Richard Silver PV

CRITIQUE OF WHO CRITERIA: “THE STANDARD”
WHO has promulgated the 2008 WHO criteria for diagnosis
of PV; however, these have never been prospectively tested.
RECENT Warnings
“An elevated venous hemoglobin concentration cannot be used as a surrogate marker
for absolute erythrocytosis”
– Johansson PL, et al. British Journal of Hematology 129: 701-705, 2005
“RCM measurement is useful for proper MPD classification ……of Ph-negative MPD”.
– Cassinat, et al. Leukemia 22:452-453, 2008
“Alternative proposal to revised WHO criteria for MPDs”
Spivak JL, Silver RT. Blood. 112:231-9, 2008
“Red cell mass measurement in patients with clinically suspected diagnosis of
polycythemia vera or essential thrombocythemia”
- Alvarez-Larran A, Ancochea A, Angona A, et al. Haematologica. 2012 Jun 11. [Epub
ahead of print]
“Prospective Evaluation of the World Health Organization Criteria for the Diagnosis of
Polycythemia Vera”
- Silver RT, Chow W, Vandris K, et al. Blood (ASH Annual Meeting Abstracts). Nov 2011;
118: Abstract 3837