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Editor: Dana Jamero djamero@xula.edu www.lshp.org<br />

Volume 18, No.1 <strong>January</strong>/<strong>February</strong> <strong>2009</strong><br />

It is hard to believe that my term in <strong>of</strong>fice for<br />

LSHP is rapidly drawing to a close. I have been blessed<br />

with a superb team <strong>of</strong> members serving the society. Our<br />

LSHP state <strong>of</strong>ficers, members <strong>of</strong> the Board <strong>of</strong> Directors<br />

(BOD), Executive staff, Committee Chairs and appointed<br />

members have been busy this year concentrating on a<br />

number <strong>of</strong> tasks that are important for the development <strong>of</strong><br />

both LSHP and the pr<strong>of</strong>ession <strong>of</strong> pharmacy.<br />

Our Treasurer, Helen Calmes, and Mathew<br />

Thomas have stepped up again this year to deliver an<br />

excellent pr<strong>of</strong>essional education program for our Annual<br />

Meeting in May. In addition, Dr. Calmes authored an<br />

excellent plan for restructuring the LSHP committees that<br />

will engage more <strong>of</strong> the membership in our activities and<br />

assist the society in handling many <strong>of</strong> our pressing issues.<br />

Jo Watkins, Chair <strong>of</strong> the Organizational Affairs Committee<br />

and her members have been diligent in carefully<br />

“tweaking” the document for the consideration <strong>of</strong> both our<br />

BOD and the general membership later this year.<br />

Organizational Affairs has also been taking some bold steps<br />

in working to build our enrolled membership this year.<br />

They will present their plans for consideration at the<br />

<strong>January</strong> 23 rd Board Meeting in Baton Rouge.<br />

Administrative Affairs Committee members, under the<br />

leadership <strong>of</strong> Connie Smith and Laurel Andrews, have<br />

assisted Organization Affairs by securing not only directory<br />

information for hospital pharmacists across the state, but<br />

have also worked with the student LSHP chapters <strong>of</strong> Xavier<br />

University COP and the ULM COP in polling their<br />

memberships for short program topics <strong>of</strong> interest to this<br />

important subset <strong>of</strong> our membership. Pharmacy students<br />

have enjoyed having their activities in the LSHP newsletter.<br />

I wish to commend Dr. Dana Jamero our esteemed editor,<br />

for her continued efforts on behalf <strong>of</strong> the society in getting<br />

our many articles and news worthy items to press. Please<br />

let Dana know that her conscientious work on the behalf <strong>of</strong><br />

LSHP is greatly appreciated!<br />

Dr. Chris Betz, from Governmental Affairs, and<br />

Winona Thomas were instrumental in helping the society<br />

work with ASHP this fall in promoting and assisting the<br />

ASHP Technician Initiative. LSHP’s President-Elect, Dr.<br />

Keturah Robinson, represented the <strong>Society</strong> at a number <strong>of</strong><br />

events at the ASHP Midyear Meeting tied to the Technician<br />

initiative. She also attended a lengthy program concerning<br />

State Chapter affiliations with ASHP. I wish to thank<br />

Keturah for assisting me in these endeavors, and also for<br />

substituting for me at the <strong>January</strong> BOD meeting. I was at<br />

FROM THE DESK OF THE PRESIDENT<br />

M.D. Anderson Cancer Center with my wife during much <strong>of</strong><br />

December and <strong>January</strong>. Dr. Cherie Robertson and her<br />

Committee Members from Pr<strong>of</strong>essional Affairs have been<br />

primarily working with issues surrounding Collaborative<br />

Practice Agreements and Immunization Certification and<br />

monitoring the “<strong>Louisiana</strong> <strong>Health</strong> First” Medicaid Reform<br />

Advisory Group (MRAG). Cherie has been reporting to our<br />

membership via e-mail blasts concerning events as they come<br />

out <strong>of</strong> this group and plans to work with LSHP, <strong>Louisiana</strong><br />

Pharmacists Association, and the <strong>Louisiana</strong> Board <strong>of</strong><br />

