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EUROTIMES<br />

Supplement November 2011<br />

17 September 2011<br />

XXIX Congress of <strong>the</strong> ESCRS<br />

Vienna<br />

Take your Practice to a New Level<br />

<strong>with</strong> <strong>the</strong> <strong>ZEISS</strong> <strong>MICS</strong> <strong>Platform</strong><br />

Supported by an unrestricted grant from<br />

ESCRS


1<br />

Take your Practice to a New Level <strong>with</strong> <strong>the</strong> <strong>ZEISS</strong> <strong>MICS</strong> <strong>Platform</strong><br />

Introduction<br />

Name<br />

Microincision cataract surgery (<strong>MICS</strong>) is a<br />

significant advance for improving outcomes<br />

in cataract surgery. Intraoperatively, <strong>the</strong><br />

technique affords improved control,<br />

increasing safety and making <strong>MICS</strong><br />

particularly useful in challenging cases.<br />

Postoperatively, patients achieve faster and better visual recovery<br />

thanks to <strong>the</strong> smaller, astigmatically neutral incision.<br />

However, operating through a smaller incision can place<br />

increased <strong>de</strong>mands on <strong>the</strong> phacoemulsification platform, and<br />

maintaining <strong>the</strong> benefits of a microincision and providing patients<br />

<strong>with</strong> excellent vision <strong>de</strong>pends on <strong>the</strong> availability of high-quality<br />

IOLs that can be <strong>de</strong>livered through an unenlarged incision.<br />

In a symposium held during <strong>the</strong> XXIX Congress of <strong>the</strong> ESCRS,<br />

leading cataract surgeons discussed how <strong>the</strong>se challenges are<br />

successfully addressed by <strong>the</strong> <strong>ZEISS</strong> <strong>MICS</strong> <strong>Platform</strong>.<br />

BLUEMIXS 180 Injector for Preloa<strong>de</strong>d <strong>MICS</strong> IOLs –<br />

New Perspectives for Today’s Mo<strong>de</strong>rn Cataract Surgery<br />

Paul Mullaney<br />

Use of <strong>the</strong> preloa<strong>de</strong>d CT ASPHINA ® 409MP IOL that comes<br />

<strong>with</strong> <strong>the</strong> single-use BLUEMIXS ® 180 injector (<strong>Carl</strong> <strong>Zeiss</strong>)<br />

enhances <strong>the</strong> safety and ease of <strong>MICS</strong> techniques and<br />

is providing excellent outcomes in a growing series of<br />

patients, according to Paul Mullaney MD.<br />

The CT ASPHINA 409MP is a single-piece, monofocal, aspheric<br />

(aberration neutral) hydrophilic acrylic (25 per cent water content)<br />

lens <strong>with</strong> a hydrophobic surface available in dioptric powers<br />

ranging from 0.0 to +32.0 D. Preloa<strong>de</strong>d in <strong>the</strong> BLUEMIXS 180<br />

injector, it can be <strong>de</strong>livered through a 1.8mm microincision.<br />

Dr Mullaney said he first implanted <strong>the</strong> preloa<strong>de</strong>d lens in<br />

October, 2010, and through September, 2011, he has used it in<br />

more than 1500 cases. Overall, taking into account his experience,<br />

feedback from <strong>the</strong> OR staff, and patient outcomes, his impressions<br />

are very favourable.<br />

“I was initially skeptical about <strong>the</strong> purported advantages of <strong>MICS</strong>,<br />

which I thought was chasing <strong>the</strong> Holy Grail for a smaller incision, and<br />

I also questioned <strong>the</strong> benefits of a preloa<strong>de</strong>d IOL. Now I appreciate<br />

both are advances for surgeons and patients,” said Dr Mullaney,<br />

consultant ophthalmologist, Sligo General Hospital, Sligo, Ireland.<br />

“The microincision affords increased anterior chamber stability<br />

intraoperatively, and use of <strong>the</strong> preloa<strong>de</strong>d CT ASPHINA 409MP<br />

IOL maintains <strong>the</strong> benefits of <strong>the</strong> microincision for minimising<br />

surgically induced astigmatism (SIA) and increasing patient comfort<br />

postoperatively. Toge<strong>the</strong>r <strong>the</strong>y are a winning combination for<br />

achieving satisfied patients.”<br />

Dr Mullaney said both he and his staff appreciate <strong>the</strong><br />

convenience of <strong>the</strong> preloa<strong>de</strong>d technology that increases surgical<br />

efficiency and avoids any potential for loading errors by <strong>the</strong> scrub<br />

nurse, while also reducing contamination risk.<br />

“The preloa<strong>de</strong>d system makes <strong>the</strong> task of IOL handling much<br />

easier for our presbyopic nurses and leaves me assured that <strong>the</strong><br />

lens will <strong>de</strong>liver properly every time, <strong>with</strong>out damaged or distorted<br />

haptics,” Dr Mullaney noted.<br />

He ad<strong>de</strong>d that using <strong>the</strong> BLUEMIXS 180 injector, <strong>the</strong> IOL is<br />

<strong>de</strong>livered <strong>with</strong> controlled and linear viscoinjection, and <strong>with</strong> <strong>the</strong><br />

single-piece <strong>de</strong>sign of <strong>the</strong> CT ASPHINA 409MP, <strong>the</strong>re is less risk of<br />

causing posterior capsule damage by <strong>the</strong> trailing or leading haptics<br />

that can occur when implanting a three-piece lens.<br />

“The ease of use and safety benefits also makes <strong>the</strong> preloa<strong>de</strong>d<br />

