Connective Tissue Formation in Wound Healing - E-thesis
Connective Tissue Formation in Wound Healing - E-thesis
Connective Tissue Formation in Wound Healing - E-thesis
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Immunohistochemistry 57<br />
In Situ hybridization 57<br />
Analysis of mRNA 58<br />
Probes 59<br />
Preparation of rat probes for type V collagen and MMP-2 and -9 60<br />
Statistical analysis 61<br />
RESULTS 62<br />
Sponge implants [ I and II ] 62<br />
Interstitial collagens <strong>in</strong> granulation tissue [ I and II ] 63<br />
MMP-2 and MMP-9 <strong>in</strong> granulation tissue [ III ] 65<br />
Growth factors <strong>in</strong> granulation tissue [ IV ] 67<br />
DISCUSSION 70<br />
Type I, III and V collagens <strong>in</strong> wound heal<strong>in</strong>g 71<br />
MMP-2 and MMP-9 <strong>in</strong> wound heal<strong>in</strong>g 73<br />
CTGF, TGF-β and PDGF <strong>in</strong> wound heal<strong>in</strong>g 75<br />
CONCLUSIONS 78<br />
ACKNOWLEDGEMENTS 80<br />
REFERENCES 82