NutraNews - DSM Nutritional Products newsletter 3/2012

No. 3 | 2012
NutraNews
DSM Nutritional Products Customer Magazine
www.nutranews.com
DSM‘s first dietary enzyme: Tolerase L
Essentials for vegetarians
Ultimate UV Protection for day care and sun care
SYN ® -TC – Another breakthrough product
in the quest for smooth skin
Are all carbohydrases the same?
Vitamin D:
the sunshine vitamin
NutraNews | No. 3: 2012 1

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Focus: Human Nutrition & Health
DSM launches the first dietary
enzyme: Lactose intolerance digestive
aid, Tolerase L
DSM launched the first dietary enzyme
in its new health benefit platform
‘Digestive Health’ at Vitafoods in Geneva
in May this year. DSM’s aim is to serve
dietary supplements manufacturers
globally, capitalizing on increased
consumer demand for products that
support digestive health.
Tolerase L is a highly effective
digestive aid for people who suffer from
lactose intolerance. It is an acid lactase
that converts lactose, a milk sugar naturally
present in dairy products, into glucose and
galactose. Approximately half the world’s
population are lactose intolerant and do not
produce any or sufficient quantities of
lactase. This leads to symptoms of
discomfort including bloating, gas, diarrhea
and abdominal cramps once the undigested
lactose reaches the large intestine.
Tolerase L acts at a low pH (optimum
activity from 3.5 to 5.5) to digest lactose in
the stomach and relieve these symptoms.
The science behind acid lactase is supported
by a positive opinion from the European
Food Safety Authority (EFSA), which has
concluded that “the lactase enzyme
contributes to breaking down lactose”.
Later this year Tolerase P will be
launched. Phytase (P) is an enzyme that
NutraNews | No. 3: 2012
Quality for Life in action: DSM’s NUTRI-FACTS
website recognized as an online provider of
objective, high-quality health information
Through DSM’s Quality for Life promise,
we aim to be a reliable partner and industry
member. This includes a dedicated
commitment to sound nutrition science.
This ambition was well illustrated in June 2012,
when www.nutri-facts.org was awarded the
3 Milk
3 Pasta
3 Pizza
3 Butter
3 Doughnuts
3 Bread
3 Pancakes
3 Ice cream
3 Biscuits
3 Cereal
helps the body absorb iron, zinc, calcium,
magnesium and phosphorus from cereal and
legume-based foods. Phytase does this by
breaking down the molecule phytate which
is rich in those foods. It releases the minerals
and makes them bioavailable for the
human body.
HONcode certification, the highest and most
trustworthy ethical standard for medical and
health-related information available on the
internet. The code of conduct of the Health on
the Net Foundation, a non-governmental
organization internationally known for its work
in the field of health information ethics,
evaluates the quality of a website in terms of
how useful, objective and transparent its
information is for health professionals and the
general public.
Typical applications for Tolerase P are
Base-of-the-Pyramid nutrition, breakfast
supplements and cereals, and pasta.
Wouter Nieboer
Global Business Manager
– Human Nutrition & Health
wouter.nieboer@dsm.com
NUTRI-FACTS offers easily accessible
information on the latest scientific news and
established facts about micronutrients in
multiple languages. Launched in 2010, the
website is now visited by 19,000 individual
users from the food industry, healthcare
professionals, and media representatives each
month. In addition, NUTRI-FACTS has
successfully established itself on Facebook
(with more than 6,000 fans and friends) and
Twitter (with about 2,000 followers).

Essentials for vegetarians Latest news
As part of our ongoing effort to deliver
solutions that help create brighter lives,
DSM has introduced the “Essentials for
Vegetarians” Health Benefit Solution
platform. Essentials for Vegetarians allows
DSM to address a strong customer desire
for solutions that reach the broadest
possible range of consumers and address
the needs of a large and growing global
consumer segment.
With an estimated 1.4 billion consumers
considered either vegetarian or semivegetarian,
this platform puts DSM out front in
serving the needs of a large consumer base
that has been the biggest single segment of
food product launches over the past two years.
