Topic 5 Nucleic Acids as Drug Targets
Topic 5 Nucleic Acids as Drug Targets
Topic 5 Nucleic Acids as Drug Targets
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3. DRUGS ACTING ON DNA<br />
Topoisomer<strong>as</strong>e II<br />
• Relieves the strain in the DNA helix by temporarily cleaving the DNA<br />
chain and crossing an intact strand through the broken strand<br />
5'<br />
Topo II<br />
Tyr<br />
3' 5'<br />
DNA<br />
• Tyrosine residues in the enzyme are involved in the chain breaking<br />
process<br />
• The residues form covalent bonds to DNA<br />
3'
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