CT ASPHINA 409MP an excellent platform for training resi<strong>de</strong>nts,”<br />

Dr Mullaney said.<br />

Reviewing his technique for lens <strong>de</strong>livery using <strong>the</strong> BLUEMIXS<br />

180 injector, Dr Mullaney said he operates through a standard<br />

incision constructed <strong>with</strong> a three-step technique to create a square<br />

architecture. When ready to implant <strong>the</strong> lens, he places <strong>the</strong> injector<br />

bevel down on <strong>the</strong> posterior lip of <strong>the</strong> wound and advances it<br />

forward using a repetitive, left-to-right twisting motion of <strong>the</strong><br />

injector. This manoeuvre allows <strong>the</strong> injector tip to track its way<br />

into <strong>the</strong> incision. Advancement is stopped when he feels a slight<br />

amount of resistance, which indicates <strong>the</strong> injector tip has reached<br />

<strong>the</strong> level of Descemet’s membrane.<br />

CT ASPHINA 409MP


Name<br />

“Improved patient comfort has<br />

been one of <strong>the</strong> big benefits<br />

I’ve noticed after <strong>MICS</strong>”<br />

Dr Mullaney <strong>de</strong>scribed two techniques for <strong>de</strong>livering <strong>the</strong> IOL.<br />

His preferred method is to use <strong>the</strong> injector to rotate <strong>the</strong> eye up to<br />

a vertical position. This causes <strong>the</strong> cornea to flip over <strong>the</strong> superior<br />

aspect of <strong>the</strong> injector and allows <strong>the</strong> tip to be moved 2-3mm<br />

fur<strong>the</strong>r into <strong>the</strong> anterior chamber so that <strong>the</strong> lens can be released<br />

into <strong>the</strong> capsular bag where it nicely unfolds.<br />

Alternatively, <strong>the</strong> lens can be injected once <strong>the</strong> tip of <strong>the</strong><br />

introducer has reached Descemet’s membrane, in which case <strong>the</strong><br />

lens will be released diagonally in <strong>the</strong> anterior chamber <strong>with</strong> <strong>the</strong><br />

base of <strong>the</strong> lens in <strong>the</strong> inferior portion of <strong>the</strong> capsular bag. It can<br />

<strong>the</strong>n be tapped gently into position in <strong>the</strong> capsular bag using a<br />

bimanual I&A tip.<br />

“When first advancing <strong>the</strong> injector, I stop at Descemet’s<br />

membrane because attempting to move it fur<strong>the</strong>r risks stromal<br />

dissection. I prefer <strong>the</strong> first technique for <strong>de</strong>livering <strong>the</strong> lens because<br />

it enables in-<strong>the</strong>-bag placement in a single manoeuvre, which has<br />

been achievable in about 80 per cent of cases,” Dr Mullaney said.<br />

“If <strong>the</strong> lens is introduced <strong>with</strong>out <strong>the</strong> injector entering <strong>the</strong> anterior<br />

chamber, because of <strong>the</strong> downward angulation of <strong>the</strong> eye, complete<br />

placement in <strong>the</strong> bag is unlikely <strong>with</strong> a single manoeuvre.”<br />

With <strong>the</strong> <strong>MICS</strong> procedure, patients enjoy good postoperative<br />

comfort, and <strong>the</strong>y have been very happy <strong>with</strong> <strong>the</strong> quality of <strong>the</strong>ir<br />

vision. There have been no postoperative complications in this<br />

relatively large series, and although follow-up is short, <strong>the</strong> lenses<br />

are very stable, and <strong>the</strong>re is no evi<strong>de</strong>nce for increased posterior<br />

capsule opacification (PCO).<br />

“Improved patient comfort has been one of <strong>the</strong> big benefits<br />

I’ve noticed after <strong>MICS</strong>. Complaints of a foreign body sensation,<br />

presumably due to <strong>the</strong> lip effect of <strong>the</strong> incision, are now rare, but<br />

were common among patients operated by using incisions larger<br />

than 2.8mm,” Dr Mullaney said.<br />

“The potential for more PCO is one worry I have <strong>with</strong> <strong>MICS</strong>,<br />

and I did experience problems <strong>with</strong> significant fibrin accumulation<br />

in some young and diabetic patients implanted <strong>with</strong> a <strong>MICS</strong> lens<br />

from ano<strong>the</strong>r manufacturer. So far, no eyes implanted <strong>with</strong> <strong>the</strong><br />

CT ASPHINA 409MP have un<strong>de</strong>rgone YAG laser capsulotomy. Of<br />

course surgical technique, including attention to meticulous cortical<br />

cleanup and polishing of <strong>the</strong> anterior capsule, is also critical for<br />

maintaining capsule clarity.”<br />

In addition to <strong>the</strong> CT ASPHINA 409MP, o<strong>the</strong>r aspheric, singlepiece<br />

<strong>ZEISS</strong> <strong>MICS</strong> IOLs are available preloa<strong>de</strong>d <strong>with</strong> <strong>the</strong> BLUEMIXS<br />

180 injector. They inclu<strong>de</strong> <strong>the</strong> monofocal CT ASPHINA 509MP, <strong>the</strong><br />

monofocal toric AT TORBI 709MP, <strong>the</strong> multifocal AT LI<strong>SA</strong> 809MP,<br />

and <strong>the</strong> multifocal toric AT LI<strong>SA</strong> toric 909MP.<br />

