KEPPRA (levetiracetam) Rx only 250 mg, 500 mg, 750 mg ... - UCB

Treatment should be initiated with a daily dose of 1000 mg/day, given as twice-daily dosing
(500 mg BID). Additional dosing increments may be given (1000 mg/day additional every 2
weeks) to a maximum recommended daily dose of 3000 mg. Doses greater than 3000 mg/day
have been used in open-label studies for periods of 6 months and longer. There is no
evidence that doses greater than 3000 mg/day confer additional benefit.
Pediatric Patients Ages 4 To 40 kg
20 mg/kg/day
(BID dosing)
500 mg/day
(1 x 250 mg
tablet BID)
1000 mg/day
(1 x 500 mg
tablet BID)
Daily Dose
40 mg/kg/day
(BID dosing)
1000 mg/day
(1 x 500 mg
tablet BID)
2000 mg/day
(2 x 500 mg
tablets BID)
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60 mg/kg/day
(BID dosing)
1500 mg/day
(1 x 750 mg
tablet BID)
3000 mg/day
(2 x 750 mg
tablets BID)
The following calculation should be used to determine the appropriate daily dose of oral
solution for pediatric patients based on a daily dose of 20 mg/kg/day, 40 mg/kg/day or 60
mg/kg/day:
Daily dose (mg/kg/day) x patient weight (kg)
Total daily dose (mL/day) = ----------------------------------------------------------------------
100 mg/mL
A household teaspoon or tablespoon is not an adequate measuring device. It is recommended
that a calibrated measuring device be obtained and used. Healthcare providers should
recommend a device that can measure and deliver the prescribed dose accurately, and provide
instructions for measuring the dosage.