DSM offers solutions designed specifically for
the nutritional needs of vegetarians as well as
addressing the even larger opportunity
represented by customers who wish to make
their products more inclusive for all
consumers, including vegetarians.
There are three primary points of focus for
vegetarians within the DSM portfolio. One is
life’sDHA – DSM’s proprietary omega-3
brand produced from algae. This provides the
Human Nutrition & Health
Events
FI South America
September 18 — 20, São Paulo, Brazil
www.fi-events.com.br/fi
Intl. Food Technology Summit & Expo
September 26 — 27, Mexico DF, Mexico
FI Asia
October 3 — 5, Jakarta, Indonesia
http://fiasia-indonesia.
ingredientsnetwork.com/
Hi Japan
October 3 — 5, Tokyo, Japan
www.hijapan.info
Intl. Food Technology Summit & Expo
October 24, Buenos Aires, Argentina
SupplySide West
November 5 – 9, Las Vegas, NV
XVI Congreso de la Sociedad
Latinoamericana de Nutrition (SLAN)
November 11 – 16, Cuba
FI Europe
November 13 – 15, Frankfurt, Germany
http://hieurope.ingredientsnetwork.com
Resveratrol conference
December 5 – 7, Leicester, UK
only reliable long-chain PUFA solution for
vegetarian consumers around the globe and fits
perfectly with our desire to expand the life’sDHA
brand to consumers around the world.
In addition DSM will introduce Tolerase P
– a phytase enzyme solution that breaks down
phytate in cereals and legume-based foods.
By breaking apart the phytate in these foods,
trapped minerals are freed for better
absorption in the human body. Tolerase P
also protects minerals added to these foods,
providing manufacturers an important new
dimension for combating mineral deficiency
around the world.
Finally, DSM produces more animal-free forms
across our ingredient portfolio than any other
manufacturer in the industry. This important
differentiator enables our customers to make
their key products appeal to a wider base of
consumers, including the growing vegetarian
population around the world.
Doug Brown
Global Marketing
Manager Dairy
doug.brown@dsm.com
DSM to acquire Ocean
Nutrition Canada to
expand its Nutritional
Lipids growth platform
DSM announced today that it has entered
into a definitive agreement with Clearwater
Fine Foods and funds managed by
Richardson Capital to acquire Ocean
Nutrition Canada for a total enterprise
value of CAD 540 million. Subject to
customary conditions, the transaction is
expected to close in H2 2012.
DSM announces new
research revealing how a
B vitamin can help lower
blood pressure
Research conducted by the University of
Ulster and published in the American
Journal of Clinical Nutrition, reveals a new
link between vitamin B2 and curbing high
blood pressure.
Around 10% of the UK population has a
specific genetic factor which can lead to
high blood pressure. The new study from
the Northern Ireland Centre for Food and
Health (NICHE) reveals that vitamin B2
can successfully lower blood pressure
within this genetically at-risk group, to an
extent that could cut the risk of stroke
death by as much as 30%.
DSM presents dietary
vitamin intakes using ‘traffic
lights’ which suggest
widespread inadequacies
in the Western World
A new assessment published in the
British Journal of Nutrition suggests that
three quarters of the population in
Germany, the UK, and the USA, does not
meet the dietary intake
recommendations of the respective
countries for a number of essential
micronutrients. Based on large-scale
population-based national dietary intake
surveys, scientists at DSM evaluated data
using a traffic light system to measure
actual intakes against national
recommendations in the UK, Germany,
the Netherlands and the USA.
Further information can be found on
www.dsmnutritionalproducts.com
NutraNews | No. 3: 2012 3

Ultimate UV Protection for day care
and sun care
Health organizations around the world are
relentless in reminding the consumer of the
detrimental effects of excessive sunbathing
and the importance of using minimum SPF
15 sunscreen products. The avoidance of
sunburn is widely accepted and is, of
course, also strongly personally motivated
as it prevents discomfort. Preventing skin
redness (erythema) is seen by most
consumers as a proof that their protection
strategy has worked. Moreover there is
even a belief that an absence of visible
damage means there is no further damage
to the skin.