Dr Mullaney has no financial interest in <strong>Carl</strong> <strong>Zeiss</strong> or its products<br />

mentioned here.<br />

Paul Mullaney – paul.mullaney@hse.ie<br />

17 September 2011 XXIX Congress of <strong>the</strong> ESCRS<br />

CT ASPHINA 409MP IOL – Technical Data<br />

BLUEMIXS 180 injector in OR<br />

2


3<br />

Take your Practice to a New Level <strong>with</strong> <strong>the</strong> <strong>ZEISS</strong> <strong>MICS</strong> <strong>Platform</strong><br />

<strong>MICS</strong> and Toric IOLs – targeting optimum outcomes<br />

Name Michael Goggin<br />

<strong>MICS</strong> <strong>with</strong> implantation of a <strong>ZEISS</strong> <strong>MICS</strong> toric IOL<br />

<strong>de</strong>livers excellent refractive results that can be<br />

attributed to <strong>the</strong> accuracy of <strong>the</strong> manufacturer’s<br />

advanced calculation algorithm (Z CALC ® ), <strong>the</strong><br />

procedure’s astigmatic neutrality, and <strong>the</strong> IOL’s rotational stability,<br />

according to Michael Goggin MD.<br />

“Cataract surgeons can address pre-existing astigmatism by<br />

placing <strong>the</strong> main incision in <strong>the</strong> steep meridian. However, this is<br />

an imprecise method of astigmatic reduction and not necessary<br />

in clear cornea <strong>MICS</strong> <strong>with</strong> a toric IOL for which keratometric SIA<br />

is essentially nil,” said Dr Goggin, The Queen Elizabeth Hospital,<br />

University of A<strong>de</strong>lai<strong>de</strong>, South Australian Institute of Ophthalmology,<br />

Woodville South, South Australia.<br />

“Surgeons can correct larger amounts of astigmatism <strong>with</strong><br />

greater accuracy using a toric IOL <strong>with</strong> an astigmatically neutral<br />

incision. The refractive outcome still will <strong>de</strong>pend on proper power<br />

selection and intraocular stability of <strong>the</strong> IOL, but <strong>the</strong>se factors are<br />

optimised using <strong>ZEISS</strong> <strong>MICS</strong> toric IOL technology.”<br />

Dr Goggin explained that a <strong>MICS</strong> technique is preferred when<br />

implanting toric IOLs because <strong>the</strong> smaller incision size <strong>with</strong> a<br />

clear corneal technique allows astigmatic neutrality 1 . However,<br />

maintaining this benefit of <strong>the</strong> <strong>MICS</strong> incision necessitates use of an<br />

IOL that can be <strong>de</strong>livered through <strong>the</strong> smaller incision.<br />

“To my knowledge, only <strong>Carl</strong> <strong>Zeiss</strong> markets toric IOLs (AT LI<strong>SA</strong> ®<br />

toric and AT TORBI ® ) that are capable of insertion through an<br />

unenlarged microincision,” he said.<br />

As an alternative, cylin<strong>de</strong>r power of <strong>the</strong> toric IOL can be selected<br />

to correct for any surgically induced astigmatism (SIA), and toric<br />

IOL power calculation formulae are <strong>de</strong>signed to correct for SIA.<br />

However, this method involves predicting postoperative corneal<br />

astigmatism, which is not exact in every case.<br />

“Using a <strong>MICS</strong> technique and <strong>MICS</strong> toric IOL that leave <strong>the</strong><br />

preoperative astigmatism unaltered is clearly preferable,” he said.<br />

Achieving precise refractive outcomes <strong>with</strong> toric IOL implantation<br />

also <strong>de</strong>pends on <strong>the</strong> accuracy of <strong>the</strong> power calculation formula, and<br />

<strong>the</strong> <strong>ZEISS</strong> algorithm is unique in incorporating additional factors that<br />

improve its performance. In addition to data on keratometry axis<br />

and corneal astigmatism power, Z CALC is <strong>the</strong> only manufacturer’s<br />

toric calculator that inclu<strong>de</strong>s anterior chamber <strong>de</strong>pth (ACD)/<br />

predicted effective lens position and axial length/IOL sphere power to<br />

<strong>de</strong>termine IOL corneal plane equivalent cylin<strong>de</strong>r power.<br />

The programme also asks surgeons for <strong>the</strong> source of axial length<br />

data (contact or immersion ultrasound or laser interferometry) and<br />

<strong>the</strong> refractive in<strong>de</strong>x used by <strong>the</strong> keratometric measurement <strong>de</strong>vice.<br />

AT TORBI 709M<br />

“...only <strong>Carl</strong> <strong>Zeiss</strong> markets toric IOLs<br />

(AT LI<strong>SA</strong> toric and AT TORBI) that<br />

are capable of insertion through<br />

an unenlarged microincision”<br />

In addition, it allows surgeons to modify sphere and cylin<strong>de</strong>r powers<br />

according to <strong>the</strong> targeted residual refraction. With <strong>the</strong>se tools to<br />

hand, rational and accurate IOL cylin<strong>de</strong>r power choices can be ma<strong>de</strong><br />

for large and small refractive errors.<br />

In a published paper, Dr Goggin and colleagues <strong>de</strong>monstrated <strong>the</strong><br />

potential for error in predicted cylin<strong>de</strong>r power using a simpler toric<br />

calculator (Alcon AcrySof Toric Calculator). This calculator does not<br />

take into account <strong>the</strong> variation in toric IOL corneal equivalent cylin<strong>de</strong>r<br />

power <strong>with</strong> ACD and IOL sphere power variations 2 . Comparing<br />