Pharmacy in preparing a letter to Sec. Alan Levine as MRAG<br />

issues develop impacting pharmacy.<br />

At the Chapter level, I am aware that delivering CE<br />

programming in our traditional evening meal format has<br />

become difficult under PHARMA guidelines. LSHP <strong>of</strong>ficers,<br />

along with help from Mrs. Craig and Mr. O’Connor, hosted a<br />

practical primer on dealing with grant funded educational<br />

programs at the Midyear Meeting in Shreveport. We were<br />

fortunate this year to secure several new presidential <strong>of</strong>ficers,<br />

among them Jessica Brady at NELSHP, Kelsey Green<br />

Trimble at NLSHP, Scott Dantonio at SCLSHP, and James<br />

Peterson from CLSHP. I pledge this next year as Past-<br />

President to work by assisting our affiliate chapters with<br />

securing available funding sources and programming for their<br />

local memberships.<br />

In closing, I wish to remind you to mark your<br />

calendars for the Annual Meeting which is scheduled for<br />

Memorial Day weekend, May 21 st -23 rd in New Orleans at the<br />

Hilton on the riverfront.<br />

Kindest regards,<br />

Marty Steffenson, Pharm.D.<br />

LSHP President<br />

INSIDE<br />

ULM & Xavier Student Chapter Updates….…….......<br />

Nominations…………………………..…………..….<br />

Pharmacy Technician Initiative……………………...<br />

LSHP Annual Meeting Preview……………………..<br />

Central Serous Chorioretinopathy………………..….<br />

PTCB Continuous Testing……………………..…..<br />

3<br />

3<br />

4<br />

5<br />

6-7<br />

8


<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists<br />

LOUISIANA SOCIETY<br />

OF HEALTH-SYSTEM PHARMACISTS<br />

2008-09 BOARD OF DIRECTORS<br />

PRESIDENT<br />

Marty Steffenson, PharmD<br />

West Monroe<br />

(318) 342-1735<br />

Steffenson@ulm.edu<br />

PAST PRESIDENT<br />

Barries Leung, PharmD<br />

New Orleans<br />

(504) 897-8586<br />

leungb@touro.com<br />

TREASURER<br />

Helen M. Calmes, PharmD<br />

New Orleans<br />

(504) 891-6774<br />

hcalme@lsuhsc.edu<br />

MEMBER AT LARGE<br />

Tommy Mannino, RPh<br />

Baton Rouge<br />

(225) 765-8441<br />

tommann40@aol.com<br />

MEMBER AT LARGE<br />

Iman Borghol, PharmD<br />

New Orleans<br />

(504) 520-5342<br />

aborghol@xula.edu<br />

MEMBER AT LARGE<br />

Laurel Andrews, PharmD<br />

Monroe<br />

(318) 342-1721<br />

landrews@ulm.edu<br />

CENTRAL-LSHP<br />

Kelly Beurlot<br />

(318) 445-3453<br />

kkbeurlot@bellsouth.net<br />

NORTH-LSHP<br />

Kelsey Trimble, PharmD<br />

(318) 675-7398<br />

kgree4@lsuhsc.edu<br />

NORTHEAST-LSHP<br />

Jessica Brady, PharmD<br />

(318) 342-1697<br />

brady@ulm.edu<br />

PRESIDENT-ELECT<br />

Keturah Robinson, PharmD<br />

New Orleans<br />

(504) 520-5049<br />

krobinson1234@bellsouth.net<br />

SECRETARY<br />

Michael Cockerham, MS, PharmD,<br />

BCOP<br />

Shreveport<br />

(318) 632-2007<br />

mcocke@lsuhsc.edu<br />

MEMBER AT LARGE<br />

Ann Wicker, PharmD<br />

Baton Rouge<br />

(225) 219-9746<br />

wicker@ulm.edu<br />

BOARD MEMBER ELECT<br />

David L<strong>of</strong>tin, RPh<br />

Shreveport<br />

(318) 746-0578<br />

david.l<strong>of</strong>tin@christushealth.org<br />

BOARD MEMBER ELECT<br />

Teresa Nash, PharmD<br />

New Orleans<br />

(504) 304-0517<br />

tnash@ochsner.org<br />

SOUTH CENTRAL-LSHP<br />

Scott Dantonio, RPh<br />

(225) 622-3714<br />

sdantonio3@eatel.net<br />

SOUTHEAST-LSHP<br />

Linda Mihm, PharmD<br />

(504) 834-7298<br />

lmihm@xula.edu<br />

SOUTHWEST-LSHP<br />

VACANT<br />

LSHP Bimonthly Newsletter LA HEALTH-SYSTEM PHARMACIST Publisher Information<br />

The LA <strong>Health</strong>-<strong>System</strong> Pharmacist is published 6 times a year by the LSHP, 8550 United Plaza Blvd., Suite 1001, Baton Rouge, LA 70809.<br />

Subscription to the LA <strong>Health</strong>-<strong>System</strong> Pharmacist is a benefit <strong>of</strong> LSHP membership. All articles published represent the opinions <strong>of</strong> the authors<br />

and do not reflect the policy <strong>of</strong> the LSHP unless so specified.<br />

