January/February 2009 - Louisiana Society of Health-System ...
January/February 2009 - Louisiana Society of Health-System ...
January/February 2009 - Louisiana Society of Health-System ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Editor: Dana Jamero djamero@xula.edu www.lshp.org<br />
Volume 18, No.1 <strong>January</strong>/<strong>February</strong> <strong>2009</strong><br />
It is hard to believe that my term in <strong>of</strong>fice for<br />
LSHP is rapidly drawing to a close. I have been blessed<br />
with a superb team <strong>of</strong> members serving the society. Our<br />
LSHP state <strong>of</strong>ficers, members <strong>of</strong> the Board <strong>of</strong> Directors<br />
(BOD), Executive staff, Committee Chairs and appointed<br />
members have been busy this year concentrating on a<br />
number <strong>of</strong> tasks that are important for the development <strong>of</strong><br />
both LSHP and the pr<strong>of</strong>ession <strong>of</strong> pharmacy.<br />
Our Treasurer, Helen Calmes, and Mathew<br />
Thomas have stepped up again this year to deliver an<br />
excellent pr<strong>of</strong>essional education program for our Annual<br />
Meeting in May. In addition, Dr. Calmes authored an<br />
excellent plan for restructuring the LSHP committees that<br />
will engage more <strong>of</strong> the membership in our activities and<br />
assist the society in handling many <strong>of</strong> our pressing issues.<br />
Jo Watkins, Chair <strong>of</strong> the Organizational Affairs Committee<br />
and her members have been diligent in carefully<br />
“tweaking” the document for the consideration <strong>of</strong> both our<br />
BOD and the general membership later this year.<br />
Organizational Affairs has also been taking some bold steps<br />
in working to build our enrolled membership this year.<br />
They will present their plans for consideration at the<br />
<strong>January</strong> 23 rd Board Meeting in Baton Rouge.<br />
Administrative Affairs Committee members, under the<br />
leadership <strong>of</strong> Connie Smith and Laurel Andrews, have<br />
assisted Organization Affairs by securing not only directory<br />
information for hospital pharmacists across the state, but<br />
have also worked with the student LSHP chapters <strong>of</strong> Xavier<br />
University COP and the ULM COP in polling their<br />
memberships for short program topics <strong>of</strong> interest to this<br />
important subset <strong>of</strong> our membership. Pharmacy students<br />
have enjoyed having their activities in the LSHP newsletter.<br />
I wish to commend Dr. Dana Jamero our esteemed editor,<br />
for her continued efforts on behalf <strong>of</strong> the society in getting<br />
our many articles and news worthy items to press. Please<br />
let Dana know that her conscientious work on the behalf <strong>of</strong><br />
LSHP is greatly appreciated!<br />
Dr. Chris Betz, from Governmental Affairs, and<br />
Winona Thomas were instrumental in helping the society<br />
work with ASHP this fall in promoting and assisting the<br />
ASHP Technician Initiative. LSHP’s President-Elect, Dr.<br />
Keturah Robinson, represented the <strong>Society</strong> at a number <strong>of</strong><br />
events at the ASHP Midyear Meeting tied to the Technician<br />
initiative. She also attended a lengthy program concerning<br />
State Chapter affiliations with ASHP. I wish to thank<br />
Keturah for assisting me in these endeavors, and also for<br />
substituting for me at the <strong>January</strong> BOD meeting. I was at<br />
FROM THE DESK OF THE PRESIDENT<br />
M.D. Anderson Cancer Center with my wife during much <strong>of</strong><br />
December and <strong>January</strong>. Dr. Cherie Robertson and her<br />
Committee Members from Pr<strong>of</strong>essional Affairs have been<br />
primarily working with issues surrounding Collaborative<br />
Practice Agreements and Immunization Certification and<br />
monitoring the “<strong>Louisiana</strong> <strong>Health</strong> First” Medicaid Reform<br />
Advisory Group (MRAG). Cherie has been reporting to our<br />
membership via e-mail blasts concerning events as they come<br />
out <strong>of</strong> this group and plans to work with LSHP, <strong>Louisiana</strong><br />
Pharmacists Association, and the <strong>Louisiana</strong> Board <strong>of</strong><br />
Pharmacy in preparing a letter to Sec. Alan Levine as MRAG<br />
issues develop impacting pharmacy.<br />
At the Chapter level, I am aware that delivering CE<br />
programming in our traditional evening meal format has<br />
become difficult under PHARMA guidelines. LSHP <strong>of</strong>ficers,<br />
along with help from Mrs. Craig and Mr. O’Connor, hosted a<br />
practical primer on dealing with grant funded educational<br />
