Odile Cohen-Haguenauer, M.D., Ph.D.

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Evaluation of potential genotoxicity • In vitro: high-throughput IS analysis: collaboration with Christof von Kalle & Manfred Schmidt: – Evolution of integration patterns ingenuity in human cells sequentially sampled over 3 months • no shift in IS distribution • no common integration site emerging – Ongoing studies: in hu primary CD34+ cells • In vivo: cancer-prone mice ongoing studies collaboration with Eugenio Montini Odile Cohen-Haguenauer, ENSC
In vitro genotoxicity studies: design Odile Cohen-Haguenauer, ENSC
Page 1 and 2: New insulated lentivectors mediatin
Page 3 and 4: Odile Cohen-Haguenauer, ENSC Object
Page 5 and 6: 4xIns2 lentis expression in CD34+ce
Page 7: In vitro test: - on 293T - on Jurka
Page 11 and 12: Number of Unique Integration Sites
Page 13 and 14: Integration Sites [%] 10 8 6 4 2 0
Page 15 and 16: -18 Systemic vector injection into
Page 17 and 18: Conclusion 1: Design and evaluation
Page 19 and 20: Chimeric integrases: study design T
Page 21 and 22: 4p ∂Pack ML 3 Chimeric integrases
Page 23 and 24: • Sustained expression of insulat

Odile Cohen-Haguenauer, M.D., Ph.D.

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