Copy, advertising and nonmember subscription inquiries should be directed to the Copy Editor, Kati Craig, at (225) 922-4520. Advertising rate<br />

sheets and deadlines are available upon request.<br />

Please send article submissions to the newsletter editor, Dana Jamero, via email at djamero@xula.edu.<br />

LSHP<br />

Why renew?<br />

Membership provides:<br />

●Pr<strong>of</strong>essional Education<br />

○ ACPE approved continuing<br />

education programs<br />

○ Discounted regisration to LSHP’s<br />

Annual & Mid Year Meeting<br />

○ CE opportunites sponsored by<br />

local chapters<br />

Page 2<br />

●Peer Networking<br />

○ Welcome receptions at statewide<br />

meetings<br />

○ Exhibit halls to meet with industry<br />

reps<br />

●Pr<strong>of</strong>essional <strong>Society</strong> Membership<br />

○ Bi-monthly newsletter featuring<br />

society news & industry information<br />

○ Pr<strong>of</strong>essional recognition through<br />

involvement<br />

If you have not renewed your<br />

membership, please do so soon!<br />

Membership renewals have been<br />

mailed! Need another? Call the<br />

<strong>of</strong>fice at (225) 922-4520, or<br />

download a membership<br />

application for you, a co-worker,<br />

or a friend at www.lshp.org.


<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 3<br />

Hello to all our fellow LSHP members! We are back<br />

from a rejuvenating Winter Break and we are kicking <strong>of</strong>f the<br />

spring semester here at ULM. The ULM LSHP student chapter<br />

anticipates a busy semester filled with programs to further<br />

develop ourselves as future practitioners. We have a few<br />

programs planned already for this semester including a<br />

"Residency Training" pr<strong>of</strong>essional development for interested<br />

students that will be lead by Dr. Jessica Brady. We are also<br />

going to host an "Asthma Education" pr<strong>of</strong>essional development<br />

for students to learn more about this disease which affects many<br />

individuals! We are once again on track to attain the coveted<br />

“Recognized Student <strong>Society</strong> <strong>of</strong> <strong>Health</strong> <strong>System</strong>s Pharmacists”<br />

status. This promises to be a great semester filled with many<br />

Xavier Student Chapter Update<br />

Ge<strong>of</strong>frey Gros<br />

Xavier Student Chapter President<br />

Happy New Year to All! We are back to school<br />

already, and things are kicking <strong>of</strong>f great! Our student chapter has<br />

much planned for this semester. We plan to be involved in<br />

multiple community service activities, as well as having very<br />

intuitive guest speakers. We’re looking forward to a great<br />

semester! We will keep you guys posted <strong>of</strong> all the events to<br />

come.<br />

We hope that each <strong>of</strong> you have a prosperous <strong>2009</strong>!<br />

LSHP Nominations!<br />

Greetings!<br />

The Nominations Committee has the following 4<br />

positions open for nomination for <strong>2009</strong>:<br />

• President-Elect<br />

• Treasurer<br />

• 2 positions for the Board <strong>of</strong> Directors<br />

(member-at-large), 2 year term<br />

The Treasurer will be elected through open ballots at<br />

the General Section during the LSHP Annual Meeting<br />

on Saturday, May 23, <strong>2009</strong>.<br />

If you would like to run one <strong>of</strong> these <strong>of</strong>fices, or you<br />

know someone who is interested, please let me know.<br />

My e-mail address is: barries.leung@touro.com .<br />

Thank you!<br />

Barries Leung, PharmD<br />

LSHP Immediate Past President<br />

ULM Student Chapter Update<br />

Kristian Fruge’<br />

ULM Student Chapter President<br />

programs for our ULM College <strong>of</strong> Pharmacy students to<br />

participate in.<br />

To update you on recent occurrences over the Winter<br />

Break, Kieu Nguyen represented our chapter at the student<br />

chapter showcase in Orlando during the ASHP Midyear Clinical<br />

Meeting. Kieu also presented a poster titled, “Emergency<br />

Preparedness & Your <strong>Health</strong>: Helping Senior Citizens <strong>of</strong><br />

<strong>Louisiana</strong> Prepare for Hurricane Season,” which was a<br />

culmination <strong>of</strong> work and dedication from Dr. Ann Wicker, Dr.<br />

Jessica Brady, Dr. Martin Steffenson, Kieu, and me. The<br />

research was made possible by a seed grant from ASHP. As you<br />

all can see, our student chapter is staying busy and promoting<br />

our pr<strong>of</strong>ession!!<br />

Congratulations to the following<br />

LSHP members and vendor<br />

representatives that were<br />

nominated for awards:<br />

<strong>Health</strong>-<strong>System</strong> Pharmacist <strong>of</strong> the Year<br />

