CURRICULUM VITAE Ting Xie, Ph.D. - Kenes
CURRICULUM VITAE Ting Xie, Ph.D. - Kenes
CURRICULUM VITAE Ting Xie, Ph.D. - Kenes
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EDUCATION<br />
<strong>CURRICULUM</strong> <strong>VITAE</strong><br />
<strong>Ting</strong> <strong>Xie</strong>, <strong>Ph</strong>.D.<br />
Associate Investigator<br />
Stowers Institute For Medical Research<br />
1000 East 50 th Street<br />
Kansas City, MO 64110<br />
(816) 926-4061<br />
tgx@stowers-institute.org<br />
1996 <strong>Ph</strong>.D., Molecular Biology and Biochemistry, Rutgers University and the<br />
University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey<br />
1990 M.S., Plant Genetics and Breeding, Beijing Agricultural University, Beijing, China<br />
1987 B.S., Agronomy, Beijing Agricultural University, Beijing, China<br />
RESEARCH AND PROFESSIONAL EXPERIENCE<br />
2005-present Associate Professor<br />
Department of Anatomy and Cell Biology, University of Kansas Medical Center<br />
2004-present Associate Investigator<br />
Stowers Institute for Medical Research, Kansas City, Missouri<br />
Germline stem cell regulation and germ cell development in Drosophila and<br />
mouse; Investigation of molecular mechanisms controlling retinal stem cells and<br />
potential applications of retinal stem cells in the treatment of glaucoma and other<br />
retinal degenerative diseases.<br />
2001-2005 Assistant Professor<br />
Department of Anatomy and Cell Biology, University of Kansas Medical Center<br />
2000-2003 Assistant Investigator<br />
Stowers Institute for Medical Research, Kansas City, Missouri<br />
Germline stem cell regulation and germ cell development in Drosophila and<br />
mouse.<br />
1996-1999 Postdoctoral fellow, Carnegie Institution of Washington/Howard Hughes<br />
Medical Institute, Baltimore, Maryland (with Dr. Allan C. Spradling)<br />
Using Drosophila ovarian germline stem cells as a model system to study adult<br />
stem cell regulation in vivo.
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<strong>Ting</strong> <strong>Xie</strong><br />
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1992-1996 Joint Graduate Program of Molecular Biology and Biochemistry of Rutgers<br />
University and the University of Medicine and Dentistry of New Jersey, New<br />
Brunswick, New Jersey (with Dr. Richard W. Padgett)<br />
Using Drosophila as a model system to study a TGF-β-like signaling pathway.<br />
1991 Teaching Assistant in the Graduate Program of Plant Science and Technology,<br />
Rutgers University, New Brunswick, New Jersey (with Dr. Chee-Kok Chin)<br />
Tissue culture and transformation of asparagus.<br />
1990 Research Scientist in the Institute of Animal Sciences, Chinese Academy of<br />
Agricultural Sciences, Beijing, China (with Professor Huazhu Geng)<br />
Tissue culture and transformation of alfalfa.<br />
1987-1990 Graduate Student in the Department of Agronomy and Graduate Program of Plant<br />
Genetics and Breeding, Beijing Agricultural University, Beijing, China (with<br />
Professor Lanpei Wu)<br />
Asparagus anther cultures.<br />
1986-1987 Undergraduate Honor Research Student in the Department of Agronomy, Beijing<br />
Agricultural University, Beijing, China (with Professor Lanpei Wu)<br />
FELLOWSHIPS AND ACADEMIC HONORS<br />
2003 M. R. and Evelyn Hudson Foundation prize<br />
1992-1995 Busch Predoctoral Fellowship, Rutgers University, New Brunswick, New Jersey<br />
1987 Excellent GPA Award, Beijing Agricultural University, Beijing, China<br />
1984-1987 Highest Academic Honor, Beijing Agricultural University, Beijing, China<br />
PROFESSIONAL AFFILIATION<br />
The Genetics Society of America<br />
The Society of Developmental Biology<br />
The International Society for Stem Cell Research<br />
The Association for Research in Vision and Ophthalmology<br />
RESEARCH GRANT SUPPORT<br />
2002-2006 NIH 1R01 GM64428-01 (Principal Investigator).<br />
“Mechanisms Regulating Germline Stem Cells in Drosophila”<br />
2007-2010 2R01 GM64428-06 (Principal Investigator).
