01.06.2013 Views

Queensland Life Sciences Industry Report 2012 (PDF, 3.5MB)

Queensland Life Sciences Industry Report 2012 (PDF, 3.5MB)

Queensland Life Sciences Industry Report 2012 (PDF, 3.5MB)

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

<strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong><br />

<strong>Report</strong> <strong>2012</strong><br />

Dr Patrick Silvey and<br />

Dr Lavinia Proctor


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

02<br />

Disclaimer<br />

This report was prepared by VenturePro Pty.<br />

Ltd. (‘VenturePro’) on behalf of the <strong>Queensland</strong><br />

Department of Science, Information Technology,<br />

Innovation and the Arts (DSITIA). The information,<br />

statements, examples, statistics and opinions<br />

(defined as ‘Information’ in this document)<br />

contained in this report have been prepared<br />

by VenturePro from material provided by, and<br />

discussions with, third parties, including the<br />

<strong>Queensland</strong> Government.<br />

Reference is made to original sources of<br />

Information where appropriate. However, no<br />

verification of the Information has been carried<br />

out by VenturePro or any of its respective agents,<br />

directors, officers or employees. VenturePro has<br />

based its report on the Information received or<br />

obtained, on the basis that such Information is<br />

accurate. The Information in this report is provided<br />

in good faith and without prejudice.<br />

DSITIA and VenturePro and its respective agents,<br />

directors, officers or employees make no express<br />

or implied representation or warranty as to<br />

the accuracy, reliability or completeness of the<br />

Information. No party should rely on any material<br />

contained in this document as a statement or<br />

representation of fact. Each party should satisfy<br />

itself as to the accuracy of the material by such<br />

independent review, investigation or analysis as<br />

it, or its advisers, may think fit. To the maximum<br />

extent permitted by law, VenturePro and DSITIA<br />

expressly disclaim any and all liability for<br />

representations or warranties, express or implied,<br />

contained in, or for omissions from, this document<br />

or any other written or oral communication<br />

transmitted or made available pursuant to this<br />

document.<br />

Acknowledgements<br />

Thank you to Ms Catrina Codd and Mr Quinton Dell<br />

for reviewing the report, and to several industry<br />

participants who reviewed survey questions or<br />

provided commentary which is included in the<br />

report. The assistance of DSITIA in conducting the<br />

study is gratefully acknowledged. We particularly<br />

appreciate the advice from, and the diligence and<br />

professionalism shown by Mr Stewart MacIntyre,<br />

Mr Brad Cuthbert, Mr Adam Pittard, Ms Sarah<br />

Bloxsom, Ms Sue Coke, Dr Debra Venables and<br />

Dr Mark Jacobs.<br />

Such a comprehensive analysis of the <strong>Queensland</strong><br />

<strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> would not be possible<br />

without the participation of so many industry<br />

members — 139 in all. We were again overwhelmed<br />

with the willingness of organisations to respond to<br />

the survey and to subject themselves to numerous<br />

highly ‘intrusive’ questions on various aspects of<br />

their business, including their revenue, expenditure<br />

and employment profile. We are grateful for the<br />

significant time commitment that they made and<br />

for the spirit within which they participated. Whilst<br />

54% of the organisations in the database were<br />

not able to participate on this occasion we were<br />

graciously received by them when following up by<br />

telephone. Thank you to all of those in the industry.<br />

Authorship<br />

The <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

was prepared by VenturePro. VenturePro provides<br />

an advisory service catering to organisations<br />

seeking funding for research initiatives or research<br />

and healthcare infrastructure. We also contribute<br />

to the development of science and innovation policy.<br />

We work closely with clients in academia, industry<br />

and government to plan for new initiatives and<br />

to prepare funding submissions, business cases,<br />

economic impact assessments and/or budgets.


Since VenturePro was established in 2005, about 75% of our<br />

clients who engaged us to play a major role in their submissions<br />

were successful, with over $400 million being awarded to over<br />

60 projects.<br />

The primary authors of this report were Dr Patrick Silvey and<br />

Dr Lavinia Proctor. We would like to acknowledge the expert<br />

contribution of Dr Lahn Straney in developing and applying the<br />

statistical methodology that enabled us to put forward estimates<br />

of key measures at a state-wide level. The principal contact at<br />

VenturePro is Dr Patrick Silvey — patrick.silvey@venturepro.com.<br />

au; Ph: +61 (7) 3010 5728; 0402 308 922.<br />

Dr Patrick Silvey (MBA, PhD, BSc (Hons))<br />

Managing Director, VenturePro Pty. Ltd<br />

Patrick has many years’ experience in delivering<br />

professional services and in the management<br />

of major consultancies with public and private<br />

sector clients, and he has worked in the venture<br />

finance industries in <strong>Queensland</strong> and California. He was previously<br />

a Director in Corporate Finance at PricewaterhouseCoopers<br />

(PwC) and a post-doctoral research fellow at The University<br />

of <strong>Queensland</strong>. He was a member of the QUT Research and<br />

Innovation Committee and the i.lab technology incubator Advisory<br />

Panel for nine years. While at PwC, Patrick was the key member of<br />

a division that focused on Companies with Extraordinary Potential<br />

and he was appointed to the PwC Global Thought Leadership<br />

Team in <strong>Life</strong> <strong>Sciences</strong> in 2004. Patrick’s MBA degree focussed on<br />

entrepreneurship and new venture finance and he was awarded a<br />

university medal from QUT in 2001 as the MBA graduate with the<br />

highest overall GPA.<br />

Dr Lavinia Proctor<br />

(PhD, Grad Cert Applied Law, BSc (Hons I))<br />

Associate Director, VenturePro Pty. Ltd.<br />

Dr Lavinia Proctor has served as an Associate<br />

Director at VenturePro for the past three<br />

years. During this time she has contributed to<br />

the development of large collaborative funding bids, business<br />

cases for infrastructure and other funding, business plans and<br />

reports for government and research sector clients. Previously,<br />

Lavinia held executive and senior management roles in two<br />

unlisted Australian biotechnology companies. In these roles,<br />

Lavinia was responsible for intellectual property management,<br />

in-licensing activities, pre-clinical product development<br />

campaigns and co-ordinating relationships with contract research<br />

organisations, granting bodies and regulatory authorities. She<br />

also was responsible for securing and managing several state<br />

and federal government grants. She holds a PhD from The<br />

University of <strong>Queensland</strong>, has co-authored fourteen peer-reviewed<br />

international publications and is currently undertaking a law<br />

degree (LLB).<br />

Dr Lahn Straney (PhD, BBiotech(Hons))<br />

Postdoctoral Fellow, Monash University<br />

and VenturePro Consultant<br />

Lahn has worked in an analytical role in various<br />

fields including environmental sciences,<br />

biotechnology, economics and health. He<br />

has provided technical and writing support for several grant<br />

applications in varied programs and scientific disciplines. Lahn<br />

has gained professional experience in market research, analytical<br />

research and statistical analysis through his previous roles and<br />

consultancies with Progen Pharmaceuticals, the Australian<br />

Institute for Commercialisation and VenturePro Pty Ltd. He<br />

has also developed and executed a number of primary surveys<br />

to industry and stakeholders on behalf of private and<br />

government clients.<br />

Suggested Citation<br />

Silvey, P. and Proctor, L. (<strong>2012</strong>). The <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong> <strong>Report</strong> <strong>2012</strong>. Brisbane: <strong>Queensland</strong> Department of<br />

Science, Information Technology, Innovation and the Arts.<br />

This work is copyright.<br />

Apart from any use as permitted under the Copyright Act 1968 (Cth),<br />

no part may be reproduced by any process without prior written<br />

permission from the <strong>Queensland</strong> Government. Enquiries concerning<br />

reproduction and rights should be addressed to the <strong>Queensland</strong><br />

Department of Science, Information Technology, Innovation and<br />

the Arts.<br />

03


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

04<br />

IMPORTANT NOTICE<br />

Statistical Limitations on Estimates Presented in this <strong>Report</strong><br />

Figures contained in this report are either for<br />

the 2010/2011 financial year or 2011 calendar<br />

year, given that Australian universities typically<br />

report on a calendar year and companies<br />

typically report on a financial year.<br />

Survey Data and Secondary Sources<br />

The information presented was collected from<br />

a primary survey of the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

(QLS) <strong>Industry</strong> (see Appendices at 14.1.2 for the<br />

industry definition) undertaken in March and April<br />

<strong>2012</strong>, and various secondary data sources as<br />

referenced throughout this report. The survey was<br />

conducted using an online survey platform (for<br />

details see Appendices at 14.1.4).<br />

For the purpose of this survey, it was assumed<br />

that the QLS <strong>Industry</strong> comprised 301 organisations<br />

in 2011 as listed in the database held by DSITIA.<br />

This database includes 252 public and private<br />

companies (referred to as ’companies’) and 49<br />

university institutes, faculties, schools, research<br />

centres or independent research organisations<br />

with a <strong>Life</strong> <strong>Sciences</strong> focus (referred to as<br />

‘research organisations’). The database comprised<br />

133 organisations deemed to fall into the<br />

‘Biotechnology’ sector, and 168 in the ‘Therapeutic<br />

Medicines and Devices’ (TMD) sector. This<br />

classification was necessary in order to draw some<br />

comparisons with separate surveys undertaken<br />

in 2007 for each of these sectors.<br />

The current survey was completed by 139<br />

organisations (46% of those within the DSITIA<br />

database), including 111 companies and 28<br />

research organisations. 49% of respondents were<br />

Biotechnology organisations and 51% were<br />

TMD organisations.<br />

All financial figures in this report are presented<br />

in Australian dollars (AU$). Where figures derived<br />

from secondary data were converted to AU$ from<br />

another currency, the conversion rates presented<br />

in the Appendices were applied. Throughout the<br />

report, figures presented in the text, tables and<br />

graphics may appear inconsistent due to rounding.<br />

Statistical Limitations on Estimates<br />

presented in this <strong>Report</strong><br />

This survey presents data from a ‘sample<br />

population’ of 139 (46%) of the 301 organisations<br />

in the DSITIA database. The industry includes<br />

a range of organisations: from major research<br />

institutions to smaller research centres, and<br />

publicly-listed companies to start-up companies.<br />

Participation in the survey was voluntary, and as<br />

a result the sample is subject to self-selection<br />

bias and may not be representative of the total<br />

population.<br />

The data gathered from this population can<br />

vary significantly and as such we considered<br />

measures in strata that pooled more homogenous<br />

populations. The distribution of values within the<br />

total dataset did not, in many cases, represent<br />

a normal distribution. This is particularly true<br />

for measures including income, expenditure and<br />

employment, where reported figures ranged from<br />

hundreds of employees and tens of millions of<br />

dollars in income or expenditure for large research<br />

institutions, down to a single employee and minimal<br />

income for a start-up company. In cases such<br />

as these, the median was deemed to be more<br />

representative of the sample population than<br />

the average.


Strata were defined by industry (TMD or Biotechnology) and<br />

organisational size, which was based on employee numbers<br />

(small, medium, and large). Strata were defined for both<br />

responders and non-responders, where possible. Within each<br />

stratum the arithmetic mean in most cases provided a reasonable<br />

measure of the central tendency.<br />

Data from the 2011 survey was compared to the 2009 survey.<br />

Where respondents had participated in both surveys, the median<br />

secular trend (measured as the ratio of the 2011 value to 2009<br />

value) was assessed for each measures of interest. Several<br />

organisations had responded to the 2009 survey but not the 2011<br />

survey. In estimating the total population, it was reasoned that the<br />

2009 data was likely to better inform our estimates of 2011 than<br />

using the mean from other respondents. The secular trend value<br />

was applied to those organisations’ values in 2009 to derive<br />

2011 estimates.<br />

The total population estimates were derived from bootstrapped<br />

estimates of the mean with each stratum. The variance of the final<br />

estimate was derived from the variance of the bootstrapped mean<br />

in each stratum. Where relevant, the data are presented with 95%<br />

confidence intervals.<br />

Given the population estimates are not necessarily derived from<br />

a representative sample they should be considered speculative<br />

and taken only as a guide to the state of the industry, relative to<br />

the reported figures from previous comparable surveys. In the<br />

QLS <strong>Industry</strong> survey 2009 and the 2007 <strong>Queensland</strong> Biotechnology<br />

<strong>Industry</strong> and <strong>Queensland</strong> TMD <strong>Industry</strong> surveys, a similar<br />

estimation method was employed. Where possible the approach<br />

used to calculate population totals are consistent with those used<br />

in previous surveys. In some cases, 2007 survey results were<br />

reanalysed using the methodology applied to the 2009 and 2011<br />

survey results.<br />

There are variations between the 2011, 2009 and 2007 surveys in<br />

terms of the specific organisations that responded to the survey<br />

in each year. Thus, the sample population is different for each<br />

survey. In addition, income data for the TMD analysis in 2007 was<br />

collected as an income range and not a specific figure as was the<br />

case in subsequent surveys. Direct comparisons between figures<br />

from different surveys may indicate change but any such changes<br />

cannot be taken as definitive.<br />

Link to Current <strong>Report</strong><br />

An electronic version of the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

<strong>Report</strong> <strong>2012</strong> can be download through the <strong>Queensland</strong><br />

Government ‘Science in <strong>Queensland</strong>’ website located at<br />

www.science.qld.gov.au<br />

Links to Previous <strong>Report</strong>s<br />

The <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> 2010<br />

www.science.qld.gov.au/dsdweb/v4/apps/web/content.cfm?id=16862;<br />

accessed 01/07/12<br />

The <strong>Queensland</strong> Biotechnology <strong>Industry</strong> <strong>Report</strong> 2008<br />

http://203.210.126.185/dsdweb/v4/apps/web/secure/docs/1593.pdf;<br />

accessed 01/07/12<br />

The <strong>Queensland</strong> Therapeutic Medicines and Devices<br />

<strong>Industry</strong> <strong>Report</strong> 2008<br />

http://203.210.126.185/dsdweb/v4/apps/web/secure/docs/1986.pdf;<br />

accessed 01/07/12<br />

05


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

06<br />

GLOSSARY OF ABBREVIATIONS<br />

$b Billions of dollars<br />

$m Millions of dollars<br />

ABS Australian Bureau of Statistics<br />

ARC Australian Research Council<br />

ANZCTR Australian and New Zealand<br />

Clinical Trials Registry<br />

ASX Australian Stock Exchange<br />

BERD Business Expenditure on<br />

Research and Development<br />

Biotech Biotechnology<br />

CAGR Compound Annual Growth Rate<br />

cGMP Current Good Manufacturing<br />

Practice<br />

CMO Contract Manufacturing<br />

Organisation<br />

CRO Contract Research Organisation<br />

DIISRTE Department of Innovation,<br />

<strong>Industry</strong>, Science, Research and<br />

Tertiary Education (Australian<br />

Government)<br />

DEEDI Former Department of<br />

Employment, Economic<br />

Development and Innovation<br />

(<strong>Queensland</strong> Government)<br />

DEEWR Department of Education,<br />

Employment and Workplace<br />

Relations (Australian<br />

Government)<br />

DSITIA Department of Science,<br />

Information Technology,<br />

Innovation and the Arts<br />

(<strong>Queensland</strong> Government)<br />

EMDG Export Market Development<br />

Grant<br />

FTE Full Time Equivalent<br />

FY Financial Year<br />

GDP Gross Domestic Product<br />

GERD Gross Domestic Expenditure on<br />

Research and Development<br />

GFC Global Financial Crisis<br />

GOVERD Government Expenditure on<br />

Research and Development<br />

GSP Gross State Product<br />

IP Intellectual Property<br />

IPO Initial Public Offering<br />

Market Cap Market Capitalisation<br />

MTAA Medical Technology Association<br />

of Australia<br />

NHMRC National Health and Medical<br />

Research Council<br />

OECD Organisation for Economic Cooperation<br />

and Development<br />

QLS <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

R&D Research and Development<br />

RO Research Organisation<br />

SME Small to Medium Enterprise<br />

TGA Therapeutic Goods<br />

Administration<br />

TMD Therapeutic Medicines and<br />

Devices<br />

UK United Kingdom<br />

USA United States of America<br />

VC Venture Capital


TABLE OF CONTENTS<br />

IMPORTANT NOTICE .................................................................................................................................................................................................................................04<br />

GLOSSARY OF ABBREVIATIONS ...........................................................................................................................................................................................................06<br />

1 EXECUTIVE SUMMARY ...................................................................................................................................................................................................................08<br />

2a SUMMARY OF KEY SURVEY FINDINGS ..................................................................................................................................................................................12<br />

2b INDUSTRY-WIDE ESTIMATES OF KEY MEASURES ...........................................................................................................................................................16<br />

3 INTRODUCTION.................................................................................................................................................................................................................................22<br />

4 PROFILE OF SURVEY RESPONDENTS ....................................................................................................................................................................................24<br />

5 EMPLOYMENT ...................................................................................................................................................................................................................................32<br />

6 EDUCATION AND SKILLING .........................................................................................................................................................................................................38<br />

7 INCOME AND EXPENDITURE ......................................................................................................................................................................................................42<br />

8 THE LISTED LIFE SCIENCES SECTOR ....................................................................................................................................................................................52<br />

<strong>Industry</strong> Comment: David Blake .......................................................................................................................................................................................................55<br />

9 SENTIMENT AND OUTLOOK ........................................................................................................................................................................................................56<br />

<strong>Industry</strong> Comment: Garry Redlich ....................................................................................................................................................................................................62<br />

10 COMMERCIAL INDICATORS ........................................................................................................................................................................................................64<br />

<strong>Industry</strong> Comment: Anne-Marie Birkill ...........................................................................................................................................................................................69<br />

11 RESEARCH AND DEVELOPMENT ..............................................................................................................................................................................................70<br />

12 EXPORTS AND INTERNATIONAL COLLABORATIONS ........................................................................................................................................................76<br />

13 SUMMARY OF KEY STATISTICS .................................................................................................................................................................................................80<br />

14 APPENDICES ......................................................................................................................................................................................................................................82<br />

07


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

08<br />

1. EXECUTIVE SUMMARY<br />

VenturePro is pleased to present the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

<strong>Report</strong> <strong>2012</strong> conducted on behalf of the <strong>Queensland</strong> Government.<br />

The report, based on a survey conducted in early<br />

<strong>2012</strong>, presents a profile of the <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong> in <strong>Queensland</strong> in the 2011 year. The report<br />

builds on findings from our previous analyses of<br />

the industry in 2007 and 2009 and it is intended to<br />

inform industry, public sector organisations and<br />

government in their efforts to support industry<br />

growth and increase international competitiveness.<br />

The traditional life sciences business model is<br />

reliant on the availability of investment capital to<br />

support a costly and often lengthy research and<br />

development (R&D) timeline. Given this, the global<br />

financial crisis (GFC) severely affected <strong>Life</strong> <strong>Sciences</strong><br />

industries. Access to capital was significantly<br />

reduced worldwide from 2009/2010, and for <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong>, the option to undertake an initial<br />

public offering (IPO) remains effectively unavailable<br />

in Australia.<br />

Our survey of 139 <strong>Life</strong> <strong>Sciences</strong> organisations<br />

in <strong>Queensland</strong> suggests that the GFC and the<br />

resulting economic environment negatively affected<br />

the performance of the industry, and in particular<br />

the private sector, in 2011. In the 2009 survey,<br />

industry expectations for the subsequent year were<br />

for lower R&D and capital expenditure, and limited<br />

access to capital. These negative expectations<br />

appear to have been well founded.<br />

Employment, income and expenditure estimates for<br />

the whole industry in <strong>Queensland</strong> 1 were all lower<br />

than those determined in our previous survey in<br />

2009. The change in total expenditure by companies<br />

was driven largely by a significant fall in estimated<br />

R&D expenditure (down by 43%). Business owners<br />

and managers will have made difficult decisions in<br />

an attempt to see out adverse economic conditions<br />

in the short-term, and position their businesses for<br />

growth as the market recovers. However, the survey<br />

also revealed a maturing private sector and one in<br />

which executives expressed a positive sentiment for<br />

the future.<br />

For research organisations in <strong>Queensland</strong>, the<br />

story, in some respects, was ‘business-as-usual’<br />

with estimates for employment and income down<br />

only marginally or at the same level compared to<br />

2009, whilst expenditure estimates were actually<br />

higher. Research organisations may have been<br />

insulated from the worst effects of the GFC in the<br />

two years to 2011, as 75% of the reported income<br />

was sourced from grants and there were increases<br />

in funding allocations to both the National Health<br />

and Medical Research Council (NHMRC) and the<br />

Australian Research Council (ARC) over the past<br />

two years. It remains to be seen whether there will<br />

be a lag period for research organisations with<br />

lower industry investment in R&D and the potential<br />

for reduced grant funding translating into reduced<br />

income in <strong>2012</strong>-2013.<br />

Access to capital as a barrier to growth<br />

The survey confirmed that access to capital<br />

remained limited in 2011, and thus a challenging<br />

operating environment will likely persist for <strong>Life</strong><br />

<strong>Sciences</strong> companies in the near future. In 2009,<br />

venture capital and debt instruments accounted<br />

for 82% of capital reported by survey participants.<br />

In the current survey they accounted for only 3.3%<br />

of funds raised. Secondary data showed that new<br />

funding commitments to Australian venture capital<br />

(VC) funds continued to decline in 2011 with three<br />

VC funds raising $120 million, down 42% from 2010<br />

and 60% from 2009. Moreover, in both 2010 and<br />

2011, the majority of VC commitments drew upon<br />

Government-backed innovation funding programs<br />

such as the Innovation Investment Fund. Exit<br />

options for VC investors in Australian <strong>Life</strong> <strong>Sciences</strong><br />

companies are limited with an IPO effectively no<br />

longer a realistic prospect.<br />

Over 70% of survey respondents agreed that<br />

limited access to capital was having a material<br />

impact on their operations. A lack of accessibility<br />

to government grant funding was identified by<br />

companies as the second most significant barrier<br />

to future income growth (companies reported only<br />

1.5% of their income arising from grants). Other<br />

barriers, risks or challenges cited by companies<br />

included the high Australian dollar, regulatory risk/<br />

compliance issues and increasing international<br />

competition.<br />

1 The raw survey data was statistically analysed in order to generate estimates for the whole <strong>Queensland</strong> industry across the<br />

key measures of income, expenditure and employment. Such estimates are subject to error and they are based on a number of<br />

assumptions outlined in this report, which may or may not hold true.


<strong>Queensland</strong>’s listed <strong>Life</strong> <strong>Sciences</strong> sector<br />

Secondary data suggests that the listed biotechnology sectors<br />

in Australia and countries such as the USA, Europe and Canada<br />

are showing some signs of a recovery from the effects of the<br />

GFC. Capital flows are returning to the ASX-listed Australian <strong>Life</strong><br />

<strong>Sciences</strong> sector, several members of which have recently begun<br />

to generate revenue, conclude significant deals and progress<br />

products to market. Positive trends are apparent for listed <strong>Life</strong><br />

<strong>Sciences</strong> firms based in <strong>Queensland</strong> with the average market<br />

capitalisation increasing from $26.2 million to $60.2 million<br />

between 2009 and 2011. Only three out of eight listed <strong>Life</strong> <strong>Sciences</strong><br />

companies in <strong>Queensland</strong> were considered microcap (market<br />

capitalisation ‹$50 million) in 2011, compared to seven out of<br />

ten in 2009.<br />

<strong>Industry</strong> profile and maturity<br />

The total number of commercial enterprises that comprise the<br />

<strong>Queensland</strong> industry grew from 235 in 2009 to 252 in 2011. This<br />

occurred despite several companies exiting the industry over<br />

the past two years due to closure, relocation or a change in<br />

operational focus away from life sciences. The emergence of new<br />

ventures, particularly in industrial biotechnology (e.g. biofuels),<br />

suggests a positive sentiment in some subsectors. Survey<br />

responses in relation to the product pipeline suggest that the<br />

industry is continuing to mature. In 2009, 34% of organisations<br />

developing therapeutics and 42% of organisations developing non<br />

therapeutics had lead products at market. For the 2011 year, the<br />

proportion of companies reporting therapeutic products at market<br />

was 69% and for those with non-therapeutic products it was 56%.<br />

Assuming the commercial success of these products, the industry<br />

should see new revenues and additional employment arising from<br />

this pipeline over the next few years.<br />

The commitment of companies to scientific research and<br />

innovation was evident despite reduced overall expenditure<br />

on R&D. The industry has a highly qualified workforce with an<br />

average of 19% of employees in the private sector holding a<br />

PhD, and the majority of companies (64%) confirming that the<br />

<strong>Queensland</strong> public sector research base was important to their<br />

future operations. Moreover, almost 40% of companies had some<br />

form of interaction with a <strong>Queensland</strong> research organisation<br />

in 2011.<br />

Business sentiment<br />

While the industry has been hit hard over the past two years by<br />

the prevailing economic environment, there was positive business<br />

sentiment and signs that some sub-sectors are holding up.<br />

Approximately 65% and 82% of respondents expected their income<br />

to increase over the coming one and three years, respectively. The<br />

number of full-time equivalent (FTE) employees was expected to<br />

increase by 5.2% over the coming year and 34.3% over the next<br />

three years with a compound annual growth rate (CAGR) of 10.3%.<br />

Approximately 43% of companies expected R&D expenditure to<br />

stay the same and 45% expected the level of R&D expenditure to<br />

increase over the next year. Only about 12% of companies expected<br />

R&D expenditure to decrease. This suggests that those companies<br />

who have weathered the effects of the GFC feel they are positioned<br />

for growth should conditions improve in the next year or two.<br />

Sentiment was even higher within research organisations with<br />

none predicting a drop in income or R&D expenditure over the<br />

coming one or three years.<br />

Outsourcing R&D and manufacturing<br />

A trend toward R&D outsourcing, which has the potential to<br />

reduce the overall cost of R&D and the time to market, was more<br />

prevalent in 2011. This suggests that investment in R&D was<br />

continuing but that less would be undertaken in-house. Australia<br />

was the most common location from which contract research<br />

organisations and contract manufacturing organisations were<br />

engaged. The other top locations included the USA, the UK<br />

and China.<br />

Comparative performance: Biotechnology versus Therapeutic<br />

Medicines and Devices<br />

A comparison of 2009 and 2011 estimates for the Biotechnology<br />

sector suggested decreases in income (-23.8%), employment<br />

(-19.3%) and R&D expenditure (-2.3%). However, total expenditure<br />

was estimated to have increased by 3.8% with higher figures for<br />

wages and salary expenditure (121%) and capital expenditure<br />

(27.2%). The Biotechnology sector, as defined in previous<br />

surveys, includes the majority of research organisations, and<br />

their generally positive figures masked the more negative<br />

performance of Biotechnology companies. When research<br />

organisations were excluded from the analysis, estimates for<br />

Biotechnology companies suggested substantial declines, with<br />

income estimates down by 45%, expenditure estimates down by<br />

65%, and employment estimates down by over 40% compared to<br />

2009. Companies in the Biotechnology sector appear to have fewer<br />

advanced products than the therapeutic medicine and devices<br />

sector (TMD).<br />

Estimates for the TMD sector in 2011 suggest a relatively modest<br />

fall in income and total expenditure (both down by under 3%).<br />

Estimates for employment and specifically R&D expenditure,<br />

were down sharply though (38% and 42% respectively) possibly<br />

reflecting cuts necessary to support the balance between total<br />

income and expenditure. The TMD sector includes several large<br />

or later-stage companies in complementary medicines, functional<br />

food/nutraceuticals and animal health, many with multiple<br />

products at market.<br />

09


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

10<br />

Looking at estimates over a longer period, from 2007 to<br />

2011, the trend is less dramatic for both sectors. For this<br />

period, the TMD sector showed a CAGR for employment of<br />

-6.4% and for income of +4.8%. The Biotechnology sector<br />

showed CAGRs of 1.3% for employment and 16.8% for<br />

income over the same period.<br />

Where to from here?<br />

In summary, it is evident that from 2010, companies in <strong>Life</strong><br />

<strong>Sciences</strong> sector were hit hard by the GFC and that publiclyfunded<br />

research organisations were at best, even. In<br />

response to the GFC, companies appear to have dramatically<br />

cut back on R&D expenditure and also reduced the number<br />

of direct employees. The estimate for wages expenditure<br />

across the private sector was actually higher. Employees<br />

shifting to higher paid casual or shorter-term contract<br />

positions, and a larger proportion of job losses occurring<br />

toward the end of 2011 may account for this observation.<br />

Whilst the average income reported per company was<br />

higher by 15%, when the data was extrapolated to the<br />

whole industry in <strong>Queensland</strong>, the total income estimate<br />

was actually down by just under 15%. The most dramatic<br />

change for businesses was a significant fall in the estimated<br />

number of FTE employees. Whilst the average number of<br />

employees per company was 21% lower, the estimated total<br />

number of employees estimated across the state was down<br />

by over 40%.<br />

Limited access to capital has typically been a constant<br />

challenge for the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>, but the<br />

GFC exacerbated the shortage of capital. Unsurprisingly,<br />

industry members who responded to the survey highlighted<br />

limited access to finance and government grant funding<br />

as the key barriers to future industry growth. With access<br />

to capital likely to remain limited in an uncertain global<br />

economic environment, the industry may remain flat with<br />

only pockets of growth occurring in individual companies<br />

with new products coming on to the market, or in subsectors<br />

where demand is strong.<br />

For the longer term, companies and research organisations<br />

are showing a commitment to research collaboration and<br />

innovation and this should see some sections of the industry<br />

competing well in international markets, and growth in<br />

the overall value of the industry and its contribution to<br />

the <strong>Queensland</strong> economy. Support from governments for<br />

innovation and industry-led R&D collaborations with the<br />

university sector, will likely encourage more business<br />

expenditure on R&D (BERD), which fell by 6% in Australia<br />

as a proportion of GDP in 2010.<br />

Global economic uncertainty aside, the positive business<br />

sentiment in terms of employment and income growth<br />

suggest that the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> in <strong>Queensland</strong> is<br />

increasing in maturity and therefore more able to withstand<br />

a downturn in the economy than it had been a decade or so<br />

ago. Caution is evident though, with respect to BERD, which<br />

was a visible casualty of the GFC across various listed <strong>Life</strong><br />

<strong>Sciences</strong> sectors (USA, Canada, Europe and Australia) in<br />

2009 and 2010. A continuation of low BERD in <strong>Queensland</strong><br />

and Australia may have negative implications for growth<br />

and international competitiveness across the sector in the<br />

longer term.


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

12<br />

2a.SUMMARY OF KEY SURVEY FINDINGS<br />

“A total of 139 respondents from both the commercial and research sectors<br />

employed 8085 FTE staff and reported income of $1.99 billion.”<br />

2.1 Profile of a Typical <strong>Queensland</strong><br />

<strong>Life</strong> <strong>Sciences</strong> Organisation<br />

Based on the median figures, a typical <strong>Life</strong><br />

<strong>Sciences</strong> company would have had the following<br />

profile in 2011:<br />

Total income of $1.8 million<br />

Eight full time equivalent employees<br />

Total expenditure of $1.6 million<br />

Based on the median figures the typical <strong>Life</strong><br />

<strong>Sciences</strong> research organisation had the following<br />

profile in 2011:<br />

Total income of $12.4 million<br />

121 full time equivalent employees<br />

Total expenditure of $17.3 million<br />

2.2 Summary of Survey Data for Key<br />

Measures<br />

The key figures from the survey are presented in<br />

Table 1 (below). This is the raw data from the survey<br />

representing the aggregated figures from the<br />

organisations who responded to the survey. There<br />

are no statistical extrapolations in this table and the<br />

figures can be compared to raw survey data for the<br />

TABLE 1: Summary of key statistics from the raw survey data 2011 i.e. no extrapolations<br />

Sample<br />

Size<br />

Total <strong>Report</strong>ed<br />

(change from 2009)<br />

Mean<br />

(change from 2009)<br />

Median<br />

Figure<br />

Employment (FTEs)<br />

All Respondents (96% of total) 135 8085 (+21%) 60 (7%) 11<br />

Companies 111 3433 (-3%) 31 (-21%) 8<br />

Research Organisations<br />

Total Income ($m)<br />

24 4652 (+48%) 194 (+73%) 121<br />

All Respondents (71% of total) 100 $1995 (+60%) $19.9 (+45%) $3.3<br />

Companies 78 $1220 (+22%) $15.6 (+15%) $1.8<br />

Research Organisations<br />

Expenditure ($m)<br />

Total Expenditure ($m)<br />

22 $774 (+219%) $35.2 (+146%) $12.4<br />

All Respondents (65% of total) 92 $1091 (+24%) $11.9 (+3%) $2.4<br />

Companies 75 $606 (-16%) $8.1 (-30%) $1.6<br />

Research Organisations<br />

Wages and Salary Expenditure ($m)<br />

17 $485 (+211%) $25.5 (+128%) $17.3<br />

All Respondents (61% of total) 85 $564 (+126%) $6.6 (+106%) $0.8<br />

Companies 69 $292 (+68%) $4.2 (+50%) $0.6<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

16 $272 (+258%) $17.0 (+215%) $14.4<br />

All Respondents (60% of total) 83 $189 (-13%) $2.3 (-23%) $0.2<br />

Companies 67 $57 (-39%) $0.9 (-44%) $0.05<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

16 $132 (+10%) $8.2 (-13%) $5.4<br />

All Respondents (62% of total) 86 $134 (+177%) $1.6 (+62%) $0.05<br />

Companies 70 $36 (+63%) $0.5 (-9%) $0.04<br />

Research Organisations 16 $98 (+273%) $6.1 (+110%) $0.5<br />

Numbers may appear inconsistent due to rounding.


