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LEVAMISOLE HYDROCHLORIDE Catalog Number: 1359302 Revision Date: March 16, 2011 Partition Coefficient: n-octanol/water: log P = 1.84 Percent Volatile: n/f Reactivity in Water: n/f Explosive Properties: n/f Oxidizing Properties: n/f Formula: C11H12N2S . HCl Molecular Weight: 240.75 Copyright © 2011 The United States Pharmacopeial Convention, Inc. All Rights Reserved. n/f = not found Page 4 of 6
LEVAMISOLE HYDROCHLORIDE Catalog Number: 1359302 Revision Date: March 16, 2011 Conditions to Avoid: Avoid exposure to light and moisture. Incompatibilities: Oxidizing agents and strong bases. Decomposition Products: When heated to decomposition, material emits very toxic fumes of NOx, SOx, and HCl. Emits toxic fumes under fire conditions. Stable? Yes Oral Rat: LD50: 180 mg/kg Oral Mouse: LD50: 223 mg/kg Other Toxicity Data: n/f Irritancy Data: n/f Corrosivity: n/f Sensitization Data: n/f Listed as a Carcinogen by: SECTION 11 - TOXICOLOGICAL PROPERTIES NTP: No IARC: No OSHA: No Other Carcinogenicity Data: Chronic administration of high doses (25 mg/kg) in New Zealand Black mice increased the rate and intensity of spontaneous lymphomas. Mutagenicity Data: Levamisole was not found to be mutagenic in dominant lethal studies in male and female mice, in an Ames test, and in a study to detect chromosomal aberrations in cultured peripheral human lymphocytes. Reproductive and Developmental Effects: Fertility and perinatal studies in the rat indicated some decrease in implantation at 120 and 240 mg levels and some decrease in viability over 60 mg per kg. No defect increases were found, but some growth retardation was found at 120 mg per kg. In pregnant rabbits given 90 mg/kg/day, an increase in fetal mortality occurred but no increase in congenital anomalies. Ecological Information: n/f SECTION 12 - ECOLOGICAL INFORMATION SECTION 13 - DISPOSAL CONSIDERATIONS Disposal: Dispose of waste in accordance with all applicable Federal, State, and local laws. SECTION 14 -TRANSPORT INFORMATION Shipping Name: Toxic solid, organic, n.o.s. (Levamisole Hydrochloride) Class: 6.1 UN Number: UN2811 Packing Group: III Hazardous Polymerization? No Additional Transport Information: n/f U.S. Regulatory Information: n/f International Regulatory Information: EINECS # 240-654-6 SECTION 10 - STABILITY AND REACTIVITY SECTION 15 - REGULATORY INFORMATION Copyright © 2011 The United States Pharmacopeial Convention, Inc. All Rights Reserved. n/f = not found Page 5 of 6
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