Unfortunately this is wrong. UV rays are quietly
causing DNA mutations, oxidative stress and
immunosuppression from the moment we
expose ourselves to sunlight and up to the
point when our skin shows the first discernible
warning signals. The smallest UV light dosage
necessary to cause sunburn is called 1 Minimal
Erythemal Dosage (MED). As long as the
radiation intensity stays below sunburn, it is
called “sub-erythemal”, and energies can be
measured in parts of an MED.
Evaluation of human skin biopsies after UV
exposure is a helpful tool to identify suberythemal
UV damage. By this experimental
set-up we have shown that even at 0.6 MED UV
light substantial DNA damage occurs, in
particular when the sub-erythemal dosage is
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Focus: Personal Care
NutraNews | No. 3: 2012
accumulated over several days – quite a
common situation during the summer months.
In fact, a 20-minute summer lunch break in
Paris could drive some areas in an exposed
facial site of a skin type 2 person to 0.7 MED,
and 30 min to slight sunburn, even.
There is a definite need to counteract this daily
exposure with at least a moderate SPF of 15 to a
level below 0.1 to 0.2 MED.
Taking the typically applied amount of a SPF 15
facial cream into account, a dosage of 0.1–0.2
MED would be reached in about two hours. At
that time sub-erythemal UVA damage also
plays a role in adding significant aging stress to
the dermal tissue. Therefore a daily care formula
needs adequate UVA protection as well.
Particularly for facial care it makes sense to go
beyond the EU recommended UVA-PF of 3:1.
What about beach holidays? Consumers seek to
spend time in the sun, and they require a
significantly higher level of protection. Easily
repeated sub-erythemal dosages would be
reached when using only the recommended
minimum of a SPF 15 sunscreen – often
consumers experience even sunburn. A
minimum of SPF 30 is therefore required.
To address all customer needs more than this
has to be considered, however. The sunscreen
formula must offer appealing features in order
Breakthrough
product plus
other exciting
innovations
that the consumer enjoys applying it. Only this
will ensure a sufficient application amount on
the skin. The consumer has only a sensory
endpoint to stop applying the product!
Therefore as much effort as goes into the
selection of the right UV filter combination
should also go into optimizing the texture.
This makes for ultimate UV protection.
Dr. Jürgen Vollhardt
Competence Manager R&D Personal Care
juergen.vollhardt@dsm.com
Personal Care
Events
IFSCC
October 15 – 18, Johannesburg,
South Africa
www.ifscc2012.co.za/coschem/index.cfm
Sepawa Congress
October 23 – 25, Fulda, Germany
www.sepawa.de/index/sepawa_2012/
sepawa_business.html
Suppliers Day at SEQC
October TBC, Madrid, Spain
In-Cosmetics Asia
November 6 – 8, Bangkok, Thailand
www.in-cosmeticsasia.com
Formulate SCS
November TBC, UK

SYN ® -TC – Another breakthrough
product in the quest for smooth skin
On 1 July 2012, DSM globally launched its
breakthrough new peptide complex
SYN ® -TC which has a rapid skin-smoothing
action. This innovative product further
extends the successful SYN ® -Peptides
product range, creating yet more choice for
consumers, who greatly value the beauty of
smooth skin.
The group of naturally occurring proteins known
collectively as collagen is the most abundant
protein in skin. It is the main component in
connective tissue and anchors the epidermis
(the outermost layer of skin) to the dermis,
which in turn protects the body’s subcutaneous
tissues. Collagen therefore makes a major
contribution to the appearance of the skin,
producing the firm and smooth look desired by
consumers. Collagen levels in the body
naturally decrease with age, however. The use
of state-of-the-art skin care ingredients helps to
deploy the unique capacities of collagen
against the signs of premature skin ageing.