TABLE 2: Commercial performance of survey respondents<br />

Measure<br />

2009 survey, which is tabulated in the Appendices (see 14.2). For<br />

the mean and the total reported amount, the percentage change<br />

from 2009 to 2011 is included in brackets.<br />

With reference to the raw aggregated data the following<br />

observations can be made:<br />

For companies, the mean figures were down for employment<br />

(-21%) and expenditure (-30%), but the mean figure for income<br />

was up (15%) on the 2009 survey.<br />

For research organisations. The mean figures for employment<br />

(73%), income (146%) and expenditure (128%) were all up.<br />

2.3 Commercial Performance<br />

Key measures of commercial performance (Table 2 – above) are<br />

presented alongside data for the same measures from previous<br />

surveys. These parameters were not assessed in the 2007 TMD<br />

Survey. The number of patents filed and out-licence agreements<br />

made were both up significantly, whilst the number of in-licences<br />

fell by about two-thirds between 2009 and 2011. Organisations<br />

reported increased use of CMOs (up 45%) and CROs (up 72%).<br />

Additional data on Patents and Licensing<br />

2007 Survey<br />

(Biotech only)<br />

Of the 272 complete patent applications filed by, or granted<br />

to survey respondents in 2011, 17% were from research<br />

organisations and 83% from companies.<br />

Twelve organisations reported 83 out-license agreements2 , while<br />

nine organisations reported 18 in-license agreements in 2011.<br />

For 17% of respondents and, to a lesser extent, for a further<br />

22% of respondents, the global economic environment<br />

2009<br />

Survey<br />

continues to be a significant consideration in determining<br />

their IP management strategy.<br />

The World Intellectual Property Organisation reported that<br />

resident patent filings by Australian inventors totalled 4.13<br />

patents per $billion GDP in 2006 and 3.33 in 2009 (latest<br />

available data).<br />

The resident patent filings by Australian inventors per<br />

US$million of R&D expenditure has declined by 47% over<br />

the past nine years, from 0.51 in 2001 to 0.24 in 2009.<br />

2.4 <strong>Industry</strong> Structure<br />

2011<br />

Survey<br />

There were 139 respondents to the QLS Survey 2011:111<br />

companies (80%) and 28 research organisations (20%).<br />

Respondents were evenly split between the Biotechnology<br />

(49%) and TMD sectors (51%).<br />

Profile of Company Respondents<br />

Change<br />

2009-2011<br />

Australian Patents Filed or Granted 50 143 272 90%<br />

Out-License Agreements 20 39 83 113%<br />

In-License Agreements 35 49 18 -63%<br />

Utilisation of Contract Manufacturing<br />

Organisations<br />

23% 33% 48% 45%<br />

Utilisation of Contract Research<br />

Organisations<br />

23% 29% 50% 72%<br />

85 (77%) were private companies, 11 (10%) were unlisted<br />

public companies and nine (8%) were publicly listed. There<br />

was one sole trader, one incorporated association and four<br />

who selected the ‘Other’ category (including two venture<br />

funds, one unincorporated joint venture and one statutory<br />

authority).<br />

13% of companies were spun-out from a <strong>Queensland</strong><br />

university or research institution.<br />

About one-third of the companies have been in existence for<br />

more than 15 years and about 18% were established within<br />

the last 5 years.<br />

A majority of companies (56%) operated within one of the five<br />

‘Human Health’ sub-sectors 3 .<br />

2 “Patent license agreements can be divided into in-licenses and out-licenses. In-licensing refers to agreements by which a party acquires the rights to use a patent,<br />

whereas out-licensing refers to agreements in which a patent holder grants a third party the right to use a patent.” Australian Law Reform Commission, Genes and<br />

Ingenuity: Gene patenting and human health (ALRC <strong>Report</strong> 99).<br />

3 The five human health sub-sectors are Pharmaceuticals, vaccines or drug discovery; Diagnostics; Complementary medicines; Functional food and nutraceuticals;<br />

Medical devices and equipment.<br />

13


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

14<br />

Profile of Research Organisation Respondents<br />

Research organisations who responded to the survey<br />

included research institutes (50%), research centres<br />

(29%), faculties (11%), university research offices<br />

responding for the university as a whole (7%) and<br />

schools (4%).<br />

The greatest concentration of research activities<br />

undertaken by research organisations (62%) was<br />

across the five segments of the Human Health<br />

sub-sector. 4<br />

2.5 Employment, Education and Skilling<br />

Survey participants employed 8085 full time equivalent<br />

(FTE) persons in <strong>Queensland</strong>, with 3433 (42%) of those<br />

employed by companies5 . Among surveyed companies,<br />

the complementary medicines sector was the largest<br />

employer with 37.6% of FTEs reported.<br />

35% of staff were employed as R&D professionals or in<br />

other technical and R&D support roles.<br />

The average salary of QLS <strong>Industry</strong> employees was<br />

estimated at $66,965 compared to an average across <strong>Life</strong><br />

<strong>Sciences</strong> roles in Australia of $74,750 and an average<br />

national wage of $71,568 (derived from various ABS data<br />

sources — see 14.4.3).<br />

Research organisations reported that, on average, 47.3%<br />

(median 42.5%) of their workforce held a PhD. An average<br />

of 19% (median 4%) of staff in companies held a PhD.<br />

Over the next five years, the most commonly anticipated<br />

skills gaps were in (1) business development; (2)<br />

commercialisation; and (3) chemistry.<br />

2.6 Income and Expenditure<br />

Respondents generated a combined income of $1995<br />

million in 2011.<br />

Companies reported that 95.2% of their income was<br />

sourced from the sale of goods and services with only<br />

1.5% from grants. By contrast, research organisations<br />

reported 8.2% of their income was sourced from the sale<br />

of goods and services and 79.5% from grants.<br />

The majority of companies (56.3%) and research<br />

organisations (63.0%) reported income growth in 2011.<br />

On average, company income grew by 14.9% (median 3%)<br />

and research organisations income by 19% (median 4%).<br />

One fifth of company respondents did not answer this<br />

question.<br />

A total of $594 million in grant income was received by<br />

survey participants in 2011, with research organisations<br />

accounting for $580 million (97.6% by value) and<br />

companies $14 million (2.4%).<br />

Companies were awarded $27.2 million in new grant<br />

funding during 2011, with $13.6 million of this funding<br />

being actually received in the same year6 .<br />

Respondents reported total expenditure of $1091 million<br />

with $564 million spent on wages and salaries (52%),<br />

$189 million on R&D (17%) and $134 million on capital<br />

items (12%).<br />

Respondents from the Human Health – Pharmaceuticals,<br />

vaccines or drug discovery sub-sector reported the<br />

highest average spend on R&D of all industry<br />

sub-sectors.<br />

Research Organisations accounted for 74% of the capital<br />

expenditure reported for 2011.<br />

2.7 Sentiment and Outlook<br />

Business sentiment was positive overall with 65% of<br />

respondents expecting their income to increase over the<br />

coming 12 months and 82% of respondents expecting<br />

their income to increase over the next three years.<br />

While the majority of companies and the majority of<br />

research organisations expected income growth over<br />

12 months and three years, about 13% of companies<br />

anticipated a decrease in total income over the next<br />

12 months and 6% anticipated a decrease in total income<br />

over the next three years. By contrast, no research<br />

organisations anticipated a fall in income in either period.<br />

The average expected quantum change in income for<br />

companies over the coming 12 months was 47% and for<br />

research organisations, 8%. Over the next three years the<br />

forecast quantum change in income for companies was<br />

136% and for research organisations, 18%.<br />

An almost equal proportion of companies anticipated<br />

that their R&D expenditure would either increase or<br />

remain the same over the coming 12 months (42%<br />

remain the same, 45% increase) and three years (44%<br />

remain the same, 45% increase). The majority of research<br />

organisations anticipated that their R&D expenditure<br />

would increase over the coming 12 months (56%) and<br />

three years (83%).<br />

Respondents believed that improved industry<br />

representation and an increased commitment by<br />

government organisations to become early adopters of<br />

<strong>Queensland</strong> innovations were two factors important for<br />

future expansion of the industry.<br />

For 71% of companies, limited access to finance was<br />

having an impact on their organisation. While 43% of<br />

companies (96) were optimistic or very optimistic that<br />

this barrier could be overcome, 19% were pessimistic or<br />

very pessimistic. Other barriers to future income growth<br />

that were highly ranked included (1) limited access to<br />

government grant funding (grants accounted for only 1.5%<br />

of company income, and companies attracted only 2.4% of<br />

the value of all grants reported in the survey);<br />

(2) increased domestic and/or international competition;<br />

and (3) the small size of the domestic market.<br />

The three greatest risks or challenges facing respondents<br />

were (1) access to sufficient capital for growth or market<br />

entry; (2) the high Australian dollar; and (3) regulatory<br />

issues.<br />

4 Ibid.<br />

5 Excluding persons paid by commission only, consultants or contractors, non-salaried directors and volunteers.<br />

6 Note that many grants are awarded for periods covering 2-3 years and, as such, the amount awarded may not be counted as income in the year that it<br />

was awarded.


2.8 Stage of Development of QLS Companies<br />

These sub-sectors are believed to be relatively mature:<br />

(a) complementary medicines; (b) functional foods and<br />

nutraceuticals; and (c) animal health (see Chapter 14 Appendix<br />

for sub-sector definitions). Respondents in these sub-sectors<br />

dedicated the majority of their effort at an advanced stage<br />

(market readiness/registration and at market) and the majority<br />

of their advanced products were near or at market.<br />

Effort within the Medical Devices and Equipment sub-sector<br />

was spread across the development cycle, indicating a pipeline<br />

of products under development across the industry.<br />

Diagnostic companies seemed to be evenly divided into those<br />

who dedicated most of their effort at advanced development<br />

stages (market release/market) and those who were focused<br />

largely on early stage development activities.<br />

The majority of effort in the pharmaceuticals, vaccines or<br />

biologics sub-sector was directed at the very early discovery/<br />

preclinical phase.<br />

2.9 Debt and Equity Finance<br />

Nine respondents reported a total of $70.5 million<br />

in financing in 2011.<br />

Existing shareholders were said to account for the majority<br />

($48.5 million, or 68.8%) of total funds raised by companies in<br />

2011 and the highest average amount invested per company.<br />

Approximately 37% of companies intended to raise debt or<br />

equity finance in the coming two years.<br />

Secondary data indicated that, in Australia, <strong>Life</strong> <strong>Sciences</strong><br />

(including healthcare) companies received 58% of all VC<br />

invested and accounted for 51% of all investee companies.<br />

The majority of VC investments in Australia (68%) were<br />

devoted to later stage investments rather than pre-seed/seed/<br />

start-up investments.<br />

2.10 Exports and International Collaborations<br />

55% of companies were involved in exporting with an average<br />

of 43% of their income derived from exports. The figures for<br />

2009 were 52% of companies exporting with export income<br />

representing an average of 33% of total income. The three<br />

largest export markets were the USA, New Zealand and UK. The<br />

three largest target markets for future exports were the USA,<br />

UK and China.<br />

42% of companies earned an average of 32% (median 20%)<br />

of their revenue from international business deals or research<br />

collaborations. The top three markets for international<br />

business deals and collaborations were the USA, UK and<br />

Japan/New Zealand.<br />

2.11 Research and Development<br />

43% of respondents outsourced R&D activity in 2011. The<br />

average amount of R&D activity outsourced was 41%.<br />

Of those who did outsource some R&D, 48% had utilised<br />

contract manufacturing services in the last year, with the top<br />

three locations for providers being Australia, USA and China.<br />

Of those who did outsource some R&D, 50% had utilised<br />

contract research services in the last year, with the top three<br />

locations for providers being Australia, USA and UK.<br />

39% of companies indicated that they had an interaction with at<br />

least one <strong>Queensland</strong> research organisation in 2011, primarily<br />

a collaborative or contract research arrangement. In the<br />

majority of instances the company had prior interaction with the<br />

research organisation in question.<br />

64% of companies indicated that the public sector research<br />

base in <strong>Queensland</strong> was important to their future operations.<br />

15


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

16<br />

2b. INDUSTRY-WIDE ESTIMATES OF KEY<br />

MEASURES<br />

“Total population estimates for the 301 QLS organisations were generated<br />

through a statistical extrapolation of aggregated data from 139 survey<br />

respondents.”<br />

2.12 Methodology and Rationale<br />

The relatively high response rate to the survey<br />

allowed us to attempt a statistical extrapolation<br />

of the data obtained. For key measures including<br />

employment, income and expenditure we employed<br />

statistical methods to estimate totals for the entire<br />

state of <strong>Queensland</strong>, based on the survey responses<br />

received and assuming that non-responders could<br />

be appropriately profiled based on the sector they<br />

are part of and their size. Respondent organisations<br />

were classified into a number of stratums based<br />

on their size with respect to the number of FTE<br />

employees.<br />

Total population estimates were derived by applying<br />

bootstrapped estimates of the mean within each<br />

stratum to the 162 organisations that were not<br />

able to participate in the survey this year (the size<br />

of each of these non-responding organisations<br />

was estimated with reference to other primary and<br />

secondary data). These estimates are presented<br />

in Table 3.<br />

These estimates should be taken at face value<br />

given that the variability in the population of nonresponders<br />

is not known. Whilst the reliability<br />

of the estimates cannot be assured, as within<br />

any statistical extrapolation, this exercise was<br />

undertaken in an attempt to enhance the utility of<br />

the raw survey data. The estimates for 2011 were<br />

derived in the same manner and using similar<br />

methodology to our estimates for the 2009 survey,<br />

and thus we offer a comparison of the estimates<br />

for those two periods.<br />

The figures are based on a statistical extrapolation<br />

of aggregated data (referred to as ‘actual’ data)<br />

from 139 organisations. These numbers were not<br />

derived through economic modelling and this is not<br />

an economic analysis of the industry. The estimates<br />

are highly variable and dependent on the statistical<br />

methodology employed (please see Important<br />

Notice for further details).<br />

Profile of the Full <strong>Industry</strong> as Represented in the<br />

<strong>Queensland</strong> Government Database<br />

In 2011, the QLS <strong>Industry</strong> included 301<br />

organisations. Of those, 133 were deemed to be<br />

operating in the Biotechnology division of the<br />

industry, and 168 in the TMD division.<br />

There were 252 public and private companies and<br />

49 research organisations.<br />

At 30 June 2011, 7.8% of ASX-listed <strong>Life</strong> <strong>Sciences</strong><br />

companies (n = 102) 7 were located in <strong>Queensland</strong><br />

and their average market capitalisation was $60.2<br />

million. The total market capitalisation for all<br />

ASX-listed Australian <strong>Life</strong> <strong>Sciences</strong> firms (102)<br />

at 30 June 2011 was $35.0 billion (or $9.1 billion<br />

excluding CSL Ltd, Cochlear Ltd and ResMed Ltd;<br />

99 companies – average market capitalisation<br />

$91.7 million).<br />

7 As listed in the PricewaterhouseCoopers <strong>Life</strong> <strong>Sciences</strong> Index.<br />

8 National Health and Medical Research Council, Successful NHMRC Grant applications for 2004 – 2009, http://www.nhmrc.gov.au/<br />

funding/funded/outcomes/projects.htm; accessed 29 May <strong>2012</strong>.<br />

9 Australian Research Council, ARC Funded Research Projects - Trends Data Set 2002 – 2009,http://www.arc.gov.au/general/<br />

searchable_data.htm


2.13 <strong>Industry</strong> Wide Estimates for 2011<br />

TABLE 3: <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> — whole of industry estimates 2011<br />

Actual Response rate Estimate for<br />

whole industry<br />

95% confidence<br />

interval<br />

2009 data for<br />

reference<br />

Employment (FTEs)<br />

All Respondents/<strong>Industry</strong> 8085 45% 14,106 13,663 - 14,550 19,731<br />

Companies 3433 44% 8008 7566 - 8451 13,442<br />

Research Organisations<br />

Income ($m)<br />

4652 49% 6098 5874 - 6323 6289<br />

All Respondents/<strong>Industry</strong> $1995 33% $4361 $4010 - $4713 $4943<br />

Companies $1220 31% $3275 $2924 - $3627 $3844<br />

Research Organisations<br />

Total Expenditure<br />

$774 45% $1086 $1013 - $1158 $1099<br />

All Respondents/<strong>Industry</strong> $1091 31% $4626 $4233 - $5019 $4682<br />

Companies $606 30% $3271 $2878 - $3664 $4177<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

$485 35% $1355 $1034 - $1676 $504<br />

All $564 28% $2141 $2016 - $2267 $1078<br />

Companies $292 27% $1323 $1197 - $1449 $929<br />

ROs<br />

R&D Expenditure ($m)<br />

$272 33% $818 $632 - $1005 $149<br />

All $189 28% $657 $628 - $686 $803<br />

Companies $57 27% $245 $215 - $274 $417<br />

ROs<br />

Capital Expenditure ($m)<br />

$132 33% $412 $282 - $541 $386<br />

All $134 29% $692 $670 - $714 $253<br />

Companies $36 28% $514 $491 - $535 $181<br />

ROs<br />

Numbers may appear inconsistent due to rounding.<br />

$98 33% $178 $113 - $244 $72<br />

Companies employed an estimated 57% of people in the<br />

industry and accounted for an estimated 62% of expenditure<br />

on wages and 37% of expenditure on R&D.<br />

Some relevant secondary data<br />

The number of bioscience degree completions from<br />

<strong>Queensland</strong> universities increased from 10,261 in 2009 to<br />

11,007 in 2010, and remained at 18% of all Australian<br />

bioscience completions.<br />

The value of NHMRC grant funding received by <strong>Queensland</strong><br />

applicants in 2011 ($116 million) was almost double that<br />

received in 2006 ($60 million). <strong>Queensland</strong>’s share of the total<br />

national NHMRC grant funding rose from 13.3% in 2006<br />

to 15.4% in 2011. 8<br />

The value of ARC grants awarded to <strong>Queensland</strong> researchers<br />

increased by 39% between 2005 and 2009, from $78.9<br />

million (2005) to $109.7 million (2009). 9<br />

17


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

18<br />

2.14 Comparison of <strong>Industry</strong> Wide Estimates<br />

from 2007 to 2011<br />

The figures presented in the following three Tables include<br />

estimates only for the <strong>Queensland</strong> <strong>Industry</strong> in 2007, 2009<br />

and 2011, based on a statistical extrapolation of data from a<br />

sample of the industry population (i.e. data from those who<br />

responded to the survey conducted in each respective year).<br />

The sample of organisations that respond will be different<br />

each year and so direct comparisons must be made in<br />

knowledge of the potential for extreme variability in the data.<br />

In 2007, the analysis of the QLS <strong>Industry</strong> involved two<br />

separate surveys: for Biotechnology and for Therapeutic<br />

Medicines and Devices (TMD). However, these two sectors<br />

overlap in terms of their definition, and a number of<br />

organisations could have fallen into either sector. For<br />

the 2009 and 2011 surveys, the Biotechnology and TMD<br />

groups were merged into a more broadly defined QLS<br />

<strong>Industry</strong>. To allow a trend analysis of key parameters for<br />

TABLE 4: <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>: whole of industry estimates — Trends a<br />

10 Australian Bureau of Statistics 6202.0 - Labour Force Australia<br />

the Biotechnology and TMD sectors since 2007, the data<br />

from the 2009 and the current survey were also analysed<br />

according to this division. Of the 301 organisations in<br />

the industry, 133 (44%) were deemed to be operating in<br />

Biotechnology, and 168 (56%) in TMD.<br />

A similar statistical methodology was employed for<br />

estimates from the 2011 and 2009 survey data. In some<br />

cases, the 2007 <strong>Queensland</strong> Biotechnology and TMD survey<br />

results were reanalysed using the methodology applied to<br />

the 2009 and 2011 survey data. Please note that income<br />

data for the TMD analysis in 2007 was collected as an<br />

income range and not a specific figure, as was the case in<br />

subsequent surveys.<br />

<strong>Queensland</strong>-wide employment estimates decreased by<br />

28.5% from the 2009 estimates (Table 4). The majority of<br />

employees were lost from companies (down by 40%), with<br />

estimates for research organisations being similar in 2009<br />

and 2011 (down by 3%).<br />

2007 Survey b 2009 Survey 2011 Survey Difference 2009-2011 CAGR 2007-2011<br />

Employment (FTEs)<br />

All <strong>Industry</strong> 15,569 19,731 14,106 -28.5% -2.4%<br />

Companies N/A 13,442 8008 -40.4%<br />

Research Organisations N/A 6289 6098 -3.1% c<br />

Qld Labour Force Growth10 Total Income ($m)<br />

1.9%<br />

All <strong>Industry</strong> $3130 $4943 $4361 -11.8% 8.7%<br />

Companies N/A $3844 $3275 -14.8%<br />

Research Organisations N/A $1099 $1086 -1.2% c<br />

Expenditure ($m)<br />

Total Expenditure ($m)<br />

All <strong>Industry</strong> N/A $4682 $4626 -1.2% c<br />

Companies N/A $4177 $3271 -21.7%<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

N/A $504 $1355 169.0%<br />

All <strong>Industry</strong> $789 $1078 $2141 98.6% 28.4%<br />

Companies N/A $929 $1323 42.4%<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

N/A $149 $818 449.0%<br />

All <strong>Industry</strong> N/A $803 $657 -18.2%<br />

Companies N/A $417 $245 -43.1%<br />

Research Organisations N/A $386 $412 6.7% c<br />

Capital Expenditure ($m)<br />

All <strong>Industry</strong> $704 $253 $692 174% -0.4%<br />

Companies N/A $181 $514 184%<br />

Research Organisations N/A $72 $178 147%<br />

a Numbers may appear inconsistent due to rounding N/A = not applicable<br />

b Combined estimates from previous Biotechnology and TMD Surveys<br />

c These changes fall within the confidence interval


It was estimated that $2141 million was spent on salaries by the<br />

<strong>Queensland</strong> industry in 2011 including $818 million by research<br />

organisations and $1323 million by companies (Table 4). This<br />

was almost double the amount estimated for 2009 due to a<br />

greater than four-fold increase for ROs and a 40% increase<br />

for companies.<br />

The estimated income across the entire <strong>Industry</strong> was $4.36<br />

billion in 2011 (Table 4). This is 11.8% lower than the $4.94 billion<br />

estimate in 2009 but 39.3% higher than the estimate in 2007<br />

(combined total from the <strong>Queensland</strong> Biotechnology and TMD<br />

Surveys). The income decline in 2011 was largely attributed to<br />

companies, with estimates down by 14.8% compared to a 1.2%<br />

decline for research organisations. Based on these estimates,<br />

the CAGR for income was 8.7% between 2007 and 2011.<br />

The estimated expenditure across the entire QLS <strong>Industry</strong><br />

was $4.63 billion in 2011 (Table 4), with just over 70% of that<br />

attributed to the private sector.<br />

2.15 Estimates for the Biotechnology Sector — 2007 to 2011<br />

TABLE 5: <strong>Queensland</strong> Biotechnology sector: whole of industry estimates 2007 — 2011<br />

For companies, employment estimates were down significantly<br />

in 2011 (by 40.4%) compared to 2009. Total expenditure was<br />

down by 21.7% most likely due to a significant (43.1%) fall in<br />

R&D expenditure. Expenditure on wages was estimated to have<br />

increased by 42%, suggesting that work previously undertaken<br />

in-house may have been outsourced, and/or that some staff had<br />

were re-engaged as sub-contractors rather than employees.<br />

Total income was down by a comparably small 14.8% (just<br />

outside the margin of error), in the face of a much greater fall<br />

in estimated expenditure. Companies may be adopting a more<br />

conservative approach, seeking to retain more of the earnings<br />

on the expectation of a continued negative economic climate.<br />

For research organisations, employment and income were down<br />

marginally and R&D expenditure was up slightly — all of these<br />

figures were within the statistical margin of error. Expenditure<br />

estimates were substantially higher possibly reflecting the draw<br />

down on funds awarded 2-3 years previous.<br />

2007 Survey* 2009 Survey 2011 Survey a Difference 2009-2011 CAGR 2007-2011<br />

Biotechnology Employment (FTEs)<br />

All Biotechnology Sector 7630 9929 8021 -19.3% 1.3%<br />

Companies 1840 3760 2150 -42.9% 4.0%<br />

Research Organisations<br />

Biotechnology Income ($m)<br />

5790 6169 5871 -4.9% 0.4%<br />

All Biotechnology Sector $896 $2185 $1665 -23.8% 16.8%<br />

Companies $395 $1093 $597 -45.4% 10.9%<br />

Research Organisations<br />

Biotechnology Expenditure ($m)<br />

Total Expenditure ($m)<br />

$501 $1092 $1068 -2.2% 20.9%<br />

All Biotechnology Sector ND $1710 $1775 3.8%<br />

Companies ND $1254 $437 -65.2%<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

ND $456 $1338 193.0%<br />

All Biotechnology Sector $502 $384 $1085 183% 21.3%<br />

Companies $348 $244 $279 14.3% -5.4%<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

$154 $140 $806 475% 51.3%<br />

All Biotechnology Sector $641 $550 $510 -7.3% -5.6%<br />

Companies $230 $170 $98 -42.4% -19.2%<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

$411 $380 $412 8.4% 0.1%<br />

All Biotechnology Sector $469 $172 $217 26.2% -17.5%<br />

Companies $41 $103 $43 -58.3% -1.2%<br />

Research Organisations<br />

* <strong>Queensland</strong> Biotechnology Survey 2007;<br />

$428 $69 $174 152% -20.2%<br />

ND = not determined a for bias corrected 95% confidence intervals for each estimate please see Chapter 13<br />

Numbers may appear inconsistent due to rounding.<br />

An estimated 8021 FTEs were employed in the Biotechnology sector.<br />

Estimates for the private biotechnology sector suggest major falls in employment, income and expenditure. Public sector research<br />

organisations in biotechnology showed marginal falls in estimates for employment and income with marked increases in expenditure,<br />

particularly that on wages.<br />

19


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

20<br />

2.16 Estimates for the Therapeutic Medicines and Devices Sector — 2007 to 2011<br />

TABLE 6: <strong>Queensland</strong> TMD sector: whole of industry estimates 2007 — 2011<br />

2007 Survey* 2009 Survey 2011Survey Difference 2009-2011 CAGR 2007-2011<br />

TMD Employment (FTEs)<br />

All TMD Sector 7939 9802 6086 -37.9% -6.4%<br />

Companies ND 9682 5859 -39.5%<br />

Research Organisations<br />

TMD Income ($m)<br />

ND 120 227 89.0%<br />

All TMD Sector $2234 $2758 $2696 -2.3% 4.8%<br />

Companies ND $2750 $2679 -2.6%<br />

Research Organisations<br />

TMD Expenditure ($m)<br />

Total Expenditure ($m)<br />

ND $7 $17 143.0%<br />

All TMD Sector ND $2930 $2851 -2.7%<br />

Companies ND $2923 $2834 -3.0%<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

ND $7 $17 143%<br />

All TMD Sector $287 $691 $1057 53.0% 38.5%<br />

Companies ND $685 $1044 52.4%<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

ND $6 $13 117.0%<br />

All TMD Sector ND $253 $147 -41.9%<br />

Companies ND $247 $147 -40.5%<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

ND $6 - -<br />

All TMD Sector $235 $80 $475 493% 19.2%<br />

Companies ND $78 $470 502%<br />

Research Organisations<br />

* <strong>Queensland</strong> TMD Survey 2007;<br />

ND = not determined<br />

ND $2 $5 150%<br />

Numbers may appear inconsistent due to rounding.<br />

An estimated 6086 FTEs were employed in the TMD sector.<br />

Companies in the TMD sector showed a major decline in estimates for employment (down almost 40%) but only marginal<br />

decreases in total income and total expenditure. R&D expenditure was down substantially (by 40.5%) but a 52.4% increase<br />

in estimates for wages and a marked increase in capital expenditure balanced this out.<br />

Given that there were only two research organisations deemed to be in the TMD sector there are no comments made on<br />

the difference between estimates from 2009 and 2011.


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

22<br />

3.INTRODUCTION<br />

“The <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> analysis covers more than<br />

12 industry sub-sectors.”<br />

3.1 <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong> Analysis<br />

The <strong>Queensland</strong> Government commissions the<br />

<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> every<br />

two years to inform policy and the development of<br />

industry assistance and support programs, and to<br />

aid in benchmarking the State’s industry nationally<br />

and internationally.<br />

The report was developed from data obtained<br />

through a survey conducted in April and May <strong>2012</strong>.<br />

A total of 139 (46%) of the 301 organisations in the<br />

industry responded to a detailed questionnaire that<br />

sought data on measures of industry performance<br />

in 2011, and sentiment for the coming years.<br />

The data collected was used to statistically<br />

derive estimates of key measures for the entire<br />

<strong>Queensland</strong> industry in 2011. A comparison was<br />

made between these statistical estimates and<br />

those from similar surveys in 2007 and 2009.<br />

3.2 <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong> Survey<br />

The basis for the report is a combination of (a) the<br />

results of the voluntary on-line survey conducted<br />

by VenturePro Pty Ltd; and (b) publicly available<br />

secondary data. The QLS <strong>Industry</strong> Survey was<br />

sent to 301 <strong>Life</strong> <strong>Sciences</strong> companies and research<br />

organisations across <strong>Queensland</strong>. This included:<br />

252 public and private companies, incorporated<br />

associations and sole traders (referred to as<br />

’companies’) (84%); and<br />

49 university faculties, schools, institutes,<br />

centres or independent research organisations<br />

TABLE 7: <strong>Industry</strong> sectors<br />

with a <strong>Life</strong> <strong>Sciences</strong> focus (referred to as<br />

‘research organisations’) (16%).<br />

With regard to research organisations, the relevant<br />

university institutes, faculties, schools or research<br />

centres were approached to complete the survey,<br />

rather than universities as a whole. The exception<br />

to this was the less-research-intensive universities<br />

who were approached via their Office for Research<br />

or equivalent. Chapter 13 of this report contains<br />

a summary of key data, while a description<br />

of the methodology applied can be found in<br />

the Appendices.<br />

For the purpose of the survey, a <strong>Life</strong> <strong>Sciences</strong><br />

organisation was defined as any company,<br />

university unit or other research organisation<br />

undertaking <strong>Life</strong> <strong>Sciences</strong>-related activities<br />

encompassed by the broad categories listed in<br />

Table 7. These categories were adapted from a<br />

previous AusBiotech definition of Biotechnology<br />

and Medical Technology in 2009, in combination<br />

with typical definitions employed for the<br />

pharmaceutical industry (see Appendices for<br />

a description of activities in each category).<br />

To enable comparisons with previous surveys,<br />

the categories listed below were also grouped<br />

into two major industry divisions: Biotechnology<br />

(organisations with core activities in agricultural,<br />

food, environmental, medical and industrial<br />

biotechnology and bioinformatics) and Therapeutic<br />

Medicines and Devices (TMD; pharmaceuticals,<br />

vaccines or drug discovery, diagnostics, medical<br />

devices and equipment, complementary medicines/<br />

functional foods and animal health).<br />

Human health – pharmaceuticals, vaccines<br />

or drug discovery<br />

Agricultural biotechnology<br />

Human health – complementary medicines Food biotechnology<br />

Human health – functional foods and<br />

nutraceuticals<br />

Environmental biotechnology<br />

Human health – diagnostics Marine<br />

Human health – medical devices and equipment Industrial biotechnology<br />

Animal health Bioinformatics<br />

<strong>Industry</strong> service provider


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

24<br />

4.PROFILE OF SURVEY RESPONDENTS<br />

“The 2011 QLS <strong>Industry</strong> survey was undertaken by 139 organisations (46%)<br />

out of 301 identified in the <strong>Queensland</strong> Government database.”<br />

4.1 Classification of <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> Organisations<br />

4.1.1 Type of Organisation Responding<br />

to the Survey<br />

Survey participants included 111 public and private<br />

companies, incorporated associations and sole<br />

traders (~80%; referred to as ’companies’) and<br />

28 university research faculties, schools, institutes,<br />

centres or independent research organisations<br />

with a <strong>Life</strong> <strong>Sciences</strong> focus (~20%; referred to as<br />

‘research organisations’).<br />

Of the 111 companies who responded to the<br />

survey, 85 were private companies (77%), 11<br />

were unlisted public companies (10%) and nine<br />

were listed companies (8%). One sole trader and<br />

one incorporated association responded. Those<br />

selecting the ‘Other’ category (4%) were identified<br />

as two venture funds, one unincorporated joint<br />

venture and one statutory authority (Figure 1).<br />

13% of respondents (18 of 111 companies)<br />

indicated that they were a spin-out from a<br />

<strong>Queensland</strong> university or research institution.<br />

Research organisations/units who responded to the<br />

survey included research institutes (50%), research<br />

centres (29%), faculties (11%), university research<br />

offices responding for the university as a whole (7%)<br />

and schools (4%)<br />

Figure 1: Breakdown of survey respondents by<br />

organisation type (139 respondents)<br />

4.1.2 Profile of Respondents by <strong>Industry</strong> Division<br />

51% of the 139 survey participants were operating<br />

in the ‘Biotechnology’ sector and 42% in the<br />

Therapeutic Medicines and Devices (TMD) sector<br />

(Table 8).<br />

TABLE 8: Respondent profile according to industry<br />

division<br />

Bio-<br />

technology<br />

Companies Research<br />

Organisations<br />

42<br />

responded<br />

of 86<br />

(49%)<br />

TMD 69<br />

responded<br />

of 166<br />

(41%)<br />

Total 111<br />

responded<br />

of 252<br />

(44%)<br />

26<br />

responded<br />

of 47<br />

(55%)<br />

2<br />

responded<br />

of 2<br />

(100%)<br />

28<br />

responded<br />

of 49<br />

(57%)<br />

Total<br />

68<br />

responded<br />

of 133<br />

(51%)<br />

71<br />

responded<br />

of 168<br />

(42%)<br />

139<br />

responded<br />

of 301<br />

(46%)<br />

4.1.3 Profile of Respondents by Organisation Size<br />

The profile of respondents to the survey was also<br />

defined by their size, based on the number of FTE<br />

employees (Table 9).<br />

TABLE 9: Respondent profile according to organisation<br />

size (number of FTEs)<br />

Small<br />

(0-30)<br />

Medium<br />

(31-100)<br />

Large<br />

(>101)<br />

TOTAL<br />

Companies 84 21 6 111<br />

Research<br />

Organisations<br />

4 7 13 24<br />

Total 88 28 19 135<br />

4.1.4 Profile of Respondents by Year of Formation<br />

Forty-six companies (~45%) were less than 10 years<br />

old. Thirty-two (31%) were between 11 and 20 years<br />

old; 24 companies (23%) were between 21 and 40<br />

years old and one company was formed over<br />

40 years ago (Table 10).