Jessica Brady<br />

Scott Dantonio<br />

George Miller<br />

Keturah Robinson<br />

Technician <strong>of</strong> the Year<br />

Lori Caruso<br />

Melanie Meade<br />

Outstanding Service Award<br />

Chris Betz<br />

Barries Leung<br />

Marty Steffenson<br />

Tommy Himel Award<br />

Mike Cockerham<br />

Charlie Jastram<br />

Tommy Mannino<br />

Industry Award<br />

Sanja Alickovic<br />

Corey Chimento<br />

Tammy Rivault<br />

Cheri Saucier<br />

Awards will be presented at the LSHP<br />

Awards Luncheon at the <strong>2009</strong> Annual<br />

Meeting on May 23 at the Hilton New<br />

Orleans Riverside.


<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 4<br />

ASHP Pharmacy Technician Initiative<br />

ASHP has begun a major technician advocacy initiative<br />

to develop an educated, certified, and registered pharmacy<br />

technician workforce in every state in order to improve<br />

medication use and safety as well as enable the pharmacist to<br />

increase patient care services. This is a goal that LSHP has long<br />

supported. The Pharmacy Technician Initiative is a wellorganized<br />

partnership between ASHP and state affiliates to<br />

advocate for state laws that require, as a prerequisite for state<br />

board registration, completion <strong>of</strong> an ASHP-accredited pharmacy<br />

technician training program and PTCB certification. This<br />

initiative will seek active adoption and involvement <strong>of</strong> state<br />

affiliates. ASHP will develop tools and resources to assist<br />

affiliates in planning and advocacy based on customized plans<br />

developed in participating states.<br />

As reported in the September/October issue <strong>of</strong> the LA<br />

<strong>Health</strong>-<strong>System</strong> Pharmacist, LSHP recently signed on to<br />

participate in ASHP’s Pharmacy Technician Initiative. A<br />

signing ceremony took place at the ASHP Midyear Meeting on<br />

December 7 in Orlando, Florida. Pictured at right is LSHP<br />

President-elect Keturah Robinson, center, at the ceremony. To<br />

her left is Dr. Henri Manasse, Jr., Ph.D, Sc.D, Executive Vice<br />

President, Chief Executive Officer <strong>of</strong> ASHP, to her right is<br />

ASHP President Kevin Colgan.<br />

Hello Fellow Pharmacy Technicians:<br />

Happy New Year to all, I am happy to report to you<br />

that our national organization, ASHP, is working on a<br />

Technician initiative that involves standardizing the role <strong>of</strong><br />

Pharmacy Technicians on a national level. Please be sure and<br />

read about it in this newsletter. It is time for us to renew our<br />

dues for LSHP. I’m sure some <strong>of</strong> you are asking why you<br />

should join. There are several reasons why. We are working<br />

hard as a society to continue to provide continuing education.<br />

We as a society need to work together to promote patient safety<br />

and a healthy work environment. Also, we as a society need to<br />

network to learn about all the resources that are available to us<br />

in order to perform our jobs to the best <strong>of</strong> our abilities. I want<br />

Technician’s Corner<br />

Winona Thomas, CPhT<br />

LSHP Pharmacy Technician Representative<br />

Keturah Robinson signs ASHP Memorandum <strong>of</strong> Understanding<br />

regarding the Pharmacy Technician Initiative<br />

<strong>Louisiana</strong> was one <strong>of</strong> 17 states who signed the<br />

agreement at this time.<br />

Below, a group <strong>of</strong> representatives who participated in<br />

the signing ceremony pause to commemorate the occasion.<br />

to invite all technicians to continue being involved in their local<br />

chapter. Send in those renewal applications, show that you have<br />

pride in yourself and your pr<strong>of</strong>ession. Please share this<br />

newsletter with your fellow technicians that are not members so<br />

they can see what our organization is all about and encourage<br />

them to join. Be proud <strong>of</strong> who you are and what you are. YOU<br />

are a CERTIFIED PHARMACY TECHNICIAN and you help to<br />

save lives.<br />

I always look forward to hearing from you. If you have<br />

any questions, concerns, suggestions or opinions please contact<br />

me at Winonathomascpht@aol.com , your Pharmacy Technician<br />

Representative for LSHP


<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 5<br />

Straight from the horse’s mouth!<br />

The LSHP Annual Meeting<br />

is coming soon!<br />

May 21-23, <strong>2009</strong><br />

Hilton New Orleans Riverside<br />

Save the date & hitch a ride to<br />

the Crescent City!<br />

Hotel Info<br />

Call the Hilton Riverside at (504) 561-0500 or 1-800-HILTONS to book your room. Be sure to tell them you are with<br />