programs at the Midyear Meeting in Shreveport. We were<br />
fortunate this year to secure several new presidential <strong>of</strong>ficers,<br />
among them Jessica Brady at NELSHP, Kelsey Green<br />
Trimble at NLSHP, Scott Dantonio at SCLSHP, and James<br />
Peterson from CLSHP. I pledge this next year as Past-<br />
President to work by assisting our affiliate chapters with<br />
securing available funding sources and programming for their<br />
local memberships.<br />
In closing, I wish to remind you to mark your<br />
calendars for the Annual Meeting which is scheduled for<br />
Memorial Day weekend, May 21 st -23 rd in New Orleans at the<br />
Hilton on the riverfront.<br />
Kindest regards,<br />
Marty Steffenson, Pharm.D.<br />
LSHP President<br />
INSIDE<br />
ULM & Xavier Student Chapter Updates….…….......<br />
Nominations…………………………..…………..….<br />
Pharmacy Technician Initiative……………………...<br />
LSHP Annual Meeting Preview……………………..<br />
Central Serous Chorioretinopathy………………..….<br />
PTCB Continuous Testing……………………..…..<br />
3<br />
3<br />
4<br />
5<br />
6-7<br />
8
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists<br />
LOUISIANA SOCIETY<br />
OF HEALTH-SYSTEM PHARMACISTS<br />
2008-09 BOARD OF DIRECTORS<br />
PRESIDENT<br />
Marty Steffenson, PharmD<br />
West Monroe<br />
(318) 342-1735<br />
Steffenson@ulm.edu<br />
PAST PRESIDENT<br />
Barries Leung, PharmD<br />
New Orleans<br />
(504) 897-8586<br />
leungb@touro.com<br />
TREASURER<br />
Helen M. Calmes, PharmD<br />
New Orleans<br />
(504) 891-6774<br />
hcalme@lsuhsc.edu<br />
MEMBER AT LARGE<br />
Tommy Mannino, RPh<br />
Baton Rouge<br />
(225) 765-8441<br />
tommann40@aol.com<br />
MEMBER AT LARGE<br />
Iman Borghol, PharmD<br />
New Orleans<br />
(504) 520-5342<br />
aborghol@xula.edu<br />
MEMBER AT LARGE<br />
Laurel Andrews, PharmD<br />
Monroe<br />
(318) 342-1721<br />
landrews@ulm.edu<br />
CENTRAL-LSHP<br />
Kelly Beurlot<br />
(318) 445-3453<br />
kkbeurlot@bellsouth.net<br />
NORTH-LSHP<br />
Kelsey Trimble, PharmD<br />
(318) 675-7398<br />
kgree4@lsuhsc.edu<br />
NORTHEAST-LSHP<br />
Jessica Brady, PharmD<br />
(318) 342-1697<br />
brady@ulm.edu<br />
PRESIDENT-ELECT<br />
Keturah Robinson, PharmD<br />
New Orleans<br />
(504) 520-5049<br />
krobinson1234@bellsouth.net<br />
SECRETARY<br />
Michael Cockerham, MS, PharmD,<br />
BCOP<br />
Shreveport<br />
(318) 632-2007<br />
mcocke@lsuhsc.edu<br />
MEMBER AT LARGE<br />
Ann Wicker, PharmD<br />
Baton Rouge<br />
(225) 219-9746<br />
wicker@ulm.edu<br />
BOARD MEMBER ELECT<br />
David L<strong>of</strong>tin, RPh<br />
Shreveport<br />
(318) 746-0578<br />
david.l<strong>of</strong>tin@christushealth.org<br />
BOARD MEMBER ELECT<br />
Teresa Nash, PharmD<br />
New Orleans<br />
(504) 304-0517<br />
tnash@ochsner.org<br />
SOUTH CENTRAL-LSHP<br />
Scott Dantonio, RPh<br />
(225) 622-3714<br />
sdantonio3@eatel.net<br />
SOUTHEAST-LSHP<br />
Linda Mihm, PharmD<br />
(504) 834-7298<br />
lmihm@xula.edu<br />
SOUTHWEST-LSHP<br />
VACANT<br />
LSHP Bimonthly Newsletter LA HEALTH-SYSTEM PHARMACIST Publisher Information<br />
The LA <strong>Health</strong>-<strong>System</strong> Pharmacist is published 6 times a year by the LSHP, 8550 United Plaza Blvd., Suite 1001, Baton Rouge, LA 70809.<br />
Subscription to the LA <strong>Health</strong>-<strong>System</strong> Pharmacist is a benefit <strong>of</strong> LSHP membership. All articles published represent the opinions <strong>of</strong> the authors<br />
and do not reflect the policy <strong>of</strong> the LSHP unless so specified.<br />
Copy, advertising and nonmember subscription inquiries should be directed to the Copy Editor, Kati Craig, at (225) 922-4520. Advertising rate<br />
sheets and deadlines are available upon request.<br />
Please send article submissions to the newsletter editor, Dana Jamero, via email at djamero@xula.edu.<br />
LSHP<br />
Why renew?<br />
Membership provides:<br />
●Pr<strong>of</strong>essional Education<br />
○ ACPE approved continuing<br />
education programs<br />
○ Discounted regisration to LSHP’s<br />
Annual & Mid Year Meeting<br />
○ CE opportunites sponsored by<br />
local chapters<br />
Page 2<br />
●Peer Networking<br />
○ Welcome receptions at statewide<br />
meetings<br />
○ Exhibit halls to meet with industry<br />
reps<br />
●Pr<strong>of</strong>essional <strong>Society</strong> Membership<br />
○ Bi-monthly newsletter featuring<br />
society news & industry information<br />
○ Pr<strong>of</strong>essional recognition through<br />
involvement<br />
If you have not renewed your<br />
membership, please do so soon!<br />
Membership renewals have been<br />
mailed! Need another? Call the<br />
<strong>of</strong>fice at (225) 922-4520, or<br />
download a membership<br />
application for you, a co-worker,<br />
or a friend at www.lshp.org.