TABLE 10: Year of inception for <strong>Life</strong> <strong>Sciences</strong> organisations<br />

(103 respondents)<br />

Years in<br />

Operation<br />

Number of<br />

companies<br />

Proportion of<br />

companies<br />

Over 40 years (pre-1972) 1 1.0%<br />

31-40 years (1972-1981) 8 7.8%<br />

21-30 years (1982-1991) 16 15.5%<br />

16-20 years (1992-1996) 9 8.7%<br />

11-15 years (1997-2001) 23 22.3%<br />

6-10 years (2002-2006) 28 27.2%<br />

2-5 years (2007-2010) 13 12.6%<br />

Under two years (2011) 5 4.9%<br />

4.1.5 <strong>Industry</strong> Sub-sector Breakdown<br />

COMPANIES<br />

Companies within the QLS <strong>Industry</strong> operate across various<br />

industry sub-sectors including:<br />

Human health (pharmaceuticals, vaccines or drug discovery;<br />

diagnostics, complementary medicines; functional foods/<br />

nutraceuticals; medical devices and equipment);<br />

TABLE 11: Breakdown of <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> companies by sub-sector<br />

Animal health;<br />

Biotechnology (agricultural, food, environmental,<br />

marine, bioinformatics); and<br />

<strong>Industry</strong> service provision.<br />

Although organisations may operate across more than one<br />

sub-sector, companies were required to select one to which they<br />

were most closely aligned based on their core activities. A majority<br />

of the 111 companies (55.9%) selected one of the ‘Human Health’<br />

sub-sectors (Table 11).<br />

RESEARCH ORGANISATIONS<br />

Research organisations were asked to apportion their activity<br />

across the various sub-sectors rather than select only one subsector<br />

as companies did. The greatest concentration of research<br />

activity undertaken by research organisations (62%) was across<br />

the five segments of the Human Health sub-sector; including<br />

pharmaceuticals, vaccines, drug discovery (36.9%), diagnostics<br />

(12.8%), medical devices and equipment (7.0%), complementary<br />

medicines (3.1%) and functional food/nutraceuticals (2.0%).<br />

The remaining 38% was spread across Environmental (10.5%),<br />

Bioinformatics (7.4%), Marine (4.3%), Agricultural Biotechnology<br />

(4.1%), Industrial (3.6%), Animal Health (2.7%), Other (4.6%) and<br />

Food Biotechnology (1.1%) (Figure 2).<br />

Sub-sector Proportion Number<br />

Human health Medical devices and equipment 55.9% 20.7% 62 23<br />

Pharmaceuticals, vaccines, drug discovery 12.6% 14<br />

Complementary medicines 9.9% 11<br />

Functional food/nutraceuticals 8.1% 9<br />

Diagnostics 4.5% 5<br />

<strong>Industry</strong> service providers 22.5% 25<br />

Animal health 5.4% 6<br />

Other 5.4% 6<br />

Biotechnology organisations across agricultural, food, environmental, industrial and bioinformatics 10.8% 12<br />

Totals 100% 111<br />

25


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

26<br />

Figure 2: Breakdown of research organisations by <strong>Life</strong> <strong>Sciences</strong> industry sub-sector (28 respondents)<br />

4.1.6 Comparative Profile of the full <strong>Queensland</strong><br />

Government <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> Database<br />

As a cross-check on the profile for respondents to the<br />

survey, the full database of 252 companies was profiled<br />

according to sub-sector.<br />

Those companies that did not respond to the survey were<br />

assigned to a division and size category based on either<br />

information from the 2009 survey or following a review of<br />

any publicly available secondary data on the organisation.<br />

The profile of the full company database was similar to that<br />

for the survey population.<br />

The sub-sector breakdown of the <strong>Queensland</strong> industry<br />

in 2011 was compared to that determined in 2009<br />

(Table 12). The profile in each year was similar, with the<br />

TABLE 12: Sub-sector Breakdown of <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> Companies — 2009 and 2011<br />

greatest concentration of activity across the five Human<br />

Health sub-sectors.<br />

4.2 Reasons for Location in <strong>Queensland</strong><br />

Companies were asked to select from six possible<br />

reasons for the location of their business in <strong>Queensland</strong>,<br />

or to provide another reason. The most commonly selected<br />

reason (63%) was ‘Originally founded in <strong>Queensland</strong> or<br />

founder based in <strong>Queensland</strong>’ (Table 13). ‘Other’ reasons<br />

given included business specific issues (e.g. acquisition<br />

of existing business, joint venture with local business,<br />

specific climate for crop growth), and lifestyle issues<br />

(e.g. climate, family).<br />

Sector 2009 2011 2011<br />

Number of companies 104<br />

(survey data)<br />

Human health – pharmaceuticals, vaccines or drug discovery<br />

111<br />

(survey data)<br />

252<br />

(full database)<br />

12.6% 9.8%<br />

Human health – diagnostics 4.5% 2.3%<br />

Human health – complementary medicines 52.9% 9.9% 10.9%<br />

Human health – functional foods/nutraceuticals 8.1% 9.8%<br />

Human health – medical devices and equipment 20.7% 25.8%<br />

Animal health 4.8% 5.4% 4.3%<br />

Biotechnology (environmental, agricultural, food, industrial, bioinformatics) 10.6% 10.8% 12.5%<br />

<strong>Industry</strong> service provider 23.1% 22.5% 21.1%<br />

Other<br />

Numbers may appear inconsistent due to rounding.<br />

8.7% 5.4% 3.5%


TABLE 13: Reasons for QLS Companies Locating in <strong>Queensland</strong><br />

Reasons Proportion of Responses<br />

Originally founded in QLD or founder based in QLD 63%<br />

Spun-out of a QLD research organisation 13%<br />

Attracted by proximity to specific research infrastructure and/or skills 6%<br />

Attracted by QLD Government grant funding, incentives or other support 5%<br />

To establish a QLD division of a national or international company 3%<br />

Favourable Regulatory environment 1%<br />

Don’t know 1%<br />

Other (please specify) 9%<br />

4.3 Activity Across the Value Chain<br />

4.3.1 Products at Market<br />

Data on the number of lead products at market support the idea<br />

that the <strong>Queensland</strong> industry is maturing (Table 14).<br />

TABLE 14: The proportion of lead products at market<br />

Year Therapeutic Non-therapeutic<br />

2009 34% 42%<br />

2011 69% 56%<br />

4.3.2 Sub-sector analysis of the value-chain<br />

The extent of ‘effort’ (e.g. funding, resourcing) dedicated to each<br />

stage of product development can be viewed as an indicator of<br />

both the maturity of the industry and the pipeline of products<br />

in development. Different types of products and services (e.g.<br />

biotechnology, therapeutic and medical devices) have distinct<br />

development pathways. In order to collect meaningful data,<br />

companies were offered questions relevant to the type of product<br />

or service they were developing. In the following section, rounding<br />

may cause numbers to appear to be inconsistent.<br />

Pharmaceuticals, Vaccines, Biologics <strong>Industry</strong> Sub-sector<br />

Companies involved in developing pharmaceuticals, vaccines or<br />

biologics dedicated the greatest effort in the very early ‘discovery/<br />

Average for the proportion of effort dedicated to each stage of development (10 respondents)<br />

Stage of Lead Product (Total of 10 stages nominated by 10 companies)<br />

Stage of Top Seven Products (Total of 32 stages nominated by 10 companies)<br />

preclinical’ phase of therapeutic development (average of 45%).<br />

An average of 34% of effort was focussed on clinical development,<br />

with the majority at Phase II. The late phase of the value chain,<br />

registration/market was the focus of an average of 21% of effort.<br />

Each pharma company nominated the development stage of their<br />

‘lead’ or single most advanced product. Responses were spread<br />

across development stages with 40% of lead products already at<br />

registration or at market. An equal proportion of lead products<br />

were in early clinical development (Phase I 10%, Phase II 30%).<br />

20% of lead products were still in a discovery/preclinical phase.<br />

Survey participants were asked to nominate the stage of<br />

development for up to seven of their most advanced products.<br />

Most products were either in discovery/preclinical phase (31%)<br />

or registration/market phase (47%). (See graph on p.24)<br />

Diagnostics <strong>Industry</strong> Sub-sector<br />

Effort was fairly evenly spread across the value chain for<br />

diagnostic companies. Lead products were either pre-market<br />

(66%) or near/at market (33%). Of the most advanced products<br />

(up to seven could be nominated), the majority (56%) were ready<br />

for market release or already at market. The remaining 44%<br />

were at various stages of product development.<br />

27


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

28<br />

Average for the proportion of effort dedicated to each stage of development (5 respondents).<br />

Stage of Lead Product (Total of nine stages nominated by five companies)<br />

Stage of Top Seven Products (Total of 25 products nominated by five companies)<br />

Animal Health <strong>Industry</strong> Sub-sector<br />

The Animal Health sub-sector appears to be a mature segment of the QLS <strong>Industry</strong> with the majority of total effort (78%)<br />

focussed at the registration/market stage. An average of 22% of total effort in this sub-sector was spent in the development<br />

or testing of new products (discovery/preclinical 12%, clinical testing 10%).<br />

All lead products (100%) and the majority (84%) of the most advanced products reported by companies in this sub-sector<br />

had already reached registration/market stage. This may, in part, reflect the lower regulatory hurdles for the development of<br />

animal health products compared to human therapeutics and medical devices, reducing both the time and cost required to<br />

reach the market.<br />

Average for the proportion of effort dedicated to each stage of development (5 respondents).<br />

Stage of Lead Product (Total of six stages nominated by five respondents)<br />

Stage of Top Seven Products (Total of 25 stages nominated by five respondents)<br />

Complementary Medicines and Functional Foods/Nutraceuticals <strong>Industry</strong> Sub-sectors<br />

The majority of effort by companies from the combined complementary medicines, functional foods and nutraceuticals<br />

sub-sectors was focussed on market readiness/market (64%). However, 31% of effort was focussed on early stage activities<br />

(discovery and proof of concept) and a further 5% in clinical development.<br />

This sub-sector appears to be relatively mature, with 80% of lead products near or at market, these companies are active<br />

in R&D and have a pipeline of products under development with about 21% of lead products and 19% of the most advanced<br />

products still at discovery, proof of concept or clinical development stages.<br />

Average for the proportion of effort dedicated to each stage of development (17 respondents)<br />

Stage of Lead Product (Total of 24 stages nominated by 17 companies)<br />

Stage of Top Seven Products (Total of 96 stages nominated by 17 companies)


Medical Devices and Equipment <strong>Industry</strong> Sub-sector<br />

Overall, effort was spread across the value chain for medical devices and equipment companies. However, about 45% of effort<br />

was focussed either at the market or regulatory approval stages. 87% of lead products from this sub-sector were in late stage<br />

development (7% commercialisation/regulatory approval and 80% at market). Despite the advanced stage of lead products,<br />

effort was expended across the development cycle with a pipeline of products likely to be under development.<br />

Average for the proportion of effort dedicated to each stage of development (15 respondents)<br />

Stage of Lead Product (Total of 15 stages nominated by 15 companies)<br />

Stage of Top Seven Products (Total of 60 stages nominated by 15 companies)<br />

Other Products/Services<br />

Other products and services included biofuels, agricultural products, electronics and environmental ‘solutions’. For these companies,<br />

an average of 43% of effort was dedicated to later stages of development.<br />

For their lead product or service, the majority were at market or near market, possibly indicating mature companies. About one-third<br />

of lead products were also in the very early stages of development (research/proof of concept).<br />

Average for the proportion of effort dedicated to each stage of development<br />

Stage of Lead Product (Total of 15 stages nominated by 15 companies)<br />

Stage of Top Seven Products (Total of 60 stages nominated by 15 companies)<br />

29


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

30<br />

4.3.3 <strong>Queensland</strong> Companies with Products<br />

in Clinical Development<br />

Development of new therapeutic products and devices is<br />

a heavily regulated process that involves a clinical phase<br />

of development during which product safety and efficacy<br />

are assessed. The Australian New Zealand Clinical Trials<br />

Registry (ANZCTR; www.anzctr.org.au) is one source of<br />

information on clinical trials conducted in Australia.<br />

The registry includes trials involving pharmaceuticals,<br />

alternative and complementary medicines, medical devices,<br />

treatments and rehabilitation therapies. Across all the<br />

relevant sectors (Table 15) at least 32 clinical stage<br />

products were identified as being under development<br />

by QLS companies.<br />

For pharmaceuticals, vaccines and biologics the<br />

development process is lengthy (10 – 15 years), expensive<br />

and heavily regulated. The expense is related to the<br />

capitalised cost of new drug approval, including the cost<br />

of all failures, which is estimated to be $1.3 billion. 11<br />

Regulation can occur through regulatory bodies, such as<br />

the Therapeutic Goods Administration (TGA), United States<br />

Food and Drug Administration, and the European Medicines<br />

Agency. Discovery and preclinical stages are followed by<br />

three distinct pre-market clinical trial phases (Phase I,<br />

II and III). Based on data from the survey, at least seven<br />

therapeutics under development by <strong>Queensland</strong> companies<br />

are currently in clinical development. Six of these had<br />

reached clinical proof of concept stage (Phase II, III). An<br />

analysis of ANZCTR identified a further two clinical trials of<br />

pharmaceuticals/vaccines or biologics being undertaken by<br />

<strong>Queensland</strong> companies in 2011/<strong>2012</strong>.<br />

TABLE 15: Number of products in clinical development by <strong>Queensland</strong> companies<br />

Complementary medicines undergo clinical development<br />

to demonstrate efficacy. ‘Registered’ complementary<br />

medicines have been evaluated by the TGA Office of<br />

Complementary Medicines for quality, safety and efficacy.<br />

‘Listed’ complementary medicines require only that the<br />

sponsor hold evidence to support efficacy. While survey<br />

respondents nominated six products in clinical development,<br />

an analysis of ANZCTR identified a further seven clinical<br />

trials of alternative or complementary medicines being<br />

funded/sponsored by <strong>Queensland</strong> companies in 2011/<strong>2012</strong>.<br />

Medical devices are regulated by the TGA Office of Devices,<br />

Blood and Tissues. Medical devices require appropriate<br />

clinical evidence to demonstrate the device conforms to the<br />

applicable provisions of the essential principles of the TGA.<br />

Survey respondents developing medical devices identified<br />

five medical device products at the clinical trial/testing stage<br />

of development. A further three products from <strong>Queensland</strong><br />

companies are in clinical development in 2011/<strong>2012</strong>,<br />

according to ANZCTR.<br />

Animal health products, including veterinary health<br />

products and veterinary chemical products, are regulated<br />

in Australia by the Australian Pesticides and Veterinary<br />

Medicines Authority. Regulatory requirements differ<br />

depending on the type of product, target species (companion<br />

animal vs. food producing animal) and whether the active<br />

ingredient is new or already registered. The regulations<br />

regarding the manufacture of animal health products<br />

and their preclinical development (preclinical safety and<br />

toxicity) have considerable overlap with those for human<br />

pharmaceuticals. Although much less extensive than human<br />

clinical trials, veterinary clinical trials also examine safety<br />

and efficacy in target species. Two veterinary products were<br />

reported by survey respondents to be in clinical development<br />

in 2011/<strong>2012</strong>.<br />

Sub-sector Survey data Registry data Total<br />

Pharmaceuticals, vaccines and biologics 7 2 9<br />

Complementary medicines/ Functional Foods and Nutraceuticals 6 7 13<br />

Medical devices 5 3 8<br />

Animal Health products 2 0 2<br />

Total 32<br />

11 Tufts Centre for the Study of Drug Development. http://csdd.tufts.edu/news/complete_story/pr_outlook_2011; accessed 10.12.12


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

32<br />

5.EMPLOYMENT<br />

“Surveyed organisations (135) reported a total of 8085 FTE staff, whilst<br />

the estimate for all 301 <strong>Life</strong> <strong>Sciences</strong> organisations in <strong>Queensland</strong> was<br />

just over 14,000.”<br />

5.1 <strong>Life</strong> <strong>Sciences</strong> Sector Employment<br />

<strong>Report</strong>ed by Respondents<br />

135 organisations reported a total of 8085 FTE staff.<br />

The number of FTEs per organisation ranged from<br />

less than one in ‘virtual’ companies to over 500<br />

employees in several institutes and university units.<br />

The average number of FTEs employed by research<br />

organisations (194) was over six times that of<br />

companies (31) (Table 16).<br />

TABLE 16: FTE Employees in the <strong>Queensland</strong><br />

<strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>, companies vs. research<br />

organisations 2011 (135 respondents)<br />

All respondents<br />

(135)<br />

Total<br />

FTEs<br />

Average<br />

FTEs<br />

Median<br />

FTEs<br />

8085 Total<br />

FTEs<br />

60<br />

11<br />

Companies<br />

(111)<br />

Average<br />

FTEs<br />

Median<br />

FTEs<br />

3433<br />

31<br />

8<br />

Research<br />

Organisations<br />

(24)<br />

Total<br />

FTEs<br />

Average<br />

FTEs<br />

Median<br />

FTEs<br />

4652<br />

194<br />

122<br />

5.1.1 Employees in Research Organisations<br />

Research organisations included centres, institutes,<br />

schools, faculties and universities, which vary<br />

significantly in unit size. The breakdown of FTEs for<br />

the research organisations that responded to the<br />

employment question is shown in Table 17.<br />

TABLE 17: Breakdown of FTEs from research<br />

organisations by unit size (24 respondents)<br />

Type of Unit Number of<br />

Responses<br />

Number<br />

of FTEs<br />

Average<br />

Number<br />

of FTEs<br />

Centre 7 450 64<br />

Institute 14 2544 182<br />

School 1 120 120<br />

Faculty 2 1538 769<br />

University 0 N/A N/A<br />

Total 24 4652 194<br />

5.1.2 Employees in Companies<br />

The total number of company FTEs reported within<br />

each industry sub-sector is shown in Table 18. For<br />

this analysis, organisations were assigned to only<br />

one industry sub-sector. Among companies, the<br />

complementary medicines sub-sector was the<br />

largest employer with 37.6% of all FTEs reported.<br />

TABLE 18: Number of FTE employees in companies by<br />

industry sub-sector in 2011 (111 respondents)<br />

Number of<br />

Companies<br />

Number<br />

of FTEs<br />

Proportion<br />

of Total<br />

FTEs<br />

Complementary<br />

Medicines<br />

Pharmaceuticals,<br />

11 1290 37.6%<br />

Vaccines or<br />

Drug Discovery<br />

14 612 17.8%<br />

Biotechnology 12 405 11.8%<br />

Medical Devices<br />

and Equipment<br />

23 344 10.0%<br />

<strong>Industry</strong> Service<br />

Provider<br />

25 305 8.9%<br />

Diagnostics 5 186 5.4%<br />

Functional Food/<br />

Nutraceuticals<br />

9 147 4.3%<br />

Animal Health 6 95 2.8%<br />

Other 6 49 1.4%<br />

Total 111 3433 100%<br />

5.1.3 Employees by <strong>Industry</strong> Division —<br />

Biotechnology and TMD<br />

The total number of FTE employees reported by<br />

71 respondents from the TMD division of the <strong>Life</strong><br />

<strong>Sciences</strong> sector was 2833, or an average of 40<br />

employees per organisation. The 64 Biotechnology<br />

organisations reported 5252 FTE employees, or an<br />

average of 82 employees per organisation (Table 19).<br />

TABLE 19: FTEs by Division — Biotechnology and TMD<br />

(135 respondents)<br />

Biotechnology TMD<br />

Total Average Total Average<br />

Companies 849 20 2584 38<br />

Research<br />

Organisations<br />

4403 200 249 124<br />

All<br />

Respondents<br />

5252 82 2833 40<br />

The number of personnel employed by QLS<br />

companies, but located interstate and overseas,<br />

is one measure of the reach of <strong>Queensland</strong><br />

companies outside the state. An average of 12<br />

FTEs per company were employed interstate and<br />

overseas (median 0.5 FTEs). The distribution of<br />

these interstate and overseas employees by subsector<br />

broadly mirrored the sub-sector distribution<br />

of employees based in <strong>Queensland</strong>.


5.2 Total Estimated <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> Employment<br />

Based on the average employment per organisation across all<br />

respondents, it was estimated that 14,106 FTEs were employed<br />

by the 301 <strong>Life</strong> <strong>Sciences</strong> companies, universities and research<br />

organisations across the State in 2011. Of those, 8021 were<br />

assumed to be in the Biotechnology sector and 6086 in TMD. The<br />

majority of Biotechnology employees (73%) were assumed to be<br />

employed by research organisations, and almost all employees in<br />

the TMD sector (96%) were assumed to be employed by companies<br />

(Table 20).<br />

TABLE 20: Estimated <strong>Queensland</strong>-wide <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

employment 2011<br />

Companies Research<br />

Organisations<br />

Total<br />

Total <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> 8008 6098 14,106<br />

Biotechnology sector only 2150 5871 8021<br />

TMD sector only 5859 227 6086<br />

Numbers may appear inconsistent due to rounding.<br />

<strong>Queensland</strong>-wide employment estimates were 28.5% lower in<br />

2011 than those in 2009 (Table 21). The majority of employees<br />

were estimated to have been lost from companies. Research<br />

organisations were estimated to have a similar number of FTEs<br />

in 2009 and 2011.<br />

TABLE 21: Estimated <strong>Queensland</strong>-wide <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

employment 2005-2011 12<br />

2005* 2007 2009 2011 Change 2009-<br />

2011<br />

All QLS Organisations<br />

Biotechnology<br />

ND 15,569 19,731 14,106 -28.5%<br />

All respondents 5215 7630 9929 8021 -19.3%<br />

Companies 1933 1840 3760 2150 -42.9%<br />

Research<br />

Organisations<br />

TMD<br />

3282 5790 6189 5871 -4.9%<br />

All respondents N/A 7939 9802 6086 -37.9%<br />

Companies N/A ND 9682 5859 -39.5%<br />

Research<br />

Organisations<br />

N/A ND 120 227 89.0%<br />

ND = not determined N/A = not applicable<br />

*Estimates from <strong>Queensland</strong> Biotechnology <strong>Industry</strong> – Benchmarking Study<br />

(2003–2005) Innovation Dynamics, Additional Data <strong>Report</strong>, April 2006. The<br />

basis for these estimates is unknown with only a limited description of the<br />

statistical methodology provided in the report, response rate for this question<br />

was not known but the overall response rate for the survey was 38%, with 32<br />

companies and 26 research institutes participating out of a database of 152.<br />

An analysis of the real employment levels reported by the<br />

52 companies who responded to both QLS surveys (2009 and<br />

2011) supported the conclusion that employment levels fell<br />

overall. 63% of these companies reported the same or lower<br />

employment levels in 2011 vs. 2009 (Figure 3). Those that<br />

reported significant employment growth (e.g. over 100%) were<br />

in the medical devices and equipment, and functional food and<br />

nutraceuticals sub-sectors.<br />

The 30 companies that reported lower levels of employment in<br />

2011 than in 2009 reduced their workforce by an average of 31%<br />

during this period, or a total of 473 FTEs. The 19 companies that<br />

reported employment growth between 2009 and 2011 reported an<br />

average workforce increase of 82%, or a total of 337 FTEs.<br />

Figure 3: Change in employment reported by companies that<br />

responded to both QLS industry surveys (2009 and 2011)<br />

An analysis of the real employment levels reported by the 14<br />

research organisations who responded to both QLS surveys (2009<br />

and 2011) revealed that 58% reported lower employment levels in<br />

2011 vs. 2009, with this group also reducing their workforce by an<br />

average of 31%. The 42% of research organisations that reported<br />

employment growth over this period grew their workforce by an<br />

average of 110%. Overall, among these 14 research organisations,<br />

the change in employment levels between 2009 and 2011 averaged<br />

+28% (median -16%) – data not shown.<br />

In order to provide some context for this study compared to the<br />

Biotechnology survey undertaken in 2007, Figure 4 (overleaf)<br />

shows the projections for employment outlined in a 2005 strategy<br />

document produced by the Government of the day (<strong>Queensland</strong><br />

Biotechnology Strategic Plan: 2005–2015). Overlaid onto this is the<br />

estimated employment attributed to <strong>Queensland</strong> Biotechnology<br />

companies (i.e. excluding research organisations) in 2005, 2007,<br />

2009 and 2011. The estimates for 2011 suggest that companies<br />

in the Biotechnology sector suffered a setback in employment<br />

between 2009 and 2011. An analysis of the Biotechnology company<br />

12 Total population estimates were derived using multiple imputation methods. See section in Appendices entitled ‘Analysis of Primary Survey Data’<br />

for a description of the methodology.<br />

33


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

34<br />

2005<br />

1,933<br />

2007<br />

1,840<br />

2009<br />

3,760<br />

2010<br />

Projection<br />

3,500<br />

employment estimates available for 2005, 2007, 2009 and<br />

2011 reveal a CAGR of 1.8% for this measure over this six<br />

year period.<br />

5.3 <strong>Queensland</strong>’s Estimated Contribution to<br />

Employment in the Australian <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong><br />

2011<br />

2,150<br />

SURVEY ESTIMATES STRATEGIC PLAN PROJECTIONS<br />

Figure 4: Progress against employment projections set in the <strong>Queensland</strong> Biotechnology Strategic Plan 2005 — 2025<br />

(figure is not to scale)<br />

The reported number of employees across the Australian<br />

<strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> varies depending on the information<br />

source and the definition of the industry being applied. For<br />

example, figures for the Australian industry do not routinely<br />

include those employed within research organisations.<br />

The Commonwealth Department of Innovation, <strong>Industry</strong>,<br />

Science, Research and Tertiary Education (DIISRTE)<br />

reported that the pharmaceuticals sector employed<br />

41,000 in 2009/2010, with 13,375 (33%) in manufacturing. 13<br />

Approximately 600 medical device companies (11% of<br />

which reside in <strong>Queensland</strong>) employ an additional 17,500<br />

people (MTAA Factbook 2011). 14 The Biotechnology sector<br />

was said by DIISRTE to include about 470 companies,<br />

but no estimates by DIISRTE of the number of employees<br />

were found. 15 Ernst & Young reported that the Australian<br />

Biotechnology <strong>Industry</strong> employed 12,620 people<br />

in 2010. 16<br />

These three figures combine to a total industry employment<br />

across Australia of 71,120 people. This rough figure<br />

would place <strong>Queensland</strong>’s contribution to employment<br />

in the Australian <strong>Life</strong> <strong>Sciences</strong> sector in 2009/2010 at<br />

2015 Projection<br />

7,500<br />

2025 Projection<br />

16,000<br />

approximately 19.8%. By comparison, the population of<br />

<strong>Queensland</strong> (at Q2 2011/<strong>2012</strong>) was 20% of the Australian<br />

population. 17<br />

According to IBISWorld (Table 22), the Australian <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong> supported approximately 37,977 jobs.<br />

These were in the Biotechnology (7513), 18 Pharmaceutical<br />

— including manufacturing and wholesaling; (18,790) 19<br />

and Medical and Surgical Equipment manufacturing<br />

(11,674) 20 sectors in 2010/2011. 21 This compares to 38,901<br />

reported by IBISWorld in 2009. 22 Although IBISWorld does<br />

not specifically report on the Medical Device industry, the<br />

addition of the estimated 17,500 Medical Devices jobs (MTAA<br />

Factbook) would bring the total Australian <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong> employment to 55,477 employees. However,<br />

the current <strong>Queensland</strong> employment estimates are not<br />

directly comparable to IBISWorld estimates. In particular,<br />

employment within industrial or ‘white’ biotechnology<br />

for example, may not be fully captured in the IBISWorld<br />

classifications. Moreover, it is unlikely that IBISWorld would<br />

include, for example, employment estimates from all of the<br />

university units involved in <strong>Life</strong> <strong>Sciences</strong>. A more suitable<br />

comparison may involve comparing the QLS company<br />

employment (estimated at 8008 FTEs) with IBISWorld<br />

estimates Australia wide (55,477). This would place the<br />

QLS <strong>Industry</strong> (excluding research organisations) at 14.4%<br />

of the total Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>.<br />

Table 23 (opposite) shows the location of the various sectors<br />

of the Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> by employment<br />

or establishments (as available), according to IBISWorld<br />

<strong>Report</strong>s (2010/2011). 23<br />

13 Pharmaceutical <strong>Industry</strong> Data card, DIISRTE, http://www.innovation.gov.au/industry/pharmaceuticalsandhealthtechnologies/pharmaceuticals/pages/<br />

pharmaceuticals<strong>Industry</strong>DataCard.aspx; accessed 11 June <strong>2012</strong>.<br />

14 Medical Technology Association of Australia (MTAA) Factbook 2011.<br />

15 http://www.innovation.gov.au/<strong>Industry</strong>/Biotechnology/Pages/default.aspx; accessed 11 June <strong>2012</strong><br />

16 Ernst & Young, Beyond Borders 2011.<br />

17 Australian Bureau of Statistics 3101.0 — Australian Demographic Statistics, Dec 2011; <strong>Queensland</strong> 4,513,000 and Australia 22,485,300.<br />

18 IBISWorld, X0001 Biotechnology in Australia, March <strong>2012</strong>.<br />

19 IBISWorld, C2543 Pharmaceutical Product Manufacturing in Australia, January <strong>2012</strong>; IBISWorld, F4797 Pharmaceutical Wholesaling in Australia,<br />

February <strong>2012</strong>.<br />

20 IBISWorld, C2832 Medical and Surgical Equipment Manufacturing in Australia, November 2011<br />

21 IBISWorld, X0001 Biotechnology in Australia, March <strong>2012</strong>; IBISWorld, C2543 Pharmaceutical Product Manufacturing in Australia, January <strong>2012</strong>;<br />

IBISWorld, C2832 Medical and Surgical Equipment Manufacturing in Australia, November 2011; IBISWorld, F4797 Pharmaceutical Wholesaling in<br />

Australia, February <strong>2012</strong>.<br />

22 See <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> 2010.<br />

23 IBISWorld, X0001 Biotechnology in Australia, March <strong>2012</strong>; IBISWorld, C2543 Pharmaceutical Product Manufacturing in Australia, January <strong>2012</strong>;<br />

IBISWorld, C2832 Medical and Surgical Equipment Manufacturing in Australia, November 2011; IBISWorld, F4797 Pharmaceutical Wholesaling<br />

in Australia, February <strong>2012</strong>.