<strong>the</strong> manufacturer’s calculated IOL corneal plane power <strong>with</strong> a<br />

corrected value allowing for sphere power variation, <strong>the</strong>y showed<br />

<strong>the</strong> magnitu<strong>de</strong> of error was small using a toric IOL <strong>with</strong> sphere and<br />

cylin<strong>de</strong>r powers in <strong>the</strong> standard range. However, <strong>the</strong>re appeared<br />

to be significant error <strong>with</strong> a low sphere, high cylin<strong>de</strong>r toric IOL. In<br />

an example based on a toric IOL <strong>with</strong> +17.0 D sphere and 6 D of<br />

IOL plane cylin<strong>de</strong>r, <strong>the</strong> manufacturer’s stated corneal plane cylin<strong>de</strong>r<br />

power could be un<strong>de</strong>restimated by 1.1 D.<br />

In <strong>the</strong> same paper, Dr Goggin and colleagues reported findings<br />

from calculations of corneal plane effective cylin<strong>de</strong>r power of <strong>the</strong><br />

IOL for 38 eyes implanted <strong>with</strong> a toric implant (SN60TT, Alcon). The<br />

results showed how <strong>the</strong> prediction of <strong>the</strong> toric effect was improved<br />

taking into account ACD and sphere power of <strong>the</strong> IOL.<br />

These concepts are illustrated by Dr Goggin’s personal results<br />

implanting <strong>ZEISS</strong> <strong>MICS</strong> toric IOLs in 52 consecutive eyes. His<br />

technique involved coaxial <strong>MICS</strong> through a 1.8mm temporal clear<br />

corneal incision that was stretched slightly after IOL insertion. Mean<br />

(SD) incision width after IOL insertion for <strong>the</strong> 52 eyes was 1.9mm<br />

(0.15). Calculations based on pre- and postoperative keratometry<br />

data showed <strong>the</strong> incision was astigmatically neutral; mean (SD) SIA<br />

was 0.5 (0.32) D. “As we’ve reported 3 , keratometric SIA of up to<br />

0.5 D is just ‘noise’, essentially indistinguishable from test-to-test<br />

variability of <strong>the</strong> measurement technique,” Dr Goggin explained.<br />

Mean (SD) distance logMAR U<strong>CV</strong>A was 0.13 (0.16), which is<br />

equivalent to 6/7.5. Among 50 eyes capable of B<strong>CV</strong>A 6/12 or<br />

better, mean (SD) distance logMAR B<strong>CV</strong>A was -0.02 (0.13), which is<br />

equivalent to 6/6.<br />

Dr Goggin has no financial interest in <strong>Carl</strong> <strong>Zeiss</strong> or its products<br />

mentioned here.<br />

Michael Goggin – michael.goggin@health.sa.gov.au<br />

References<br />

1. Kaufmann C, Krishnan A, Lan<strong>de</strong>rs J, et al. Astigmatic neutrality in biaxial<br />

microincision cataract surgery. J Cataract Refract Surg 2009;35:1555-62<br />

2. Goggin M, Moore S, Esterman A. Outcome of toric intraocular lens<br />

implantation after adjusting for anterior chamber <strong>de</strong>pth and intraocular<br />

lens sphere equivalent power effects. Arch Ophthalmol 2011;<br />

129:998-1003<br />

3. Goggin M, Patel I, Billing K, Esterman A. Variation in surgically induced<br />

astigmatism estimation due to test-to-test variations in keratometry.<br />

J Cataract Refract Surg 2010;36:1792-3


<strong>MICS</strong> & VISTHESIA for a High Level<br />

of Patients’ Satisfaction<br />

Paul O’Brien Name<br />

Use of a pain relief ophthalmic viscoelastic <strong>de</strong>vice<br />

(OVD; VISTHESIA ® , <strong>Carl</strong> <strong>Zeiss</strong>) during <strong>MICS</strong> assures<br />

intraoperative comfort throughout <strong>the</strong> procedure and<br />

<strong>the</strong>refore optimises patient satisfaction <strong>with</strong> <strong>the</strong> surgical<br />

experience, according to Paul O’Brien MD.<br />

Noting that he practises in both private and public hospital<br />

settings, Dr O’Brien said he currently performs about 50 cataract<br />

procedures per month. About half of those cases are <strong>MICS</strong>, and he<br />

uses <strong>the</strong> CT ASPHINA 409MP <strong>with</strong> <strong>the</strong> BLUEMIXS 180 injector in all<br />

eyes un<strong>de</strong>rgoing a <strong>MICS</strong> procedure.<br />

“About 95 per cent of my cases are done <strong>with</strong> topical<br />

anaes<strong>the</strong>sia, and I always use VISTHESIA because it maintains<br />

comfort for my patients and so for me as well,” said Dr O’Brien,<br />

consultant ophthalmologist, Blackrock Clinic, Royal Victoria Eye &<br />

Ear Hospital, Dublin, Ireland.<br />

He ad<strong>de</strong>d that he consi<strong>de</strong>rs any patient who is not suitable<br />

for topical anaes<strong>the</strong>sia as a candidate for general anaes<strong>the</strong>sia.<br />