Various types of collagen exist. Skin care
products have traditionally focused primarily on
collagen I, using ingredients to stimulate this
form of collagen to smooth the skin. Other
types of collagen, however – most notably
types III, IV, VII, and XVII – also make a major
contribution to the functionality of the skin.
SYN ® -TC makes use of three tailor–made
peptides (short polymers of amino acid
monomers linked by peptide bonds) to increase
in vitro the formation of undamaged, stable and
homogenous collagen types in the skin. These
best-in-class synthetic peptides have been
formulated and combined to achieve a visible
benefit for smoother skin and an overall
improved young looking skin appearance.
Extended in vitro studies using macro
photographs and computer-based
3-dimensional skin imaging have confirmed a
visible benefit in only 28 days.
SYN ® -TC is the result of DSM’s consumer-driven
approach to generate added value for its
customers by offering an exciting new cosmetic
ingredient with rapid action for skin smoothing.
Mathias Gempeler
Senior Global Marketing Manager Skin Care
mathias.gempeler@dsm.com
NutraNews | No. 3: 2012 5

6
Focus: Animal Nutrition & Health
DSM’s Optimum Vitamin Nutrition
concept to appear as e-book
Following the appearance of the 12 th
edition of DSM’s Optimum Vitamin
Nutrition (OVN) levels in
February of this year, this work has
been made available as an e-book in
cooperation with 5M publishing.
Electronic copies in PDF format can
be purchased and downloaded from
www.optimumvitaminnutrition.com
Independent nutritionists from around the
world and nutritionists from DSM reflect
scientific advances on animal performance
and production, as well as changing
industry conditions.
Latest news
DSM expands Italian
premix offering with
products for the homemixing
industry
DSM is pleased to announce the
acquisition of the Italian animal health
and nutrition premix specialist Cilpaz
S.r.l. through its Italian operation Istituto
delle Vitamine S.p.A. This acquisition is
a further milestone in the
implementation of DSM’s strategy DSM
in Motion: driving focused growth.
Continued value growth within the
company’s Nutrition cluster of businesses
is a key component of this strategy.
DSM to acquire Tortuga
to strengthen animal
nutrition business
DSM announced that it has entered into
a definitive agreement to acquire
Tortuga Companhia Zootécnica Agrária
(Tortuga) in an all cash transaction for a
total enterprise value of about €465
million (BRL 1,160 million). Depending
on the actual 2012 EBITDA result, an
adjustment in the purchase price up to
a maximum enterprise value of about
€490 million can be made, based on
the same EBITDA-multiple. Subject to
customary conditions, the transaction is
expected to close in Q1 2013.
Further information can be found on
www.dsmnutritionalproducts.com
NutraNews | No. 3: 2012
The resulting book, Optimum Vitamin Nutrition
– in the Production of Quality Animal Foods,
comprises seven chapters that will provide a
phantastic reference for the many nutritionists,
veterinarians and other technicians around the
world involved in animal nutrition.
The book will also provide a useful basis for
future research into the as-yet undiscovered
See you at EuroTier 2012!
This year DSM will again be participating
at EuroTier, the world’s leading exhibition
for animal husbandry.
At EuroTier 2010, some 140,000 visitors –
approximately 24,000 of them from outside
Germany – came to gather information about
machinery and equipment, genetics, farm
inputs and services for modern animal
husbandry as well as potentials in the field of
bioenergy and local energy supply. More than
1,900 exhibitors were present.
ways in which vitamins can play a role in
providing a growing global human population
with adequate quantities of nutritious and safe
food in a sustainable way, respecting both
animal welfare and the environment.
Gilberto Litta
Global Category Manager Vitamins
gilberto.litta@dsm.com
EuroTier 2012 will be held at the Exhibition
Grounds in Hanover from 13–16 November.
The DSM Nutritional Products Animal Nutrition
& Health team looks forward to welcoming
you to booth G-21 in Hall 14 (14-G21) this year.