TABLE 22: IBISWorld industry statistics 2010/2011<br />

Sector Number of Enterprises Employment Revenue ($m)<br />

Biotechnology 498 7513 $7073<br />

Pharmaceutical Manufacturing 151 13,375 $9350<br />

Pharmaceutical Wholesaling 197 5415 $10,715<br />

Medical and Surgical Equipment 1893 11,674 $3015<br />

TABLE 23: Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> location of establishments (IBISWorld)<br />

State Biotechnology (by<br />

employment)<br />

5.4 Anticipated Employment Growth<br />

Across all companies, the forecast average growth in employees<br />

over the coming 12 months was 5.2%. The number of employees<br />

was forecast to rise from 3433 to 3612 FTEs, or an average of 33<br />

FTE employees per company (up from 31 in 2011).<br />

The average increase in company employees in the sector over the<br />

next three years was forecast to be 34.3% (CAGR of 10.3%). This<br />

would bring total employees within companies who responded to<br />

the survey to 4612 FTEs in 2014 (an average of 44 employees per<br />

company) (Table 24).<br />

TABLE 24: Predicted employment growth from <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> companies<br />

Actual -<br />

2011<br />

Forecast -<br />

12 months<br />

Forecast -<br />

3 years<br />

Number of respondents 111 109 106<br />

Total FTEs Across<br />

Companies<br />

3433 3612 4612<br />

Average per Respondent 31 33 44<br />

CAGR* Across Companies - 5.2% 10.3%<br />

Employment forecasts provided by companies in the 2009 survey<br />

indicated a positive business sentiment at that time. However,<br />

based on the 2011 employment data, these forecasts appear not<br />

to have been met. In 2009, the average number of employees per<br />

company was forecast to rise from 39 in 2009 to 41 in 2010 and to<br />

55 in <strong>2012</strong>. The average number of FTEs across companies in 2011<br />

was only 31, indicating a decline on the average reported in 2009.<br />

Pharmaceutical<br />

Manufacturing<br />

(by establishments)<br />

Medical and Surgical<br />

Equipment Manufacturing<br />

(by establishments)<br />

5.5 Employment of Contractors<br />

Company respondents were asked to nominate the total number<br />

of FTE contractors retained over the past 12 months. 57%<br />

of companies (62 of 110 respondents) reported a total of 271<br />

FTE contractors, representing approximately 7.3% of the QLS<br />

workforce (given that 111 respondent companies reported 3433<br />

FTE employees). In 2010, the ABS reported that contractors<br />

comprised 9.8% of the Australian workforce. 24<br />

On average, there were 4.4 FTE contractors per company (median<br />

of 2.0 FTEs). The majority (94%; 58 respondents) reported<br />

contractor numbers of less than 10 and this group averaged<br />

2.3 contractors per company. Four companies (6%) reported<br />

10 or more contractors (average of 35.0 FTEs). A breakdown of<br />

contractor numbers by industry sub-sector is shown in Table 25.<br />

TABLE 25: Proportion of employees and contractors in companies<br />

by industry sub-sector in 2011 (111 respondents)<br />

Proportion of<br />

Total FTEs<br />

Pharmaceutical<br />

Wholesaling<br />

(by establishments)<br />

Victoria 48% 29% 25.2% 27.5%<br />

New South Wales 20% 34% 32.2% 40.5%<br />

<strong>Queensland</strong> 15% 17% 17.0% 18.0%<br />

South Australia 9% 7% 9.0% 5.0%<br />

Western Australia 6% 11% 11.3% 6.5%<br />

Tasmania 1% 2% 3.3% 1.0%<br />

ACT 1% 0% 1.7% 1.0%<br />

NT - - 0.3% 0.5%<br />

24 Australian Bureau of Statistics 6359.0 — Forms of Employment, Australia, November 2010.<br />

Proportion of<br />

Contracted FTEs<br />

Pharmaceuticals, Vaccines<br />

or Drug Discovery<br />

17.8% 29.0%<br />

Diagnostics 5.4% 3.0%<br />

Medical Devices and Equipment 10.0% 10.6%<br />

Complementary Medicines 37.6% 23.0%<br />

Functional Food/Nutraceuticals 4.3% 5.1%<br />

Animal Health 2.8% 2.6%<br />

Biotechnology 11.8% 17.5%<br />

<strong>Industry</strong> Service Provider 8.9% 4.5%<br />

Other 1.4% 4.7%<br />

Total 100% 100%<br />

35


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

36<br />

5.6 Employment Categories<br />

Across all respondents (133), the greatest proportion of<br />

employees held roles in R&D (35.1%; R&D professionals<br />

and technical staff plus support staff delivering R&D<br />

related services) and administration/management (22.7%).<br />

Marketing and sales accounted for 12.8% of employees,<br />

with manufacturing and bioprocessing accounting for<br />

12.1%. Remaining staff were employed in clinical trials<br />

(4.8%), quality assurance (4.1%), regulatory (2.0%) and other<br />

categories (6.4%) (Figure 5; Table 26).<br />

Figure 5: Distribution of employees across employment<br />

categories (133 respondents)<br />

Consistent with our previous analyses of the QLS <strong>Industry</strong>,<br />

the majority of staff within research organisations (72.5%)<br />

were involved in performing R&D or providing technical<br />

support. There was an increase in employment in the<br />

R&D related categories of 12.5% in 2011 compared to the<br />

2009 survey. 26.5% of employees in companies were<br />

engaged in R&D activities in 2011, compared to 22.4% in<br />

2009. A number of work categories were found almost<br />

exclusively in companies, including manufacturing and<br />

bioprocessing, quality assurance, regulatory professionals<br />

and sales and marketing. This reflects the commercial<br />

activity of companies in manufacturing and marketing<br />

regulated products.<br />

TABLE 26: Breakdown of work categories by organisation<br />

classification (131 respondents)<br />

All<br />

Respondents<br />

Company RO<br />

R&D professionals and<br />

technical staff<br />

26.4% 20.1% 53.8%<br />

Marketing and sales 12.8% 15.6% 0.6%<br />

Management/Executive 12.7% 14.7% 3.9%<br />

Manufacturing and bio<br />

processing<br />

12.1% 14.8% 0.2%<br />

Administration/Human<br />

resources<br />

10.0% 10.6% 7.3%<br />

Support staff delivering<br />

R&D related services<br />

8.7% 6.4% 18.7%<br />

Other 6.4% 5.3% 11.3%<br />

Clinical trials 4.8% 5.1% 3.4%<br />

Quality assurance 4.1% 5.0% 0.3%<br />

Regulatory<br />

professionals<br />

2.0% 2.4% 0.4%<br />

The breakdown of work categories revealed in the 2007,<br />

2009 and 2011 surveys is provided in Table 27. The greatest<br />

change in employee roles in the past two years was a<br />

reduction in the proportion of management/administrative<br />

roles from 31.7% in 2009 to 22.7% in 2011. This may be a<br />

result of organisations rationalising staffing levels in<br />

non-research related roles in response to the GFC.<br />

TABLE 27: Breakdown of work categories across multiple<br />

surveys<br />

Work Category Biotechnology<br />

Survey<br />

2007<br />

R&D Professionals<br />

and Technical Staff<br />

Support Staff<br />

Delivering R&D<br />

Related Services<br />

TMD<br />

Survey<br />

2007<br />

QLS<br />

Survey<br />

2009<br />

QLS<br />

Survey<br />

2011<br />

43.3% 17.1% 25.8% 26.4%<br />

3.1% 4.5% 6.2% 8.7%<br />

Manufacturing and<br />

Bioprocessing<br />

5.3% 14.9% 9.2% 12.1%<br />

Quality Assurance<br />

and Clinical Trials<br />

6.6% 7.1% 7.2% 8.9%<br />

Regulatory<br />

Professionals<br />

3.7% ND 2.7% 2.0%<br />

Marketing and<br />

Sales<br />

7.6% 26.6% 10.6% 12.8%<br />

Management/<br />

Executive<br />

Administration and<br />

Human Resources<br />

19.0%<br />

19.1%<br />

10.7%<br />

16.8%<br />

14.9%<br />

12.7%<br />

10.0%<br />

Other 11.4% ND 6.6% 6.4%<br />

5.7 Wage and Salary Expenditure<br />

All respondents (85, one outlier removed) reported $563.8<br />

million in expenditure on wages/salaries, an average of $6.6<br />

million per organisation and a median of $800,000. Wage<br />

and salary costs averaged 52% of total expenditure per<br />

organisation.<br />

Research organisations (16) reported an average annual<br />

wage and salary expenditure approximately four times that<br />

of companies (69). The median value was approximately<br />

25 times that of companies (Table 28). This is a significant<br />

change compared to the total and average/median wage and<br />

salary expenditure data provided by survey respondents in<br />

2009. In 2011, almost $200 million more in expenditure on<br />

wages and salaries was reported by research organisations<br />

(for a similar number of organisations) than in 2009.<br />

Moreover, in 2009, the average annual wage and salary<br />

expenditure of research organisations was only twice that<br />

of companies and the median annual wage expenditure was<br />

only eight times that of companies.


TABLE 28: Wage and Salary Expenditure of QLS organisations 2011<br />

(85 respondents)<br />

Companies RO All<br />

Number of organisations 69 16 85<br />

Total Wage and Salary<br />

expenditure ($m)<br />

$291.6 $272.1 $563.8<br />

Average salary expenditure<br />

per organisation ($m)<br />

$4.2 $17.0 $6.6<br />

Median salary expenditure per<br />

organisation ($m)<br />

$0.56 $14.38 $0.80<br />

It was estimated that QLS organisations spent approximately $2.14<br />

billion on wages/salaries in 2011 (Table 29). This amount is 98.6%<br />

higher than the combined estimates reported for 2009.<br />

The median figures from the survey data suggested an implied<br />

average wage of $54,600 for the private sector compared to<br />

research organisations, where the implied average wage was<br />

$67,600. The reliability of this estimate cannot be assured as<br />

university units will typically have to approximate the number<br />

of staff deemed to be working in <strong>Life</strong> <strong>Sciences</strong> and then estimate<br />

salary expenditure, whereas companies will typically have a<br />

more defined workforce in that regard and, therefore, more<br />

accurate data.<br />

5.8 Comparative <strong>Life</strong> <strong>Sciences</strong> Wages<br />

According to the ABS, across all industries, the average annual<br />

salary for Australian and <strong>Queensland</strong> employees in 2011 was<br />

$71,568 and $69,945, respectively. 25 Employment and expenditure<br />

medians from the current survey suggest an average annual<br />

salary of $66,965 for QLS employees in 2011. As a cross-check,<br />

a measure of the typical Australian <strong>Life</strong> <strong>Sciences</strong> wage in 2011<br />

was determined by taking a simple average of three ABS salary<br />

data reporting categories (Scientific, Education, Health-related)<br />

to arrive at $74,750. 26<br />

TABLE 29: Total Wage and Salary Expenditure by QLS organisations<br />

A comparison of the average QLS wage estimated in 2009 and<br />

2011 (Table 30) suggests that the average QLS wage, in both<br />

research organisations and the private sector, has fallen over this<br />

period. This may reflect the lower proportion of staff employed<br />

in executive, management, human resources and administrative<br />

roles (see section 5.6) and an increase in the outsourcing of<br />

activities requiring highly skilled personnel.<br />

TABLE 30: Average Wages of <strong>Life</strong> Science <strong>Industry</strong> Employees<br />

in <strong>Queensland</strong> 2009 and 2011<br />

2011 2009<br />

All Respondents $66,965 $77,732<br />

Companies $54,600 $78,107<br />

Research<br />

Organisations<br />

$67,600 $75,819<br />

A comparison of the average QLS <strong>Industry</strong> wage to selected<br />

countries is presented in Table 31. This simple analysis suggests<br />

that the average <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> salary is comparable<br />

to those in several other member countries of the OECD.<br />

TABLE 31: Estimated average <strong>Life</strong> <strong>Sciences</strong> wages, an international<br />

comparison 27<br />

Region Source Year Average Annual<br />

Wage (AU$)<br />

<strong>Queensland</strong> Current Survey 2011 $66,965<br />

Australia ABS 2011 $74,750<br />

New Zealand Statistics<br />

New Zealand<br />

2011 $46,536<br />

USA United States<br />

Dept. of Labor<br />

2010 $69,447<br />

Canada Statistics Canada 2011 $60,638<br />

Sweden Statistics Sweden 2010 $67,114<br />

2007 2009 2011<br />

BIO TMD BIO TMD BIO TMD<br />

Total <strong>Report</strong>ed Wage and Salary Expenditure ($m) $104 $63 $104 $146 $308 $256<br />

$167 $250 $564<br />

Average Wage and Salary Expenditure per Organisation ($m) $2.4 $1.4 $2.5 $4.1 $6.9 $7.2<br />

$1.9 $3.2 $7.0<br />

Total QLS <strong>Industry</strong> Wage and Salary Expenditure ($m) $502 $287 $387 $691 $1085 $1057<br />

Numbers may appear inconsistent due to rounding.<br />

$789 $1078 $2141<br />

25 Australian Bureau of Statistics, 6302.0 — Average Weekly Earnings, Australia, Aug 2011, Persons; Full Time; Adult; Total earnings ; Professional, Scientific and<br />

Technical Services, Education and Training; and Health Care and Social Assistance.<br />

26 Ibid.<br />

27 Note that the estimated wages presented are based on proxies for the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>. Detail on the approach used to calculate these estimates is provided in<br />

the methodology section in the appendix to this report.<br />

37


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

38<br />

6.EDUCATION AND SKILLING<br />

“The QLS <strong>Industry</strong> is highly skilled and receptive to providing new graduates<br />

with career opportunities.”<br />

6.1 Tertiary Education<br />

It was estimated that 82,698 students graduated<br />

from science degrees in Australia in 2009 and<br />

89,675 in 2010 (latest available year). This analysis<br />

was based on DEEWR data and an assumption<br />

that higher education ‘science’ courses were those<br />

which fell within the DEEWR categories of Natural<br />

and Physical <strong>Sciences</strong>, Information Technology,<br />

Engineering and Related technologies, Agriculture,<br />

Environmental and Related Studies and Health.<br />

<strong>Queensland</strong> universities accounted for 14,903 (18%)<br />

of science graduates in 2009 and 15,732 (18%)<br />

in 2010. 28 The OECD reported that in Australia in<br />

2010, the percentage of science and engineering<br />

graduates among total university graduates at<br />

20.4% was close to the OECD average. 29<br />

The number of bioscience completions in Australia<br />

increased by 7.9% from 56,182 graduates in 2009<br />

to 60,617 in 2010. The number of bioscience<br />

completions from <strong>Queensland</strong> universities<br />

increased from 10,261 in 2009 to 11,007 in 2010,<br />

but remained at 18% of Australian bioscience<br />

completions (Figure 6). 30<br />

Figure 6: Bioscience degree completions 2005 – 2010<br />

6.2 Graduate Opportunities in the QLS<br />

<strong>Industry</strong><br />

Survey participants were asked to what extent they<br />

agreed with the statement — “Our organisation<br />

provides career opportunities to new science<br />

graduates or early career scientists”. Over 90% of<br />

research organisations (22) and 43% of companies<br />

(106) agreed or strongly agreed with this statement<br />

(Figure 7).<br />

Figure 7: QLS industry support of science<br />

graduates and early career scientists<br />

(128 respondents)<br />

6.3 Higher Degree Qualification in the<br />

QLS Workforce<br />

The number of individuals in the workforce with<br />

a PhD provides at least some indication of the<br />

extent to which an industry engages in, or relies<br />

upon, research and innovation. The number of<br />

PhD qualified personnel in the general Australian<br />

workforce has been reported at 7.8 per 1000<br />

workers compared to the USA at 11 and Germany<br />

at 20. 31 In 2007, graduates in a scientific discipline<br />

accounted for 25.2% of all Australian doctoral<br />

graduates. 32<br />

In the current survey, across all respondents, an<br />

average of 24.1% (median 11.0%) of the workforce<br />

was PhD qualified. By comparison, a New Zealand<br />

study in 2011 reported that 14% of employees<br />

in core biotechnology organisations were PhD<br />

qualified. 33<br />

28 Commonwealth Department of Education, Employment and Workplace Relations (DEEWR), Award Course Completions for All<br />

Students by State, Higher Education Provider and Broad Field of Education.<br />

29 OECD Science, Technology and <strong>Industry</strong> Outlook 2010: country profiles.<br />

30 Commonwealth Department of Education, Employment and Workplace Relations (DEEWR), Award Course Completions for<br />

All Students by State, Higher Education Provider and Broad Field of Education. http://www.deewr.gov.au/HigherEducation/<br />

Publications/HEStatistics/Publications/Pages/2010FullYear.aspx. ‘Bioscience’ courses were defined as those falling within the<br />

categories of Natural and Physical <strong>Sciences</strong>, Agriculture, Environmental and Related Studies and Health.<br />

31 ANU submission to the parliamentary inquiry into research training and research workforce issues in universities, 2008; www.<br />

aph.gov.au/Parliamentary_Business/Committees/House_of_Representatives_Committees?url=/isi/research/subs.htm; accessed 1st<br />

July <strong>2012</strong>.


Research organisations reported that, on average, 47.3% of their<br />

workforce held a PhD (median figure was 42.5%). A 2008 survey<br />

by the Australian Society for Medical Research generally supports<br />

these findings. In this survey, 39% of all staff, and 65% of research<br />

staff in medical research institutes and university departments<br />

were said to have held a PhD. 34<br />

The percentage of PhD qualified personnel reported by companies<br />

in the current survey varied considerably, but the overall average<br />

was 19% (median 4%). This is comparable with data from a<br />

pharmaceutical industry survey undertaken by Medicines Australia<br />

in 2009, which revealed that 5% of company staff held a PhD and<br />

14% held a Masters degree. 35 41% of companies reported no PhD<br />

qualified personnel, 19% reported that over half of their workforce<br />

was PhD qualified and 3.6% of companies reported that all of their<br />

staff had a PhD. Those with a high proportion of PhD qualified staff<br />

(›70%) were typically either small, start-up biopharmaceutical<br />

companies spun-out of <strong>Queensland</strong> research organisations or<br />

service providers/industry consultants.<br />

The Australian Council for Educational Research reported in 2008<br />

that private sector employers did not particularly value nor seek<br />

personnel qualified with research PhD or Masters degrees in<br />

the mathematics and science fields, and instead sought degree<br />

and honours graduates. 36 53.6% of persons employed in the ABS<br />

industry category of Professional, Technical and Scientific Services<br />

in 2010 were tertiary qualified, compared to 23.0% of the general<br />

population. 37 However, the typical level and type of qualification<br />

held by an employee will vary depending on the stage of company<br />

development. 38,39 Overall, tertiary qualifications in the Australian<br />

workforce are becoming more prevalent with 24% of workers (aged<br />

15-64) holding a degree in 2011 compared to 17% in 2001. 40<br />

6.4 Predicted Skill Gaps<br />

6.4.1 Skills Gaps — All Respondents<br />

Survey participants were asked to nominate anticipated skills<br />

gap(s) over the next five years from a list of 15 options (including<br />

an ‘Other’ category). A total of 132 responses were received and<br />

the proportion of responses for each category was expressed<br />

as a percentage of this total (Figure 8). The most common<br />

expected skills gaps were in commercialisation (11%), business<br />

development (11%), and chemistry (10%). 6% of respondents did<br />

not anticipate any skill shortages over the period.<br />

Figure 8: Predicted skill gaps to emerge over the next five years<br />

(<strong>2012</strong>-2016) (132 respondents)<br />

‘Manufacturing or other trade skills’ (9%) ranked fourth and<br />

further interrogation of those responses revealed a range of skills<br />

expected to be in high demand, including:<br />

1. all general trades e.g. electricians, plumbers, construction,<br />

electrical fitter, boiler makers, steel fabricators, welders,<br />

machinists (5 respondents);<br />

2. production and production engineering (3 respondents);<br />

3. electronics (2 respondents);<br />

4. upholstery skills (2 respondents in the medical devices and<br />

equipment subsector);<br />

5. pharmaceutical dose form operators — e.g. tableting, injectable<br />

dose room experience (2 respondents); and<br />

6. a range of other skills each nominated by a single respondent:<br />

GMP cell culture production<br />

rapid prototyping<br />

32 OECD (<strong>2012</strong>) Measuring Innovation: a New Perspective; accessed 11th July <strong>2012</strong>; www.oecd.org/document/10/0,3746,en_2649_34273_45155146_1_1_1_1,00.html<br />

33 Statistics New Zealand, NZ Bioscience Survey 2011.<br />

34 Schofield, D., (2009) ‘Planning the Health and Medical Research Workforce 2010-2019’, Australian Society for Medical Research.<br />

35 The Australian Pharmaceutical <strong>Industry</strong>: Winds of Change, <strong>Report</strong> of the 2009 Medicines Australia Member Economic Survey<br />

36 Edwards, D., and Smith, T.F. (2008) ‘Supply, demand and approaches to employment by people with postgraduate research qualifications<br />

in science and mathematics’, Australian Council for Educational Research.<br />

37 Australian Bureau of Statistics, 6227.0.30.001 — Survey of Education and Work, Australia 2010<br />

38 The Allen Consulting Group, (2010) ‘Victorian biotechnology industry skills review’, <strong>Report</strong> to the Victorian Department of Innovation,<br />

<strong>Industry</strong> and Regional Development.<br />

39 OECD (2009), “Tertiary level educational attainment for age group 25-64”, Education: Key Tables from OECD, No. 3.<br />

40 Australian Bureau of Statistics 6227.0 — Education and Work, Australia, May 2011.<br />

39


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

40<br />

pharmaceutical compounding<br />

formulation of various galenic forms of complementary<br />

medicines<br />

biofuel and systems design and manufacture<br />

maintenance engineering<br />

micro assembly<br />

process manufacturing of mixtures of chemicals<br />

food production and quality assurance<br />

engineering, process operators & chemical<br />

related operations<br />

general manufacturing — hand tools, workplace<br />

health and safety.<br />

6.4.2 Skills Gaps — 2009 versus 2011<br />

A future skills gap in chemistry was anticipated by<br />

respondents in both 2009 and 2011 (Table 32). Although<br />

marketing and preclinical/clinical trial management were<br />

in the top three anticipated skills gaps in 2009, neither<br />

were highly ranked in 2011. Business development,<br />

commercialisation and manufacturing and trade skills were<br />

new entries to the top three future skills gaps in 2011.<br />

TABLE 32: Future Skill Gaps Anticipated in 2009 and 2011<br />

2009 2011<br />

Skill Gap Proportion<br />

of<br />

Responses<br />

Marketing 15% Business<br />

Development<br />

Skill Gap Proportion<br />

of<br />

Responses<br />

11%<br />

Chemistry 13% Commercialisation 11%<br />

Preclinical/<br />

Clinical Trial<br />

Management<br />

12% Chemistry 10%<br />

6.4.3 Skills Gaps — Research Organisations versus<br />

Companies<br />

Companies and research organisations differed in their<br />

expectations for skill gaps within the coming five year period<br />

(Table 33). ‘Business Development’ was the most commonly<br />

cited skill gap for companies. Research organisations<br />

identified ‘Bioinformatics’ (including statistical genetics)<br />

as the skill area of greatest need over the next five years.<br />

‘Chemistry’ the highest rating anticipated skill shortage<br />

for research organisations in 2009, was equal fifth in the<br />

current survey suggesting the predicted shortage had<br />

been partially met or did not materialise for research<br />

organisations as expected.<br />

TABLE 33: Most common anticipated skill gaps by organisation<br />

classification 2011<br />

Companies Research Organisations<br />

Business<br />

development<br />

Manufacturing and<br />

other trade skills<br />

Commercialisation<br />

skills<br />

No anticipated<br />

skills gaps<br />

11.2% Bioinformatics/<br />

statistical genetics<br />

10.5% Commercialisation<br />

skills<br />

10.1% Preclinical or clinical<br />

trials research<br />

management<br />

6.4% No anticipated<br />

skills gaps<br />

13.5%<br />

11.5%<br />

11.5%<br />

3.8%<br />

A small survey of 37 Victorian biotechnology companies in<br />

2010 cited unmet demand for skills in regulatory affairs,<br />

clinical strategy, and project management. 41 Clinical<br />

research management skills were also identified as an area<br />

of need for research organisations and to a lesser extent<br />

companies, in the current survey. The current survey did<br />

not include ‘regulatory affairs’ as a specific answer option,<br />

but this skill was nominated in the ‘Other’ category by two<br />

companies. An AusBiotech survey in 2011 42 revealed that<br />

biotechnology companies anticipated growth in the number<br />

of ‘scientists and clinical trial staff’ as well as those in ‘sales<br />

and marketing’.<br />

41 The Allen Consulting Group, ‘Victorian Biotechnology <strong>Industry</strong> Skills Review’ (2010) <strong>Report</strong> to the Victorian Department of Innovation, <strong>Industry</strong> and<br />

Regional Development.<br />

42 AusBiotech Biotechnology <strong>Industry</strong> Position Survey http://www.ausbiotech.org/data/downloads/Biotechnology%20survey%20<strong>2012</strong>_Final.pdf; accessed<br />

26.05.<strong>2012</strong>


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

42<br />

7.INCOME AND EXPENDITURE<br />

“Surveyed organisations (135) reported a combined income of $1995 million<br />

in 2011, whilst the estimate for all 301 <strong>Life</strong> <strong>Sciences</strong> organisations in<br />

<strong>Queensland</strong> was just over $4360 million.”<br />

7.1 Income<br />

7.1.1 Total <strong>Report</strong>ed Income<br />

Survey respondents (100) reported a total income of $1995 million in 2011 (Table 34). The average income<br />

across respondents was $19.9 million and the median was $3.3 million. 53% of this income ($1060 million)<br />

was reported by biotechnology organisations and 47% ($936 million) by TMD organisations. The average<br />

income reported for companies was $15.6 million, or less than half that for research organisations at<br />

$35.2 million.<br />

TABLE 34: <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> Income, Companies vs. Research Organisations 2011<br />

(100 respondents)<br />

All respondents (100) Companies (78) Research Organisations (22)<br />

Total Income ($m) $1994.6 $1220.0 $774.4<br />

Average Income ($m) $19.9 $15.6 $35.2<br />

Median Income ($m) $3.3 $1.75 $12.4<br />

Table 35 shows the total and average income reported by companies according to the sub-sector.<br />

TABLE 35: Income by industry sub-sector 2009 (78 respondents)<br />

Number of<br />

Organisations<br />

Organisations<br />

reporting income<br />

Income<br />

($m)<br />

Average<br />

($m)<br />

Complementary Medicines 11 9 $269 $29.9<br />

Medical Devices and<br />

Equipment<br />

23 15 $434 $28.9<br />

Pharmaceuticals, Vaccines<br />

or Drug Discovery<br />

14 7 $144 $20.5<br />

Biotechnology 12 9 $167 $18.5<br />

Diagnostics 5 5 $57 $11.3<br />

<strong>Industry</strong> Service Provider 25 18 $114 $6.3<br />

Other 6 4 $12 $3.1<br />

Animal Health 6 6 $15 $2.5<br />

Functional Food/<br />

Nutraceuticals<br />

9 5 $9 $1.8<br />

Across all organisations 111 78 $1,220 $20.1<br />

7.1.2 Sources of Income<br />

The majority of income across all respondents (94) was generated from the sale of goods or services (57%)<br />

and grant funding (36%). A small proportion of total income was derived from philanthropic funding sources<br />

(2%) and licenses or royalties (0.3%) (Figure 9).


Figure 9: Total income generated by respondents, by income category<br />

(94 respondents)<br />

Income sources for companies and research organisations differed<br />

markedly. Companies reported 95.2% of their income from the<br />

sale of goods and services with only 1.5% from grants. Research<br />

organisations reported 8.2% of income from the sale of goods and<br />

services and 79.5% from grants (Figure 10).<br />

Figure 10: Income sources for companies and research organisations<br />

(94 respondents)<br />

7.1.3 <strong>Queensland</strong> Wide Income Estimates<br />

Based on an extrapolation of the data presented above, it was<br />

estimated that the QLS <strong>Industry</strong> generated $4.36 billion in income<br />

in 2011; comprising of $3.28 billion from companies and $1.09<br />

billion from research organisations (Table 36).<br />

43 IBISWorld, X0001 Biotechnology in Australia, March <strong>2012</strong><br />

TABLE 36: Estimated <strong>Queensland</strong>-wide <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> income<br />

($m) 2011<br />

Companies Research<br />

Organisations<br />

Total<br />

Biotechnology $597 $1068 $1665<br />

TMD $2678 $17 $2695<br />

<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

$3275 $1086 $4361<br />

<strong>Industry</strong> (Estimated)<br />

Numbers may appear inconsistent due to rounding<br />

The 2011 income estimates are 11.8% lower than those for 2009.<br />

The decline is largely accounted for by Biotechnology companies,<br />

with estimates for this group 45.4% lower than in 2009. The<br />

declines for research organisations and TMD companies all fall<br />

within the margin of error and so are therefore not statistically<br />

significant.<br />

TABLE 37: Estimated <strong>Queensland</strong>-wide <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> income<br />

($m) 2005 to 2011<br />

2005* 2007 2009 2011 Change<br />

2009-2011<br />

All Respondents N/A $3130 $4943 $4361 -11.8%<br />

Biotechnology<br />

sector only<br />

$696 $896 $2185 $1665 -23.8%<br />

Companies $292 $395 $1093 $597 -45.4%<br />

Research<br />

Organisations<br />

$404 $501 $1092 $1069 -2.2%<br />

TMD sector only N/A $2234 $2758 $2695 -2.3%<br />

Companies N/A ND $2751 $2678 -2.7%<br />

Research<br />

Organisations<br />

N/A ND $7 $17 143%<br />

ND – Not determined N/A – not available<br />

** Estimates from <strong>Queensland</strong> Biotechnology <strong>Industry</strong> – Benchmarking<br />

Study (2003–2005) Innovation Dynamics, Additional Data <strong>Report</strong>, April<br />

2006. The basis for these estimates is unknown with no description of<br />

the statistical methodology provided in the report, response rate for this<br />

question was not known but the overall response rate for the survey was<br />

38%, with 32 companies and 26 research institutes participating out of a<br />

database of 152.<br />

Numbers may appear inconsistent due to rounding.<br />

According to IBISWorld the Australian Biotechnology <strong>Industry</strong> (498<br />

enterprises) received revenue of $7.07 billion in 2010/2011. 43 The<br />

estimate for <strong>Queensland</strong> Biotechnology companies in the current<br />

survey ($597 million) represents 8.4% of the IBISWorld national<br />

estimate (IBISWorld estimates do not include activity within<br />

research organisations).<br />

43


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

44<br />

Figure 11 shows the projections for revenue set in a 2005<br />

strategic plan for the industry (<strong>Queensland</strong> Biotechnology<br />

Strategic Plan: 2005–2015). Overlaid onto this is the estimated<br />

income attributed to <strong>Queensland</strong> Biotechnology companies<br />

(i.e. excluding research organisations) from surveys in<br />

2005, 2007, 2009 and 2011. This data reveals a CAGR of<br />

12.7% over six years. The estimated income for <strong>Queensland</strong><br />

Biotechnology companies in 2011, at $597 million, aligns<br />

with the 2010 projection of $600 million.<br />

7.1.4 Income Growth in 2011<br />

The average income reported in 2011 ($19.9 million; Table<br />

34) was up by 45% compared with 2009 ($13.7 million)<br />

and the majority of companies (56.3%) and research<br />

organisations (63.0%) reported income growth in 2011<br />

(Figure 12). 24.1% of companies and 29.6% of research<br />

organisations reported no change in income. A higher<br />

proportion of companies (19%) relative to research<br />

organisations (7.4%), reported a decline in income. For<br />

those that did report a fall in income, the average decline<br />

was about 23% (Table 38 and Figure 12). It should be noted<br />

that one fifth of companies that provided income data, did<br />

not respond to this question on income growth.<br />

Across all respondents (114), an average increase in income<br />

of 15.8% (median 4%) was reported for 2011. The average<br />

increase for companies was 14.9% (median 3%) and for<br />

research organisations it was 19% (median 4%). In 2009,<br />

an average increase in income of 22% was reported for all<br />

respondents. The average increase for companies was 21%<br />

and for research organisations, 26%.<br />

Table 38 shows the average change in income amongst<br />

those that reported an increase or fall over the 2011 year.<br />

44 Ernst & Young, Beyond Borders, 2011<br />

45 Ibid<br />

2005<br />

$292m<br />

2007<br />

$395m<br />

2009<br />

$1.1b 2010<br />

Projection<br />

$600m<br />

2011<br />

$597m<br />

2015 Projection<br />

$1.5b<br />

SURVEY ESTIMATES STRATEGIC PLAN PROJECTIONS<br />

Figure 11: Progress against revenue projections set in the <strong>Queensland</strong> Biotechnology Strategic Plan 2005 — 2025<br />

