Comparison of Candesartan vs Amlodipine Comparison of ...

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% Isolated systolic hypertension 0 ‐10 Cardiac ‐20 mortality ‐30 ‐40 ‐50 ‐46 ‐60 60 Stroke ‐40 ‐42 LIFE SCOPE
Irbesartan <strong>vs</strong>. atenolol in hypertension & LVH: L VMI reduction LVMI (%) 0 -5 -10 -15 -20 12 Week 24 48 12 Week Week 24 48 -5% 5% -8% Malmqvist K, K Kahan Kahan T T et et al. al J Hypertens 2001:19(6);1167-76. -16% - 1% -4% 4% Irb <strong>vs</strong>. Ate p = 0.024 Irbesartan p < 0.001 Atenolol p < 0.001 Irbesartan Atenolol -9%
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Comparison of Candesartan vs Amlodi
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30 20 10 0 ‐10 ‐20 ‐30 ‐40
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LIFE Incidence of Diabetes Mellitus
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m2 Change in LVVMI (g/m ) LIFE Echo
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ARBs for New-onset Atrial Fibrillat
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% New-onset AF with ARB Preventive
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Beyond BP effect of ARBs • Hi Hig
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CASE CASE-J CASE J CCandesartan d t
Page 18 and 19: Outline of the study Objectives : A
Page 20 and 21: Dosage Schedule Schedule 1 month BP
Page 22 and 23: Endpoints Primary imary Endpoints A
Page 24 and 25: Patient Characteristics Ttl Total n
Page 26 and 27: Antihypertensive Antihypertensive D
Page 28 and 29: Comparison of Cardiovascular Cardio
Page 30 and 31: Time Time-specific Time Time-specif
Page 32 and 33: Renal Renal Events Events per 1000
Page 34 and 35: CASE-J vs. VALUE
Page 36 and 37: Primary endpoint VALUE (Valsartan)
Page 38 and 39: BP reduction during studies mmHg SB
Page 40 and 41: All-cause mortality (CASE-J Primary
Page 42 and 43: New New-onset New New-onset onset D
Page 44 and 45: Conclusions Candesartan and Amlodip
Page 46 and 47: Background ACE ACE-inhibitors i hib
Page 48 and 49: Eligibility Inclusion criteria : An
Page 50 and 51: Endpoint Primary Endpoint Major Adv
Page 52 and 53: Patient Characteristics (1) Candesa
Page 54 and 55: Medications at at Randomization Ran
Page 56 and 57: Primary Primary Endpoint Cumulative
Page 58 and 59: Candesartan vs vs Standard Standard
Page 60 and 61: Subgroup Subgroup analysis analysis
Page 62 and 63: Summary IIn comparison i with i h s
Page 64: Conclusions Candesartan and Amlodip
Page 70: Predictors of new-onset atrial fibr
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Comparison of Candesartan vs Amlodipine Comparison of ...

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