However, Dr O’Brien said he was confi<strong>de</strong>nt recommending<br />

VISTHESIA to surgeons who are consi<strong>de</strong>ring switching from<br />

subTenon’s injections to topical anaes<strong>the</strong>sia.<br />

“Speaking from experience training resi<strong>de</strong>nts, VISTHESIA has<br />

ma<strong>de</strong> <strong>the</strong> transition to <strong>MICS</strong> <strong>with</strong> topical anaes<strong>the</strong>sia relatively easy<br />

and straightforward,” he commented.<br />

Each package of VISTHESIA inclu<strong>de</strong>s two 0.3ml ampoules of<br />

VISTHESIA topical containing 0.3 per cent sodium hyaluronate<br />

and two per cent lidocaine plus a 0.8ml syringe of VISTHESIA<br />

intracameral containing one per cent lidocaine and 1.0 per cent<br />

or 1.5 per cent sodium hyaluronate. The sodium hyaluronate in<br />

VISTHESIA topical protects and hydrates <strong>the</strong> cornea, reducing <strong>the</strong><br />

need for drops during surgery and maintaining corneal clarity,<br />

and <strong>with</strong> <strong>the</strong> ample volume of VISTHESIA intracameral, <strong>the</strong>re is<br />

generally enough product left over after intracameral instillation for<br />

use in filling <strong>the</strong> cartridge of <strong>the</strong> BLUEMIXS 180 injector.<br />

“It is very rare that I need a second syringe of viscoelastic to<br />

finish <strong>the</strong> case even after using some of <strong>the</strong> material to fill <strong>the</strong> IOL<br />

cartridge,” he said.<br />

Dr O’Brien noted that he started performing phacoemulsification<br />

un<strong>de</strong>r topical anaes<strong>the</strong>sia in 2001 and un<strong>de</strong>rtook a study<br />

investigating its performance using amethocaine in 100 consecutive<br />

patients 1 . The patients received no sedation or intracameral<br />

anaes<strong>the</strong>sia, and <strong>the</strong>y were asked to rate <strong>the</strong>ir pain during sequential<br />

stages of <strong>the</strong> procedure using a visual analog scale of zero to 10.<br />

“...I always use VISTHESIA because<br />

it maintains comfort for my<br />

patients and so for me as well”<br />

OVD: VISTHESIA<br />

Phacoemulsification was associated <strong>with</strong> <strong>the</strong> highest mean pain<br />

score (1.18) followed by IOL insertion (0.84), and none of <strong>the</strong> mean<br />

pain scores for any of <strong>the</strong> intraoperative stages was significantly<br />

higher than <strong>the</strong> mean reported for instillation of <strong>the</strong> topical<br />

anaes<strong>the</strong>tic drops (0.47).<br />

“Based on <strong>the</strong>se data, after I administer <strong>the</strong> topical anaes<strong>the</strong>tic,<br />

I always tell my patients that any subsequent unpleasant sensation<br />

is unlikely to be any worse than <strong>the</strong> little bit of grittiness <strong>the</strong>y<br />

just experienced. This information reassures and relaxes <strong>the</strong>m,”<br />

commented Dr O’Brien.<br />

Discussing his technique for using VISTHESIA in his topical<br />

anaes<strong>the</strong>sia cases, Dr O’Brien first cautioned that <strong>the</strong> outer surface<br />

of <strong>the</strong> ampoules of VISTHESIA topical are not sterile, and so <strong>the</strong><br />

product should not be placed on <strong>the</strong> instrument tray. He begins by<br />

first placing a single drop of 0.5 per cent proxymethacine into both<br />

of <strong>the</strong> patient’s eyes.<br />

Placing this anes<strong>the</strong>tic in <strong>the</strong> unoperated eye helps to prevent<br />

any discomfort that patients might experience if any povidoneiodine<br />

used during <strong>the</strong> prep splashes into <strong>the</strong> fellow eye,”<br />

Dr O’Brien explained. In his protocol, Dr O’Brien uses povidoneiodine<br />

for <strong>the</strong> scrubbing of <strong>the</strong> patient’s eye.<br />

VISTHESIA topical is only instilled on <strong>the</strong> operated eye at <strong>the</strong><br />

beginning of <strong>the</strong> surgery. Once <strong>the</strong> instillation is ma<strong>de</strong>, he injects<br />

VISTHESIA intracameral, noting that he also places some product<br />

over <strong>the</strong> clear cornea incision as he believes that may reduce <strong>the</strong><br />

risk of recurrent corneal erosion.<br />

After cataract removal is completed, he uses a wound-assisted<br />

IOL insertion technique <strong>with</strong> <strong>the</strong> BLUEMIXS 180 injector to <strong>de</strong>liver<br />

<strong>the</strong> CT ASPHINA 409MP preloa<strong>de</strong>d IOL in his <strong>MICS</strong> cases.<br />

“I find <strong>the</strong>re is less twisting and turning of <strong>the</strong> injector using <strong>the</strong><br />

wound-assisted technique, and even though lens insertion can be<br />

one of <strong>the</strong> more painful surgical steps, no patients have complained<br />

about discomfort when I use VISTHESIA,” Dr O’Brien said.<br />

Note: VISTHESIA is not for sale in UK or Portugal.<br />

Dr O’Brien has no financial interest in <strong>Carl</strong> <strong>Zeiss</strong> or its products<br />

mentioned here.<br />

Paul O’Brien – mrpaulobrien@mac.com<br />

Reference<br />

17 September 2011 XXIX Congress of <strong>the</strong> ESCRS<br />

Surgery<br />

1. O’Brien OD, Fulcher T, Wallace D, Power W. Patient pain during different<br />

stages of phacoemulsification using topical anes<strong>the</strong>sia. J Cataract Refract<br />

Surg 2001;27:880-3<br />

4


5<br />

Take your Practice to a New Level <strong>with</strong> <strong>the</strong> <strong>ZEISS</strong> <strong>MICS</strong> <strong>Platform</strong><br />

