Clinical-laboratorial characteristics Toxocara canis serology and ...

Rev Panam Infectol 2010;12(1):47-53.
Table 1. Demographic, clinical-laboratory characteristics
of the hospitalized children with tropical pyomyositis from
January 1997 to July 2008 in Manaus - Amazonas
Retrospective Prospective
Demographic characteristics
Age average
Age in femaleª
7.9 (SD 4.7) 8.4 (SD 4.4)
1 to 5 14 (50.0%) 2 (25.0%)
6 to 10 5 (17.8%) 4 (50.0%)
11 to 14
Age in male
9 (32.1%) 2 (25.0%)
b
1 to 5 20 (29.8%) 6 (40.0%)
6 to 10 17 (25.4%) 2 (13.3%)
11 to 14
Sex
30 (44.8%) 7 (46.7%)
Female 28 (29.5%) 8 (34.8%)
Male
Clinical characteristics
67 (70.7%) 15 (65.2%)
Fever 87 (91.6%) 20 (87.0%)
Indurations 93 (97.9%) 20 (87.0%)
Fluctuation
Single muscle
17 (17.9%) 7 (30.4%)
Involvement
Multiple muscle
63 (66.3%) 15 (67.2%)
involvement
Lab characteristic
32 (33.7%) 8 (34.8%)
Anaemia (Hg < 10,0g) 36 (37.9%) 10 (43.5%)
Eosinophilia (> 6 %) 42 (44.2%) 6 (26.1%)
Leukocytosis (> 10.000) 77 (81.1% 21 (91.3%)
Leukopenia (< 4.000) 1 (1.1%) 0 (0%)
ªx² 3.490 p= 0.175; bx² 3.652 p= 0.161
Table 2. T. canis serology in hospitalized children with
tropical pyomyositis associated by age
50
T. canis serology
Positive Negative
Age 1 to 5 3 (30.0%) 4 (50.0%)
6 to 10 3 (30.0%) 2 (25.0%)
11 to 14 4 (40.0%) 2 (25.5%)
Total 10 (52.6%) 8 (42.1%)
x² 0.80 p= 0.671; N=19; One case (5.3%) resulted serology indeterminate.
for 23 children from the prospective phase and it was
negative for 100% of them. Also T. canis serology was
investigated in this population and was positive for
52.6% (10/19) (table 2).
The majority of patients (83.0% - 98/118) were
diagnosed in the first week of symptoms evolution,
13.6% (16/118) in supurative stage and 3.4% (4/118)
in late stage. There was no significant difference
between the presence of anti-T. canis antibodies and
development of dissemination or complications. Three
of the children with positive serology were diagnosed
in the early stage of the disease and shown severe or
moderate prognostic score (table 3).
It was observed that presence of anemia in the late
stage was statistical significant when compared to the
Table 3. Analyses of the hospitalized children with tropical
pyomyositis morbidity associated to T. canis serology
T. canis serology
Morbidity variables
Fever
Positive Negative
Total
Yes 9 (52.9%) 8 (47.0%) 17 (100%)
No
Muscular Group
1 (100.0%) 0 (0.0 %) 1 (100%)
Single 7 (53.8%) 6 (46.1%) 13 (100%)
Multiple
Clinical stage
3 (60.0%) 2 (40.0%) 5 (100%)
Invasive 9 (60.0%) 6 (40.0%) 15 (100%)
Supurative 1 (33.3%) 2 (66.6%) 3 (100%)
Late
Dissemination
0 (0%) 0 (0%) 0 (100%)
Yes 3 (50.0%) 2 (40.0%) 5 (100%)
No
Complication
7 (53.8%) 6 (46.2%) 13 (100%)
Sim 3 (75.0%) 1 (25.0%) 4 (100%)
Não
Severity score
7 (50.0%) 7 (50.0%) 14 (100%)
Mild 7 (50.0%) 7 (50.0%) 14 (100%)
Moderate 2 (66.6%) 1 (33.3%) 3 (100%)
Severe
Re-hospitalization
1 (100.0%) 0 (0%) 1 (100%)
Yes 1 (100.0%) 0 (0%) 1 (100%)
No 9 (52.9%) 8 (47.1%) 17 (100%)
Table 4. Predisposal features, clinical-laboratory and
morbidity of the tropical pyomyositis in the different
clinical stages
Variables Stages
Initial Supurative Late
Entrance door
Yes 78 13 2
No
Co-morbidity
20 3 2
Yes 3 0 0
No
Muscular group
95 16 4
Single 64 13 1
Multiple
Dissemination
34 3 3
Yes 29 6 0
No
Complications
69 10 4
Yes 15 5 0
No
Re-hospitalization
83 11 4
Yes 4 2 1
No
Anaemia*
94 14 3
Yes 37 5 4
No
Leukocytosis
57 10 0
Yes 82 13 3
No
Leukopenia
12 2 1
Yes 1 0 0
No
Eosinophilia
94 15 4
Yes 37 9 2
No 57 6 2
* x²6.23 p=0.044, by Fisher test.