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 3<br />
Hello to all our fellow LSHP members! We are back<br />
from a rejuvenating Winter Break and we are kicking <strong>of</strong>f the<br />
spring semester here at ULM. The ULM LSHP student chapter<br />
anticipates a busy semester filled with programs to further<br />
develop ourselves as future practitioners. We have a few<br />
programs planned already for this semester including a<br />
"Residency Training" pr<strong>of</strong>essional development for interested<br />
students that will be lead by Dr. Jessica Brady. We are also<br />
going to host an "Asthma Education" pr<strong>of</strong>essional development<br />
for students to learn more about this disease which affects many<br />
individuals! We are once again on track to attain the coveted<br />
“Recognized Student <strong>Society</strong> <strong>of</strong> <strong>Health</strong> <strong>System</strong>s Pharmacists”<br />
status. This promises to be a great semester filled with many<br />
Xavier Student Chapter Update<br />
Ge<strong>of</strong>frey Gros<br />
Xavier Student Chapter President<br />
Happy New Year to All! We are back to school<br />
already, and things are kicking <strong>of</strong>f great! Our student chapter has<br />
much planned for this semester. We plan to be involved in<br />
multiple community service activities, as well as having very<br />
intuitive guest speakers. We’re looking forward to a great<br />
semester! We will keep you guys posted <strong>of</strong> all the events to<br />
come.<br />
We hope that each <strong>of</strong> you have a prosperous <strong>2009</strong>!<br />
LSHP Nominations!<br />
Greetings!<br />
The Nominations Committee has the following 4<br />
positions open for nomination for <strong>2009</strong>:<br />
• President-Elect<br />
• Treasurer<br />
• 2 positions for the Board <strong>of</strong> Directors<br />
(member-at-large), 2 year term<br />
The Treasurer will be elected through open ballots at<br />
the General Section during the LSHP Annual Meeting<br />
on Saturday, May 23, <strong>2009</strong>.<br />
If you would like to run one <strong>of</strong> these <strong>of</strong>fices, or you<br />
know someone who is interested, please let me know.<br />
My e-mail address is: barries.leung@touro.com .<br />
Thank you!<br />
Barries Leung, PharmD<br />
LSHP Immediate Past President<br />
ULM Student Chapter Update<br />
Kristian Fruge’<br />
ULM Student Chapter President<br />
programs for our ULM College <strong>of</strong> Pharmacy students to<br />
participate in.<br />
To update you on recent occurrences over the Winter<br />
Break, Kieu Nguyen represented our chapter at the student<br />
chapter showcase in Orlando during the ASHP Midyear Clinical<br />
Meeting. Kieu also presented a poster titled, “Emergency<br />
Preparedness & Your <strong>Health</strong>: Helping Senior Citizens <strong>of</strong><br />
<strong>Louisiana</strong> Prepare for Hurricane Season,” which was a<br />
culmination <strong>of</strong> work and dedication from Dr. Ann Wicker, Dr.<br />
Jessica Brady, Dr. Martin Steffenson, Kieu, and me. The<br />
research was made possible by a seed grant from ASHP. As you<br />
all can see, our student chapter is staying busy and promoting<br />
our pr<strong>of</strong>ession!!<br />
Congratulations to the following<br />
LSHP members and vendor<br />
representatives that were<br />
nominated for awards:<br />
<strong>Health</strong>-<strong>System</strong> Pharmacist <strong>of</strong> the Year<br />
Jessica Brady<br />
Scott Dantonio<br />
George Miller<br />
Keturah Robinson<br />
Technician <strong>of</strong> the Year<br />
Lori Caruso<br />
Melanie Meade<br />
Outstanding Service Award<br />
Chris Betz<br />
Barries Leung<br />
Marty Steffenson<br />
Tommy Himel Award<br />
Mike Cockerham<br />
Charlie Jastram<br />
Tommy Mannino<br />
Industry Award<br />
Sanja Alickovic<br />
Corey Chimento<br />
Tammy Rivault<br />
Cheri Saucier<br />
Awards will be presented at the LSHP<br />
Awards Luncheon at the <strong>2009</strong> Annual<br />
Meeting on May 23 at the Hilton New<br />
Orleans Riverside.