Quality of Life Following Implantation of AT LI<strong>SA</strong><br />

vs. O<strong>the</strong>r Multifocal IOLs<br />

Name Jorge L Alió<br />

Results from a prospective, randomised, parallel-group (four<br />

arms) study un<strong>de</strong>rscore <strong>the</strong> importance of looking beyond<br />

near visual acuity outcomes when assessing <strong>the</strong> benefits of<br />

a multifocal IOL, according to Jorge L Alió MD, PhD.<br />

Global evaluation of <strong>the</strong> outcomes for <strong>the</strong> study that compared<br />

three multifocal and one monofocal IOLs showed that <strong>the</strong><br />

AT LI<strong>SA</strong> ® 809M (<strong>Carl</strong> <strong>Zeiss</strong>), a full diffractive, aspheric multifocal<br />

IOL, offered <strong>the</strong> best profile overall consi<strong>de</strong>ring impact on visual<br />

acuity, functional performance, optical effects and quality of<br />

life. The study also showed that although patients implanted<br />

<strong>with</strong> ano<strong>the</strong>r multifocal IOL benefited <strong>with</strong> increased near vision<br />

function, <strong>the</strong>y failed to achieve improvement in quality of life.<br />

“Quality of life data are complex and can be difficult to interpret<br />

because psychology is involved and patient perceptions may be<br />

influenced by multiple factors. However, I am convinced this type<br />

of information represents <strong>the</strong> best way to un<strong>de</strong>rstand if we are<br />

helping our cataract surgery patients,” said Dr Alió, professor and<br />

chairman of ophthalmology, Instituto Oftalmológico <strong>de</strong> Alicante,<br />

Universidad Miguel Hernan<strong>de</strong>z, Alicante, Spain.<br />

“Although we know that implantation of a multifocal IOL<br />

improves near vision, surgeons must realise this technology can<br />

also cause photic phenomena, including halos and glare, along<br />

<strong>with</strong> contrast sensitivity loss. As <strong>de</strong>monstrated in our study and<br />

representing a first-time finding, quality of life after multifocal IOL<br />

implantation does not always improve when patients gain near vision<br />

function if that benefit occurs at <strong>the</strong> cost of poor quality of vision.”<br />

Dr Alió and colleagues investigated vision-related quality of life<br />

after cataract surgery using a validated Spanish version of <strong>the</strong><br />

25-item National Eye Institute Visual Function questionnaire (NEI<br />

VFQ-25). They enrolled 88 patients un<strong>de</strong>rgoing bilateral cataract<br />

surgery, ages 49 to 85 years, who were randomly assigned into<br />

four equal groups to be implanted <strong>with</strong> <strong>the</strong> AT LI<strong>SA</strong> 809M, a<br />

spherical monofocal IOL (CT 48S, <strong>Carl</strong> <strong>Zeiss</strong>), a refractive multifocal<br />

IOL (ReZoom, Abbott Medical Optics), or <strong>the</strong> +4 D add, apodized<br />

hybrid diffractive multifocal IOL (SN6AD3; AcrySof ReSTOR, Alcon).<br />

Patients received <strong>the</strong> same IOL in both eyes.<br />

The quality of life questionnaire along <strong>with</strong> wavefront<br />

aberrometry measurement of high or<strong>de</strong>r aberrations (HOA) and<br />

tests of near and far visual acuity, reading speed, and contrast<br />

sensitivity were performed preoperatively and postoperatively<br />

at scheduled visits through six months. The statistical analyses<br />

inclu<strong>de</strong>d correlation testing to un<strong>de</strong>rstand how visual parameters<br />

influenced different quality of life items <strong>with</strong> different IOLs.<br />

Summarising some of <strong>the</strong> key findings, Dr Alió noted that<br />

while correlation analyses showed better near visual acuity and<br />

reading acuity were strongly associated <strong>with</strong> improved perceptions<br />

of quality of vision, wellness and general health, patients<br />

implanted <strong>with</strong> <strong>the</strong> monofocal IOL still benefited <strong>with</strong> a significant<br />

improvement in quality of life. Despite <strong>the</strong>ir lack of recovery<br />

of near vision, <strong>the</strong> monofocal IOL patients achieved significant<br />

improvements in a variety of tasks, including <strong>the</strong> ability to find<br />

items on a crow<strong>de</strong>d shelf, read street signs and store names, and<br />

navigate down stairs or curbs in dim light or at night. In addition,<br />

<strong>the</strong> monofocal IOL was associated <strong>with</strong> <strong>the</strong> best contrast sensitivity<br />

among <strong>the</strong> four implants and was best for driving vision.<br />

Results for <strong>the</strong> multifocal IOLs showed far vision was best <strong>with</strong><br />

<strong>the</strong> AT LI<strong>SA</strong> and <strong>the</strong> results were comparable to those achieved in<br />

<strong>the</strong> monofocal group. Patients implanted <strong>with</strong> <strong>the</strong> diffractive<br />

AT LI<strong>SA</strong> multifocal IOL and <strong>the</strong> hybrid apodized ReSTOR multifocal<br />

IOL showed improved performance of near tasks, such as reading<br />

newspapers or shaving, and improvement in performance of near<br />

vision function was better <strong>with</strong> <strong>the</strong> two diffractive technologies<br />

(AT LI<strong>SA</strong> and ReSTOR) than <strong>with</strong> <strong>the</strong> refractive, ReZoom IOL.<br />