PUBLICATIONS<br />
2/5/07<br />
“Mechanisms Regulating Germline Stem Cells in Drosophila”<br />
Total direct cost, $680,000.<br />
<strong>Ting</strong> <strong>Xie</strong><br />
Page 3 of 8<br />
Zhigang Jin and <strong>Ting</strong> <strong>Xie</strong> (2007). Dcr-1 Maintains Drosophila ovarian stem cells. Current<br />
Biology (in press).<br />
Xiaoqing Song, Gerald B. Call, Daniel Kirilly and <strong>Ting</strong> <strong>Xie</strong> (2007). Notch Signaling Controls<br />
Germline Stem Cell Niche Formation in the Drosophila Ovary. Development (in press).<br />
Zhigang Jin and <strong>Ting</strong> <strong>Xie</strong> (2006). Germline specification: small things have a big role. Current<br />
Biology 16, R966-967.<br />
Rongwen Xi and <strong>Ting</strong> <strong>Xie</strong> (2005). Stem cell renewal regulated by chromatin remodeling factors.<br />
Science 310, 1487-1489.<br />
Rongwen Xi and <strong>Ting</strong> <strong>Xie</strong> (2005). Pelota, a translation regulator, is essential for controlling selfrenewal<br />
and division of germline stem cells in the Drosophila ovary. Development 132, 5365-<br />
5374.<br />
Daniel Kirilly, Eric Spana, Norbert Perrimon, Richard Padgett and <strong>Ting</strong> <strong>Xie</strong> (2005). BMP<br />
signaling is required for maintaining somatic stem cells in the Drosophila ovary. Developmental<br />
Cell 9, 651-662.<br />
Rongwen Xi, Daniel Kirilly and <strong>Ting</strong> <strong>Xie</strong> (2005). Differences between germline stem cells and<br />
somatic stem cells. Curr. Opin. Genet. Dev. 15, 381-387.<br />
Linheng Li and <strong>Ting</strong> <strong>Xie</strong> (2005). Stem cell niche: Hypothesis, concept, structure and function.<br />
Annu. Rev. Cell Dev. Biol. 21, 605-631.<br />
Marco Wong, Zhigan Ji and <strong>Ting</strong> <strong>Xie</strong> (2005). Molecular and genetic mechanisms underlying<br />
stem cell regulation in the Drosophila ovary. Annu. Rev. Genet 39, 173-195.<br />
<strong>Ting</strong> <strong>Xie</strong>, Eihachiro Kawase, Daniel Kirilly and Marco D. Wong (2005). Intimate relationships<br />
with their neighbors: tales of stem cells in Drosophila reproductive systems. Developmental<br />
Dynamics 232, 775-790.<br />
Xiaoqing Song, Marco D. Wong, Eihachiro Kawase, Rongwen Xi, Bee C. Ding, John J.<br />
McCarthy and <strong>Ting</strong> <strong>Xie</strong> (2004). BMP signals from niche cells directly repress transcription of a<br />
differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary.<br />
Development 131, 1353-1364.
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Eihachiro Kawase Marco D. Wong, Bee C. Ding and <strong>Ting</strong> <strong>Xie</strong> (2004). Two BMP-like signaling<br />
pathways directly control the maintenance of germline stem cells in the Drosophila testis.<br />
Development 131, 1365-1375.<br />
Xiaoqing Song and <strong>Ting</strong> <strong>Xie</strong> (2003). The wingless signaling is required for the maintenance and<br />
proliferation of somatic stem cells in the Drosophila ovary. Development 103, 3259-3268.<br />
Chun-Hong Zhu and <strong>Ting</strong> <strong>Xie</strong> (2003). Clonal expansion of ovarian germline stem cells during<br />
niche formation in Drosophila. Development 130, 2579-2588.<br />
Xiaoqing Song and <strong>Ting</strong> <strong>Xie</strong> (2002). DE-cadherin-mediated cell adhesion is essential for<br />
maintaining somatic stem cells in the Drosophila ovary. Proc. Natl. Acad. Sci 99, 14813-8.<br />
Xiaoqing Song, Chun-Hong Zhu, Chuong Doan and <strong>Ting</strong> <strong>Xie</strong> (2002). Germline stem cells<br />
anchored by adherens junctions in the Drosophila ovary niches. Science 296, 1855-1857.<br />
<strong>Ting</strong> <strong>Xie</strong> and Allan C. Spradling (2001). The Drosophila ovary: an in vivo stem cell system.<br />
Stem Cell Biology (Cold Spring Harbor Monograph Series), D. R. Marshak, R. L. Gardner and<br />
D. Gottlieb, eds., 129-148.<br />
<strong>Ting</strong> <strong>Xie</strong> and Allan C. Spradling (2000). A niche maintaining germ line stem cells in the<br />
Drosophila Ovary. Science 290, 328-330.<br />