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 4<br />
ASHP Pharmacy Technician Initiative<br />
ASHP has begun a major technician advocacy initiative<br />
to develop an educated, certified, and registered pharmacy<br />
technician workforce in every state in order to improve<br />
medication use and safety as well as enable the pharmacist to<br />
increase patient care services. This is a goal that LSHP has long<br />
supported. The Pharmacy Technician Initiative is a wellorganized<br />
partnership between ASHP and state affiliates to<br />
advocate for state laws that require, as a prerequisite for state<br />
board registration, completion <strong>of</strong> an ASHP-accredited pharmacy<br />
technician training program and PTCB certification. This<br />
initiative will seek active adoption and involvement <strong>of</strong> state<br />
affiliates. ASHP will develop tools and resources to assist<br />
affiliates in planning and advocacy based on customized plans<br />
developed in participating states.<br />
As reported in the September/October issue <strong>of</strong> the LA<br />
<strong>Health</strong>-<strong>System</strong> Pharmacist, LSHP recently signed on to<br />
participate in ASHP’s Pharmacy Technician Initiative. A<br />
signing ceremony took place at the ASHP Midyear Meeting on<br />
December 7 in Orlando, Florida. Pictured at right is LSHP<br />
President-elect Keturah Robinson, center, at the ceremony. To<br />
her left is Dr. Henri Manasse, Jr., Ph.D, Sc.D, Executive Vice<br />
President, Chief Executive Officer <strong>of</strong> ASHP, to her right is<br />
ASHP President Kevin Colgan.<br />
Hello Fellow Pharmacy Technicians:<br />
Happy New Year to all, I am happy to report to you<br />
that our national organization, ASHP, is working on a<br />
Technician initiative that involves standardizing the role <strong>of</strong><br />
Pharmacy Technicians on a national level. Please be sure and<br />
read about it in this newsletter. It is time for us to renew our<br />
dues for LSHP. I’m sure some <strong>of</strong> you are asking why you<br />
should join. There are several reasons why. We are working<br />
hard as a society to continue to provide continuing education.<br />
We as a society need to work together to promote patient safety<br />
and a healthy work environment. Also, we as a society need to<br />
network to learn about all the resources that are available to us<br />
in order to perform our jobs to the best <strong>of</strong> our abilities. I want<br />
Technician’s Corner<br />
Winona Thomas, CPhT<br />
LSHP Pharmacy Technician Representative<br />
Keturah Robinson signs ASHP Memorandum <strong>of</strong> Understanding<br />
regarding the Pharmacy Technician Initiative<br />
<strong>Louisiana</strong> was one <strong>of</strong> 17 states who signed the<br />
agreement at this time.<br />
Below, a group <strong>of</strong> representatives who participated in<br />
the signing ceremony pause to commemorate the occasion.<br />
to invite all technicians to continue being involved in their local<br />
chapter. Send in those renewal applications, show that you have<br />
pride in yourself and your pr<strong>of</strong>ession. Please share this<br />
newsletter with your fellow technicians that are not members so<br />
they can see what our organization is all about and encourage<br />
them to join. Be proud <strong>of</strong> who you are and what you are. YOU<br />
are a CERTIFIED PHARMACY TECHNICIAN and you help to<br />
save lives.<br />
I always look forward to hearing from you. If you have<br />
any questions, concerns, suggestions or opinions please contact<br />
me at Winonathomascpht@aol.com , your Pharmacy Technician<br />
Representative for LSHP
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 5<br />
Straight from the horse’s mouth!<br />
The LSHP Annual Meeting<br />
is coming soon!<br />
May 21-23, <strong>2009</strong><br />
Hilton New Orleans Riverside<br />
Save the date & hitch a ride to<br />
the Crescent City!<br />
Hotel Info<br />
Call the Hilton Riverside at (504) 561-0500 or 1-800-HILTONS to book your room. Be sure to tell them you are with<br />
LSHP to receive the group room rate <strong>of</strong> $199 for a single or double room. Be sure to book by April 17!<br />
Educational Programming<br />
The program committee is working hard to book speakers to present on topics you want to know about! You will be<br />
able to earn approximately 17 ACPE-accredited hours. Topics tentatively scheduled to be included are: Electrolytes,<br />
Pharmacy Cognitive Services, Zero Tolerance for Failure: Pharmacists Fight Back, the Ethics <strong>of</strong> End <strong>of</strong> Life Care,<br />
Hyperglycemic Management, Transplantation, Antifungals, Pediatrics, Thrombopoietic Growth Factors, Litigation and<br />
Law.<br />
Take part<br />
Information will be distributed soon regarding the interactive poster session. You will also have the opportunity to visit<br />
with vendors from many pharmaceutical companies during our exhibition.<br />
Network<br />
As always, the Thursday Welcome Reception will <strong>of</strong>fer a chance to visit with old friends and create new relationships<br />
with pharmacists, pharmacy technicians and students from across the state, and in many different practice settings.<br />
Honor the best <strong>of</strong> LSHP<br />
The Saturday Awards lunch honor the winners <strong>of</strong> the Annual LSHP Awards.<br />
More information to follow<br />
Watch your mailboxes and the LSHP website, www.lshp.org , for more information.