LSHP to receive the group room rate <strong>of</strong> $199 for a single or double room. Be sure to book by April 17!<br />

Educational Programming<br />

The program committee is working hard to book speakers to present on topics you want to know about! You will be<br />

able to earn approximately 17 ACPE-accredited hours. Topics tentatively scheduled to be included are: Electrolytes,<br />

Pharmacy Cognitive Services, Zero Tolerance for Failure: Pharmacists Fight Back, the Ethics <strong>of</strong> End <strong>of</strong> Life Care,<br />

Hyperglycemic Management, Transplantation, Antifungals, Pediatrics, Thrombopoietic Growth Factors, Litigation and<br />

Law.<br />

Take part<br />

Information will be distributed soon regarding the interactive poster session. You will also have the opportunity to visit<br />

with vendors from many pharmaceutical companies during our exhibition.<br />

Network<br />

As always, the Thursday Welcome Reception will <strong>of</strong>fer a chance to visit with old friends and create new relationships<br />

with pharmacists, pharmacy technicians and students from across the state, and in many different practice settings.<br />

Honor the best <strong>of</strong> LSHP<br />

The Saturday Awards lunch honor the winners <strong>of</strong> the Annual LSHP Awards.<br />

More information to follow<br />

Watch your mailboxes and the LSHP website, www.lshp.org , for more information.


<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 6<br />

Central Serous Chorioretinopathy<br />

Nicole Ehrlicher, PharmD Candidate & Lisa DiGioia-Ross, PharmD<br />

Central serous chorioretinopathy or central serous<br />

retinopathy (CSR) is a disease that involves a retinal detachment<br />

<strong>of</strong> the macular layers <strong>of</strong> the eye in which fluid leaks into the<br />

subretinal space. The detachment can cause tears or breaks in<br />

the retinal pigment epithelium which leads to the build up <strong>of</strong> this<br />

endogenous fluid or edema. CSR is usually idiopathic in nature<br />

and self-limiting with about 80% <strong>of</strong> patients regaining 20/25<br />

vision or better. Unfortunately, patients with CSR have a 40-<br />

50% risk <strong>of</strong> recurrence in the same eye. CSR usually results in<br />

blurred, distorted vision or metamorphopsia, a gray blind spot in<br />

the central vision, and/or flashes <strong>of</strong> light or photopsia.<br />

CSR occurs most commonly in males between the ages<br />

<strong>of</strong> 20-55 who are considered to have Type A personalities.<br />

People with Type A personalities are usually extremely<br />

competitive, impatient, time conscious, aggressive, and<br />

sometimes considered workaholics. CSR is uncommon in the<br />

African American population; however, it is extremely severe in<br />

the Hispanic and Asian populations. Women tend to develop<br />

CSR at a later age compared to men. Patients diagnosed after<br />

the age <strong>of</strong> 50 usually have the disorder bilaterally and usually<br />

have a history <strong>of</strong> corticosteroid use or severe uncontrolled<br />

hypertension.<br />

Even though the pathophysiology <strong>of</strong> CSR is not well<br />

understood, stress seems to play a role in the development <strong>of</strong> the<br />

disease. Stress causes stimulation <strong>of</strong> the sympathetic nervous<br />

system which in turn can cause local weakness in the Bruch’s<br />

membrane (a transparent inner membrane <strong>of</strong> the choroid which<br />

is in contact with retinal pigment epithelium). This subsequently<br />

leads to the leakage <strong>of</strong> fluid secondary to a defect in the retinal<br />

pigment epithelium and ultimately, could cause a focal<br />

detachment <strong>of</strong> the retina. Another hypothesis claims the<br />

pathophysiology involves an abnormal ion transport across the<br />

retinal pigment epithelium which can result in focal choroidal<br />

vasculopathy. Other hypothetical systemic causes include<br />

hypertension, organ transplantation, systemic lupus<br />

erythematosus (SLE), Cushing’s syndrome, steroid use, and<br />

gastroesophogeal reflux disease (GERD). All <strong>of</strong> these systemic<br />

conditions are associated with a high level <strong>of</strong> stress and cortisol<br />

release. Also there has been a correlation between Helicobacter<br />

pylori and CSR. Approximately 70% <strong>of</strong> CSR patients are<br />

infected with Helicobacter pylori. Further studies are needed to<br />

determine if an infection with Helicobacter pylori is a risk<br />

factor.<br />

It has been shown in many clinical trials that prolonged<br />

corticosteroid use can exacerbate central serous retinopathy.<br />

Corticosteroids play a role in the expression <strong>of</strong> adrenergic<br />

receptors which when stimulated by the sympathetic nervous<br />

system, cause the release <strong>of</strong> catecholamines (epinephrine,<br />

norepinephrine, and dopamine). This release occurs mainly<br />

during stressful situations and therefore, may contribute to the<br />

pathogenesis <strong>of</strong> CSR. A study <strong>of</strong> 50 CSR patients showed that<br />