(figure is not to scale)<br />

2025<br />

Projection<br />

$4.0b<br />

Figure 12: Estimated income growth for respondents, 2011<br />

(114 respondents)<br />

TABLE 38: Income change in the 2011 year (112 respondents)<br />

Number of<br />

respondents<br />

nominating<br />

Average<br />

Those reporting no growth 29 N/A<br />

Companies 21 N/A<br />

Research Organisations 8 N/A<br />

Those reporting a fall in income 19 -22.8%<br />

Companies 17 -23.5%<br />

Research Organisations 2 -33.0%<br />

Those reporting income growth 65 34.4%<br />

Companies 49 34.7%<br />

Research Organisations<br />

N/A - not available<br />

16 33.6%<br />

Ernst & Young reported that across the listed sectors in the<br />

US, Europe, Canada and Australia, revenue grew by 8% in<br />

both 2009 and 2010 (Table 39). Listed US companies reported<br />

10% income growth in 2009 and 2010, while listed Canadian<br />

Biotechnology companies reported 1% growth in 2010 and<br />

9% in 2010. 44 The Australian listed Biotechnology sector<br />

reported growth in revenue of 17% in 2010. 45


TABLE 39: Growth in income in the listed biotechnology sectors<br />

in different regions 46<br />

Region Year<br />

2009 2010<br />

US, Europe, Canada and Australia 8% 8%<br />

European companies 8% 12%<br />

US companies* 10% 10%<br />

Canadian companies + 9% 1%<br />

Australian companies<br />

N/A - not available<br />

* USA figures excluding Genentech acquired by Roche<br />

N/A 17%<br />

+ Canadian figures excluding Biovail acquired by Valeant Pharmaceuticals<br />

According to the BioSpectrum Asia-Pacific <strong>Industry</strong> Survey,<br />

the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> in Asia-Pacific grew 3.4% in 2009<br />

with revenues of $110.9 billion. The highest growth Asia-Pacific<br />

countries in 2009 were China, India, South Korea, Australia and<br />

Singapore. The same survey in 2010 indicated industry growth<br />

of 16.6% and revenue of $128.3 billion. The scope of this survey<br />

was limited to core <strong>Life</strong> <strong>Sciences</strong> companies (pharmaceuticals,<br />

biotechnology and medical devices) across Australia, New<br />

Zealand, China, India, Malaysia, Singapore, South Korea<br />

and Taiwan. 47<br />

7.2 Grant Income<br />

Federal and State government and non-government grant<br />

programs are an important source of funding in high-technology<br />

and high-risk industries. For research organisations, grants<br />

represent the most significant source of income for basic and<br />

applied research. For companies, grants and other funding<br />

programs can provide valuable funding to support business<br />

expansion, R&D, innovation and exporting.<br />

The <strong>2012</strong>/2013 Federal Budget provided some ongoing support<br />

for business innovation. 48 The Innovation Investment Fund<br />

received $100 million to develop fund managers with experience<br />

in the early stage venture capital industry and encourage the<br />

development of new companies which are commercialising<br />

R&D. Commercialisation Australia was allocated $294 million<br />

over the five years to 2014, with ongoing funding of $82 million<br />

per year after 2014, to support innovative Australian companies<br />

and entrepreneurs through four main grant programs. The R&D<br />

Tax Incentive, which applied from 1 July 2011, includes a 45%<br />

refundable tax offset for SMEs (aggregated turnover of less<br />

than $20 million) and a 40% non-refundable tax offset for all<br />

other companies. The R&D Tax Incentive is expected to provide<br />

support for small and medium-sized enterprises to the value of<br />

approximately $1.8 billion.<br />

7.2.1 Total Grant Income<br />

Total reported grant income in 2011 across 93 respondents was<br />

$594 million (companies $14 million; research organisations<br />

$580 million).<br />

Companies (38) reported $27.2 million in new grant funding during<br />

2011 with an average grant size of $716,000. Of the funds awarded,<br />

$13.6 million was drawn down in 2011.<br />

Research organisations reported a total of $168.8 million in<br />

new grant funding during 2011. <strong>Report</strong>ing the average grant<br />

size is not possible as the majority of research organisations<br />

reported funding from granting bodies, such as NHMRC and<br />

ARC, in aggregate.<br />

7.2.2 Grant Programs<br />

COMPANIES<br />

Twenty-seven companies nominated 27 grant programs (see<br />

full list in the Appendices) from which funds were awarded in<br />

2011. Commonwealth Government grant programs provided the<br />

greatest number of grants for companies (60.5%). The <strong>Queensland</strong><br />

Government, across several programs, accounted for 27.9% of<br />

grants awarded to companies.<br />

The top three individual grant schemes accessed by companies<br />

(by number of grants reported) were:<br />

1. Commonwealth R&D Tax Concession/Offset (18.6%)<br />

2. <strong>Queensland</strong> Government Smart Futures Fund (14.0%)<br />

3. AusTrade Export Market Development Grant (7.0%)<br />

RESEARCH ORGANISATIONS<br />

14 research organisations nominated 49 grant programs (see full<br />

list in the Appendices) from which funds were awarded in 2011.<br />

The top three grant programs accessed by research organisations<br />

(by amount of funding awarded) were:<br />

1. NHMRC (48.5%)<br />

2. ARC (20.0%)<br />

3. <strong>Queensland</strong> Health (8.2%)<br />

7.3 Federal Funding for Institutional Medical<br />

and Biotechnology Research<br />

In 2010, Commonwealth Government expenditure on health and<br />

medical research was approximately 0.09% of gross domestic<br />

product (GDP), down from 0.11% in 2006. In 2006, Australia was<br />

ranked fourth amongst OECD countries for health R&D as a<br />

percentage of GDP. However, by 2010, Australia had fallen to tenth<br />

position, behind the USA, Norway, UK, Canada, Portugal, Estonia,<br />

Korea, Luxembourg and Spain, and now invests 18% less than the<br />

OECD average (Figure 13 — overleaf). 49<br />

Federal Government grants administered by the NHMRC and<br />

the ARC are a significant source of funding for medical and<br />

biotechnology research conducted at research institutions. Other<br />

significant Federal funding programs for health and medical<br />

research include the Cooperative Research Centres (CRC)<br />

program (supporting end user driven research collaborations) and<br />

the Health and Hospitals Fund (for building and upgrading health<br />

and medical research and training facilities across Australia).<br />

46 Ernst & Young, Beyond Borders, 2011.<br />

47 BioSpectrum Asia-Pacific <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> Survey 2009 and 2010, www.biospectrumasia.com; accessed 29 May <strong>2012</strong><br />

48 The Hon Greg Combet AM MP, Media Releases Innovation the key to driving productive industries 08 May <strong>2012</strong> http://minister.innovation.gov.au/gregcombet/<br />

MediaReleases/Pages/InnovationTheKeyToDrivingProductiveIndustries.aspx; accessed 29 May <strong>2012</strong>.<br />

49 OECD Science, Technology and <strong>Industry</strong> Scoreboard 2011, Targeting New Growth Areas , Health innovation.<br />

45


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

46<br />

Figure 13: Government spending on health and medical R&D in OECD countries (%GDP)<br />

NHMRC funding levels increased five-fold between<br />

2005/2006 and 2010/2011 and represent an increasing<br />

proportion of Commonwealth expenditure on R&D. 50 The<br />

research workforce directly supported by NHMRC research<br />

funding was more than 8000 in 2010. 51<br />

In 2011, concerns that the Commonwealth Government<br />

intended to cut NHMRC funding prompted a relatively strong<br />

response from the research community. 52 The funding cuts<br />

did not materialise in 2011 or <strong>2012</strong> and, under the Federal<br />

budget for <strong>2012</strong>/2013, the ARC will receive $879 million in<br />

<strong>2012</strong>/2013, an increase of 4.8%, and the NHMRC will receive<br />

$853 million in <strong>2012</strong>/2013, an increase of 8.5%.<br />

A Strategic Review of Health and Medical Research in<br />

Australia was commissioned by the Australian Government<br />

in late 2011. The Review is to report by early 2013 and<br />

recommend a 10-year strategic health and medical research<br />

plan for the nation. 53 It was noted in the terms of reference<br />

for the review that:<br />

“Whereas Australia has been highly successful in research and<br />

development up to the proof of concept stage, there is broad<br />

agreement that significant opportunities exist to improve our<br />

success in turning these discoveries into outcomes, including<br />

commercial ventures….The review will take into account<br />

broader Government policy, including the Government’s fiscal<br />

strategy, and will focus on optimising Australia’s capacity to<br />

produce world class health and medical research to 2020.”<br />

7.3.1 NHMRC and ARC Funding for <strong>Queensland</strong> Research<br />

Organisations<br />

<strong>Queensland</strong>’s share of NHMRC funding rose fairly steadily<br />

from 13.3% in 2006 to 15.4% in 2011 (Figure 14). The amount<br />

of funding received by <strong>Queensland</strong> applicants in 2011 ($116<br />

million) was almost double that in 2006 ($60 million). The<br />

NHMRC’s total allocation nationally over the same period<br />

grew by 67%, from $451 million to $755 million.<br />

In 2011, two <strong>Queensland</strong> research organisations placed in<br />

the top 10 recipients of NHMRC funding — The University<br />

of <strong>Queensland</strong> (4th) and the <strong>Queensland</strong> Institute of Medical<br />

Research (9th). 54 Overall, <strong>Queensland</strong> applicants had a<br />

success rate of 19%, lower than the national 2011 average<br />

of 23%. 55<br />

Figure 14: Value of NHMRC grants awarded, <strong>Queensland</strong> vs.<br />

Australia 2006 – 2011 56<br />

50 ‘Shaping Up: Trends and Statistics in Funding Health and Medical Research’, Research Australia, July 2011.<br />

51 Ibid.<br />

52 Budget cut rumours alarm health researchers, Tim Dean, Australian <strong>Life</strong> Scientist, 06 April, 2011. http://www.lifescientist.com.au/article/382327/<br />

budget_cut_rumours_alarm_health_researchers/<br />

53 http://www.mckeonreview.org.au/; accessed 26 May <strong>2012</strong><br />

54 NHMRC Research Funding Facts Book 2011; http://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/nh154_research_funding_facts_<br />

book_111214.pdf; accessed 29 May <strong>2012</strong>.


ARC funding has grown from $298.3 million in 2002/2003 to $708.7<br />

million in 2011/<strong>2012</strong>, or a 63% increase in funding over nine years<br />

(or 10.1% CAGR). 57 Figures 15 and 16 illustrate the share of ARC<br />

grants, in terms of number and value, which have been awarded<br />

to <strong>Queensland</strong> institutions between 2005 and 2009. Data beyond<br />

2009 is not currently available. 267 ARC grants were awarded to<br />

<strong>Queensland</strong> researchers in 2009 representing 16.4% of the total<br />

number awarded nationally.<br />

Figure 15: Number of ARC grants awarded, <strong>Queensland</strong> vs.<br />

Australia 2005 – 2009 58<br />

7.4 Expenditure<br />

7.4.1 <strong>Report</strong>ed Expenditure<br />

TABLE 40: <strong>Report</strong>ed expenditure in the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

Respondents<br />

(% response)<br />

Figure 16: Value of ARC grants awarded, <strong>Queensland</strong> vs. Australia<br />

2005 – 2008 58<br />

The value of ARC grants awarded to <strong>Queensland</strong> researchers<br />

increased by 39% between 2005 and 2009, from $78.9 million to<br />

$109.7 million (Figure 16). Over the same period, the amount of<br />

funding awarded nationally rose by 9.3%. As a percentage of the<br />

national total, <strong>Queensland</strong>’s share of ARC funding dropped from<br />

18.0% in 2008 to 16.7% in 2009.<br />

92 respondents reported total expenditure of $1091 million with $564 million (52%) spent on wages and salaries, $189 million (17%)<br />

on R&D and $134 million (12%) on capital items (Table 40).<br />

55 Ibid.<br />

56 National Health and Medical Research Council, Successful NHMRC Grant applications for 2004 – 2009, http://www.nhmrc.gov.au/funding/funded/outcomes/projects.<br />

htm; accessed 29 May <strong>2012</strong>.<br />

57 ‘Shaping Up: Trends and Statistics in Funding Health and Medical Research’, Research Australia, July 2011.<br />

58 Australian Research Council, ARC Funded Research Projects — Trends Data Set 2002 – 2009, http://www.arc.gov.au/general/searchable_data.htm; accessed15 June<br />

<strong>2012</strong>.<br />

59 Australian Research Council, ARC Funded Research Projects — Trends Data Set 2002 – 2009, http://www.arc.gov.au/general/searchable_data.htm; accessed 15 June<br />

<strong>2012</strong>.<br />

Total<br />

($m)<br />

Average<br />

($m)<br />

Proportion of total expenditure<br />

(all, companies, or all ROs)<br />

Total Expenditure ($m) 92 (66%) $1091 $11.9 -<br />

Companies (excl. outlier) 75 (68%) $606 $8.1 -<br />

Research Organisations 17 (61%) $485 $28.5 -<br />

Wage and Salary Expenditure ($m) 85 (61%) $564 $6.6 52%<br />

Companies 69 (63%) $292 $4.2 48%<br />

Research Organisations 16 (57%) $272 $17.0 57%<br />

R&D Expenditure ($m) 83 (60%) $189 $2.3 17%<br />

Companies 67 (61%) $57 $0.9 9%<br />

Research Organisations 16 (57%) $132 $8.2 27%<br />

Capital Expenditure ($m) 86 (62%) $134 $1.6 12%<br />

Companies 70 (64%) $36 $0.5 6%<br />

Research Organisations 16 (57%) $97 $6.1 20%<br />

47


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

48<br />

While the proportion of total expenditure on salary and<br />

wages was comparable for companies and research<br />

organisations, the proportion of expenditure on R&D and<br />

capital items differed markedly. Average R&D expenditure<br />

accounted for less than 10% of total expenditure among<br />

companies but 27% among research organisations. Only 6%<br />

of company expenditure was for capital items, compared to<br />

20% for research organisations.<br />

Expenditure data was also analysed according to the division<br />

into which the respondent was classified (Biotechnology or<br />

TMD) — this breakdown is shown in Table 41.<br />

TABLE 41: <strong>Report</strong>ed expenditure in biotechnology and<br />

TMD sectors<br />

Respondents Total ($m) Average ($m)<br />

Total Expenditure<br />

($m)<br />

92 $1091 $11.9<br />

Biotechnology 50 $646 $12.9<br />

TMD 42 $445 $10.6<br />

Wage and Salary<br />

Expenditure ($m)<br />

85 $564 $6.6<br />

Biotechnology 45 $308 $6.9<br />

TMD 40 $255 $6.4<br />

R&D Expenditure<br />

($m)<br />

83 $189 $2.3<br />

Biotechnology 44 $173 $3.9<br />

TMD 39 $16 $0.4<br />

Capital<br />

Expenditure ($m)<br />

86 $134 $1.6<br />

Biotechnology 46 $106 $2.3<br />

TMD 40 $28 $0.7<br />

The total and average expenditure on wages, R&D and<br />

capital items for companies by industry sub-sector is<br />

tabulated below (Table 42).<br />

TABLE 42: <strong>Report</strong>ed expenditure by companies by industry subsector (75 respondents)<br />

Total Expenditure<br />

($606m)<br />

N Average<br />

($m, rounded)<br />

7.4.2 Estimated <strong>Queensland</strong>-Wide Expenditure in the <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong><br />

<strong>Queensland</strong>-wide industry expenditure estimates were<br />

developed from a statistical extrapolation of the data<br />

collected from survey respondents. Estimates for 2009 and<br />

2011 were developed with a similar statistical methodology.<br />

Estimates for the 2007 survey cannot be compared at the<br />

same level, as some of these figures are not available for the<br />

TMD sector and, in some cases, the questions asked in 2007<br />

required different inputs, necessitating some alterations in<br />

the statistical methodology.<br />

Estimates of total expenditure were largely similar in 2009<br />

and 2011. Wages expenditure and capital expenditure rose<br />

whilst R&D expenditure dropped.<br />

Wage and salary expenditure estimates across the<br />

<strong>Queensland</strong> industry grew by 98.6% since 2009, which<br />

seems incongruous with a drop in employment estimates of<br />

28.5% over the same period. An analysis of raw survey data<br />

revealed that wage and salary expenditure accounted for<br />

52% of total expenditure reported in 2011 compared to 29%<br />

in 2009.<br />

There were at least two factors which may have influenced<br />

the reporting on wages. Participants had the option to<br />

provide an actual figure for wage and salary expenditure or<br />

express it as a percentage of total expenditure. In addition,<br />

survey participants were asked to estimate the number of<br />

employees as at June 30, 2011. Elevated wage and salary<br />

expenditure relative to the number of employees reported<br />

could indicate that a significant number of employees were<br />

lost toward the end of the financial year.<br />

Wage and Salary<br />

Expenditure ($292m)<br />

N Average<br />

($m, rounded)<br />

R&D Expenditure<br />

($57m)<br />

N Average<br />

($m, rounded)<br />

All respondents 75 $8.1 69 $4.2 67 $0.9<br />

Pharmaceuticals, Vaccines or Drug<br />

Discovery<br />

10 $13.1 9 $8.7 9 $3.4<br />

Diagnostics 4 $8.5 3 $1.7 4 $0.1<br />

Medical Devices and Equipment 13 $1.2 12 $0.8 11 $0.1<br />

Complementary Medicines 7 $19.9 5 $5.4 5 $0.2<br />

Functional Food/Nutraceuticals 5 $1.2 5 $0.6 5 $0.4<br />

Animal Health 5 $2.4 5 $0.8 5 $0.2<br />

Biotechnology 9 $11.0 8 $2.8 8 $1.9<br />

<strong>Industry</strong> Service Provider 17 $9.6 17 $8.4 16 $0.3<br />

Other 5 $1.4 5 $0.6 4 $0.0


Estimates for capital expenditure dropped by 64% between 2007 and 2009. Similar results were reported across the Australian economy<br />

at this time 60 possibly reflecting the initial impact of the GFC. For 2011, capital expenditure estimates were similar to 2007 estimates<br />

(Table 43).<br />

TABLE 43: Estimated expenditure by the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> 2007 – 2011<br />

2007 2009 2011 Change:<br />

2009-2011<br />

Total Expenditure ($m) ND $4682 $4626 -1.2%<br />

Companies ND $4177 $3271 -21.7%<br />

Research Organisations ND $504 $1355 168.9%<br />

Wage and Salary Expenditure ($m) $789 $1078 $2141 98.6%<br />

Companies ND $929 $1323 42.4%<br />

Research Organisations ND $149 $818 449.0%<br />

R&D Expenditure ($m) ND $803 $657 -18.2%<br />

Companies ND $417 $245 -43.1%<br />

Research Organisations ND $386 $412 -6.7%<br />

Capital Expenditure ($m) $704 $253 $692 173.5%<br />

Companies ND $181 $514 184.0%<br />

Research Organisations ND $72 $178 147.2%<br />

Numbers may appear inconsistent due to rounding ND – not determined ;<br />

TABLE 44: Estimated expenditure by the Biotech and TMD sectors<br />

2007 2009 2011<br />

Biotech TMD Biotech TMD Biotech TMD<br />

Total Expenditure ($m) ND ND $1751 $2930 $1775 $2851<br />

Wage and Salary Expenditure ($m) $502 $287 $389 $691 $1085 $1057<br />

R&D Expenditure ($m) $469 $235 $80 $172 $510 $147<br />

Capital Expenditure ($m) $641 ND $253 $550 $217 $475<br />

ND – not determined<br />

7.5 Expenditure on R&D in Australia — Secondary Data<br />

According to the OECD, “expenditure on R&D is one of the most<br />

widely used measures of innovation inputs. R&D intensity (R&D<br />

expenditure as a percentage of GDP) is used as an indicator of<br />

an economy’s relative degree of investment in generating new<br />

knowledge.” 61<br />

In 2008, Australia accounted for 1.94% of R&D expenditure by<br />

OECD countries (most recent data available) and reported gross<br />

expenditure on R&D (GERD; including expenditure on R&D by<br />

business enterprises, higher education institutions, government<br />

and private non-profit organisations) of 2.21% of GDP, close to<br />

the OECD average of 2.33%. In Australia, the majority of GERD<br />

is by business (60.8%), followed by higher education (12.2%),<br />

government (12.3%) and private non-profit (2.7%).<br />

R&D expenditure in the <strong>Life</strong> <strong>Sciences</strong> sector is also a barometer<br />

of the economic climate and business confidence. According<br />

to an Ernst & Young report, R&D expenditure by biotechnology<br />

60 Australian Bureau of Statistics data indicted capital expenditure on equipment, plant and machinery fell a seasonally adjusted 7.1% in the 12 months to June 2009.<br />

Australian Bureau of Statistics 5625.0 — Private New Capital Expenditure and Expected Expenditure, Australia June 2009.<br />

61 OECD Science, Technology and <strong>Industry</strong> Scoreboard 2011, Building Knowledge, R&D expenditure<br />

62 Ernst & Young, Beyond Borders, 2010<br />

63 Ernst & Young, Beyond Borders, 2011.<br />

companies across the listed sectors in the USA, Europe, Canada<br />

and Australia fell by 21% in 2009 and then rose by 2% in 2010<br />

(Table 45). 62<br />

TABLE 45: Change in R&D expenditure of listed biotechnology sectors<br />

from 2009 to 2010 63<br />

Region 2009 2010<br />

Listed companies in USA, Europe,<br />

Canada, Australia<br />

-21% 2%<br />

US companies* -13% 3%<br />

European companies -2% 5%<br />

Canadian companies + -44% -7%<br />

Australian companies<br />

N/A – not available;<br />

N/A 16%<br />

* USA figures excluding Genentech which was acquired by Roche;<br />

+ Canadian figures excluding Biovail which was acquired by Valeant<br />

Pharmaceuticals<br />

49


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

50<br />

According to the BioSpectrum Asia-Pacific <strong>Industry</strong> Survey,<br />

the Asia-Pacific region did not experience the same<br />

contraction in R&D expenditure as the listed Biotechnology<br />

sectors in the USA, Europe, Canada and Australia. The<br />

survey, which included Australia-New Zealand, China, India,<br />

Malaysia, Singapore, South Korea and Taiwan, reported that<br />

the average R&D expenditure in the Asia Pacific region in<br />

2010 was 12.34% of total expenditure, compared to 9.44%<br />

in 2009. 64 By comparison, in 2011, R&D expenditure reported<br />

by QLS companies was 9% of total expenditure. In 2009, this<br />

figure was 13%.<br />

7.5.1 Business Expenditure on R&D (BERD)<br />

The average BERD across OECD countries in 2008/2009 was<br />

1.62% of GDP. Australia was ranked 14th (out of 34) in the<br />

OECD rankings in 2008/2009 ahead of the UK, Canada and<br />

New Zealand. Figures for 2009/2010 were not available. An<br />

analysis of those countries that reported 2009/2010 BERD<br />

data revealed that Israel led the OECD countries (3.42% of<br />

GDP), followed by Finland (2.83% of GDP), Sweden (2.55%<br />

of GDP), and Japan (2.53% of GDP). 65<br />

Between 2005/2006 and 2008/2009 the OECD average BERD<br />

as a percentage of GDP grew, with a CAGR of 1.46% (Figure<br />

17). Over the same period Australian BERD as a percentage<br />

of GDP grew with a CAGR of 8.45%. However, for the first<br />

time in a decade, Australian BERD dropped in 2009/2010.<br />

Australian BERD totalled $16.7 billion or 1.30% of GDP in<br />

FY2010, $579 million less than FY2009 (1.38% GDP) — a<br />

3.35% decline in actual figures and a 6% decline in BERD<br />

as a proportion of GDP. 66<br />

Figure 17: Business expenditure on R&D as a percentage<br />

of GDP 2004 – 2010 67<br />

The reduction in BERD did not occur uniformly across<br />

businesses of all sizes. 68 Businesses with over 200<br />

employees accounted for the majority of total BERD (69%)<br />

in 2009/2010 and experienced the greatest reduction<br />

in R&D expenditure between 2008/2009 and 2009/2010<br />

(5%). Businesses employing between 20–199 employees<br />

accounted for 19% of BERD and experienced a 0.5%<br />

increase. Those businesses employing between 5-19 staff<br />

accounted for 9% of BERD and reported a decrease of<br />

4%. The smallest businesses, 0–4 staff, registered an 8%<br />

increase in BERD but accounted for only 4% of total BERD<br />

in 2009/2010.<br />

ABS figures suggest that from 2007 to 2010, <strong>Queensland</strong><br />

businesses accounted for an average of 14.2% of total<br />

national BERD (Figure 18). <strong>Queensland</strong> BERD as a<br />

percentage of the national total was 13.6% in 2007<br />

and 14.1% in 2010.<br />

Figure 18: Business expenditure on R&D, <strong>Queensland</strong> vs.<br />

Australia 2007 – 2010 69<br />

In comparison with other Australian states, <strong>Queensland</strong><br />

ranked fourth in terms of total BERD in FY2010 (Figure 19).<br />

Figure 19: Business expenditure on R&D <strong>Queensland</strong> vs.<br />

other states, 2009/201070 Figure 20 compares <strong>Queensland</strong> and other Australian<br />

States in terms of their BERD in professional, scientific<br />

and technical industries in FY2010.<br />

64 BioSpectrum Asia-Pacific <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> Survey 2009 and 2010, www.biospectrumasia.com<br />

65 OECD Science, Technology and <strong>Industry</strong> Scoreboard 2011<br />

66 Australian Bureau of Statistics 8104.0 - Research and Experimental Development, Businesses, Australia, 2009-10<br />

67 Australian Bureau of Statistics, 8104.0 Research and Experimental Development, Business Australia, 2009-20010<br />

68 Ibid.<br />

69 Australian Bureau of Statistics, 8104.0 Research and Experimental Development, Business Australia, 2009/2010<br />

70 Australian Bureau of Statistics, 8104.0 Research and Experimental Development, Business Australia, 2009/2010.<br />

71 Australian Bureau of Statistics, 8104.0 Research and Experimental Development, Business Australia, 2009/2010.


Figure 20: Business expenditure on professional, scientific and<br />

technical R&D in <strong>Queensland</strong> vs. other states, FY201071 7.5.2 Government Expenditure on R&D (GOVERD)<br />

Government expenditure on R&D (GOVERD) may be used as<br />

a proxy for assessing government investment in innovation. 72<br />

Based on ABS data, between 2006/2007 and 2008/2009 Australian<br />

GOVERD increased by 10% in real terms but as a proportion<br />

of GDP it dropped slightly from 0.28% to 0.27%. Despite this,<br />

Australia’s GOVERD/GDP ratio remained close to the OECD<br />

average of 0.26% in FY2008 (data for subsequent years is not<br />

available). In FY2008, Australia ranked tenth in the OECD for<br />

GOVERD as a proportion of GDP. Iceland, Korea and Germany<br />

were the top three countries. In 2008/2009, 13% of GOVERD was<br />

directed to health and medical research.<br />

ABS data indicated that in FY2009 the Australian and State<br />

Governments spent a total of $3.42 billion on R&D including $0.48<br />

billion in <strong>Queensland</strong>. 73 The dollar value of GOVERD increased in<br />

<strong>Queensland</strong> between FY2005 and FY2009 (Figure 21).<br />

Figure 21: Government expenditure on R&D, by state,<br />

2005 – 2009<br />

72 Commonwealth Department of Innovation, <strong>Industry</strong>, Science and Research, (2011) ‘Australian Innovation System <strong>Report</strong> 2011’. http://www.innovation.gov.au/<br />

Innovation/Policy/Pages/AustralianInnovationSystem<strong>Report</strong>.aspx<br />

73 Australian Bureau of Statistics, 8109.0 - Research and Experimental Development, Government and Private Non-Profit Organisations, Australia,<br />

2008–2009.<br />

51


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

52<br />

8.THE LISTED LIFE SCIENCES SECTOR<br />

“Eight of the 102 <strong>Life</strong> <strong>Sciences</strong> companies listed on the Australian Stock<br />

Exchange at 30 June 2011 were located in <strong>Queensland</strong>.”<br />

8.1 The ASX-Listed Australian <strong>Life</strong> <strong>Sciences</strong><br />

Sector<br />

The BioForum Quarterly Review published by<br />

PricewaterhouseCoopers (PwC), charts the<br />

Australian <strong>Life</strong> <strong>Sciences</strong> Index, which included<br />

102 companies (64 pharmaceutical/biotechnology<br />

and 38 medical devices companies) listed on<br />

the Australian Stock Exchange (ASX) as at 30<br />

June 2011. 74 While the number of ASX-listed <strong>Life</strong><br />

<strong>Sciences</strong> companies fell from 120 at 30 June 2009<br />

to 102 as at 30 June 2011, their combined total<br />

market capitalisation (market cap) grew over this<br />

period (Table 46). The PwC <strong>Life</strong> <strong>Sciences</strong> index grew<br />

by 4% in 2011, compared to 3% in 2009.<br />

In 2010, Australian <strong>Life</strong> <strong>Sciences</strong> companies<br />

dominated the top 50 fastest growing ‘bio’<br />

companies in the Asia Pacific region, with 25<br />

entries, including all of the top five fastest growing<br />

companies. 75 <strong>Queensland</strong> companies, BioProspect<br />

and Anteo Diagnostics were at positions 19 and<br />

37, respectively.<br />

8.2 The ASX-Listed <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> Sector<br />

Eight of the 102 (7.8%) <strong>Life</strong> <strong>Sciences</strong> companies<br />

listed on the ASX at 30 June 2011 were located in<br />

<strong>Queensland</strong> (Table 47). 77 Of those, four (50%) were<br />

operating in ‘pharmaceuticals, vaccines or drug<br />

discovery’, two (25%) were in the medical devices<br />

and equipment sector and two (25%) were in<br />

biotechnology.<br />

Since the previous QLS survey (to 30 June 2009),<br />

CBio Limited was added to the ASX (Feb 2010) and<br />

three other companies were removed: Occupational<br />

& Medical Innovations Limited was delisted, after<br />

being placed into voluntary administration; Peplin<br />

Limited was acquired by Leo Pharma in Denmark<br />

(Nov 2009) for AU$348.4 million; and Incitive<br />

Limited was purchased by Hawley Oil and Gas in<br />

February 2010, who subsequently demerged their<br />

biotechnology assets. They are, therefore, no longer<br />

part of the <strong>Life</strong> <strong>Sciences</strong> sector.<br />

In 2009, the majority of ASX-listed companies<br />

in <strong>Queensland</strong> (seven of ten companies) were<br />

TABLE 46: Size and market capitalisation of ASX-listed <strong>Life</strong> <strong>Sciences</strong> companies 2009 and 2011 76<br />

Sector 2009 2011<br />

No. Companies Market Cap<br />

($b)<br />

No. Companies Market Cap<br />

($b)<br />

Australian <strong>Life</strong> <strong>Sciences</strong> 120 $31.0 102 $35.0<br />

Pharmaceutical/Biotechnology 73 $22.8 64 $24.0<br />

Medical Devices 47 $8.2 38 $11.0<br />

Australian <strong>Life</strong> <strong>Sciences</strong><br />

(excluding CSL, COH, RMD)*<br />

117 $4.5 99 $9.1<br />

Pharmaceutical/Biotechnology<br />

(excluding CSL)*<br />

72 $3.4 63 $6.6<br />

Medical Devices (excluding COH, RMD)* 45 $1.1 36 $3.0<br />

*CSL = CSL Ltd, COH = Cochlear Ltd RMD = ResMed Ltd.<br />

74 PwC BioForum, Edition 29, Quarter 4 FY09, August 2009. http://www.pwc.com.au/industry/technology/publications/bioforum.htm<br />

75 ‘Asia’s Fastest 50 Companies’, BioSpectrum Asia (October 2011) vol 6, issue 10, page 42. ‘Bio companies’ include Pharma,<br />

Medtech, Biotech and Bioservices companies.<br />

76 PwC BioForum, Edition 29, Quarter 4 FY09, August 2009 and PwC BioForum, Edition 36, Quarter 4 FY11, August 2011.<br />

77 ASX-Listed companies by sector at http://www.asx.com.au/asx/research/listedCompanies.do; Deloitte <strong>Queensland</strong> Index, a review<br />

of <strong>Queensland</strong> listed companies on the Australian Securities Exchange (ASX), 85th Edition.


considered ‘microcap’ — with a market cap of less than $50<br />

million. As at 30 June 2011, only three of eight companies were<br />

‘microcap’. All but one of the companies that were listed in both<br />

2009 and 2011 increased their market cap during this period<br />

(Table 47).<br />

TABLE 47: Market capitalisation of ASX-Listed <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> companies 78<br />

Company Code <strong>Life</strong> <strong>Sciences</strong><br />

Sub-sector<br />

Alchemia<br />

Limited<br />

ACL Pharma,<br />

vaccines or<br />

drug discovery<br />

Analytica Limited ALT Medical devices<br />

and equipment<br />

Anteo<br />

Diagnostics<br />

(previously<br />

Bio-Layer)<br />

BioProspect<br />

Limited<br />

ADO Pharma,<br />

vaccines or<br />

drug discovery<br />

CBio Limited CBZ Pharma,<br />

vaccines<br />

or drug<br />

discovery<br />

Impedimed<br />

Limited<br />

Progen<br />

Pharmaceuticals<br />

Ltd<br />

Market Cap ($m)<br />

2009* 2011 + Change<br />

$57.0 $117.0 105%<br />

$7.5 $12.3 64%<br />

$1.8 $53.4 2867%<br />

BPO Biotechnology $8.3 $8.9 8%<br />

IPD Medical devices<br />

and equipment<br />

PGL Pharma<br />

vaccines or<br />

drug discovery<br />

N/A $98.2 N/A<br />

$62.3 $89.2 43%<br />

$21.0 $5.7 -73%<br />

Tissue Therapies TIS Biotechnology $12.5 $97.0 676%<br />

* As at 30 June 2009 + As at 30 June, 2011<br />

8.3 Market Capitalisation — <strong>Queensland</strong>, Australia,<br />

New Zealand and Canada<br />

Figure 22 shows the average market cap of <strong>Queensland</strong> and<br />

Australian listed <strong>Life</strong> <strong>Sciences</strong> firms, as at 30 June 2011. The<br />

average market cap of the non-major Australian <strong>Life</strong> <strong>Sciences</strong><br />

firms on the ASX (i.e. excluding CSL, RMD and COH) was $91.7<br />

million. For the <strong>Queensland</strong> based firms, the average market<br />

cap was approximately one third lower at $60.2 million.<br />

Figure 22: Average market capitalisation of ASX-listed <strong>Life</strong><br />

<strong>Sciences</strong> firms, <strong>Queensland</strong> vs. Australia, 30 June 2011<br />