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 6<br />
Central Serous Chorioretinopathy<br />
Nicole Ehrlicher, PharmD Candidate & Lisa DiGioia-Ross, PharmD<br />
Central serous chorioretinopathy or central serous<br />
retinopathy (CSR) is a disease that involves a retinal detachment<br />
<strong>of</strong> the macular layers <strong>of</strong> the eye in which fluid leaks into the<br />
subretinal space. The detachment can cause tears or breaks in<br />
the retinal pigment epithelium which leads to the build up <strong>of</strong> this<br />
endogenous fluid or edema. CSR is usually idiopathic in nature<br />
and self-limiting with about 80% <strong>of</strong> patients regaining 20/25<br />
vision or better. Unfortunately, patients with CSR have a 40-<br />
50% risk <strong>of</strong> recurrence in the same eye. CSR usually results in<br />
blurred, distorted vision or metamorphopsia, a gray blind spot in<br />
the central vision, and/or flashes <strong>of</strong> light or photopsia.<br />
CSR occurs most commonly in males between the ages<br />
<strong>of</strong> 20-55 who are considered to have Type A personalities.<br />
People with Type A personalities are usually extremely<br />
competitive, impatient, time conscious, aggressive, and<br />
sometimes considered workaholics. CSR is uncommon in the<br />
African American population; however, it is extremely severe in<br />
the Hispanic and Asian populations. Women tend to develop<br />
CSR at a later age compared to men. Patients diagnosed after<br />
the age <strong>of</strong> 50 usually have the disorder bilaterally and usually<br />
have a history <strong>of</strong> corticosteroid use or severe uncontrolled<br />
hypertension.<br />
Even though the pathophysiology <strong>of</strong> CSR is not well<br />
understood, stress seems to play a role in the development <strong>of</strong> the<br />
disease. Stress causes stimulation <strong>of</strong> the sympathetic nervous<br />
system which in turn can cause local weakness in the Bruch’s<br />
membrane (a transparent inner membrane <strong>of</strong> the choroid which<br />
is in contact with retinal pigment epithelium). This subsequently<br />
leads to the leakage <strong>of</strong> fluid secondary to a defect in the retinal<br />
pigment epithelium and ultimately, could cause a focal<br />
detachment <strong>of</strong> the retina. Another hypothesis claims the<br />
pathophysiology involves an abnormal ion transport across the<br />
retinal pigment epithelium which can result in focal choroidal<br />
vasculopathy. Other hypothetical systemic causes include<br />
hypertension, organ transplantation, systemic lupus<br />
erythematosus (SLE), Cushing’s syndrome, steroid use, and<br />
gastroesophogeal reflux disease (GERD). All <strong>of</strong> these systemic<br />
conditions are associated with a high level <strong>of</strong> stress and cortisol<br />
release. Also there has been a correlation between Helicobacter<br />
pylori and CSR. Approximately 70% <strong>of</strong> CSR patients are<br />
infected with Helicobacter pylori. Further studies are needed to<br />
determine if an infection with Helicobacter pylori is a risk<br />
factor.<br />
It has been shown in many clinical trials that prolonged<br />
corticosteroid use can exacerbate central serous retinopathy.<br />
Corticosteroids play a role in the expression <strong>of</strong> adrenergic<br />
receptors which when stimulated by the sympathetic nervous<br />
system, cause the release <strong>of</strong> catecholamines (epinephrine,<br />
norepinephrine, and dopamine). This release occurs mainly<br />
during stressful situations and therefore, may contribute to the<br />
pathogenesis <strong>of</strong> CSR. A study <strong>of</strong> 50 CSR patients showed that<br />
26 patients (52%) had a history <strong>of</strong> exogenous steroid use. In<br />
addition, most retinas reattach spontaneously once systemic<br />
corticosteroids are discontinued. <strong>System</strong>ic corticosteroid use is<br />
the most prevalent risk factor for developing or exacerbating<br />
CSR and should be avoided in patients with this disease.<br />
There has also been some speculation that Viagra®<br />
(sildenafil) may have a relationship to CSR, although a causal<br />
relationship has not been established. However, a retrospective<br />
study showed that 8 out <strong>of</strong> 11 patients taking sildenafil and<br />