26 patients (52%) had a history <strong>of</strong> exogenous steroid use. In<br />

addition, most retinas reattach spontaneously once systemic<br />

corticosteroids are discontinued. <strong>System</strong>ic corticosteroid use is<br />

the most prevalent risk factor for developing or exacerbating<br />

CSR and should be avoided in patients with this disease.<br />

There has also been some speculation that Viagra®<br />

(sildenafil) may have a relationship to CSR, although a causal<br />

relationship has not been established. However, a retrospective<br />

study showed that 8 out <strong>of</strong> 11 patients taking sildenafil and<br />

diagnosed with CSR had improved vision upon discontinuation.<br />

Therefore, most physicians do not recommend the use <strong>of</strong><br />

sildenafil in patients with refractory CSR. Other agent that<br />

should be avoided in patients with CSR includes aspirin and<br />

caffeine plus other stimulants and possibly non-steroidal antiinflammatory<br />

drugs (NSAIDs). In addition, since elevated<br />

opiate levels from use <strong>of</strong> heroin or morphine have also been<br />

associated with CSR it would be best to avoid using these agents<br />

as well.<br />

Patients with CSR can present with symptoms <strong>of</strong> visual<br />

loss, metamorphopsia, decrease or distortion in central vision,<br />

scotoma, loss <strong>of</strong> color perception and loss <strong>of</strong> contrast sensitivity.<br />

Most patients complain <strong>of</strong> objects being distorted in some way<br />

and miniaturized. However, CSR can be asymptomatic and is<br />

usually unilateral. Some classic signs <strong>of</strong> CSR include local<br />

serous detachment <strong>of</strong> the retina usually within the region <strong>of</strong> the<br />

macula, serous fluid void <strong>of</strong> any lipid or heme, retinal<br />

epithelium irregularities, and possible subretinal fibrin<br />

deposition. CSR is commonly diagnosed by using optical<br />

coherence topography (OCT) and fluorescein angiogram (FA).<br />

If the OCT shows subretinal fluid, retinal pigment epithelium<br />

detachment, neurosensory macula detachment, and any retinal<br />

atrophy resulting from a chronic disease state, it may be<br />

suggestive <strong>of</strong> CSR. The FA is able to detect leaks at the level <strong>of</strong><br />

the retinal pigment epithelium, and in about 10-15% <strong>of</strong> patients,<br />

a classic “smoke stack” appearance <strong>of</strong> the leak will be present.<br />

Even though CSR has serious signs and symptoms, the<br />

prognosis is usually good if the disease in caught in the early<br />

stages. As mentioned earlier, about 80% <strong>of</strong> patient will have<br />

20/25 vision or better leaving only 20% failing to recover vision<br />

<strong>of</strong> 20/30 or better. Most <strong>of</strong> the patients failing to regain adequate<br />

vision usually have a chronic form <strong>of</strong> CSR secondary to another<br />

uncontrolled disease (i.e. hypertension or SLE). Patients with<br />

chronic CSR usually have chronic serous retinal detachment<br />

caused by severe retinal pigment epithelium atrophy and only<br />

regain about 20/200 vision. Even if the disease is detected early,<br />

there is a risk <strong>of</strong> about 50% recurrence <strong>of</strong> CSR in the same the<br />

eye.<br />

The treatment and management <strong>of</strong> CSR is not well<br />

defined. Laser photocoagulation is commonly used in the<br />

treatment <strong>of</strong> CSR to cauterize the subretinal leak areas and<br />

prevent fluid from escaping. Laser photocoagulation is usually<br />

only used during the following complications <strong>of</strong> CSR: a serous<br />

detachment <strong>of</strong> greater than four months or recurrence <strong>of</strong> CSR in<br />

the same or opposite eye with visual deficits. Laser<br />

photocoagulation is also used if the serous detachment is more<br />

than 300 micrometers from the center <strong>of</strong> the fovea. If laser<br />

treatment is concentrated too close to the macula, it can leave a<br />

permanent blind spot. If the leak is too close to the macula, then<br />

transpupillary thermotherapy has been used as a lower risk<br />

alternative laser treatment. Laser treatment has been shown to<br />

CSR continues on next page


CSR continued<br />

<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 7<br />

slow the progression <strong>of</strong> the disease and decrease the risk <strong>of</strong><br />

