Odile Cohen-Haguenauer, M.D., Ph.D.
Odile Cohen-Haguenauer, M.D., Ph.D.
Odile Cohen-Haguenauer, M.D., Ph.D.
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100%<br />
10%<br />
1%<br />
70,00%<br />
60,00%<br />
50,00%<br />
40,00%<br />
30,00%<br />
20,00%<br />
10,00%<br />
0,00%<br />
In vivo reconstitution of humanised NOG mice<br />
% GFP+ cells over 24 weeks<br />
Evolution of CD45+/GFP+ cells<br />
Mouse 7 Mouse 8 Mouse 9 Mouse 10 Mouse 11 Mouse 12<br />
0 5 10 15 20 25<br />
Time (weeks)<br />
Evolution of CD45+ cells<br />
Mouse 7 Mouse 8 Mouse 9 Mouse 10 Mouse 11 Mouse 12<br />
0 5 10 15 20 25<br />
Time (weeks)<br />
<strong>Odile</strong> <strong>Cohen</strong>-<strong>Haguenauer</strong>, ENSC<br />
(collaboration with D. Klatzmann)<br />
Dcaro 4xIns2<br />
Control<br />
24 weeks<br />
Follow-up<br />
CD45+<br />
CD45+CD34<br />
+<br />
In vivo genetic stability of insulator<br />
in hu-HSCs : BM samples week 24<br />
100,00%<br />
10,00%<br />
1,00%<br />
Mouse 7 Mouse 8 Mouse 9 Mouse 10 Mouse 11 Mouse 12<br />
0 5 10 15 20 25<br />
Time (weeks)
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