diagnosed with CSR had improved vision upon discontinuation.<br />
Therefore, most physicians do not recommend the use <strong>of</strong><br />
sildenafil in patients with refractory CSR. Other agent that<br />
should be avoided in patients with CSR includes aspirin and<br />
caffeine plus other stimulants and possibly non-steroidal antiinflammatory<br />
drugs (NSAIDs). In addition, since elevated<br />
opiate levels from use <strong>of</strong> heroin or morphine have also been<br />
associated with CSR it would be best to avoid using these agents<br />
as well.<br />
Patients with CSR can present with symptoms <strong>of</strong> visual<br />
loss, metamorphopsia, decrease or distortion in central vision,<br />
scotoma, loss <strong>of</strong> color perception and loss <strong>of</strong> contrast sensitivity.<br />
Most patients complain <strong>of</strong> objects being distorted in some way<br />
and miniaturized. However, CSR can be asymptomatic and is<br />
usually unilateral. Some classic signs <strong>of</strong> CSR include local<br />
serous detachment <strong>of</strong> the retina usually within the region <strong>of</strong> the<br />
macula, serous fluid void <strong>of</strong> any lipid or heme, retinal<br />
epithelium irregularities, and possible subretinal fibrin<br />
deposition. CSR is commonly diagnosed by using optical<br />
coherence topography (OCT) and fluorescein angiogram (FA).<br />
If the OCT shows subretinal fluid, retinal pigment epithelium<br />
detachment, neurosensory macula detachment, and any retinal<br />
atrophy resulting from a chronic disease state, it may be<br />
suggestive <strong>of</strong> CSR. The FA is able to detect leaks at the level <strong>of</strong><br />
the retinal pigment epithelium, and in about 10-15% <strong>of</strong> patients,<br />
a classic “smoke stack” appearance <strong>of</strong> the leak will be present.<br />
Even though CSR has serious signs and symptoms, the<br />
prognosis is usually good if the disease in caught in the early<br />
stages. As mentioned earlier, about 80% <strong>of</strong> patient will have<br />
20/25 vision or better leaving only 20% failing to recover vision<br />
<strong>of</strong> 20/30 or better. Most <strong>of</strong> the patients failing to regain adequate<br />
vision usually have a chronic form <strong>of</strong> CSR secondary to another<br />
uncontrolled disease (i.e. hypertension or SLE). Patients with<br />
chronic CSR usually have chronic serous retinal detachment<br />
caused by severe retinal pigment epithelium atrophy and only<br />
regain about 20/200 vision. Even if the disease is detected early,<br />
there is a risk <strong>of</strong> about 50% recurrence <strong>of</strong> CSR in the same the<br />
eye.<br />
The treatment and management <strong>of</strong> CSR is not well<br />
defined. Laser photocoagulation is commonly used in the<br />
treatment <strong>of</strong> CSR to cauterize the subretinal leak areas and<br />
prevent fluid from escaping. Laser photocoagulation is usually<br />
only used during the following complications <strong>of</strong> CSR: a serous<br />
detachment <strong>of</strong> greater than four months or recurrence <strong>of</strong> CSR in<br />
the same or opposite eye with visual deficits. Laser<br />
photocoagulation is also used if the serous detachment is more<br />
than 300 micrometers from the center <strong>of</strong> the fovea. If laser<br />
treatment is concentrated too close to the macula, it can leave a<br />
permanent blind spot. If the leak is too close to the macula, then<br />
transpupillary thermotherapy has been used as a lower risk<br />
alternative laser treatment. Laser treatment has been shown to<br />
CSR continues on next page
CSR continued<br />
<strong>Louisiana</strong> <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists Page 7<br />
slow the progression <strong>of</strong> the disease and decrease the risk <strong>of</strong><br />
recurrence in the same eye; however, it has not been proven to<br />
improve the final vision prognosis. Patients with chronic CSR<br />
seem to have a better prognosis when laser photocoagulation is<br />
used in the management <strong>of</strong> the disease.<br />
There is currently no standard pharmacologic therapy<br />
that is indicated for CSR. Many treatments are investigational<br />
and are <strong>of</strong>ten used <strong>of</strong>f-label. Most <strong>of</strong> the pharmacological<br />