recurrence in the same eye; however, it has not been proven to<br />

improve the final vision prognosis. Patients with chronic CSR<br />

seem to have a better prognosis when laser photocoagulation is<br />

used in the management <strong>of</strong> the disease.<br />

There is currently no standard pharmacologic therapy<br />

that is indicated for CSR. Many treatments are investigational<br />

and are <strong>of</strong>ten used <strong>of</strong>f-label. Most <strong>of</strong> the pharmacological<br />

treatments available are only used in patients with CSR that are<br />

complicated with choroidal neovascularization (CNV).<br />

Photodynamic therapy (PDT) has been used successfully <strong>of</strong>flabel<br />

in the treatment <strong>of</strong> CSR. PDT is indicated in for treatment<br />

<strong>of</strong> wet macular degeneration with CNV; therefore, PDT is usually<br />

only used when CSR is complicated with subfoveal CNV. PDT<br />

uses the medication Visudyne® (verteporfin) which is given by<br />

an intravenous injection. Verteporfin is activated by a nonthermal<br />

laser which targets CNV through a contact lens that is placed on<br />

the cornea. This photoactivation results in the generation <strong>of</strong> free<br />

radicals and subsequently leads to local endothelial damage and<br />

capillary closure by temporarily causing choroidal vessel<br />

occlusion. The main complications <strong>of</strong> PDT are macular ischemia<br />

from the local vessel occlusion and angiogenesis or re-growth <strong>of</strong><br />

new blood vessels. A prospective trial was conducted in which<br />

26 eyes <strong>of</strong> 24 patients with CSR were treated with PDT. A<br />

statistically significant change in visual acuity from baseline to<br />

24 months (P=.03) was shown. Another small study used PDT on<br />

five eyes with chronic CSR. All five eyes showed improvement<br />

in vision, reduction <strong>of</strong> fluid leakage, reduction <strong>of</strong> subretinal fluid<br />

accumulation, and reduction <strong>of</strong> serous detachment. PDT is most<br />

beneficial when used early in the disease progression and when<br />

the patient has clinical findings <strong>of</strong> CNV.<br />

Another medication used in the treatment <strong>of</strong> CSR is the<br />

vascular endothelial growth factor (VEGF) inhibitor, Avastin®<br />

(bevacizumab). Bevacizumab is commonly used for the<br />

treatment <strong>of</strong> age related macular degeneration complicated with<br />

CNV. VEGF is responsible for angiogenesis; therefore, when<br />

inhibited should prevent the formation <strong>of</strong> new blood vessels<br />

which is a complication associated with CNV. Bevacizumab is<br />

administered intravitreally at a usual dose <strong>of</strong> 1.25mg.<br />

Bevacizumab is very effective at eliminating CNV leakage and<br />

the further progression <strong>of</strong> CNV; however, more studies are<br />

warranted to assess the long term safety and efficacy <strong>of</strong><br />

intravitreal bevacizumab. Currently, bevacizumab is only used in<br />

the treatment <strong>of</strong> CSR when the patient has CNV or has chronic<br />

CSR. Other investigational agents include acetazolamide,<br />

labetalol and other beta-blockers, mifepristone and ketoconazole<br />

to treat refractory cases <strong>of</strong> CSR.<br />

Since the pathology <strong>of</strong> CSR is primarily based on stress,<br />

there are several pharmacologic techniques that may help such as<br />

exercise, meditation and yoga. These techniques have not been<br />

clinically proven to treat CSR; however, by decreasing the<br />

mediator <strong>of</strong> the disease, stress, these techniques may have the<br />

potential to prevent progression <strong>of</strong> the disease when used in<br />

combination with other treatments.<br />

In conclusion, the cause <strong>of</strong> CSR is usually idiopathic in<br />

nature; however, it is speculated to be based on increased stress.<br />

Fortunately, about 80% <strong>of</strong> CSR cases are self-limiting. Most CSR<br />