The average market cap of the non-majors and the listed<br />

<strong>Queensland</strong> firms dropped below 2007 levels during 2008<br />

and 2009, a period which coincides with the GFC (2008-2009)<br />

(Figure 23). The average market cap for Australian and <strong>Queensland</strong><br />

listed firms grew in both 2010 and 2011. 79<br />

Figure 23: Average market capitalisation of ASX-listed <strong>Life</strong><br />

<strong>Sciences</strong> firms, <strong>Queensland</strong> vs. Australia, at Q4 2007-2011<br />

To put the listed market cap figures into some perspective, the<br />

<strong>Queensland</strong> and Australian averages were compared to those for<br />

New Zealand and Canada.<br />

In some respects, the New Zealand <strong>Life</strong> <strong>Sciences</strong> sector provides<br />

a useful comparator for <strong>Queensland</strong>. Both regions have a similar<br />

population base (<strong>Queensland</strong> 4,580,282 80 ; New Zealand<br />

4,407,500 81 ) and a similar number of resident <strong>Life</strong> <strong>Sciences</strong><br />

78 Market capitalisation data sourced from PwC BioForum Edition 36, Quarter 4 FY11, August 2011.<br />

79 Market capitalisation data sourced from PwC Quarterly BioForum Publications Q4, 2007, PwC BioForum, Edition 25, Quarter 4 FY08, August 2008, PwC BioForum,<br />

Edition 29, Quarter 4 FY09, August 2009, PwC BioForum, Edition 33, Quarter 4 FY10/Quarter 1 FY11, November 2010, Edition 36, Quarter 4 FY11, August 2011.<br />

80 <strong>Queensland</strong> Government Office of Economic and Statistical Research, http://www.oesr.qld.gov.au/products/tables/erp-lga-reformed-qld/index.php. (30 June 2011).<br />

81 New Zealand Government, Statistics New Zealand, Population Indicators, http://www.stats.govt.nz/browse_for_stats/population/estimates_and_projections/popindicators.aspx<br />

53


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

54<br />

organisations (<strong>Queensland</strong> 301; New Zealand 276 (defined as<br />

Bioscience) 82 . <strong>Queensland</strong> reported a similar average market<br />

cap ($60.2 million) as New Zealand ($68.8 million), both of<br />

which were lower than the average market cap of the nonmajor<br />

Australian firms.<br />

Canada and Australia share a high standard of living, health<br />

and education, spend similar amounts on health R&D as a<br />

percentage of GDP 83 and, in recent years, both have sought<br />

to develop their bioscience capability. 84 There is, however,<br />

a considerable difference in population between the two<br />

nations (Canada: 34,869,747 85 and Australia: 22,682,566 86 ).<br />

A comparison of the Canadian and Australian listed <strong>Life</strong><br />

Science sectors reveals that the average size of publicly<br />

listed <strong>Life</strong> <strong>Sciences</strong> companies in Canada was lower than<br />

listed Australian <strong>Life</strong> <strong>Sciences</strong> companies (Table 48). This<br />

most likely reflects a higher maturity in the Canadian sector<br />

and greater access to capital and customers in the US<br />

market.<br />

TABLE 48: International comparison of average listed market<br />

capitalisation (AU$m) 87<br />

Region Date Total<br />

Market Cap<br />

<strong>Queensland</strong> Jun<br />

2011<br />

New Zealand<br />

(ex major; FPH)<br />

Australia (ex majors;<br />

RMD, COH, CSL)<br />

Oct<br />

2010<br />

Jun<br />

2011<br />

Average<br />

Market Cap<br />

$482 $60.2<br />

$619 $68.8<br />

$9,074 $91.7<br />

Australia Jun<br />

2011<br />

$35,003 $343.0<br />

Canada - <strong>Life</strong> <strong>Sciences</strong>* Dec<br />

2011<br />

$21,400 $180.0<br />

Canada - Biotechnology 2010 $5,176 $82.1<br />

* Please note the TSX/TSXV listed <strong>Life</strong> <strong>Sciences</strong> sector includes<br />

healthcare facilities and health services, which are both sub-sectors<br />

not included in the definition of <strong>Life</strong> <strong>Sciences</strong> for the QLS survey<br />

and report.<br />

82 NZBio 2010 Bioscience <strong>Industry</strong> <strong>Report</strong>. http://www.nzbio.org.nz/portals/3/files/Final%202010%20Bioscience%20<strong>Industry</strong>%20<strong>Report</strong>.pdf<br />

83 OECD Science and Technology Scorecard 2011, Health R&D in government budget appropriations or outlays for R&D, 2010. Canada (2008) 0.1% GDP;<br />

Australia (2010) 0.09% GDP.<br />

84 Bruce Rasmussen, (2005) ‘Developing the Biomedical Industries in Canada and Australia: An Innovation Systems Approach’, (Working Paper No. 24),<br />

Victoria: Victorian University of Technology.<br />

85 Statistics Canada, www.statcan.gc.ca/ig-gi/pop-ca-eng.htm; accessed 1 July <strong>2012</strong><br />

86 ABS Population Clock, www.abs.gov.au; accessed 1 July <strong>2012</strong><br />

87 PwC BioForum Publication Edition 36, Quarter 4 FY11, August 2011; Canadian TSX/TSXV listed <strong>Life</strong> <strong>Sciences</strong> sector data December 2011 accessed at<br />

http://www.tmx.com/en/pdf/<strong>Life</strong><strong>Sciences</strong>_Sector_Profile.pdf; NZBio 2010 Bioscience <strong>Industry</strong> <strong>Report</strong>; Ernst & Young, Beyond Borders 2011.


By David Blake, Editor of BioShares<br />

INDUSTRY COMMENTARY<br />

THE LISTED LIFE SCIENCES SECTOR IN AUSTRALIA<br />

— NOT ONE SIZE FITS ALL<br />

A neat one size fits all description of the<br />

state of Australia’s listed life sciences<br />

sector has become an impossibility<br />

since the GFC in 2008 began a process of<br />

constant damage to some companies but<br />

left others merely bruised and even some<br />

others unscathed. A high Australian dollar<br />

has not helped sales focused life science<br />

firms and healthcare system budgets<br />

and some export markets have weakened<br />

company earnings of late.<br />

What is known is that the number of listed<br />

life science companies has declined from<br />

a peak of 134 in 2008 to 100 in <strong>2012</strong>, with<br />

a contraction more likely to continue for<br />

as long as global economic conditions<br />

remain poor.<br />

The hundred or so life science companies<br />

listed on the ASX are a diverse group of<br />

companies in terms of market value,<br />

scale of operations, scope of business and<br />

market focus. There are 29 companies<br />

capitalised at less than $10 million, 49 are<br />

capitalised at less than $20 million and 18<br />

capitalised at less than $100 million. There<br />

are five companies capitalised at greater<br />

than $1 billion.<br />

The activities of ASX listed life science<br />

firms range from medical device<br />

manufacture and sales, vaccines and<br />

immune therapy product manufacture, cell<br />

therapy and wound healing development,<br />

assessment and diagnostic technologies<br />

including molecular, bio-sensor and<br />

algorithmic approaches, biological storage<br />

technologies, sleep apnoea management<br />

products and many more.<br />

Roughly 7-8% of ASX-listed life science<br />

companies are foreign firms lacking direct<br />

links to Australia. Biotech identity is a<br />

tricky classification issue given that quite<br />

a number of listed companies are US<br />

entities, which own operating subsidiaries<br />

in Australia.<br />

Investment in biotech stocks has been a<br />

stock picking activity for quite some time,<br />

a strategy which is a function of the time it<br />

takes for medical technology businesses to<br />

arrive at valuation inflection points,<br />

leaving many companies without vital<br />

news flow to attract investor interest.<br />

The Bioshares Index for example was down<br />

23.5% between June <strong>2012</strong> and June 2011.<br />

However, 22 stocks posted share price<br />

gains of greater than 20% for the same<br />

period. That’s not such bad going in<br />

dismal times.<br />

Ongoing key issues for investors in<br />

life science stocks include execution<br />

risk, otherwise known as financing<br />

risk, reflecting a company’s capacity to<br />

support the business objectives it has<br />

set itself. Investment flows have been<br />

biased towards later stage companies in<br />

the past few years, with companies such<br />

as Mesoblast, Alchemia, QRxPharma,<br />

Starpharma, Prima Biomed and<br />

Phosphagenics raising sizable tranches of<br />

capital to support pivotal clinical studies.<br />

New listings (the IPO market) have all but<br />

dried up with only one, Osprey Medical<br />

completed in <strong>2012</strong>, following three in 2011,<br />

and two in 2010.<br />

One risk that has recently been elevated<br />

in importance is regulatory risk. Several<br />

submissions to drug regulators from<br />

Australian firms, e.g. Pharmaxis, Mayne<br />

Pharma and QRxPharma, have been<br />

knocked back at the first round leaving<br />

both investors and the companies<br />

concerned in a state of shock. These<br />

first-cycle requests for more data can be<br />

expected to have a negative impact on<br />

investment in the sector<br />

The highlight for Australian life science<br />

investors in the last two years was the<br />

payment of a $100 million dividend by<br />

Acrux in April 2011, following the receipt<br />

of license-based payments from Eli Lilly<br />

for the testosterone drug Axiron. Rather<br />

than retaining the cash for another stage<br />

of business development, by paying<br />

shareholders a dividend, the board of<br />

Acrux elected to send a clear signal that<br />

investment decisions are ultimately the<br />

prerogative of shareholders.<br />

55


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

56<br />

9.SENTIMENT AND OUTLOOK<br />

“Overall business sentiment was positive with the majority of companies<br />

and the majority of research organisations expecting income growth over<br />

the coming 12 months and three years.”<br />

The survey findings on business sentiment and<br />

industry outlook are fairly reliable indictors for<br />

the future of the sector given that the majority of<br />

respondents held senior executive roles in their<br />

organisation. About 70% of respondents held the<br />

position of CEO, Director, Managing Director or<br />

General Manager. 16% of respondents held other<br />

management roles such as Technical Manager,<br />

Operations Manager, Quality Assurance Manager,<br />

Sales and Marketing Manager. The remaining<br />

15% of respondents held a range of 15 different<br />

administration roles.<br />

Approximately 52% of those responding on behalf<br />

of research organisations held executive roles<br />

including Director, Deputy Director, Executive Dean,<br />

Deputy Executive Dean, or Director of Research;<br />

and 22% held senior roles such as Research<br />

Manager, Grants Manager, Business Manager,<br />

and Operations Manager. The remaining (26%)<br />

held seven different administrative roles.<br />

9.1 Business Sentiment<br />

9.1.1 Income Expectations<br />

The majority of all respondents to the 2011 survey<br />

expected their total income to increase over the<br />

next 12 months (65%) and over the next three<br />

years (82%).<br />

The majority of companies expected income growth<br />

over 12 months (65%) and three years (82%). About<br />

13% anticipated a decrease in total income over the<br />

next 12 months and 6% anticipated a decrease in<br />

total income over the next three years (Figure 24).<br />

By contrast, research organisations anticipated that<br />

income would either increase (12 months (65%);<br />

three years (90%)) or remain the same (12 months<br />

(35%); three years (10%)) over both periods (Figure<br />

24), with none expecting income to fall.<br />

Table 49 presents the average forecast change<br />

in income for all respondents, companies and<br />

research organisations over the coming 12 months<br />

and three years (the number of respondents to<br />

each question are shown in brackets).<br />

TABLE 49: Average forecast change in income over<br />

12 months and three years<br />

Average Expected Change in Income<br />

12 months 3 years<br />

All respondents +40.4% (n=120) +116.1% (n=121)<br />

Companies +46.9% (n=100) +135.5% (n=101)<br />

Research<br />

Organisations<br />

+8.1% (n=20) +17.9% (n=20)<br />

Table 50 breaks down the average income change<br />

for those specifically expecting either (a) an<br />

increase or (b) a decrease in income.<br />

TABLE 50: Quantum of Change Amongst those<br />

Forecasting an Increase or Decrease in Income<br />

(99 respondents)<br />

12 months 3 years<br />

N Average N Average<br />

Those anticipating no growth<br />

Companies 24 - 14 -<br />

Research<br />

Organisations<br />

7 - 2 -<br />

Those anticipating a fall in income<br />

Companies 12 -39% 6 -86%<br />

Research<br />

Organisations<br />

0 - 0 -<br />

Those anticipating income growth<br />

Companies 64 +81% 81 +175%<br />

Research<br />

Organisations<br />

13 +13% 18 +20%<br />

Figure 24: Income forecasts for companies (left) and research organisations (right), <strong>2012</strong>, 2014<br />

(number of respondents: companies, 100 research organisations, 21)


9.1.2 R&D Expenditure Forecasts<br />

An almost equal proportion of companies anticipated that their<br />

R&D expenditure would either increase or remain the same over<br />

the coming 12 months (42% remain the same, 45% increase) and<br />

three years (44% remain the same, 45% increase). The remaining<br />

companies anticipated a fall in R&D expenditure in 12 months<br />

(12%) and three years (11%) (Table 51; Figure 25).<br />

Figure 25: R&D expenditure expectations for companies (left)<br />

and research organisations (right), <strong>2012</strong>, 2014 (number of<br />

respondents: 73 companies and 18 research organisations)<br />

Of those companies who provided estimates for their increased<br />

R&D expenditure (33), the average predicted growth was 97% for<br />

the coming 12 months and 138% for the coming three years. For<br />

those who expected a fall in R&D expenditure, the average for<br />

those who qualified the estimate was a decline of 62% in the next<br />

12 months (9 companies) and 64% in three years (8 companies).<br />

There were no research organisations anticipating a decline<br />

in R&D expenditure over the next one–three years. About 44%<br />

of research organisations anticipated R&D expenditure would<br />

remain the same whilst 56% expected an increase over the coming<br />

12 months. For the coming three-year period 83% of research<br />

organisations anticipated an increase in R&D expenditure<br />

and 17% anticipated no change.<br />

TABLE 51: R&D Expenditure Forecasts — 12 months and three years<br />

Expecting<br />

change<br />

12 months 3 years<br />

Average<br />

change<br />

forecast<br />

Expecting<br />

change<br />

88 Biotechnology <strong>Industry</strong> Position Survey April <strong>2012</strong>; 50 respondents drawn from listed <strong>Life</strong> <strong>Sciences</strong> companies and AusBiotech member companies. http://www.<br />

ausbiotech.org/data/downloads/Biotechnology%20survey%20<strong>2012</strong>_Final.pdf; accessed 26.05.<strong>2012</strong><br />

Average<br />

change<br />

forecast<br />

Companies<br />

Increase 45% 97% 45% 138%<br />

Remain the same 42% - 44% -<br />

Decrease<br />

Research Organisations<br />

12% -62% 11% -64%<br />

Increase 56% 10% 83% 17%<br />

Remain the same 44% - 17% -<br />

Decrease 0% 0% 0% 0%<br />

9.1.3 Business Sentiment in the Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

In the current survey, the majority of companies forecast<br />

increases in income over the next one (64%) and three years<br />

(81%). The figures in 2009 were 71% and 88% for one and three<br />

years respectively. However, in 2011, 42% of companies predicted<br />

income would remain the same in the coming 12 months,<br />

compared to 15% in 2009.<br />

45% of companies expected R&D expenditure to increase in 2011<br />

compared to 64% in 2009. Lower expectations for R&D expenditure<br />

among companies in 2011 could suggest a level of uncertainty in<br />

income forecasts.<br />

The AusBiotech Biotechnology <strong>Industry</strong> Position Survey of 50 <strong>Life</strong><br />

<strong>Sciences</strong> companies in January <strong>2012</strong> 88 also indicated positive<br />

business sentiment across the Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>.<br />

They reported that 68% of respondents characterised 2011 as a<br />

good or excellent year, and that, in the coming year, 82% expected<br />

their business to grow, and 58% expected to increase the number<br />

of staff.<br />

By contrast, the 2009 AusBiotech Biotechnology <strong>Industry</strong> Position<br />

Survey revealed a sentiment of caution.<br />

“[In] the 2009 survey by AusBiotech of members...48% of those<br />

surveyed expected to reduce staff numbers and no company indicated<br />

they expected to hire.”<br />

57


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

58<br />

In an early 2011 article, David Blake, Co-editor of BioShares<br />

wrote:<br />

“The ASX-listed biotech sector has gone through a period of<br />

tremendous transformation in the last two years as a dozen<br />

or more companies have matured into successful companies,<br />

generating revenues or verging on having products registered.<br />

At the same time upwards of 30 have had to close their<br />

doors or significantly change their business….However, with<br />

the Nasdaq Biotech Index, …showing a very strong uptrend,<br />

perhaps biotech, not just in the US, but in Australia and<br />

elsewhere is about to be very popular with investors again.” 89<br />

Some of the deals that will have contributed to positive<br />

industry sentiment include the following:<br />

Cephalon offered to pay Mesoblast $130 million upfront<br />

and another $220 million to acquire a nearly 20 per<br />

cent stake in the company in December 2010. The total<br />

deal value, should Mesoblast achieve development and<br />

commercial milestones, could reach US$1.7 billion.<br />

Acrux licenced its testosterone treatment to Eli Lilly in<br />

March 2010 in a deal worth up to US$335 million plus<br />

potential royalties of about US$220 million.<br />

Qiagen acquired all the ordinary shares in Australian<br />

diagnostics company Cellestis Ltd in August 2011 in<br />

a deal worth $341 million.<br />

9.2 Outlook — Barriers, Risks and Challenges<br />

9.2.1 Opportunities for <strong>Industry</strong> Expansion<br />

Survey participants (82) commented on strategies to assist<br />

expansion of the industry. Respondents selected from ten<br />

options including an ‘Other’ option (Table 52).<br />

TABLE 52: Areas that will assist expansion of the<br />

<strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

Rank Area Proportion<br />

of total<br />

responses<br />

1 Improved industry representation 17%<br />

2 Government organisations becoming early<br />

adopters of <strong>Queensland</strong> innovations<br />

15%<br />

3 <br />

research or manufacturing facilities<br />

<br />

and educational institutions<br />

12%<br />

5 Increased foreign investment into Australia 10%<br />

6 <br />

<br />

9%<br />

8 Skills enhancement through university<br />

courses<br />

8%<br />

9 Improved engagement between clinicians<br />

and researchers<br />

3%<br />

- Other (see below) 5%<br />

Responses (direct quotes shown) in the ‘Other’ category<br />

included:<br />

Leveraging the skills and professional networks that exist<br />

Trade base and support just to keep R&D and<br />

manufacture alive at all<br />

Scholarships to enhance skills development in industry<br />

Grants for collaboration with SMEs<br />

Reduced regulatory framework<br />

Changes to investment rules to allow investment capital<br />

to flow to commercial R&D organisations<br />

Reinstate Commercial Ready Program; abolish payroll<br />

tax for R&D/manufacturing firms<br />

Maintaining staff capability as a large cohort move<br />

towards retirement over the next 10 years<br />

Several respondents offered comments (direct quotes)<br />

on roles for government in encouraging expansion of<br />

the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>:<br />

“Bet on the innovators — with real money, not just moral<br />

support or programs which require innovators to spend<br />

money on other researchers”<br />

“Very important that Government do not encroach on<br />

successful commercial entities already established in<br />

<strong>Queensland</strong> such as contract manufacturing, or building<br />

such facilities [where they] already exist. Very important<br />

to train researchers [on] how to commercialise research<br />

outcomes or have systems in place that allow publicly<br />

funded research to be commercialised for [the]<br />

public good.”<br />

9.2.2 Barriers to Future Income Growth — Access to Capital<br />

In the 2009 survey, a lack of access to capital was identified<br />

as the most significant barrier to future growth and the<br />

greatest risk/challenge facing organisations. This is not a<br />

new concern, with limited access to finance or capital also<br />

identified as the major barrier to growth by respondents<br />

to the <strong>Queensland</strong> TMD Survey in 2007. Access to capital<br />

is an issue that affects companies right across the<br />

Australian Biotechnology <strong>Industry</strong> 90 as well as those active<br />

in innovation in any Australian industry. For innovative<br />

Australian companies, limited access to funds and skilled<br />

personnel were the two most commonly identified barriers<br />

to innovation in an ABS study published in 2010. 91<br />

A similar situation is evident in many international <strong>Life</strong><br />

<strong>Sciences</strong> industries, including the USA, Canada and New<br />

Zealand. Jones Lang LaSalle in a <strong>Life</strong> <strong>Sciences</strong> Cluster<br />

<strong>Report</strong> 92 noted that:<br />

“investment capital will be the biggest hurdle for Canada’s<br />

emerging <strong>Life</strong> <strong>Sciences</strong> sector. The recession reduced spending<br />

in the sector and although venture capital returned in 2011,<br />

it remains in short supply.”<br />

89 D Blake, ‘Will The IPO Market Open For Australian Biotechs in 2011?’, AFG Venture Group Dispatches.<br />

90 AusBiotech, ‘Biotechnology <strong>Industry</strong> Position Survey’, January <strong>2012</strong><br />

91 Australian Bureau of Statistics 8158 — Innovation in Australian businesses, 2008-09, quoted in Australian Government, ‘Australian Innovation System<br />

<strong>Report</strong> 2011’acessed at http://www.innovation.gov.au/AIS<strong>Report</strong>.<br />

92 Jones Lang LaSalle, ‘<strong>Life</strong> <strong>Sciences</strong> Cluster <strong>Report</strong>, Global 2011’; accessed 4th July <strong>2012</strong>. www.joneslanglasalle.com/ResearchLevel1/Global_<strong>Life</strong>%20<br />

<strong>Sciences</strong>%20Cluster%20<strong>Report</strong>_2011_gb.pdf.


Similarly, the major constraint to both the R&D and<br />

commercialisation activities of New Zealand bioscience companies<br />

in 2005, 2007 and 2009, was access to capital. 93<br />

In January 2011, US President Obama announced a new<br />

initiative, Startup America designed to ‘accelerate high-growth<br />

entrepreneurship’. Recognizing that access to capital was a<br />

critical barrier to the creation and growth of innovative start-up<br />

companies, the initiative included strategies designed to unlock<br />

access to capital and reduce barriers to entrepreneurship. 94<br />

In the current survey, companies were asked to comment on the<br />

extent to which limited access to finance was impacting their<br />

business. For 72% of respondents (97), limited access to finance<br />

was having an impact (very significantly, 32%; significantly, 21%;<br />

moderately, 19%). 28% of respondents indicated that this barrier<br />

was having little or no impact (Figure 26).<br />

Figure 26: Impact of limited access to finance of QLS companies<br />

(97 respondents)<br />

43% of companies (96) were optimistic or very optimistic that this<br />

barrier could be overcome e.g. through successful capital raising,<br />

deploying other strategies to raise funds, or alternative strategic<br />

directions. 19% were pessimistic or very pessimistic about<br />

overcoming the barriers to accessing capital (Figure 27).<br />

Figure 27: Outlook of companies affected by limited access<br />

to finance (96 respondents)<br />

9.2.3 Barriers to Future Income Growth<br />

(other than access to finance)<br />

Looking beyond the issue of access to capital, survey participants<br />

(104) nominated other major barriers to future income growth<br />

from eleven options including an ‘Other’ category (Table 53).<br />

TABLE 53: Barriers to future revenue growth<br />

Rank Area Proportion of total<br />

responses<br />

1 Limited access to government grant<br />

funding<br />

15.6%<br />

2 Small size of domestic market 13.0%<br />

Increased domestic and/or international<br />

competition<br />

12.8%<br />

4 Increased regulatory compliance costs 11.9%<br />

5 Inability to secure skilled technical and<br />

managerial staff<br />

11.0%<br />

6 Access to overseas markets 9.8%<br />

7 Increased patent protection costs 6.9%<br />

8 Lack of access to analytical testing,<br />

research or clinical trial services<br />

5.9%<br />

Lack of commercialisation experience or<br />

expertise (e.g. to reach proof of concept)<br />

10 Inability to outsource sufficient<br />

manufacturing capacity<br />

5.7%<br />

3.8%<br />

11 Other 3.6%<br />

9.2.4 Risks and Challenges<br />

Survey respondents (111) nominated the issues that they<br />

considered to be the major risks or challenges facing their<br />

organisation (Table 54). Respondents were able to select more<br />

than one risk.<br />

TABLE 54: Major risks or challenges facing QLS organisations<br />

Rank Risk/challenge Proportion of total<br />

responses<br />

1 Access to sufficient capital for growth<br />

or market entry<br />

14.0%<br />

2 High Australian Dollar 12.8%<br />

Regulatory Issues 12.8%<br />

4 Global financial turmoil 11.7%<br />

Access to R&D funding 11.7%<br />

6 Workforce challenges<br />

(e.g. skills shortages)<br />

11.5%<br />

7 Competition 8.9%<br />

8 Consumer behaviour 7.3%<br />

9 Climate change and associated<br />

regulatory change<br />

3.1%<br />

10 Technology and systems 2.5%<br />

11 Transport and distribution 2.0%<br />

12 Other 1.7%<br />

93 NZBIO 2010 Bioscience <strong>Industry</strong> <strong>Report</strong> 2010; commissioned by the Ministry for Science and Innovation. www.nzbio.org.nz/portals/3/files/Final%202010%20<br />

Bioscience%20<strong>Industry</strong>%20<strong>Report</strong>.pdf; accessed 4th July <strong>2012</strong>.<br />

94 See The White House accessed at http://www.whitehouse.gov/economy/business/startup-america.<br />

59


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

60<br />

Figure 28: Major risk or challenge facing QLS organisations (111 respondents)<br />

Access to sufficient capital for growth or market entry<br />

was the highest risk or challenge for companies (94<br />

respondents). Research organisations (17 respondents)<br />

nominated access to R&D funding as their highest risk or<br />

challenge (Figure 28).<br />

9.3 Feedback on Government Engagement with<br />

the <strong>Industry</strong><br />

Participants in the survey provided feedback on initiatives<br />

of the <strong>Queensland</strong> Government and made suggestions<br />

on areas for Government intervention to support industry<br />

growth into the future.<br />

Approximately 42% of companies (69) and 70% of<br />

research organisations (10) were positive about the<br />

level of engagement between the <strong>Queensland</strong> Government,<br />

typically DSITIA (referred to by its previous name ‘DEEDI’,<br />

by respondents) and the industry. 35% of companies<br />

and 20% of research organisations offered some critical<br />

comment. The remainder were neutral.<br />

A selection of comments that captured the essence of<br />

participant responses are provided below.<br />

Comments (Direct quotes — some quotes may have been<br />

truncated/edited for clarity):<br />

Very much so — they do a great job with limited resources/<br />

guidelines/capacities.<br />

It is my impression that over the past three years the<br />

department is less interested in supporting biotechnology<br />

developments.<br />

Yes, but DEEDI could do more to engage with industry. A lot<br />

of resources have been directed to universities and research<br />

institutes. SMEs have struggled and many have closed.<br />

Generally very pleased that DEEDI is interested and<br />

providing some tangible support to this industry sector.<br />

In the future [we would] suggest less money spent on<br />

research and more money spent on genuine development.<br />

The DEEDI and DERM [<strong>Queensland</strong> Department of<br />

Environment and Resource Management] direct support<br />

is critical to our future to continue to deliver the community<br />

and industry benefits of R&D.<br />

More can be done to provide skilled staff and programs<br />

to encourage engagement of industry with higher education<br />

in healthcare sector. The healthcare industry base in<br />

<strong>Queensland</strong> is mainly complementary medicines and devices<br />

not drugs or biotech. These industries employ many more<br />

staff. Programs to encourage the development of SMEs in<br />

the space have generally failed, but programs to support<br />

larger players to employ more people seem<br />

to be lacking.<br />

Funding for research is limited, commercialisation<br />

mentoring is limited.<br />

Yes, we would always be happy for the Department and<br />

government to provide more direct support however I think<br />

both should be proud of their support and encouragement<br />

of the industry.<br />

Yes, with the level of industry involvement; No, with the level<br />

of involvement with individual companies.<br />

No. DEEDI could be more proactive in building links with<br />

new businesses rather than simply posting programs onto<br />

websites and expecting that new business owners will have<br />

the time, inclination and technical ability to access the<br />

information.<br />

Yes, the Department’s Smart Futures Funding and other<br />

schemes such as NIRAP have been vital in providing<br />

Fellowships for early and mid-career researchers,<br />

developing industry alliances and funding NCRIS facilities<br />

and their support staff.


Our organisation’s experience in working with personnel employed<br />

by DEEDI has been highly positive. Personnel have on all occasions<br />

been thoroughly professional and always helpful.<br />

DEEDI interact very well with research organisations and provide<br />

a reasonably good level of service. DEEDI events are great. <strong>2012</strong><br />

scheduled events including the ‘Development Pathway’ workshop<br />

series are beneficial for early and late career researchers and<br />

postgraduate students. The Smart Futures scheme is fantastic and<br />

should be run annually. One criticism: where philanthropic money<br />

has been raised independently by [our organisation] for large<br />

research programs this money has not been matched by the State<br />

Government on application. This is disappointing. There are very<br />

limited opportunities to attract matching dollars through Federal<br />

funding schemes.<br />

The Department’s economic development domain appears to<br />

be skewed in favour of large organisations and projects, not<br />

the sort of smaller value-adding projects that are key to SMEs<br />

building equity value and making themselves investor-ready.<br />

The one program that appears to be relevant to SMEs (the Proof<br />

of Concept grant) is not well constructed, as it precludes either<br />

IP protection (patents) or full-time wages to key researchers<br />

within a company. The key problems for researchers within an<br />

SME are (a) to have enough income to enable them to work<br />

full-time on their companies to build enough value/construct a<br />

prototype to be attractive to Australian or overseas investors, and<br />

(b) to have a source of financial support to assist in patenting/<br />

patent preservation, required before engaging with multinational<br />

companies (to provide precisely the kind of market signal that<br />

investors require). The Commonwealth R&D tax concessions are<br />

of limited use in this respect, due to the way they are structured,<br />

limiting their utility for cash-poor SMEs. This issue is particularly<br />

bitter in the current economic climate, where debt and equity<br />

resources are both very limited, preventing the initial cash flows<br />

that the R&D tax concession scheme assumes the marketplace<br />

would provide. Obviously regulation and oversight is required to<br />

prevent wage claims and patent expenditure from being ‘gamed’,<br />

but the appropriate solution is scrutiny by project officers within the<br />

Department, not fixed regulatory exclusions that kill off the utility<br />

and relevance of the grant scheme. What is needed is initial grant<br />

funding to ‘prime the pump’ such as the <strong>Queensland</strong> Government’s<br />

former (excellent) Innovation Start-Up Scheme. There is an<br />

opportunity and a need for the <strong>Queensland</strong> Government to show<br />

leadership where the Commonwealth Government has failed,<br />

and in so doing render <strong>Queensland</strong> a more attractive place for<br />

innovation to prosper and provide economic benefits.<br />

61


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

62<br />

By Garry Redlich, Managing Director<br />

and Chief Executive Officer, Implicit<br />

Bioscience Ltd<br />

INDUSTRY COMMENTARY<br />

THE LIFE SCIENCES COMPANY PERSPECTIVE<br />

The gap between discovery and commercialisation has never been greater for the<br />

<strong>Queensland</strong> life sciences sector. Since the last report in 2009, the so-called “valley<br />

of death” has grown to look more like the Grand Canyon. However, <strong>Queensland</strong> is<br />

now on the cusp of enjoying the fruits of a decade of government and philanthropic<br />

investment in the new institutes that gleam in the winter sun on our university<br />

campuses. Molecular targets, drugs, vaccines and devices are about to start piling<br />

up inside these fabulous places.<br />

But who will carry these discoveries from the bench to the bedside and then to<br />

the pharmacy?<br />

Whatever source you look at (Venturesource, NVCA, EY, PWC, Burrill) venture money for<br />

life sciences is way down. Eagle Street lawyers and accountants who paper such deals<br />

tell us (as if we didn’t know) that the Australian capital market is shut for our sector. The<br />

market pricing for listed ASX life science stocks metes out cruel and unusual punishment<br />

to investors.<br />

<strong>Queensland</strong> companies with real commercial experience in bringing life science<br />

discoveries to market are fewer and smaller than they were three years ago. Those that<br />

have survived are tougher and more determined than ever. The local ecosystem is still<br />

alive, but it is massively weighted to the early stage end.<br />

Do we really want to terminate the value chain for <strong>Queensland</strong> just five or ten percent<br />

down the path towards the prize? Just as we have decided to refine our bauxite and<br />

smelt our own aluminium, we must recognise the challenge of commercialising our<br />

life sciences — at least through early stage clinicals. After all, more Australians are<br />

employed in the pharma industry than the motor vehicle manufacturers, yet our voice<br />

is rarely heard.<br />

Indigestion may not kill the patient, but a decade of disillusionment awaits the faculties<br />

of our landmark research institutes unless we find a way to solve this problem. We cannot<br />

fund world-class laboratories only to ‘Fedex’ our discoveries overseas from the lab door.<br />

Time will tell whether the sector will be supported to prevent this happening.