treatments available are only used in patients with CSR that are<br />
complicated with choroidal neovascularization (CNV).<br />
Photodynamic therapy (PDT) has been used successfully <strong>of</strong>flabel<br />
in the treatment <strong>of</strong> CSR. PDT is indicated in for treatment<br />
<strong>of</strong> wet macular degeneration with CNV; therefore, PDT is usually<br />
only used when CSR is complicated with subfoveal CNV. PDT<br />
uses the medication Visudyne® (verteporfin) which is given by<br />
an intravenous injection. Verteporfin is activated by a nonthermal<br />
laser which targets CNV through a contact lens that is placed on<br />
the cornea. This photoactivation results in the generation <strong>of</strong> free<br />
radicals and subsequently leads to local endothelial damage and<br />
capillary closure by temporarily causing choroidal vessel<br />
occlusion. The main complications <strong>of</strong> PDT are macular ischemia<br />
from the local vessel occlusion and angiogenesis or re-growth <strong>of</strong><br />
new blood vessels. A prospective trial was conducted in which<br />
26 eyes <strong>of</strong> 24 patients with CSR were treated with PDT. A<br />
statistically significant change in visual acuity from baseline to<br />
24 months (P=.03) was shown. Another small study used PDT on<br />
five eyes with chronic CSR. All five eyes showed improvement<br />
in vision, reduction <strong>of</strong> fluid leakage, reduction <strong>of</strong> subretinal fluid<br />
accumulation, and reduction <strong>of</strong> serous detachment. PDT is most<br />
beneficial when used early in the disease progression and when<br />
the patient has clinical findings <strong>of</strong> CNV.<br />
Another medication used in the treatment <strong>of</strong> CSR is the<br />
vascular endothelial growth factor (VEGF) inhibitor, Avastin®<br />
(bevacizumab). Bevacizumab is commonly used for the<br />
treatment <strong>of</strong> age related macular degeneration complicated with<br />
CNV. VEGF is responsible for angiogenesis; therefore, when<br />
inhibited should prevent the formation <strong>of</strong> new blood vessels<br />
which is a complication associated with CNV. Bevacizumab is<br />
administered intravitreally at a usual dose <strong>of</strong> 1.25mg.<br />
Bevacizumab is very effective at eliminating CNV leakage and<br />
the further progression <strong>of</strong> CNV; however, more studies are<br />
warranted to assess the long term safety and efficacy <strong>of</strong><br />
intravitreal bevacizumab. Currently, bevacizumab is only used in<br />
the treatment <strong>of</strong> CSR when the patient has CNV or has chronic<br />
CSR. Other investigational agents include acetazolamide,<br />
labetalol and other beta-blockers, mifepristone and ketoconazole<br />
to treat refractory cases <strong>of</strong> CSR.<br />
Since the pathology <strong>of</strong> CSR is primarily based on stress,<br />
there are several pharmacologic techniques that may help such as<br />
exercise, meditation and yoga. These techniques have not been<br />
clinically proven to treat CSR; however, by decreasing the<br />
mediator <strong>of</strong> the disease, stress, these techniques may have the<br />
potential to prevent progression <strong>of</strong> the disease when used in<br />
combination with other treatments.<br />
In conclusion, the cause <strong>of</strong> CSR is usually idiopathic in<br />
nature; however, it is speculated to be based on increased stress.<br />
Fortunately, about 80% <strong>of</strong> CSR cases are self-limiting. Most CSR<br />
cases are exacerbated by prolonged steroid use and usually<br />
resolve once the steroids have been discontinued. If the disease<br />
does not resolve on its own, the pharmacologic options that are<br />
available include PDT and bevacizumab.<br />
References:<br />
Carvalho-Recchia CA, Yannuzzi LA, Negrao S, Spaide RF,<br />
Freund KB, Rodriguez-Coleman H, et<br />
al. Corticosteroids and central serous<br />
chorioretinopathy. Ophthalmology. Oct; 2002; 109<br />
(10):1834-7.<br />
Emedicine from WebMD. Central Serous Choiroretinopathy.<br />
Accessed at http://www.emedicine.com/oph/<br />
topic689.htm. Accessed on June 16, 2008.<br />
Ergun E, Tittl M, Stur M. Photodynamic Therapy with<br />
verteporfin in subfoveal choroidal neovascularization<br />
secondary to central serous chorioretinopathy. Arch<br />