Our colleagues from DSM Biogas will also be
participating at this year’s BioEnergy exhibition.
Maria-del-Mar Arteaga
Promotions & Launch Manager, Europe
maria-del-mar.arteaga@dsm.com

Are all
carbohydrases
the same?
Carbohydrates in cereals and defatted
protein sources are the main source of
energy in all livestock diets.
In common feed ingredients, they fall into
two categories:
1. Storage carbohydrates such as starch and
simple sugars, which are relatively easy to
digest, but not 100 % digestible.
2. Structural carbohydrates that include
dietary fibers commonly referred to as
non-starch polysaccharides (NSP). These are
primarily located in the cell wall of every cell
in the plant.
To access and utilize the starch inside the cells,
the cell wall must be broken down. The
composition of the cell wall varies greatly from
cereal to cereal. This means that different
carbohydrases are required to start the process
of nutrient release.
In cereals (maize, wheat, barley and rye) the cell
wall is chiefly made up of arabinoxylans and
beta-glucans. To successfully break down these
cell walls, the animal requires enzymes called
xylanases and beta-glucanases. These must be
provided with the feed, as the animal does not
secrete them. On the other hand, in plants such
as the main protein crops (soybeans, sunflower,
rape and canola) the cell wall is composed of
xyloglucans and pectin. These are more difficult
to break down and require the action of other
enzymes (glucanases and pectinases).
Even with fine grinding, some cell walls will only
be partly degraded, while others will remain
intact. This means that the nutrients inside the
cell remain largely inaccessible to the animal.
Adding exogenous carbohydrases to the diet
therefore increases the extent of cell wall
breakdown and improves nutrient digestibility.
It is thus quite obvious that not all
carbohydrases are the same. It therefore follows
that commercial products cannot be classed as
‘all being the same’. For example, a diet rich in
barley (that contains primarily beta-glucans)
will require a beta-glucanase to fully take
advantages of the benefits of an exogenous
carbohydrase. By contrast, a diet rich in wheat
(that contains primarily arabinoxylans) requires
a xylanase.
Depending on the raw material being used, the
appropriate carbohydrase should be selected
for maximum efficiency!
Inge Knap
Global Category Manager Feed Enzymes
inge.knap@dsm.com
Animal Nutrition & Health
Events
International Poultry & Pig show
Japan 2012
September 20 — 22, Montreal, Canada
www.aabp.org
VIV China
September 23 — 25, Beijing, China
www.vivchina.nl/en/Exposant.aspx
DSM European Pig Conference
September 25 — 26, Poznan, Poland
World Dairy Expo
October 2 – 6, Madison, WI, USA
www.worlddairyexpo.com
Philsan Convention
October TBC, Manila, Philippines
100 years anniversary event
November 1, Tokyo, Japan
www.eurotier.com
November 13 – 16, Hannover, Germany
http://www.eurotier.com/
Aquaculture Conference
Asia Pacific 2012
November 21 – 23, Bangkok, Thailand
NutraNews | No. 3: 2012 7

Vitamin D – ‘The Sunshine Vitamin’
As we celebrate the 100 th anniversary of
vitamins, let us call to mind the crucial role
they play in our health and wellbeing.
Vitamin D, known as the ‘sunshine vitamin’,
is crucially important to both human and
animal health.
The main benefits of vitamin D include:
• Bone health – improves bone mineral
density and is crucial in aiding calcium
absorption;
• Muscle strength – allows the maintenance
of normal muscle function;
• Immune system support.
A ‘bright’ nutrient for human health
Unlike other types of vitamins which are
primarily acquired through dietary sources, the
major source for vitamin D is the sun. This may
lead to deficiency, particularly as vitamin D is
not abundant in food. The main food sources of
Vitamin D are sardines, salmon, mackerel,
meat, milk and eggs. However, one would need
to consume around 40 eggs per day to meet
the recommended daily intake.