Zhao Liu, <strong>Ting</strong> <strong>Xie</strong> and Ruth Steward (1999). Lis1, the Drosophila homolog of human<br />
lissencephaly disease gene is required for germline cell division and oocyte differentiation.<br />
Development 126, 4477-4488.<br />
<strong>Ting</strong> <strong>Xie</strong> and Allan C. Spradling (1998). decapentaplegic is essential for the maintenance and<br />
division of germline stem cells in the Drosophila ovary. Cell 94, 251-260.<br />
A. C. Spradling, M. De Cuevas, D. Drummond-Barbosa, L. Keyes, M. Lily, M. Pepling, and<br />
<strong>Ting</strong> <strong>Xie</strong> (1997). The Drosophila germarium: stem cells, germline cysts and oocytes. Cold<br />
Spring Harbor Symposia on Quantitative Biology Vol. LXII, 25-34.<br />
Alyce L. Finelli, <strong>Ting</strong> <strong>Xie</strong>, Cyndy C. Bossie, Ronald K. Blackman, and Richard W. Padgett<br />
(1995). The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila<br />
development. Genetics 141, 271-281.<br />
Richard W. Padgett, Alyce L. Finelli, Cathy C.Savage, <strong>Ting</strong> <strong>Xie</strong>, and Soe-Hee Cho (1995). The<br />
tolloid-related genes in invertebrates. The Astacins-Structure and Function of a New Protein<br />
Family, R. Zwilling and W. Stocker, eds.<br />
<strong>Ting</strong> <strong>Xie</strong>, Alyce L. Finelli and Richard W. Padgett (1994). The Drosophila saxophone gene: a<br />
serine-threonine kinase receptor of TGF-β superfamily. Science 263, 1756-1759.
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Alyce L. Finelli, Cyndy C. Bossie, <strong>Ting</strong> <strong>Xie</strong> and Richard W. Padgett (1994). Mutational analysis<br />
of the Drosophila tolloid gene, a human BMP-1 homologue. Development 120, 861-870.<br />
JOURNAL AFFILIATIONS<br />
2004-present: the editorial board of Developmental Dynamics<br />
2005-present: the editorial board of Current Stem Cell Research & Therapy<br />
2006-Present: the editorial board of Cell Research<br />
Ad Hoc Reviewer: Cell<br />
Current Biology<br />
Development<br />
Developmental Biology<br />
Developmental Cell<br />
Developmental Dynamics<br />
Genes & Development<br />
Genetics<br />
Genesis<br />
Journal of Cell Science<br />
Mechanism of Development<br />
Oncogene<br />
PNAS<br />
Nature<br />
Science<br />
Stem Cells<br />
INVITED PRESENTATIONS<br />
Dec, 2007 International stem cell meeting in Dominican Republic<br />
Nov, 2007 International stem cell meeting in Shanghai<br />
Oct, 2007 University of New Mexico<br />
Sept, 2007 Ottawa Health Research Institute<br />
July, 2007 Chinese Society of Biological Investigators meeting in Beijing<br />
June, 2007 Developmental Biology Gordon Conference<br />
June, 2007 International stem cell meeting in Israel<br />
May, 2007 University of Texas Southwestern Medical center<br />
May, 2007 Nanotechnology session, ARVO meeting
March, 2007 Sigma Xi, University of Kansas Chapter<br />
March, 2007 Keystone Stem Cell Meeting<br />
Mar, 2007 Stem Cell Symposium in Israel<br />
Nov, 2006 Stem Cell Symposium in Turkey<br />
Aug, 2006 Primate Research Conference in Yunan, China<br />
2/5/07<br />
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Institute for Biochemistry and Cell Biology, Chinese Academy of Sciences,<br />
Shanghai, China<br />
May, 2006 Department of Biology, McGill University, Montreal, Canada<br />
Mar 2006 Department of Biology, University of Utah, Salt Lake City<br />
Feb, 2006 Department of <strong>Ph</strong>armacology, University of Kansas, Kansas City<br />
Jan, 2006 Division of <strong>Ph</strong>armaceutical Sciences, University of Missouri-Kansas City<br />
Dec, 2005 Minisymposium “Differentiation and Cancer” at the 45 th Annual Meeting of the<br />
American Society for Cell Biology<br />
Nov 2005 Department of Cell Biology, Harvard Medical School, Boston<br />
Van Andel Research Institute, Grand Rapids<br />
July 2005 Institute of Zoology, Chinese Academy of Sciences (CAS), China<br />
Institute of Biophysics, CAS, China<br />
Institute of Genetics and Developmental Biology, CAS, China<br />
National Institute of Biological Sciences, Beijing, China<br />