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

64<br />

10.COMMERCIAL INDICATORS<br />

“Existing shareholders contributed the majority of total funds raised<br />

by companies in 2011 (68.8%). While ‘Other private equity’ was also<br />

a significant source of finance (19.9%), Venture capital accounted for<br />

only 2.9% of the total raised in 2011.”<br />

10.1 Commercialisation<br />

10.1.1 Commercialisation — All Respondents<br />

Respondents ranked the strategies they would<br />

likely employ to commercialise their main<br />

technology, product or service. The top three<br />

strategies in 2009 and 2011 are shown in Table 55.<br />

Figure 29 shows the spread of responses for each of<br />

the options. The most likely strategy was in-house<br />

development (Table 55; Figure 29). The strategies<br />

most often referred to as ‘least likely’ in both 2009<br />

and 2011, were an initial public offering (IPO) or the<br />

spinning out of a company.<br />

TABLE 55: Most likely commercialisation strategy to<br />

be employed (90 respondents)<br />

Rank 2011 2009<br />

1 In-house development In-house development<br />

2 Collaborative venture Out-Licensing<br />

3 Out-Licensing Collaborative venture<br />

10.1.2 Commercialisation –<br />

Companies vs. Research Organisations<br />

The highest ranking commercialisation strategies<br />

for companies (74 respondents) and research<br />

organisations (16 respondents) are shown in<br />

Table 56.<br />

TABLE 56: Most likely commercialisation<br />

strategy employed<br />

Rank Companies Research<br />

Organisations<br />

1 In-house development Out-licensing<br />

2 Collaborative venture Collaborative venture<br />

3 Out-Licensing Spin-out company<br />

The majority of companies (40 of 69 companies;<br />

58%) intended to fully commercialise their<br />

technology/product or complete early stage<br />

commercialisation activities (e.g. later stage clinical<br />

development, pilot plant; 12 of 69 companies; 17%),<br />

before realising their primary commercial outcome.<br />

A minority of companies indicated that they planned<br />

to only complete proof-of-concept activities (9%) or<br />

the R&D phase (3%) before realising their primary<br />

commercial outcome.<br />

In contrast, the majority of research organisations<br />

indicated their intention to realise their primary<br />

commercial outcome following completion of<br />

the R&D phase (9 out of 16; 56%) or proof of<br />

concept (5 out of 16; 31%). None intended to take<br />

their technology/product through to early or full<br />

commercialisation.<br />

Figure 29: Strategies respondents will likely employ to commercialise their main technology (90 respondents)


10.2 Finance<br />

10.2.1 Debt and Equity Finance Raised in 2011<br />

In the current survey, 14% of companies (11 respondents out of 78)<br />

raised debt or equity capital during 2011. Nine companies (11%)<br />

were willing to report on the amount raised, which totalled $70.5<br />

million (Figure 30). In the 2009 survey, 23 respondents out of 72<br />

raised $85.6 million.<br />

Figure 30: Debt and equity finance raised in 2011 (9 respondents)<br />

Existing shareholders contributed the majority of total funds<br />

raised by companies in 2011 ($48.5 million, or 68.8%) at an<br />

average of $5.39 million per company. ‘Other private equity’ was<br />

also a significant source of finance (19.9%). Venture capital (VC)<br />

accounted for only $2 million of reported financing (2.9% of the<br />

total) in 2011 compared to $42.9 million (50% of the total) in 2009<br />

(Table 57). There was also a much higher amount of debt reported<br />

in 2009 ($27.5 million from seven companies) compared to<br />

$300,000 from three companies in 2011.<br />

10.2.2 Strategies for Raising Finance<br />

Approximately 37% of company respondents (29 of 78 respondents)<br />

intended to raise finance in the coming two years. Private equity,<br />

debt and VC funding were the top three financing mechanisms<br />

reported in both the 2009 and 2011 surveys.<br />

27 respondents nominated a range of government assistance<br />

programs that they would seek to access as part of their financing<br />

strategy. The R&D Tax Concession/Incentive, Commercialisation<br />

Australia and Innovation Investment Funds were the three most<br />

cited programs (Figure 31).<br />

95 Australian Financial Review, ‘Float review: no survivors’, 28 December 2011<br />

96 PwC BioForum Publication Edition 36, Quarter 4 FY11, August 2011<br />

TABLE 57: Funds raised through debt and equity finance<br />

(24 respondents)<br />

Source of<br />

Funds<br />

Amount raised<br />

(proportion<br />

of total)<br />

2011 (‘000) 2009 (‘000)<br />

Average<br />

per<br />

company<br />

Amount raised<br />

(proportion<br />

of total)<br />

Average<br />

per<br />

company<br />

Debt $300 (0.4%) $30 $27,500 (32%) $3900<br />

Venture<br />

Capital<br />

Angel<br />

investment<br />

Existing<br />

shareholders<br />

$2000 (2.9%) $220 $42,900 (50%) $7100<br />

$700 (1.0%) $70 $2400 (3%) $600<br />

$48,500 (68.8%) $5390<br />

Other Private<br />

Equity<br />

$14,000 (19.9%) $1560<br />

$12,900 (15%) $2200<br />

Other $5000 (7.1%) $560<br />

TOTAL $70,500 $85,600<br />

Figure 31: Government assistance programs that respondents<br />

may access (27 respondents)<br />

10.2.3 Innovation Funding in Australia<br />

At the time the QLS <strong>Industry</strong> <strong>Report</strong> for 2009 was prepared, the<br />

GFC had begun to negatively affect the availability of capital,<br />

probably due to the perception that the likelihood of achieving<br />

a successful IPO or trade sale was greatly reduced. This sentiment<br />

seems to be continuing to affect the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong>, with<br />

capital raised through IPOs in Australia in 2011 being the lowest<br />

in more than a decade. 95 There were only two <strong>Life</strong> <strong>Sciences</strong> IPOs<br />

in FY2010, C-Bio Ltd and the US company, Reva Medical<br />

(Figure 32). 96 The two <strong>Life</strong> <strong>Sciences</strong> IPOs on the ASX in FY2011,<br />

65


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

66<br />

were international companies, Bioniche from Canada,<br />

which is cross-listed on the ASX and TSX, and US company,<br />

GI Dynamics.<br />

Across the biotechnology industry globally, the number of<br />

IPOs dropped in FY2011. The median ‘age’ of companies<br />

at IPO has increased from five years (1999–2001) to<br />

nine years (2008–2010), making exits more difficult and<br />

putting pressure on VCs, whose funds often have 10 year<br />

timeframes. 97<br />

Figure 32: <strong>Life</strong> <strong>Sciences</strong> company IPOs on the ASX, 2007-2011 98<br />

According to the Australian Private Equity & Venture Capital<br />

Association, total private equity and VC funds raised during<br />

FY2011 grew by 72% compared to FY2010. 99 However, new<br />

funding commitments to Australian VCs continued a decline<br />

that commenced in FY2008. Three VC funds raised a total<br />

of $120 million in FY2011, down 35% from FY2010 (13 funds<br />

raised $158 million) and 40% from FY2009 (7 funds raised<br />

$299 million). In both 2010 and 2011, the majority of VC<br />

commitments were from Government-backed innovation<br />

funding programmes e.g. Innovation Investment Fund. In<br />

Australia, <strong>Life</strong> <strong>Sciences</strong> (including healthcare) 100 companies<br />

received 58% of all VC amounts invested and accounted for<br />

51% of all investee companies. 101<br />

These investment trends have significant implications<br />

for <strong>Life</strong> <strong>Sciences</strong> companies, particularly because VC<br />

funding is often critical for early stage development of new<br />

technologies. Investments tended to favour later stage<br />

companies, later stage funding rounds and existing investee<br />

companies, with follow-on rounds accounting for 70% of<br />

total VC amounts invested in FY2010. 102 Data from the OECD<br />

also showed that the majority of VC investments in Australia<br />

(68%) were devoted to later stage investments rather than<br />

pre-seed/seed/start-up investments. 103 This trend across<br />

the Australian <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> is mirrored in the<br />

results from the current survey: 88.7% of reported capital<br />

was sourced from existing shareholders and ‘other private<br />

equity’, whilst venture capital and business angel funding<br />

provided less than 4% of finance raised.<br />

According to the Ernst & Young Beyond Borders report,<br />

large debt financings by mature, profitable biotechnology<br />

companies in the US grew by 150% in 2010. However, once<br />

debt financings by mature companies were removed from<br />

the dataset, a 20% decline in the amount of the remaining<br />

‘innovation capital’ was evident. The majority of this funding<br />

(82.6%) was received by 20% of companies, while the bottom<br />

20% of companies raised 0.4% of total funds. As in previous<br />

years, Ernst & Young described an industry divided by the<br />

‘haves’ and ‘have nots’, with funds concentrated into a<br />

smaller group of companies. 104<br />

In Australia, BioShares reported that the publicly-listed<br />

biotechnology industry raised $630 million in 2011, up 14%<br />

on the $554 million in 2010. 105 However, Ernst & Young<br />

noted that medical devices companies rather than core<br />

biotechnology companies were increasingly benefiting from<br />

capital raised. 106<br />

10.3 Intellectual Property<br />

Patent application filings are one parameter used to indicate<br />

innovation activity and the importance placed on patents<br />

is evidenced by the estimated 7.3 million that were in force<br />

worldwide in 2010. 107<br />

The number of patent filings globally declined by 3.6% in<br />

2009 but increased by 7.2% in 2010 to 1.98 million, driven<br />

by applications from China and the US. The number<br />

of PCT patent filings globally fell by 4.8% in 2009 and<br />

this decline is likely a consequence of the GFC and its<br />

impact on the availability of capital to fund innovation and<br />

commercialisation, leading to reduced R&D expenditure and<br />

more selective expenditure on IP protection. The number<br />

of PCT filings grew by 5.7% in 2010, with applications<br />

from China, Japan and Korea accounting for 94% of this<br />

increase. 108<br />

The number of patent applications where Australia is listed<br />

as the country of origin, declined in 2009 for the first time<br />

since 1999 (Figure 33 – opposite).<br />

An analysis was done of the number of published patents<br />

originating in Australia across four main technology areas<br />

relevant to the <strong>Life</strong> <strong>Sciences</strong> sector (i.e. biotechnology,<br />

pharmaceuticals, environmental technology and food<br />

chemistry). This analysis revealed that, with the exception<br />

of pharmaceutical patents, the steady increase in patent<br />

applications across all sectors between 2002 and 2005<br />

97 Ernst & Young, Beyond Borders, 2011<br />

98 PwC BioForum Publication Edition 36, Quarter 4 FY11, August 2011, PwC BioForum, Edition 25, Quarter 4 FY08, August 2008.<br />

99 Australian Private Equity & Venture Capital Association<br />

100 Note: AVCAL’s <strong>Life</strong> <strong>Sciences</strong> definition includes healthcare<br />

101 Australian Private Equity & Venture Capital Association, Yearbook, 2011<br />

102 Australian Private Equity & Venture Capital Association, Yearbook, 2011<br />

103 OECD (2011), Entrepreneurship at a Glance 2011, based on OECD Entrepreneurship Financing Database, June 2011.<br />

104 Ernst & Young, Beyond Borders 2011<br />

105 Australian <strong>Life</strong> Scientist, ‘A new year, a new look and good news is rolling in already’, 12 January, <strong>2012</strong><br />

106 Ernst & Young, Beyond Borders, 2011<br />

107 World Intellectual Property Organisation, World Intellectual Property Indicators, 2011, http://www.wipo.int/export/sites/www/freepublications/en/<br />

intproperty/941/wipo_pub_941_2011.pdf<br />

108 World Intellectual Property Organisation, World Intellectual Property Indicators, 2011.


Figure 33: Number of patent applications originating in<br />

Australia, 1995–2010<br />

has not been evident in subsequent years (Figure 34). 109 Across<br />

OECD countries, Australia accounted for 1.5% of pharmaceutical<br />

patents filed under the PCT, 2007-09.<br />

The World Intellectual Property Organisation reported that<br />

resident patent filings by Australian inventors were 4.13 patents<br />

per $b GDP in 2006 and 3.33 in 2009 (last available year). 110 The<br />

resident patent filings by Australian inventors per US$m of R&D<br />

expenditure has declined 47% over the past nine years, from 0.51<br />

in 2001 to 0.24 in 2009 (Figure 35). 111 This is considered a measure<br />

of patent productivity and the decline may be the consequence<br />

of a number of factors; including the increased cost of R&D<br />

activities and patent protection leading to more focused patenting<br />

strategies. A similar decline occurred in the UK. Filings in Canada<br />

were 26% higher in 2009 than they were in 2001, and the figure for<br />

the US was 3.6% over the same period (Figure 35). 112<br />

Figure 34: Number of patent applications by specific<br />

technology area originating in Australia, 2002–2009<br />

Figure 35: Number of patents filed per US$m R&D expenditure,<br />

2001–2009<br />

Granted patents provide a period of protection from others<br />

infringing the claimed invention. This enables time to<br />

commercialise the invention and a period of market exclusivity.<br />

Granted patents, particularly those in US, EU or Japan, are often<br />

seen as indicators of success in the <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> and<br />

are often critical in demonstrating value to potential partners<br />

or investors.<br />

The US is the largest and most lucrative pharmaceutical and<br />

healthcare market in the world and Australian organisations<br />

typically seek to file patents in the US since it is a key market for<br />

potential products and partnerships. Figure 36 shows the total<br />

number of US <strong>Life</strong> <strong>Sciences</strong> patents and patent applications<br />

granted and applied for by Australian individuals and organisations<br />

(as determined by the residence of the first-named inventor),<br />

each year between 2007 and 2011. The data is for three relevant<br />

technology classes, (1) drug, bio-affecting and body treating<br />

compositions, (2) molecular biology and microbiology chemistry<br />

and (3) analytical and immunological testing. 113<br />

Figure 36: US <strong>Life</strong> <strong>Sciences</strong> patents and patent applications;<br />

Australian organisations/individuals, 2007–2011 114<br />

10.3.1 Patents and License Agreements<br />

In the current survey, a total of 272 patent applications were<br />

reported as filed or granted by 28 respondents (213 for 21<br />

companies and 59 for seven research organisations). In<br />

comparison, 143 patents and patent applications were granted and<br />

filed by 38 companies in 2009. The average number of patents filed<br />

or granted in 2011 was 9.7 and the median was 2.0. Biotechnology<br />

organisations reported 88% of filed or granted patents and those<br />

in TMD accounted for the remaining 12%.<br />

83 out-license agreements were negotiated by 12 organisations<br />

in 2011, with one company accounting for 60 of those agreements.<br />

97.6% of out-license agreements were achieved by Biotechnology<br />

organisations and 2.4% by TMD companies (data not shown).<br />

Ten organisations nominated a combined value of $9.2 million<br />

(average $0.9 million) for their out-license agreements (data<br />

not shown).<br />

A comparison of the number of out-license agreements reported<br />

by Biotechnology organisations through the past four surveys is<br />

shown in Table 58. The number of agreements per respondent has<br />

been increasing.<br />

109 Source: WIPO Statistics Database, December 2011<br />

110 World Intellectual Property Organisation, World Intellectual Property Indicators, 2011,<br />

111 Ibid.<br />

112 Ibid.<br />

113 US Patent and Trademark Office, ‘Patenting in Technology Classes — Breakout By Geographic Origin, 2011, http://www.uspto.gov<br />

114 US Patent and Trademark Office, ‘Patenting in Technology Classes — Breakout By Geographic Origin, 2011, http://www.uspto.gov<br />

67


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

68<br />

TABLE 58: Out-license agreements reported by biotechnology<br />

organisations<br />

No. of<br />

Respondents<br />

Out-License<br />

Agreements<br />

No.<br />

Agreements<br />

per<br />

Respondent<br />

Biotechnology<br />

2005<br />

58 17 0.29<br />

Biotechnology<br />

2007<br />

65 20 0.31<br />

Biotechnology<br />

2009<br />

81 39 0.48<br />

Biotechnology<br />

2011<br />

116 83 0.70<br />

NB: Comparable longitudinal data is not available for the TMD sector<br />

Nine organisations reported a total of 18 in-license<br />

agreements in 2011. A comparison of in-license agreements<br />

reported by Biotechnology organisations through the<br />

past three surveys is shown in Table 59. The number<br />

of in-licensing agreements per respondent has fallen<br />

significantly.<br />

TABLE 59: In-license agreements reported by biotechnology<br />

organisations in 2009 and 2011<br />

Biotechnology<br />

2007<br />

Biotechnology<br />

2009<br />

Biotechnology<br />

2011<br />

No. of<br />

Respondents<br />

In-License<br />

Agreements<br />

No.<br />

Agreements<br />

per<br />

Respondent<br />

65 35 0.54<br />

83 49 0.59<br />

116 18 0.16<br />

NB: Comparable longitudinal data is not available for the TMD sector<br />

10.3.2 IP Management Strategy<br />

In the current survey, participants specified to what<br />

extent their IP management strategy is influenced by the<br />

changing global economic situation and the challenges and<br />

opportunities created by changes to patent law in China,<br />

India and the US.<br />

The global economic situation continues to be a significant<br />

influence on the development of the IP strategy for 17%<br />

of respondents and some influence for a further 22% of<br />

respondents. Changes to patent laws in China, the US and<br />

India are significantly influencing the development of IP<br />

strategy for 16% of respondents and having some influence<br />

on a further 24% (Figure 37).<br />

Figure 37: The effect of the global economic situation and<br />

patent law change on IP management (116 respondents)


By Anne-Marie Birkill, Partner at<br />

OneVentures Innovation Fund<br />

INDUSTRY COMMENTARY<br />

VC INVESTMENT IN THE LIFE SCIENCES SECTOR<br />

IN AUSTRALIA — PLEASE, SIR, I WANT SOME MORE<br />

Many commentators have noted that post-GFC the availability of VC funding for the <strong>Life</strong><br />

<strong>Sciences</strong> sector in Australia has diminished considerably, which is a shame, given the<br />

Australian Governments large investment in life sciences R&D, the quality of the people<br />

backed by this investment, the standard of the facilities available in which to perform that<br />

R&D and the potential of many of the outcomes of this investment and effort. In the two<br />

years since OneVentures launched in early 2010, we have seen more than 100 life sciences<br />

sector investment opportunities (roughly 15% of total deal flow) and invested in just two of<br />

these (out of a total of six investments to date, so 33% of investments by number) despite<br />

seeing a number of other companies in which we would have liked to invest. As one of<br />

a handful of investors placing capital in the life sciences sector, we simply don’t have<br />

sufficient funds under management (FUM) to be able to service the quality deal flow<br />

we see.<br />

What we are seeing is effectively a “broken pipeline” – we push loads of funding into the<br />

early stages of developing our life sciences opportunity via the ARC and NHMRC, then for<br />

the lucky few commercialisation grants and angel funding develop those opportunities<br />

a little further, then there is a great gaping hole through which only the best of the best<br />

(or the luckiest or the most tenacious) pass — with only a handful of life sciences deals<br />

receiving venture capital every year. Like water escaping a leaking pipe it is just such an<br />

awful waste. We need a concerted effort to increase the total FUM otherwise we risk not<br />

only continuing this wastage, but disrupting the very fabric of our life sciences industry.<br />

On the bright side, we are seeing some potential superstars emerging. Recently,<br />

OneVentures led a $15M syndicated investment in Vaxxas Pty Ltd, a company developing a<br />

new medical device for vaccine delivery using a game-changing micro needle technology<br />

(NanopatchTM) developed at The University of <strong>Queensland</strong>. The NanopatchTM, which<br />

is pain-free, more effective and may reduce the requirement to refrigerate vaccines<br />

is targeting a multi-billion market and is already receiving strong interest from big<br />

pharmaceutical companies for use with their vaccines. Alongside other VCs OneVentures<br />

has also invested in Hatchtech Pty Ltd (Melbourne), the developer of a proprietary next<br />

generation head lice treatment, DeOvo, which has successfully completed a Phase IIb<br />

clinical trial and is poised to enter Phase III. Subject to regulatory approval, market launch<br />

is anticipated in late 2014. DeOvo is a head lice product that kills both lice and eggs<br />

treating all life cycle stages of the organism in a single application.<br />

These examples are indicative of the very high quality and of the commercial potential<br />

of R&D coming out of our research institutions. More VC funding, managed by fund<br />

managers with the expertise and experience to efficiently take them out of the laboratory<br />

and toward commercial success, is essential if we are to seed the next crop of Peplins,<br />

Acruxs and Cochlears. Like Oliver Twist the sector may survive but can’t thrive on<br />

thin gruel.<br />

69


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

70<br />

11.RESEARCH AND DEVELOPMENT<br />

“Contracted R&D is expected to account for 37.1% of global<br />

expenditure on R&D by 2018.”<br />

11.1 R&D Outsourcing<br />

According to GBI Research, the contract research<br />

industry worldwide grew by 12% between 2009<br />

and 2010 and represented an estimated 25.3% of<br />

total pharmaceutical R&D expenditure in 2010. As<br />

a result of anticipated growth, contracted R&D is<br />

expected to account for 37.1% of global expenditure<br />

on R&D by 2018. 115<br />

According to Kalorama Information,<br />

“Driven by pressures to reduce costs, companies are<br />

increasingly implementing outsourcing strategies to<br />

increase revenues through faster drug development.<br />

By decreasing their in-house facilities and staff,<br />

and outsourcing more of their R&D functions,<br />

pharmaceutical and biotechnology companies are<br />

reshaping the drug development services industry.” 116<br />

11.1.1 Outsourcing by QLS Organisations<br />

43% (92) of survey participants outsourced R&D<br />

in 2011. Of these, the average proportion of R&D<br />

outsourced was 41%.<br />

47% of companies (36 out of 76 respondents)<br />

outsourced R&D in 2011. The average amount of<br />

R&D outsourced by companies was 44% (median<br />

of 32.5%). By comparison, in the 2009 survey,<br />

companies outsourced an average of 30% of total<br />

Figure 38: Key areas of R&D outsourced (76 respondents)<br />

R&D. For the 36 companies that did outsource<br />

R&D, the types of R&D most likely to be outsourced<br />

are shown in Table 60. As might be expected, these<br />

were the least likely activities to be outsourced by<br />

research organisations.<br />

TABLE 60: R&D activities most commonly outsourced<br />

by companies.<br />

R&D Activity Proportion of<br />

responses<br />

Analytical lab work 22%<br />

Clinical trials 17%<br />

Manufacturing of products for<br />

clinical trials<br />

13%<br />

Preclinical research 13%<br />

With respect to research organisations, four out of<br />

16 that responded to this question in the current<br />

survey outsourced an average of 6.3% of their total<br />

R&D in 2011 (median of 6.5%). By comparison, in<br />

2009, research organisations outsourced 9% of<br />

their total R&D.<br />

Figure 38 lists the full set of responses. Examples<br />

from the ‘Other’ category included clinical and<br />

regulatory consulting and large animal toxicity<br />

testing.<br />

115 Contract Research Organizations Market to 2018: Public-Private Partnerships to Strengthen Research Capacities and Advance<br />

Clinical Development Programs, (<strong>2012</strong>) GBI Research.<br />

116 Outsourcing in Drug Development: The Contract Research (Clinical Trial) Market,(<strong>2012</strong>), Kalorama Information


11.1.2 Contract Manufacturing<br />

Half (48%) of the companies that outsource R&D engaged a<br />

contract manufacturing organisation (CMO) during 2011. In 2009<br />

only 33% of respondents reported that they had engaged a CMO.<br />

Companies (15) spent a combined total of $46.2 million on CMO<br />

services in 2011. The average expenditure on CMO services per<br />

company was $3.1 million and the median was $129,000.<br />

The top five countries in which CMO suppliers were located were<br />

Australia, USA, China, India and Malaysia (Figure 39). In 2009, the<br />

top five CMO supplier locations were Australia (46%), USA (21%),<br />

China (6%), United Kingdom (6%) and New Zealand (6%).<br />

Figure 39: Location of CMO suppliers utilised by QLS organisations<br />

(18 respondents)<br />

Figure 40 illustrates the location of CMOs by the proportion of<br />

expenditure incurred in each location. Where multiple countries<br />

were specified, the company’s expenditure was assumed to be<br />

split evenly.<br />

While Australia comprised 34.4% of CMO engagements, it made<br />

up only 11.3% of expenditure. By contrast, China and India<br />

accounted for 15.6% and 12.6% of engagements, respectively,<br />

but were responsible for 29.8% and 27.6% of expenditure. This<br />

could imply that larger projects or more costly R&D activities<br />

are being outsourced to companies in China and India rather<br />

than in Australia.<br />

Figure 40: Location of CMO suppliers according to the proportion<br />

of expenditure by QLD companies (15 respondents)<br />

11.1.3 Contract Research<br />

18 companies (out of 36 respondents; 50%) indicated that they had<br />

used a contract research organisation (CRO) during 2011. Of these,<br />

15 spent a total of $11.8 million, with an average of $790,000 and<br />

median of $458,000. By comparison, 29% reported that they had<br />

engaged a CRO in 2009 and spent an average of $657,600 each.<br />

The 18 companies nominated 27 countries in which CRO service<br />

suppliers were located. The top three locations for CROs utilised<br />

by companies were Australia (40%), USA (22%) and the UK (18.5%).<br />

India, Russia, the European Union and the United Arab Emirates<br />

were also represented.<br />

Figure 41: Location of CRO suppliers utilised by QLS organisations<br />

(38 respondents)<br />

71


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

72<br />

Of the four research organisations that outsourced some<br />

R&D, two utilised a CRO in 2011 spending $140,000, in<br />

Switzerland and the USA. Figure 41 shows the use of CROs<br />

across all respondents by their location.<br />

The location of CROs by the proportion of expenditure<br />

incurred in each location is illustrated below (Figure 42).<br />

Where multiple countries were specified, the organisation’s<br />

expenditure was assumed to be split evenly. Note that the<br />

expenditure for the CRO service sourced from the European<br />

Union was not provided.<br />

Figure 42: Location of CRO suppliers according the the<br />

proportion of expenditure by QLS companies<br />

(17 respondents)<br />

11.2 Interaction with Research Organisations<br />

In the current survey, companies commented on their<br />

interactions with <strong>Queensland</strong> research organisations over<br />

the past year. 39% of 99 respondents reported at least one<br />

interaction with a <strong>Queensland</strong> research organisation. A total<br />

of 78 different interactions were noted.<br />

Table 61 shows the percentage of reported interactions<br />

attributed to the various research organisations. Where<br />

respondents nominated specific units, centres or institutes<br />

of a research organisation they have been aggregated to<br />

produce a total for the whole organisation.<br />

TABLE 61: Interactions between companies and research<br />

organisations in <strong>Queensland</strong><br />

Research Organisations Interactions<br />

<strong>Report</strong>ed<br />

The University of <strong>Queensland</strong> 39%<br />

<strong>Queensland</strong> University of Technology 14%<br />

Griffith University 9%<br />

Commonwealth Scientific and Industrial<br />

Research Organisation<br />

8%<br />

DEEDI (now known as DSITIA) 7%<br />

James Cook University 5%<br />

University of Southern <strong>Queensland</strong> 4%<br />

Co-operative Research Centres<br />

(three CRCs)<br />

4%<br />

<strong>Queensland</strong> Institute of Medical Research 3%<br />

Other (5 individual research organisations) 7%<br />

For the majority of interactions that occurred in the past<br />

year, respondents indicated that they had previously had<br />

a similar interaction with that research organisation.<br />

This suggests that companies were building on existing<br />

relationships with <strong>Queensland</strong> research organisations.<br />

The majority of the interactions between companies<br />

and research organisations involved either research<br />

collaboration (36%) or contract research (15%) (Table 62).<br />

TABLE 62: Types of Interactions between QLS companies and<br />

research organisations<br />

Rank Type of Interaction Proportion<br />

1 Research collaboration 36%<br />

2 Contract research 15%<br />

3 Provision of other services 9%<br />

4 Business development/<br />

Commercialisation services<br />

8%<br />

5 <br />

<br />

6 <br />

<br />

<br />

7 <br />

<br />

<br />

6%<br />

4%<br />

3%<br />

8 Joint venture 1%<br />

Survey participants also characterised the benefits<br />

of these interactions and recurring themes in their<br />

responses included:<br />

Transactional benefits of providing a service to research<br />

organisations<br />

Access to unique expertise, skills, facilities, equipment<br />

and compliance infrastructure<br />

Provision of a base for all R&D activities with<br />

a wide range of benefits<br />

Networking, industry leads<br />

New product leads discovered and/or proven<br />

Commercial outcomes and relationships<br />

Access to intellectual property/technology<br />

Access to deal flow/investment opportunities.<br />

The majority of companies (64%) valued to some extent<br />

or another, the <strong>Queensland</strong> public sector research base.<br />

27% believed it was of little importance for their future<br />

operations (Figure 43).<br />

Company participants in the survey were asked to what<br />

extent they agreed with the statement —<br />

“Our organisation is well informed about the public sector<br />

R&D capacity and capability that is available in <strong>Queensland</strong>”.<br />

51% (49 of 97 respondents) agreed or strongly agreed<br />

with this statement (Figure 44). 26% neither agreed nor<br />

disagreed.


Figure 43: Importance of <strong>Queensland</strong> public sector research<br />

base to QLS companies (98 respondents)<br />

Figure 44: Knowledge of the capacity and capability of <strong>Queensland</strong><br />

public sector research base amongst QLS companies<br />

(97 respondents)<br />

11.3 Improving Collaboration between <strong>Industry</strong> and<br />

Research Organisations<br />

44% of companies indicated that they were interested in DSITIA<br />

providing a service that would link businesses with public sector<br />

research organisations that may have the capacity to meet their<br />

R&D needs.<br />

Companies commented on ways in which the capacity of public<br />

sector research organisations to collaborate with industry could<br />

be enhanced or improved. Responses from 46 companies fell<br />

into four major themes. Selected comments from each<br />

theme, which capture the overall sentiments expressed, are<br />

included below:<br />

1. Develop mechanisms to better connect companies with<br />

information on public sector research activity, expertise,<br />

equipment and facilities.<br />

Comments related to this theme are directly transcribed below<br />

(some are truncated/edited).<br />

Increased opportunities to network, ‘roadshows’ by public<br />

sector organisations about key areas of research<br />

Work closely with industry and ensure high level<br />

understanding of issues and opportunities to support<br />

new and emerging industries<br />

The information is there; it is just hard to look for it and<br />

to spend enough time on it under current circumstances<br />

Having a one-stop shop where organisations can go<br />

to locate needed services/skills would be useful for<br />

all in this sector rather than having to try to locate<br />

people directly<br />

A database of chemical analytical instruments that are<br />

available for use at a fee would be great<br />

2. Support business R&D and collaborative relationships with<br />

public sector research organisations through grant funding<br />

and incentives.<br />

Comments related to this theme are directly transcribed below<br />

(some are truncated/edited).<br />

If there were grants to encourage SME collaboration,<br />

it would make a big difference<br />

Proof of concept funding<br />

One of our companies received a Research Partnerships<br />

Program grant in <strong>2012</strong> — very, very beneficial<br />

Cash flow subsidies/loans would allow us to overcome<br />

R&D issues and be more competitive with companies<br />

in China<br />

[Assistance in understanding the various] grants available<br />

and how to secure them<br />

3. Address structural issues that inhibit collaboration between<br />

the public and private sector.<br />

Comments related to this theme are directly transcribed below<br />

(some are truncated/edited).<br />

One of the main problems is the administrative fees<br />

charged by universities or medical institutes for research.<br />

As a small company we like to see our money directly<br />

support the research project of interest rather than<br />

one third or more going on the nebulous item called<br />

‘administration fee’<br />

Reduce the contract research charges by <strong>Queensland</strong><br />

universities to external commercial organisations as they<br />

are not price competitive with research institutes in other<br />

countries<br />

At the moment, IP sharing protocols in <strong>Queensland</strong> public<br />

sector research organisations are too old-fashioned,<br />

dating from a time when most available R&D resources<br />

and expertise belonged to such organisations, entitling<br />

them to the lion’s share of equity/benefit. This limits<br />

the modern attractiveness of partnering with such<br />

organisations…..Consequently, the terms for collaborative<br />

IP generation and commercialisation have to be revised<br />

if <strong>Queensland</strong> public-sector research organisations are<br />

to be kept in the loop; otherwise, <strong>Queensland</strong> technology<br />

companies will actively prefer to partner overseas<br />

In the health and medical research area I think there<br />

needs to be a much greater alignment/engagement of<br />

<strong>Queensland</strong> Health by DEEDI and vice versa<br />

A willingness to take on small projects — value $10,000<br />

approximately<br />

73


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

74<br />

4. Improve the understanding that research organisations<br />

have of the R&D needs of companies.<br />

Comments related to this theme are directly transcribed<br />

below (some are truncated/edited)<br />

It is very difficult to get research institutions excited<br />

(about industry collaboration) partly because it is<br />

not their core business and I believe they also lack<br />

the appropriate resources to make it happen<br />

Understand the customer. Gain an appreciation of<br />

what they need in terms of regulations, cost and<br />

deliverables. Provide a tangible and professional<br />

service set; research may be good but packaging<br />

and delivery is close to impossible<br />

Public sector research organisations [need to]<br />

understand the wants and needs of industry,<br />

including market conditions, reimbursement<br />

and regulatory barriers


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

76<br />

12. EXPORTS AND INTERNATIONAL<br />

COLLABORATIONS<br />

“Over half of respondents exported goods and services, deriving an average<br />

of 39% of their income from exports in 2011 (compared to 33% in 2009).”<br />

Figure 45: Largest export markets by country (58 respondents)<br />

12.1 Exporting and Export Markets<br />

12.1.1 Export Revenue<br />

Sixty-three organisations (54% of 116 respondents)<br />

exported goods and services. The average amount<br />

of their income derived from exports in 2011 was<br />

39%. In the 2009 survey, this average was 33%.<br />

For companies only (52) the average was 43%<br />

of their income (median 15%) and for research<br />

organisations the average was 12.5% (median 10%).<br />

12.1.2 Current Export Markets<br />

Figure 46: Largest export market regions for the QLS <strong>Industry</strong> (58 respondents)<br />

Respondents (58) nominated the following<br />

countries as their three largest export markets<br />

(Figure 45):<br />

1. United States of America<br />

2. New Zealand<br />

3. United Kingdom<br />

The ‘Other’ category included 11 countries<br />

(see the Appendices for a list of these countries).<br />

Asia was the largest export market region for QLS<br />

organisations (Figure 46). North America, Oceania<br />

and Europe also represented significant markets.