Ophthalmol. 2004; 122:37-41.<br />
Fraunfelder FW, Fraunfelder FT. Central serous retinopathy<br />
associated with Sildenafil. Retina. 28(4):606-609. April<br />
2008.<br />
Lexi Comp S<strong>of</strong>tware for PDA. Lexi Comp Inc. 2008.<br />
Rioddan-Eva P, Whitcher JP. Vaughns and Asbury General<br />
Ophthalmology 17 th edition. McGraw Hill 2008. Page<br />
200-201.<br />
Sharma T et al. Visual Outcome after discontinuation <strong>of</strong><br />
Corticosteroids in Atypical Severe Central Serous<br />
Chorioretinopathy. Ophthalmology.2004; 111:1708-<br />
1714.<br />
Taban M, Boyer DS, Thomas EL. Chronic Central Serous<br />
Chorioretinopathy: Photodynamic Therapy. American<br />
Journal <strong>of</strong> Ophthalmology.2004; 137: 1073-1080.<br />
The Wills Eye Manual 4 th edition. Lippincott & Wilkins.<br />
Pages 261-262.<br />
http://www.cushings-help.com/csr.htm Accessed on<br />
<strong>February</strong> 3, <strong>2009</strong><br />
http://www.mdsupport.org/library/ketoconazole.html<br />
Accessed on <strong>February</strong> 3, <strong>2009</strong><br />
Mark your calendars & make your reservations!<br />
ASHP Summer Meeting<br />
June 1417, <strong>2009</strong> Village <strong>of</strong> Rosemont, Illinois
Pharmacy Technician Certification Board (PTCB)<br />
Unveils New Testing Features for <strong>2009</strong>:<br />
PTCB Exam to be Offered daily; Test Results Given to Candidates Immediately<br />
Washington, D.C. – The Pharmacy Technician Certification<br />
Board (PTCB) – the pioneer in the certification <strong>of</strong> pharmacy<br />
technicians - announced that on April 1, <strong>2009</strong>, the PTCB<br />
Examination will be available in continuous testing format at<br />
Pearson Pr<strong>of</strong>essional Centers nationwide. PTCB also announced<br />
that exam candidates will receive an <strong>of</strong>ficial pass or fail result at<br />
the test center after the completion <strong>of</strong> the exam, effective immediately.<br />
The PTCB certification program is the only certification<br />
endorsed by the American Pharmacists Association (APhA), the<br />
American <strong>Society</strong> <strong>of</strong> <strong>Health</strong>-<strong>System</strong> Pharmacists (ASHP), the<br />
National Association <strong>of</strong> Boards <strong>of</strong> Pharmacy (NABP) and other<br />
pr<strong>of</strong>essional pharmacy organizations. The PTCB examination is<br />
administered in all 50 states, DANTES testing centers worldwide,<br />
and in Guam and Puerto Rico, and is included in the regulations<br />
<strong>of</strong> 30 states. The transition to on-demand, year round exam availability<br />
is designed to meet increasing demand from educators,<br />
employers and pharmacy technicians. PTCB candidate demographics<br />
and numbers have expanded steadily over PTCB’s 14<br />
years as the industry leader in certifying pharmacy technicians. In<br />
2008, PTCB tested over 50,000 pharmacy technicians and has<br />
certified 330,425 CPhTs since inception in 1995, through the<br />
examination and transfer process.<br />
"As industry demand continues to grow and more states<br />
like Texas require pharmacy technicians to be PTCB certified as<br />
part <strong>of</strong> the registration process, we recognized the need to evolve<br />
our program," said Melissa Murer Corrigan, RPh, Executive Director<br />
and CEO <strong>of</strong> PTCB. "Similar to NAPLEX (the pharmacist<br />
licensure exam), pharmacy technicians soon will be able to take<br />
the test on-demand and learn their pass/fail status immediately.<br />
These new features will support patient safety and enhance customer<br />
service."<br />
The current quarterly administration <strong>of</strong> the PTCB examination<br />
will conclude on March 31, <strong>2009</strong>. Eligible exam candidates<br />
applying after April 1, <strong>2009</strong> will be authorized to test immediately,<br />
and may schedule an exam appointment in the 90 days<br />
following approval. Candidates will continue to schedule examination<br />
appointments at any <strong>of</strong> the over 200 Pearson Pr<strong>of</strong>essional<br />
Centers nationwide and internationally at DANTES testing centers<br />
in the continuous testing format.<br />
The PTCB national Pharmacy Technician Certification<br />
Examination (PTCE) certification program is accredited by the<br />
National Commission for Certifying Agencies (NCCA).