Peking University, Beijing, China<br />
June 2005 The Third International Society of Stem Cell Research Conference<br />
Jan 2005 The International Glaucoma Conference at Myanmar<br />
Oct 2004 Germ Cells, Cold Spring Harbor Laboratory<br />
Sept 2004 The Glaucoma Foundation’s Eleventh Annual International Think Tank, New<br />
York<br />
July, 2004 The 10 th SCBA annual meeting at Beijing<br />
June, 2004 The Crete Drosophila Conference, Greece
2/5/07<br />
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June, 2004 The Second International Society of Stem Cell Research Conference at Boston<br />
April, 2004 Institute of Zoology, Chinese Academy of Sciences, Beijing<br />
April, 2004 Institute of Microbiology, Chinese Academy of Sciences, Beijing<br />
April, 2004 International Glaucoma Conference, Beijing<br />
Mar, 2004 Stem Cell Workshop at the 45 th Annual Drosophila Conference<br />
Mar, 2004 Waksman Institute, Rutgers University<br />
Feb. 2004 The Children’s Hospital Medical Center at Cincinnati<br />
Nov. 2003 The Biennal Kansas-Missouri Reproductive Biology Symposium<br />
Sept 2003 The Glaucoma Foundation’s Tenth Annual International Think Tank, Boston<br />
June 2003 The Eye Foundation, UMKC medical School<br />
Dec 2002 Stowers Institute for Medical Research<br />
Nov 2002 University of Missouri-Columbia, Department of Animal Sciences<br />
Oct 2002 University of Missouri-Kansas City, Department of <strong>Ph</strong>armacology<br />
July 2002 The Glaucoma Foundation’s Ninth Annual International Think Tank, Chicago,<br />
Illinois<br />
May 2002 Midwest Developmental Biology Meeting, Columbia, Missouri.<br />
April 2002 43rd Annual Drosophila Research Conference, San Diego, California<br />
Feb 2002 University of Kansas Medical Center, Department of Biochemistry and Molecular<br />
Biology, Kansas City, Kansas<br />
October 2001 Institute of Zoology, Chinese Academy of Sciences, Beijing, China<br />
August 2001 University of Kansas Medical Center, Department of Cell Biology and Anatomy,<br />
Kansas City, Kansas<br />
March 2001 42nd Annual Drosophila Research Conference, Gametogenesis session<br />
Sept 2000 University of Missouri-Columbia, Division of Biological Sciences
GRANT REVIEW<br />
2006 Steering committee for K-INBRE (Kansas)<br />
2005 Cancer UK<br />
2004 The Glaucoma Foundation, New York<br />
Israel Science Foundation<br />
Ad hoc NIH review panel for stem cell aging<br />
2003 The Glaucoma Foundation, New York<br />
University of Kansas Medical Center Lied Pilot grant review panel<br />
Austrian Science Fund<br />
2002 The Glaucoma Foundation, New York<br />
2002 University of Kansas Medical Center, intramural<br />
2000 University of Missouri-Kansas City, intramural<br />
SERVICE AND COMMITTEE ASSIGNMENTS<br />
2/5/07<br />
<strong>Ting</strong> <strong>Xie</strong><br />
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2000-2002 Animal Care and Use Committee (IACUC), Chair, Stowers Institute for Medical<br />
Research<br />
TEACHING<br />
2006 Advanced Cell and Developmental Biology<br />
2005 Advanced Cell and Developmental Biology<br />
2004 Advanced Cell and Developmental Biology<br />
2003 Graduate Seminar Course<br />
PREVIOUS AND CURRENT TRAINEES<br />
Trainees Period Current Position<br />
Gerald Call, <strong>Ph</strong>D 1/02-2/04 HHMI Instructor<br />
Eihachiro Kawase, <strong>Ph</strong>D 6/01-10/04 Assistant professor<br />
Kyoto University<br />
Chun-Hong Zhu, <strong>Ph</strong>D 5/01-4/03<br />
Dazhi Liu, University of Kansas 6/03-12/05 Master’s degree<br />
Rongwen Xi, <strong>Ph</strong>D 1/03-1/2006 Assistant professor<br />
National Institute of<br />
Biological Sciences<br />
Marco Wong, <strong>Ph</strong>D and MD; 5/03-Current Postdoc<br />
Jiaxi Zhou 10/04-Current Postdoc<br />
Zhigang Jin 2/05-current Postdoc<br />
Changjiang Weng 10/05-current Postdoc<br />
Daniel Kirilly, University of Kansas 9/02-9/06 postdoc in Signapore<br />
Shuyi Chen, University of Kansas 6/03-Current Graduate Student<br />
Lei Pan, Chinese Academy of Sciences 2/06-Current Visiting student
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