The US, New Zealand and the UK continue to be the top countries<br />

for exports since they were first noted in 2007. In 2011, countries<br />

in the Asian region had a greater presence in the top 5 countries<br />

for export (Table 63).<br />

TABLE 63: Highest ranked export markets 2007, 2009 and 2011<br />

Rank Biotech<br />

2007 #<br />

TMD<br />

2007<br />

<strong>Life</strong> <strong>Sciences</strong><br />

2009<br />

1 USA USA USA USA<br />

2 New<br />

Zealand<br />

3 France New<br />

Zealand<br />

4 UK Singapore<br />

Hong Kong<br />

Japan<br />

UK New<br />

Zealand<br />

UK UK<br />

Japan<br />

Singapore<br />

<strong>Life</strong> <strong>Sciences</strong><br />

2011<br />

New<br />

Zealand<br />

Malaysia<br />

5 Japan Europe Europe Japan<br />

Canada<br />

Korea<br />

China<br />

Singapore<br />

# Defined in the <strong>Queensland</strong> Biotechnology <strong>Report</strong> 2008 as International<br />

Business Deals or Exports<br />

Figure 47: Largest export target markets by country (48 respondents)<br />

12.1.3 Future Export Markets<br />

Respondents (48) nominated those markets they planned to target<br />

(Figure 47), with the top five being:<br />

1. USA 3. China 5. Germany<br />

2. UK 4. New Zealand<br />

The ‘Other’ category included 15 individual countries (see the<br />

Appendices for a list of these countries).<br />

Examining data from previous surveys, the USA, UK and New<br />

Zealand continue to be key target markets for export (Table 64).<br />

TABLE 64: Future target export markets 2007, 2009, 2011<br />

Rank Biotech<br />

2007#<br />

TMD 2007 <strong>Life</strong><br />

<strong>Sciences</strong><br />

2009<br />

<strong>Life</strong><br />

<strong>Sciences</strong><br />

2011<br />

1 USA USA USA USA<br />

2 UK Europe Japan UK<br />

3 China New New China<br />

Zealand Zealand<br />

4 Japan UK UK New<br />

Zealand<br />

5 New<br />

Zealand<br />

Asia Europe Germany<br />

# Defined in the <strong>Queensland</strong> Biotechnology <strong>Report</strong> 2008 as International<br />

Business Deals or Exports<br />

77


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

78<br />

12.1.4 Market Entry<br />

All respondents who export goods or services were asked to select from five possible market entry options. Companies (55)<br />

nominated a total of 80 market entry options with the most commonly selected option being the export of finished product<br />

(53%). Research organisations (7) nominated ten market entry options with the most commonly selected option being the<br />

export of services (70%) (Figure 48).<br />

Apart from the five reasons offered in the survey, there were six ‘Other’ reasons given including export of raw ingredients;<br />

export of data, specimens, and samples; via networks collaborations and alliances; and through installing an offshore<br />

business development appointee.<br />

Figure 48: Export market entry options (62 respondents)<br />

12.2 International Business Deals, Research Collaborations & Alliances<br />

12.2.1 Revenue from International Business Deals<br />

42 of 100 (42%) companies reported earning revenue from international business deals or research collaborations.<br />

An average of 32% (median 20%) of revenue was derived from international business deals and collaborations.<br />

12.2.2 Current Markets for International Business Deals and Collaborations<br />

Of all the international business deals and collaborations reported by respondents, 69% were international business deals<br />

and 31% were research collaborations. In 2009 and 2011 both were most commonly located in the USA.<br />

Figure 49: International business deals and research collaborations by region


TABLE 65: Markets for international business deals and collaborations<br />

2009, 2011<br />

Rank 2011 2009<br />

1 USA USA<br />

2 UK China<br />

3 Japan, New Zealand UK<br />

Asia, North America and Europe were the top three regions for<br />

deals and collaborations in 2011 (Figure 49).<br />

12.2.3 Future Markets for International Business Deals<br />

and Collaborations<br />

Companies (38) nominated the countries they planned to target for<br />

international business deals or research collaborations within the<br />

next three years (Table 66). The US (23%) and UK (16%) remained<br />

as the top two target countries in 2009 and 2011. Third position<br />

was held by Japan and New Zealand (7%). In 2011, China dropped<br />

to fourth place with Germany (5%).<br />

TABLE 66: Target markets for international business deals and<br />

collaborations 2009, 2011<br />

Rank 2011 2009<br />

1 USA USA<br />

2 UK UK<br />

3 Japan, New Zealand China<br />

79


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

80<br />

13.SUMMARY OF KEY STATISTICS<br />

TABLE 67: Key 2011 <strong>Queensland</strong>-wide Estimates — QLS <strong>Industry</strong>, Biotechnology and TMD Divisions<br />

Measure<br />

Employment (FTEs)<br />

Estimate 95% Confidence Interval (Bias<br />

Corrected and Accelerated)<br />

All Respondents 14,106 13,663 – 14,550<br />

Companies 8008 7566 – 8451<br />

Research Organisations<br />

Biotechnology sector<br />

6098 5874 – 6323<br />

Companies 2150 1825 – 2475<br />

Research Organisations<br />

TMD sector<br />

5871 5647 – 6096<br />

Companies 5859 5558 – 6159<br />

Research Organisations<br />

Income ($m)<br />

277 N/A<br />

All Respondents $4361 $4010 – $4713<br />

Companies $3275 $2924 – $3627<br />

Research Organisations<br />

Biotechnology sector<br />

$1086 $1013 – $1158<br />

Companies $597 $522 – $673<br />

Research Organisations<br />

TMD sector<br />

$1067 $996 – $1141<br />

Companies $2678 $2335 – $3022<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

$17 N/A<br />

All Respondents $2141 $2016 – $2267<br />

Companies $1323 $1197 – $1449<br />

Research Organisations<br />

Biotechnology sector<br />

$818 $632 – $1005<br />

Companies $279 $226 – $332<br />

Research Organisations<br />

TMD sector<br />

$806 $619 – $992<br />

Companies $1044 $930 – $1157<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

$13 N/A<br />

All Respondents $657 $628 - $686<br />

Companies $245 $215 - $274<br />

Research Organisations<br />

Biotechnology sector<br />

$412 $282 - $541<br />

Companies $98 $86 - $110<br />

Research Organisations $412 $282 - $541


TMD sector<br />

Companies $147 $120 - $174<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

$- N/A<br />

All Respondents $692 $670 - $714<br />

Companies $514 $491 - $535<br />

Research Organisations<br />

Biotechnology sector<br />

$178 $113 - $244<br />

Companies $43 $40 - $47<br />

Research Organisations<br />

TMD sector<br />

$174 $109 - $239<br />

Companies $470 $448 - $492<br />

Research Organisations $5 N/A<br />

TABLE 68: Overview of Raw Survey Data and <strong>Queensland</strong>-wide Estimates for Key Measures<br />

Sample Size (N) Mean Median Total <strong>Report</strong>ed Total Estimated<br />

Total Income ($m)<br />

All Respondents 100 $19.9 $3.3 $1995 $4361<br />

Companies 78 $15.6 $1.8 $1220 $3275<br />

Research Organisations<br />

Employment (FTEs)<br />

22 $35.2 $12.4 $774 $1086<br />

All Respondents 135 60 11 8085 14,106<br />

Companies 111 31 8 3433 8008<br />

Research Organisations<br />

Total Expenditure ($m)<br />

24 194 121 4652 6098<br />

All Respondents 92 $11.9 $2.4 $1091 $4626<br />

Companies 75 $8.1 $1.6 $606 $3271<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

17 $25.5 $17.3 $485 $1355<br />

All Respondents 85 $6.6 $0.8 $564 $2141<br />

Companies 69 $4.2 $0.6 $292 $1323<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

16 $17.0 $14.4 $272 $818<br />

All Respondents 83 $2.3 $0.2 $189 $657<br />

Companies 67 $0.9 $0.05 $57 $245<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

16 $8.2 $5.4 $132 $412<br />

All Respondents 86 $1.6 $0.05 $134 $692<br />

Companies 70 $0.5 $0.04 $36 $514<br />

Research Organisations 16 $6.1 $0.5 $98 $178<br />

81


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

82<br />

14.APPENDICES<br />

14.1 Methodology<br />

The following section defines the data sources used<br />

in the study; limitations of the data collected; and<br />

data that was unavailable.<br />

14.1.1 Primary Data<br />

All primary data included in this report was<br />

collected from QLS companies and research<br />

organisations through an industry survey conducted<br />

in March and April <strong>2012</strong>. The methodology<br />

employed to conduct the survey is described below.<br />

14.1.2 Defining the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong><br />

<strong>Industry</strong><br />

For the purpose of the QLS Survey 2011, the QLS<br />

<strong>Industry</strong> was defined as any company, university<br />

institute, faculty, school or centre or research<br />

institution that is undertaking <strong>Life</strong> <strong>Sciences</strong> related<br />

activities in one or more of the industry sub-sectors<br />

described below. These sub-sectors were adapted<br />

from the AusBiotech definition of Biotechnology<br />

in combination with Pharmaceutical industry<br />

definitions.


<strong>Industry</strong> Sector Examples<br />

Human health:<br />

Pharmaceuticals, vaccines or drug discovery<br />

Human health:<br />

Complementary medicines, nutraceuticals<br />

Human health:<br />

Functional foods<br />

Human health:<br />

Diagnostics<br />

Human health:<br />

Medical devices and equipment<br />

(e.g. vaccines, immune stimulants, biopharmaceuticals, rational drug design or<br />

combinatorial chemistry)<br />

(e.g. gene identification, gene constructs, gene delivery or xenotransplants)<br />

<br />

(e.g.DNA/RNA/protein sequencing and databases for humans, plants, animals and microorganisms<br />

or structure function studies)<br />

<br />

<br />

<br />

<br />

<br />

<br />

(e.g. probiotics, unsaturated fatty acids)<br />

(e.g. immunodiagnostics, gene probes or biosensors)<br />

<br />

(e.g. MRI)<br />

<br />

Animal health <br />

genetic engineering, animal breeding or anti-microbials)<br />

Agricultural biotechnology (e.g. tissue culture, embryogenesis, genetic markers, genetic engineering, plant<br />

breeding, floriculture, forestry)<br />

(e.g. biofertilisers, biopesticide, bioherbicides, biological additives, microbial pest<br />

control, hormones, pheromones, and other agrichemicals)<br />

Food biotechnology (e.g. Food products, food components, enzymes, yeasts, bacteria culture)<br />

Environmental (e.g. treatment of organic emissions to air/water)<br />

<br />

(land, air, water) or toxic waste sites<br />

(e.g. detection of toxic substances using bioindicators, biosensors or immunodiagnostics)<br />

<br />

bioprocessing (e.g. biopulping, biobleaching)<br />

Marine <br />

Industrial (white biotechnology) <br />

(e.g. peptides, proteins, nucleotides, hormones, growth factors)<br />

(e.g. monomers, fuels, lubricants, fine chemical feed<br />

stocks, cosmetics)<br />

<br />

alternative energy; development of novel biomaterials; use of plants and enzymes to generate<br />

industrial products<br />

<br />

as pollution and waste generation, for the same level of industrial production<br />

Bioinformatics <br />

management, mining and use of life-science information<br />

<strong>Industry</strong> service provider <br />

regulatory consultants, business consultants and other industry service providers<br />

83


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

84<br />

14.1.3 Development of Survey Questionnaire<br />

The survey questionnaire was based largely on the question<br />

set used in the previous QLS <strong>Industry</strong> Survey 2009. This<br />

approach was adopted so that as much as possible of the<br />

data collected would be comparable with that from the<br />

previous surveys. Additional questions were added to gather<br />

data in new areas of interest for the State.<br />

The questionnaire was submitted to DSITIA for review<br />

and approval prior to launching the survey online. The<br />

questionnaire was designed to gather data on key measures<br />

of economic, research, commercialisation and education<br />

performance. These measures included:<br />

Core Data<br />

<strong>Industry</strong> Performance<br />

Number of establishments<br />

Years established<br />

<strong>Industry</strong> sector distribution<br />

Economic Performance<br />

Number of employees<br />

Change in employee numbers over previous 12 months<br />

Total expenditure on salaries and wages/average wage<br />

Revenues<br />

Number of ASX listed companies<br />

Market capitalisation of listed companies<br />

Exports (value and key markets)/Imports<br />

Commercialisation Performance<br />

Number of products/services in development and<br />

associated stage of development<br />

Education/Skilling Performance<br />

Distribution of skills (work categories)<br />

R&D Performance<br />

R&D expenditure<br />

Additionality Data<br />

Reasons for location in <strong>Queensland</strong><br />

Interactions with the public research base<br />

Which institutes and faculties?<br />

Nature of interaction<br />

Benefits gained from interaction<br />

What would have happened otherwise?<br />

Level of satisfaction with the public research base, with<br />

reasons<br />

Importance of public research base to future<br />

operations<br />

Distinguish between university spinouts and others<br />

Interactions with <strong>Queensland</strong> Government programs<br />

Which programs?<br />

Benefits gained<br />

117 www.surveygizmo.com<br />

What would have happened in the absence of the<br />

program?<br />

Level of satisfaction with the program, with reasons<br />

Sector Specific Data<br />

Economic Performance<br />

<strong>Life</strong> scientists in workforce<br />

Revenues to include income from grants<br />

Income generated by international business deals<br />

Key international collaborations / alliances<br />

Commercialisation Performance<br />

Patents lodged<br />

Angel/VC investment secured<br />

Spin off companies formed<br />

Clinical trials<br />

Licences issued<br />

Education/Skilling Performance<br />

Science Higher Education degrees awarded<br />

by QLD institutions<br />

Bioscience Higher Education degrees awarded<br />

by QLD institutions<br />

R&D Performance<br />

Citations/Publications<br />

Capital Raising Strategy for next 12 months<br />

Venture capital<br />

Angel investors<br />

Mergers and acquisitions<br />

In-licensing and out-licensing<br />

IPOs<br />

Private options<br />

Commercialisation strategy by QLD institutions<br />

Bioscience Higher Education degrees awarded<br />

by QLD institutions<br />

14.1.4 Distribution of Survey and Collection of Responses<br />

The online survey platform, Survey Gizmo, 117 was used to<br />

deliver the survey to organisations on the industry contact<br />

database provided by the DSITIA. The most senior or most<br />

relevant, contact within each organisation was selected to<br />

receive the survey invitation via an e-mail with a hyperlink<br />

to the survey. Contacts were excluded in cases where a<br />

sub-division of that organisation, which has a greater focus<br />

on <strong>Life</strong> <strong>Sciences</strong>, was already represented in the survey.<br />

For example, the central administration of <strong>Queensland</strong><br />

universities was generally excluded as a number of <strong>Life</strong><br />

<strong>Sciences</strong> focused schools, centres and institutes within each<br />

institution were included in the database.<br />

The survey initially closed on Friday 13 April <strong>2012</strong>, with<br />

additional responses received until 30 April <strong>2012</strong>. Prior to<br />

the close of the survey and in the fortnight following the first


close, brief follow-up telephone calls were made to contacts that<br />

had not declined to participate in the survey (through the opt-out<br />

facility) but had not yet completed the questionnaire.<br />

The database of organisations that comprise the QLS <strong>Industry</strong><br />

has undergone some change since the 2009 survey. Fourteen<br />

<strong>Life</strong> <strong>Sciences</strong> companies, primarily small start-up technology<br />

companies, are no longer operating. Other companies are now<br />

located outside <strong>Queensland</strong> or are no longer operating in a<br />

sub-sector of the QLS <strong>Industry</strong>. However, the overall number of<br />

companies in the sector has grown through additions across all<br />

sub-sectors, particularly in the area of Industrial Biotechnology,<br />

which includes several new biofuel companies. A total of 139<br />

organisations out of the 301 organisations in the DSITIA <strong>Life</strong><br />

<strong>Sciences</strong> database (46%) undertook the survey.<br />

14.1.5 Analysis of Primary Survey Data<br />

At the conclusion of the survey period, the full data set collected<br />

through the online industry survey was downloaded from the<br />

server of the survey tool provider. All electronic copies of the<br />

survey were removed from the server on completion of the project.<br />

Raw survey data was incorporated into a data spreadsheet from<br />

which all data outputs and analyses presented in the report<br />

were derived. The total, mean and median was calculated for all<br />

quantitative data collected.<br />

Total population estimates were derived using multiple imputation<br />

methods. A complete list of <strong>Life</strong> <strong>Sciences</strong> companies was<br />

compiled through consultation with DSITIA. The organisation<br />

classification (company/RO) and estimated organisation size<br />

(classified as small, medium or large) were used in a regression<br />

equation to estimate missing data points.<br />

Given the non-parametric distribution of the data, the total<br />

population estimates and confidence intervals were estimated<br />

using bootstrap methods. The organisation classification and size<br />

served as strata for the re-sampling. The confidence intervals<br />

presented are 95% bias corrected and accelerated to account for<br />

the typical right skew of count and, in particular, financial data.<br />

These methods are superior to mean imputation methods in that<br />

known information can be used to inform the missing value, and<br />

as such are likely to provide a more accurate representation<br />

of the industry.<br />

14.1.6 <strong>Industry</strong> Size versus Response Rate Survey conducted<br />

in 2009 and 2011<br />

Number of respondents to surveys in 2009 and 2011<br />

2009 2011<br />

Total Number of organisations<br />

in the Government database<br />

296 301<br />

Number of companies in the database 235 252<br />

Number of research organisations<br />

in the database<br />

60 49<br />

Total Number of organisations<br />

responding to survey<br />

134 139<br />

Number of companies responding<br />

to survey<br />

104 111<br />

Number of research organisations<br />

responding to survey<br />

30 28<br />

85


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

86<br />

14.2 Comparative Raw Data from the <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> Survey 2009<br />

Summary of key statistics from the raw survey data 2009 (i.e. no extrapolations)<br />

Sample Size Mean Median Total <strong>Report</strong>ed<br />

Employment (FTEs)<br />

All Respondents 119 56 12 6,673<br />

Companies 91 39 10 3,538<br />

Research Organisations<br />

Total Income ($m)<br />

28 112 65 3,135<br />

All Respondents 91 $13.70 $1.50 $1,246<br />

Companies 74 $13.60 $1.20 $1,003<br />

Research Organisations<br />

Total Expenditure ($m)<br />

17 $14.30 $6.20 $243<br />

All Respondents 76 $11.50 $1.50 $877<br />

Companies 62 $11.63 $1.20 $720<br />

Research Organisations<br />

Wage and Salary Expenditure ($m)<br />

14 $11.17 $5.30 $156<br />

All Respondents 77 $3.20 $0.57 $250<br />

Companies 63 $2.80 $0.43 $174<br />

Research Organisations<br />

Capital Expenditure ($m)<br />

14 $5.40 $3.40 $76<br />

All Respondents 49 $0.99 $0.10 $48.40<br />

Companies 40 $0.55 $0.09 $22.10<br />

Research Organisations<br />

R&D Expenditure ($m)<br />

9 $2.90 $1.57 $26.30<br />

All Respondents 73 $3.00 $0.30 $216<br />

Companies 60 $1.60 $0.23 $94<br />

Research Organisations 13 $9.40 $3.90 $122


14.3 Location of the <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong><br />

The map (below) provides a representation of the location<br />

of the 301 organisations that comprise the QLS <strong>Industry</strong><br />

as listed in the database held by DSITIA.<br />

Each unnumbered circle represents one QLS organisation.<br />

Where more than one organisation is located in the same<br />

postcode, the number of organisations appears inside the<br />

circle. Due to the large number of organisations located<br />

in the Brisbane and Gold Coast areas these locations<br />

appear as insets.<br />

87


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

88<br />

14.4 Secondary Research<br />

Secondary research was conducted to supplement primary<br />

data collected in the survey. Wherever possible, the same<br />

data source that was referred to in the 2009 survey was used<br />

in the preparation of this report. In cases where these data<br />

sources were not available or where the data source had not<br />

yet been updated by the publisher, an alternate data source<br />

was, where possible, identified and used in the preparation<br />

of the report.<br />

The following section describes the secondary data<br />

presented in this report.<br />

14.4.1 <strong>Industry</strong> Sub-Sector Breakdown<br />

Secondary data was collected on the Australian <strong>Life</strong><br />

<strong>Sciences</strong> <strong>Industry</strong> as a whole. This data was extracted<br />

from various sources. Due to differences between the<br />

industry sub-sector classifications used by IBISWorld and<br />

AusBiotech, 118 the secondary data presented in this report<br />

was not directly comparable with primary data collected<br />

through the survey in all cases.<br />

14.4.2 Market Capitalisation<br />

Data on the market capitalisation of listed biotechnology<br />

companies was collected for <strong>Queensland</strong>, Australia, New<br />

Zealand, and Canada. Market capitalisation data was<br />

collected from the following sources:<br />

(a) Market capitalisation data was sourced from PwC<br />

Quarterly BioForum Publications. Specifically, PwC<br />

BioForum Q4, 2007; PwC BioForum, Edition 25, Quarter<br />

4 FY2008, August 2008; PwC BioForum, Edition 29,<br />

Quarter 4 FY2009, August 2009; PwC BioForum, Edition<br />

33, Quarter 4 FY2010/Quarter 1 FY2011, November 2010;<br />

Edition 36, Quarter 4 FY2011, August 2011.<br />

(b) Market Capitalisation in countries other than Australia:<br />

Canada: Canadian listed <strong>Life</strong> <strong>Sciences</strong> sector is<br />

resident on the Toronto Stock Exchange (TSX/TSXV).<br />

The TSX/TSXV listed <strong>Life</strong> <strong>Sciences</strong> sector at 31st of<br />

December 2011 was accessed online http://www.tmx.<br />

com/en/pdf/<strong>Life</strong><strong>Sciences</strong>_Sector_Profile.pdf. Please<br />

note the TSX/TSXV listed <strong>Life</strong> <strong>Sciences</strong> sector includes<br />

healthcare facilities and health services, which are<br />

both sub-sectors not included in the definition of <strong>Life</strong><br />

<strong>Sciences</strong> for the QLS survey and report. Information<br />

regarding the Canadian listed biotechnology sector was<br />

sourced from Ernst & Young’s, Beyond Borders 2011<br />

<strong>Report</strong>.<br />

New Zealand: The market capitalisation of New<br />

Zealand <strong>Life</strong> <strong>Sciences</strong> companies listed on both the<br />

New Zealand Stock Exchange (NZX) and Australian<br />

Stock Exchange (ASX) at November 2008 were defined<br />

in the NZBio 2010 Bioscience <strong>Industry</strong> <strong>Report</strong>.<br />

14.4.3 Average Wages<br />

Data on the average wages earned by employees of <strong>Life</strong><br />

<strong>Sciences</strong> companies was collected for <strong>Queensland</strong>;<br />

Australia; USA; Canada and Sweden. Wages data for UK and<br />

New Zealand was not available in sufficient detail to identify<br />

<strong>Life</strong> <strong>Sciences</strong> wages over other industries. Average wages<br />

data was collected from the following sources:<br />

Average Wages, <strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong><br />

vs. <strong>Queensland</strong> All Industries:<br />

118 The industry sub-sector definitions published by AusBiotech were adopted for the preparation of this report<br />

The average wage calculated from data collected in the<br />

primary survey was compared to the average wage paid<br />

to <strong>Queensland</strong> workers across all industries. <strong>Queensland</strong><br />

average wage data was sourced from the Australian Bureau<br />

of Statistics, 6302.0 – Average Weekly Earnings, Australia,<br />

Aug 2011, Persons; Full Time; Adult; Total earnings.<br />

Average <strong>Life</strong> <strong>Sciences</strong> Wages, International Comparison:<br />

<strong>Queensland</strong>: Average wages for <strong>Queensland</strong> <strong>Life</strong><br />

<strong>Sciences</strong> employees were calculated based on the salary<br />

expenditure and employment data collected through the<br />

current industry survey. Data was for the 2011 year.<br />

Australia: Average wages for Australian <strong>Life</strong> <strong>Sciences</strong><br />

employees were estimated based on data sourced from<br />

the ABS publication ‘Australian Bureau of Statistics,<br />

6302.0 – Average Weekly Earnings, Australia, Aug 2011,<br />

Persons; Full Time; Adult; Total earnings’. <strong>Life</strong> <strong>Sciences</strong><br />

employees in Australia were defined as those within the<br />

occupation categories of Professional, Scientific and<br />

Technical Services. Data was current as at August 2011.<br />

New Zealand: Average wages data for New Zealand<br />

<strong>Life</strong> <strong>Sciences</strong> employees were estimated based on data<br />

sources from the Statistics New Zealand publication<br />

‘Quarterly Employment Survey, June 2011. <strong>Life</strong> <strong>Sciences</strong><br />

employees in New Zealand were defined as those within<br />

the occupation category of Professional, scientific,<br />

technical admin and support services. Data was current<br />

as at June 2011.<br />

USA: Average wages data for Biotechnology sector<br />

employees in the USA was sourced from the United States<br />

Department of Labor, Bureau of Labor Statistics, May<br />

2011 National <strong>Industry</strong>-Specific Occupational Employment<br />

and Wage Estimates. <strong>Life</strong> <strong>Sciences</strong> employees in the<br />

US were defined as those within the categories of life<br />

scientists, agricultural and food scientists, animal<br />

scientists, food scientists and technologists, soil and<br />

plant scientists, biological scientists, biochemists<br />

and biophysicists, microbiologists, medical scientists,<br />

chemists, agricultural and food science technicians,<br />

biological technicians and chemical technicians. Data was<br />

for the calendar year 2010.<br />

Sweden: Average wages data for <strong>Life</strong> <strong>Sciences</strong> employees<br />

in Sweden was sourced from the Statistics Sweden<br />

publication, private sector, non-manual workers. Average<br />

total monthly salary and salary dispersion by occupational<br />

group 2010. <strong>Life</strong> <strong>Sciences</strong> employees in Sweden were<br />

defined as those within the categories of <strong>Life</strong> <strong>Sciences</strong><br />

professionals, <strong>Life</strong> <strong>Sciences</strong> technicians, mathematicians<br />

and statisticians, architects, engineers and related<br />

professionals, physical and engineering science<br />

technicians, production and operations managers. Data<br />

was for the calendar year 2010.


Canada: Average wages data for <strong>Life</strong> <strong>Sciences</strong> employees in<br />

Canada was sourced from the Statistics Canada publication,<br />

‘Earnings, average weekly, by industry’. <strong>Life</strong> <strong>Sciences</strong><br />

professionals in Canada were defined as those within the<br />

category – Professional, scientific and technical services. No<br />

additional sub-sectors were available. Data was for 2011.<br />

14.4.4 Venture Capital Investment<br />

Data on VC investment in <strong>Life</strong> <strong>Sciences</strong> companies was collected<br />

for Australia and the OECD from the following sources:<br />

VC Investment in <strong>Life</strong> <strong>Sciences</strong>, Australia: sourced from the<br />

ABS publication, Venture Capital and Later Stage Private Equity,<br />

Australia.<br />

Australian Private Equity & Venture Capital Association,<br />

Yearbook, 2011<br />

OECD (2011), Entrepreneurship at a Glance 2011, based on<br />

OECD Entrepreneurship Financing Database, June 2011<br />

14.4.5 National Competitive Grants<br />

Grants provided by the NHMRC and the ARC were identified as<br />

a measure of success in attracting funding for basic and applied<br />

<strong>Life</strong> <strong>Sciences</strong> research. The NHMRC funds institutional medical<br />

research of all types while the ARC funds research across all<br />

disciplines including <strong>Life</strong> <strong>Sciences</strong>. Data on NHMRC and ARC<br />

grants awarded to each State by number and value was sourced<br />

from the NHMRC Grant Funding 2000 – 2011 (www.nhmrc.gov.<br />

au/funding/funded/outcomes/projects.htm) and the ARC Funded<br />

Research Projects — Trends Data Set 2002 – 2009.<br />

14.4.6 Business Expenditure on Research and Development<br />

(BERD)<br />

Data on BERD and scientific and technical related BERD for<br />

<strong>Queensland</strong> and Australia was sourced from the ABS publication,<br />

Australian Bureau of Statistics, 8104.0 Research and Experimental<br />

Development, Business Australia, 2009/2010. Comparative OECD<br />

data was sourced from the OECD, <strong>Sciences</strong>, Technology and<br />

<strong>Industry</strong> Scoreboard, 2011.<br />

14.4.7 Government Expenditure on Research and Development<br />

(GOVERD)<br />

Data on GOVERD for <strong>Queensland</strong> and Australia was sourced from<br />

the Australian Bureau of Statistics publication, 8109.0 – Research<br />

and Experimental Development, Government and Private Non-<br />

Profit Organisations, Australia, 2008-2009 (later years were not<br />

available). Disaggregated data showing expenditure by field of<br />

research by state was not available for inclusion in this report.<br />

Comparative OECD data was also sourced from within ABS 8109.0<br />

– Research and Experimental Development, Government and<br />

Private Non-Profit Organisations, Australia, 2008-2009.<br />

14.4.8 Science Graduates<br />

Data on science degree completions from <strong>Queensland</strong> and<br />

Australian institutions was sourced from the Commonwealth<br />

Government, DEEWR publication, Award Course Completions<br />

for All Students by State, Higher Education Provider and Broad<br />

Field of Education, 2010. Science degrees were defined as the<br />

combination of the following fields of education; Natural and<br />

physical sciences, Information technology, Engineering and<br />

related technologies, Agriculture, environmental and related<br />

studies. Data was for the calendar years 2005 – 2010.<br />

Data on bioscience degree completions from <strong>Queensland</strong> and<br />

Australian institutions was sourced from the DEEWR publication,<br />

Award Course Completions for All Students by State, Higher<br />

Education Provider and Broad Field of Education. Bioscience<br />

degrees were defined as the combination of the following<br />

fields of education – Health; Natural and Physical Science; and<br />

‘Agriculture, Environmental and Related Studies’. Data was for the<br />

calendar years 2005 – 2010.<br />

14.4.9 Currency Conversion Rates*<br />

Currency Exchange<br />

rate (AU$)<br />

Currency Exchange<br />

rate (AU$)<br />

Canada dollar $0.961 New Zealand dollar $0.761<br />

Sweden kronor $0.145 US dollar $0.978<br />

* Exchange rates were sourced from www.xe.com on 1st December 2011<br />

14.4.10 Grant Schemes Accessed by Respondents and defined<br />

as ‘Other’ in the summary<br />

Grant schemes accessed by companies<br />

Smart Futures (RIPP, NIRAP, RPP, POC)<br />

Biopharmaceuticals Australia<br />

Australian Apprentice Incentives<br />

Export Market Development Grant<br />

What’s your big idea <strong>Queensland</strong>?<br />

Best Practice Support Projects<br />

Australian Biological Resources Study<br />

Aus<strong>Industry</strong> (IIF, R&D Tax Concession/ Incentive, COMET)<br />

DERM<br />

Wage Subsidy<br />

DEEDI<br />

ARC Linkage<br />

<strong>Queensland</strong> Health<br />

Co-operative Research Centres Program<br />

National eResearch Architecture Taskforce Projects<br />

Enterprise Connect RiB<br />

ABR<br />

ABRI<br />

Sugar R&D Corporation<br />

Australian Aid International<br />

Commercialisation Australia (POC)<br />

Grant schemes accessed by research organisations<br />

ARC (Linkage, Discovery, Infrastructure)<br />

Australian Stem Cell Centre<br />

Motor Neurone Disease Australia<br />

Smart Futures (RIPP, NIRAP, RPP, POC)<br />

<strong>Queensland</strong> Health (OHMR)<br />

RDC<br />

NCRIS<br />

EIF<br />

NHMRC<br />

89


<strong>Queensland</strong> <strong>Life</strong> <strong>Sciences</strong> <strong>Industry</strong> <strong>Report</strong> <strong>2012</strong><br />

90<br />

RBWHF<br />

Therapeutic Innovation Australia<br />

UQ<br />

PCFA<br />

CRC Program<br />

14.4.11 Export Markets defined as ‘Other’ in the summary<br />

Switzerland Philippines<br />

Russian Federation Nepal<br />

Vietnam Pakistan<br />

Mexico Fiji<br />

Egypt Mali<br />

Malta<br />

14.4.12 Export Target Markets defined as ‘Other’<br />

in the summary<br />

Switzerland Russian Federation<br />

Indonesia Samoa<br />

Spain Solomon Islands<br />

Italy Vanuatu<br />

Bangladesh Kiribati<br />

Sweden Vietnam<br />

Pakistan Norway<br />

Denmark

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!