Reading speed was best in <strong>the</strong> AT LI<strong>SA</strong> patients followed by patients<br />

implanted <strong>with</strong> <strong>the</strong> ReSTOR IOL, whose performance was superior<br />

to <strong>the</strong> ReZoom IOL group.<br />

“Correlation analyses for patients implanted <strong>with</strong> <strong>the</strong> refractive<br />

ReZoom multifocal IOL showed reading improved when HOA<br />

RMS is low, but among <strong>the</strong> multifocal IOLs, <strong>the</strong> refractive ReZoom<br />

induced more HOA than <strong>the</strong> aspheric ReSTOR and AT LI<strong>SA</strong>. In <strong>the</strong><br />

ReSTOR group, we also found an inverse relationship between<br />

contrast sensitivity and reading difficulty, and contrast sensitivity<br />

was better for <strong>the</strong> AT LI<strong>SA</strong> than <strong>with</strong> <strong>the</strong> ReSTOR,” said Dr Alió.<br />

Driving difficulty was also related to contrast sensitivity, and as<br />

contrast sensitivity was worse <strong>with</strong> <strong>the</strong> ReSTOR IOL than <strong>with</strong> <strong>the</strong><br />

AT LI<strong>SA</strong>, <strong>the</strong> apodized hybrid diffractive ReSTOR multifocal IOL was<br />

also associated <strong>with</strong> more driving difficulties comparing <strong>the</strong> two<br />

diffractive lenses.<br />

Dr Alió conclu<strong>de</strong>d <strong>with</strong> a global evaluation of <strong>the</strong> IOLs taking<br />

into account <strong>the</strong>ir impact on visual performance and quality of<br />

life. In categories of far vision, near vision, reading speed, contrast<br />

sensitivity function and effects on HOA, <strong>the</strong> AT LI<strong>SA</strong> performed<br />

equal to or better than each of <strong>the</strong> three o<strong>the</strong>r IOLs, and it was<br />

superior to all of <strong>the</strong> o<strong>the</strong>r implants in improving quality of life.<br />

Using an Olympic medal analogy, Dr Alió conclu<strong>de</strong>d <strong>the</strong> AT LI<strong>SA</strong><br />

receives <strong>the</strong> gold medal.<br />

Dr Alió has no financial interest in <strong>Carl</strong> <strong>Zeiss</strong> or its products<br />

mentioned here.<br />

Jorge Alió – jlalio@vissum.com<br />

AT LI<strong>SA</strong> 809M


First Experience <strong>with</strong> <strong>the</strong> <strong>ZEISS</strong> VI<strong>SA</strong>LIS 500<br />

Phaco Machine<br />

Name Ekkehard Fabian<br />

The VI<strong>SA</strong>LIS 500 is a new state-of-<strong>the</strong>-art modular<br />

phacoemulsification and vitrectomy system that enables safe<br />

and efficient surgery, according to Ekkehard Fabian MD.<br />

“There are benefits for operating through a smaller<br />

incision, but <strong>MICS</strong> also places increased <strong>de</strong>mands on <strong>the</strong> phaco<br />

machine for maintaining safety and efficiency. The VI<strong>SA</strong>LIS 500<br />

was <strong>de</strong>signed <strong>with</strong> <strong>MICS</strong> capabilities in mind, and its innovative<br />

features provi<strong>de</strong> surgeons <strong>with</strong> flexibility benefits while also<br />

assuring control,” said Dr Fabian, private practice, AugenCentrum<br />

Rosenheim, Germany.<br />

Dr Fabian was involved in <strong>the</strong> <strong>de</strong>velopment of <strong>the</strong> VI<strong>SA</strong>LIS 500<br />

platform. Two mo<strong>de</strong>ls are available – <strong>the</strong> VI<strong>SA</strong>LIS S500 for cataract<br />

surgery and <strong>the</strong> VI<strong>SA</strong>LIS V500 for combined cataract and/or<br />

vitreoretinal surgery.<br />

Highlighting <strong>the</strong> features of <strong>the</strong> VI<strong>SA</strong>LIS 500 machines for<br />

cataract surgery, Dr Fabian mentioned <strong>the</strong> Surge Security Software<br />

that constantly analyses <strong>the</strong> intraocular environment and uses <strong>the</strong><br />

information to adjust pump function to maintain high chamber<br />

stability. In addition, <strong>the</strong> VI<strong>SA</strong>LIS 500 offers a wi<strong>de</strong> selection of<br />

ultrasound emission mo<strong>de</strong>s including cold phaco, an advanced<br />

fluidics system <strong>with</strong> dual pump technology, a dual-linear footpedal<br />

and an intuitive, user-friendly graphic user interface.<br />

The dual-linear footpedal is hardware that is familiar to those<br />

who do retinal surgery or are accustomed to operating <strong>with</strong><br />

Venturi pump-based units. It has benefits of allowing surgeons<br />

to in<strong>de</strong>pen<strong>de</strong>ntly control aspiration and phaco power in or<strong>de</strong>r<br />

to maximise safety and efficiency while also providing ease in<br />

changing functions.“Using <strong>the</strong> footpedal, <strong>the</strong> surgeon can adjust<br />