cases are exacerbated by prolonged steroid use and usually<br />

resolve once the steroids have been discontinued. If the disease<br />

does not resolve on its own, the pharmacologic options that are<br />

available include PDT and bevacizumab.<br />

References:<br />

Carvalho-Recchia CA, Yannuzzi LA, Negrao S, Spaide RF,<br />

Freund KB, Rodriguez-Coleman H, et<br />

al. Corticosteroids and central serous<br />

chorioretinopathy. Ophthalmology. Oct; 2002; 109<br />

(10):1834-7.<br />

Emedicine from WebMD. Central Serous Choiroretinopathy.<br />

Accessed at http://www.emedicine.com/oph/<br />

topic689.htm. Accessed on June 16, 2008.<br />

Ergun E, Tittl M, Stur M. Photodynamic Therapy with<br />

verteporfin in subfoveal choroidal neovascularization<br />

secondary to central serous chorioretinopathy. Arch<br />

Ophthalmol. 2004; 122:37-41.<br />

Fraunfelder FW, Fraunfelder FT. Central serous retinopathy<br />

associated with Sildenafil. Retina. 28(4):606-609. April<br />

2008.<br />

Lexi Comp S<strong>of</strong>tware for PDA. Lexi Comp Inc. 2008.<br />

Rioddan-Eva P, Whitcher JP. Vaughns and Asbury General<br />

Ophthalmology 17 th edition. McGraw Hill 2008. Page<br />

200-201.<br />

Sharma T et al. Visual Outcome after discontinuation <strong>of</strong><br />

Corticosteroids in Atypical Severe Central Serous<br />

Chorioretinopathy. Ophthalmology.2004; 111:1708-<br />

1714.<br />

Taban M, Boyer DS, Thomas EL. Chronic Central Serous<br />

Chorioretinopathy: Photodynamic Therapy. American<br />

Journal <strong>of</strong> Ophthalmology.2004; 137: 1073-1080.<br />

The Wills Eye Manual 4 th edition. Lippincott & Wilkins.<br />

Pages 261-262.<br />

http://www.cushings-help.com/csr.htm Accessed on<br />

<strong>February</strong> 3, <strong>2009</strong><br />

http://www.mdsupport.org/library/ketoconazole.html<br />

Accessed on <strong>February</strong> 3, <strong>2009</strong><br />

Mark your calendars & make your reservations!<br />

ASHP Summer Meeting<br />

June 14­17, <strong>2009</strong> Village <strong>of</strong> Rosemont, Illinois


Pharmacy Technician Certification Board (PTCB)<br />

Unveils New Testing Features for <strong>2009</strong>:<br />

PTCB Exam to be Offered daily; Test Results Given to Candidates Immediately<br />

Washington, D.C. – The Pharmacy Technician Certification<br />

Board (PTCB) – the pioneer in the certification <strong>of</strong> pharmacy<br />

technicians - announced that on April 1, <strong>2009</strong>, the PTCB<br />

Examination will be available in continuous testing format at<br />

Pearson Pr<strong>of</strong>essional Centers nationwide. PTCB also announced<br />

that exam candidates will receive an <strong>of</strong>ficial pass or fail result at<br />

the test center after the completion <strong>of</strong> the exam, effective immediately.<br />

The PTCB certification program is the only certification<br />

endorsed by the American Pharmacists Association (APhA), the<br />

American <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists (ASHP), the<br />

National Association <strong>of</strong> Boards <strong>of</strong> Pharmacy (NABP) and other<br />

pr<strong>of</strong>essional pharmacy organizations. The PTCB examination is<br />

administered in all 50 states, DANTES testing centers worldwide,<br />

and in Guam and Puerto Rico, and is included in the regulations<br />

<strong>of</strong> 30 states. The transition to on-demand, year round exam availability<br />

is designed to meet increasing demand from educators,<br />

employers and pharmacy technicians. PTCB candidate demographics<br />

and numbers have expanded steadily over PTCB’s 14<br />

years as the industry leader in certifying pharmacy technicians. In<br />

2008, PTCB tested over 50,000 pharmacy technicians and has<br />

certified 330,425 CPhTs since inception in 1995, through the<br />

examination and transfer process.<br />

"As industry demand continues to grow and more states<br />

like Texas require pharmacy technicians to be PTCB certified as<br />

part <strong>of</strong> the registration process, we recognized the need to evolve<br />

our program," said Melissa Murer Corrigan, RPh, Executive Director<br />

and CEO <strong>of</strong> PTCB. "Similar to NAPLEX (the pharmacist<br />

licensure exam), pharmacy technicians soon will be able to take<br />

the test on-demand and learn their pass/fail status immediately.<br />

These new features will support patient safety and enhance customer<br />

service."<br />

The current quarterly administration <strong>of</strong> the PTCB examination<br />

will conclude on March 31, <strong>2009</strong>. Eligible exam candidates<br />

applying after April 1, <strong>2009</strong> will be authorized to test immediately,<br />

and may schedule an exam appointment in the 90 days<br />

following approval. Candidates will continue to schedule examination<br />

appointments at any <strong>of</strong> the over 200 Pearson Pr<strong>of</strong>essional<br />

Centers nationwide and internationally at DANTES testing centers<br />

in the continuous testing format.<br />

The PTCB national Pharmacy Technician Certification<br />

Examination (PTCE) certification program is accredited by the<br />

National Commission for Certifying Agencies (NCCA).

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