Topic 5 Nucleic Acids as Drug Targets
Topic 5 Nucleic Acids as Drug Targets
Topic 5 Nucleic Acids as Drug Targets
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3. DRUGS ACTING ON DNA<br />
3.2 Alkylating agents<br />
Mechlorethamine analogues<br />
Aromatic ring - e withdrawing effect<br />
N is less nucleophilic<br />
Less reactive alkylating agent<br />
Selective for stronger nucleophiles<br />
(e.g. guanine)<br />
N<br />
Cl<br />
Cl<br />
O<br />
HN<br />
O<br />
N<br />
H<br />
Uracil mustard<br />
Used vs leukemia<br />
Attached to a nucleic acid building<br />
block<br />
Concentrated in f<strong>as</strong>t growing cells<br />
(tumours)<br />
Some selectivity<br />
N<br />
Cl<br />
Cl
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