Vitamin D deficiency is thought to be the most
common medical condition in the world today,
and is a major health challenge globally. It can
lead to rickets or osteoporosis – a condition
that reduces the quality and density of the
bones, which in turn may increase the risk of
falling and of subsequent bone fractures. More
recently, evidence of additional health
benefits associated with vitamin D have
emerged, including enhancement of the
immune system, reduction of blood pressure,
and lowering the risk of diseases including
colon cancer and multiple sclerosis.
Colophon
NutraNews is published quarterly by DSM Nutritional Products Ltd. P.O. Box 2676, Building 241, 4002 Basel, Switzerland.
Editorial Board: S. Adamietz, K. Cselovszky, C. Frederiksen, C. Hafner, A. Hehir, D. Laue
Designer: V-One Design Solutions Ltd, Dunstable, United Kingdom
Translation: transparent ® Language Solutions GmbH, Berlin, Germany
Printer: Burger Druck, Waldkirch, Germany
The NutraNews team welcomes comments and suggestions: nutranews.dnp@dsm.com
www.nutranews.com © DSM Nutritional Products Ltd. 2012
Disclaimer: Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the accuracy,
reliability, or completeness of the information. This brochure only contains scientific and technical information for business to business use. Country or region-specific information
should also be considered when labelling or advertising to final consumers. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is
distributed without warranty of any kind, either expressly or implied. In no event shall DSM be liable for any damages arising from the reader’s reliance upon, or use of, these materials.
The reader shall be solely responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please
contact your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlands and/or other
countries unless explicitly stated otherwise.
8
NutraNews | No. 3: 2012
The elderly are one group at greater risk of
deficiency, as they have a reduced capacity to
synthesize vitamin D in the skin through
exposure to sunlight. Infants, the overweight or
obese, vegetarians and people who are
home-bound are also potentially at risk of
vitamin D deficiency. To avoid the adverse
effects of vitamin D deficiency and capitalize
on its benefits, both researchers and medical
experts recommend supplementation of the
diet. In addition, several major developed
nations have recently announced significant
increases in their daily intake recommendations
for this vital nutrient, a potent reminder that all
age groups of all populations should make
sure they are getting enough vitamin D.
Optimizing animal health
Vitamin D is essential not only for humans, but
also for animals. Vitamin D and its metabolites
DSM and the International Osteoporosis
Foundation (IOF) have joined forces to
launch an interactive global map on vitamin
D deficiency. The
aim of this initiative,
launched in
September, is to
illustrate vitamin D
status worldwide
and raise awareness
among policymakers
and the
public at large of
vitamin D
insufficiency and
the need for action.
The map, based on scientific evidence,
shows that there levels of vitamin D vary
greatly between countries. Contrary to
popular belief, warmer countries are not
give poultry, for example, the boost they need
to cope with the challenges of modern poultry
farming. Vitamin D also enables the birds to
develop better skeletal strength, stronger eggs
and healthier chicks, and to deliver better
breeding results. Healthier animals mean
healthier people. Scientific studies have
demonstrated a direct link between optimum
vitamin nutrition for farm animals and the
nutritional value of food of animal origin. For
example, the vitamin content in eggs is directly
related to the vitamin content in the hen’s diet.
This means that when hens are given more
vitamins, they lay more nutritious eggs.
Vitamin D plays an important role in human
and animal health. Meeting the daily
recommended intake levels is essential to
prevent diseases, reduce healthcare costs,
and improve quality of life.
Interactive global map on vitamin D
deficiency launched
immune to vitamin D deficiency. The elderly
are particularly affected. With an ageing
population and higher life expectancy, the
Vitamin D status (> 18 year olds) around the world
When available, winter values were used to calculate the
mean 250HD levels.
situation is likely
to deteriorate if the
challenge of
inadequate vitamin
D availability is not
addressed in a
timely manner.
Insufficient levels
of vitamin D have a
significant impact
on human health
and may lead to rickets in children and
osteoporosis and a subsequent risk of
falling and fractures in the elderly (or adults).
It also has an adverse economic impact as it
causes healthcare costs to increase.