br />
(93to195)<br />
60per1000 105per1000<br />
(55to202)<br />
48per1000 37per1000<br />
(27to51)<br />
RR1.08<br />
(0.33to3.5)<br />
RR0.60<br />
(0.41to0.89)<br />
RR0.33<br />
(0.22to0.49)<br />
RR0.74<br />
(0.52to1.06)<br />
RR0.62<br />
(0.43to0.9)<br />
RR1.75<br />
(0.91to3.37)<br />
RR0.78<br />
(0.57to1.06)<br />
NoofParticipants<br />
(studies)<br />
485<br />
(1study)<br />
636<br />
(1study)<br />
551<br />
(1study)<br />
560<br />
(1study)<br />
554<br />
(1study)<br />
528<br />
(1study)<br />
3577<br />
(2studies)<br />
Qualityoftheevidence<br />
(GRADE)<br />
⊕○○○<br />
verylow 1,2,3<br />
⊕⊕⊕⊕<br />
high<br />
⊕⊕⊕○<br />
moderate 1<br />
⊕⊕○○<br />
low 1,3<br />
⊕⊕⊕○<br />
moderate 1<br />
⊕⊕○○<br />
low 1,3<br />
⊕⊕○○<br />
low 1,4<br />
Comments
Change language