<strong>the</strong> operative technique in a variety of ways to maintain safety, such<br />

as switching between programs and changing bottle height. By<br />

reducing <strong>de</strong>pen<strong>de</strong>nce on nursing assistance for changing functions,<br />

this technology also increases OR efficiency,” Dr Fabian said.<br />

“I begin surgery <strong>with</strong> a peristaltic<br />

pump and switch to <strong>the</strong> venturi<br />

pump after completing <strong>the</strong> first<br />

two quadrants”<br />

With <strong>the</strong> VI<strong>SA</strong>LIS 500 dual pump system, surgeons can enjoy<br />

on-<strong>the</strong>-fly switching between Venturi (vacuum-based) and rise-time<br />

controlled peristaltic (flow-based) pumps and take advantage of <strong>the</strong><br />

individual performance characteristics of <strong>the</strong> two mo<strong>de</strong>s according to<br />

<strong>the</strong>ir surgical needs while also maximising efficiency and safety.<br />

Noting that he had a long-standing preference for a peristaltic<br />

pump, Dr Fabian said that since he began using new venturi-type<br />

machines, he increasingly integrated <strong>the</strong> Venturi pump into his<br />

surgical technique. This happened also <strong>with</strong> <strong>the</strong> VI<strong>SA</strong>LIS 500 so<br />

that currently, he uses <strong>the</strong> Venturi mo<strong>de</strong> for <strong>the</strong> entire procedure<br />

in nearly all cases.<br />

Using an intraoperative vi<strong>de</strong>o, he <strong>de</strong>monstrated <strong>the</strong><br />

performance of <strong>the</strong> VI<strong>SA</strong>LIS 500 <strong>with</strong> <strong>the</strong> Venturi pump in a <strong>MICS</strong><br />

case. After good hydrodissection and hydro<strong>de</strong>lineation, <strong>the</strong> phaco<br />

tip could be maintained in <strong>the</strong> centre while <strong>the</strong> nuclear pieces<br />

came directly to <strong>the</strong> tip.“With a Venturi pump, vacuum is created<br />

instantly by <strong>the</strong> pump thus providing immediate followability.<br />

Using a peristaltic pump, vacuum is created on occlusion of <strong>the</strong><br />

phaco tip thus providing better holdability. Today’s dual pump<br />

17 September 2011 XXIX Congress of <strong>the</strong> ESCRS<br />

machines like <strong>the</strong> VI<strong>SA</strong>LIS 500 have this better followability but do<br />

not lose <strong>the</strong> holdability functionality,” he explained.<br />

“The peristaltic pump offers greater anterior chamber stability.<br />

However, when using <strong>the</strong> Venturi pump during fragment removal,<br />

<strong>the</strong>re is no need to move <strong>the</strong> tip to chase <strong>the</strong> fragments, and that<br />

is not possible when operating <strong>with</strong> a peristaltic pump unless high<br />

settings are used,” he said.<br />

Dr Fabian noted that if he is particularly concerned about<br />

maintaining anterior chamber stability, such as in an eye <strong>with</strong> a very<br />

narrow anterior chamber, he begins surgery using <strong>the</strong> peristaltic<br />

pump and switches to <strong>the</strong> Venturi after completing removal of <strong>the</strong><br />

first two quadrants.“In situations where <strong>the</strong>re is very low volume in<br />

<strong>the</strong> anterior chamber, I want to control vacuum, and I prefer to use<br />

<strong>the</strong> peristaltic pump for increased stability,” he said.<br />

Dr Fabian also observed, that pump choice also reflects individual<br />

surgeon preference, and different surgeons may use a variety of<br />

different techniques in which <strong>the</strong>y incorporate both pumps into <strong>the</strong>ir<br />

surgical protocol. For example, one surgeon may start <strong>the</strong> procedure<br />

using <strong>the</strong> peristaltic pump for chopping and mobilising quadrants<br />

and <strong>the</strong>n switch to <strong>the</strong> Venturi pump for removing <strong>the</strong> epinucleus<br />

and OVD. Ano<strong>the</strong>r surgeon might also start using <strong>the</strong> peristaltic<br />

pump for sculpting and chopping, but switch to <strong>the</strong> Venturi pump<br />

for segment removal, while a third surgeon might start using<br />

<strong>the</strong> Venturi pump for chopping, switch to <strong>the</strong> peristaltic pump<br />

for fragment removal, and revert to <strong>the</strong> Venturi pump to finish<br />

epinucleus and cortex removal.<br />

With VI<strong>SA</strong>LIS 500, surgeons have <strong>the</strong> possibility to flexibly <strong>de</strong>fine<br />

<strong>the</strong>ir own surgical protocol to optimise <strong>the</strong> balance between high<br />

patient safety and surgery efficiency, Dr Fabian said.<br />

<strong>ZEISS</strong> surgery solution offers surgeons o<strong>the</strong>r innovative products<br />

for improving workflow efficiency and surgical results, including<br />

FORUM and CALLISTO eye ® . FORUM is a software product for digital<br />

integration of clinical data from compatible diagnostic instruments.<br />

CALLISTO eye offers remote microscope control, integrated HD<br />

vi<strong>de</strong>o documentation, patient data display in <strong>the</strong> OR and a range of<br />

assistance functions, inclu<strong>de</strong> Z ALIGN ® , a vi<strong>de</strong>o-supported tool for<br />

guiding precise intraoperative axis alignment of toric IOLs.<br />

Dr Fabian has no financial interest in <strong>Carl</strong> <strong>Zeiss</strong> or its products<br />

mentioned here.<br />

Ekkehard Fabian – prof.fabian@augencentrum.<strong>de</strong><br />

6


ESCRS<br />

EUROTIMES<br />

Supplement November 2011<br />

17 September 2011<br />

XXIX Congress of <strong>the</strong> ESCRS<br />

Supported by an unrestricted grant from

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