rptEntry Form Print - US Pharmacopeial Convention
rptEntry Form Print - US Pharmacopeial Convention
rptEntry Form Print - US Pharmacopeial Convention
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LEVAMISOLE HYDROCHLORIDE<br />
Catalog Number: 1359302 Revision Date: March 16, 2011<br />
Conditions to Avoid: Avoid exposure to light and moisture.<br />
Incompatibilities: Oxidizing agents and strong bases.<br />
Decomposition Products: When heated to decomposition, material emits very toxic fumes of NOx, SOx, and HCl. Emits toxic fumes<br />
under fire conditions.<br />
Stable? Yes<br />
Oral Rat: LD50: 180 mg/kg<br />
Oral Mouse: LD50: 223 mg/kg<br />
Other Toxicity Data: n/f<br />
Irritancy Data: n/f<br />
Corrosivity: n/f<br />
Sensitization Data: n/f<br />
Listed as a Carcinogen by:<br />
SECTION 11 - TOXICOLOGICAL PROPERTIES<br />
NTP: No IARC: No OSHA: No<br />
Other Carcinogenicity Data: Chronic administration of high doses (25 mg/kg) in New Zealand Black mice increased the rate and<br />
intensity of spontaneous lymphomas.<br />
Mutagenicity Data: Levamisole was not found to be mutagenic in dominant lethal studies in male and female mice, in an Ames test,<br />
and in a study to detect chromosomal aberrations in cultured peripheral human lymphocytes.<br />
Reproductive and Developmental Effects: Fertility and perinatal studies in the rat indicated some decrease in implantation at 120 and<br />
240 mg levels and some decrease in viability over 60 mg per kg. No defect increases were<br />
found, but some growth retardation was found at 120 mg per kg. In pregnant rabbits given<br />
90 mg/kg/day, an increase in fetal mortality occurred but no increase in congenital<br />
anomalies.<br />
Ecological Information: n/f<br />
SECTION 12 - ECOLOGICAL INFORMATION<br />
SECTION 13 - DISPOSAL CONSIDERATIONS<br />
Disposal: Dispose of waste in accordance with all applicable Federal, State, and local laws.<br />
SECTION 14 -TRANSPORT INFORMATION<br />
Shipping Name: Toxic solid, organic, n.o.s. (Levamisole Hydrochloride)<br />
Class: 6.1<br />
UN Number: UN2811<br />
Packing Group: III<br />
Hazardous Polymerization? No<br />
Additional Transport Information: n/f<br />
U.S. Regulatory Information: n/f<br />
International Regulatory Information: EINECS # 240-654-6<br />
SECTION 10 - STABILITY AND REACTIVITY<br />
SECTION 15 - REGULATORY INFORMATION<br />
Copyright © 2011 The United States <strong>Pharmacopeial</strong> <strong>Convention</strong>, Inc. All Rights Reserved. n/f = not found Page 5 of 6
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