Advances in biosensors: principle, architecture and applications

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of aptamer to overcome this limitation. Aptamer properties such as their high specificity,
small size, modification and immobilization versatility, regenerability or conformational
change induced by the target binding have been successfully exploited to optimize a variety of
bio-sensing formats (Schneider et al 2010). Aptamer based biosensor has been widely used in
various application. Recently sufficient progress has been made in biomimetics sensor and
aptasensor for clinical application (Vallet-Regi and Arcos 2008). This including clinical
diagnostics to detect pathogen, virus and infectious disease (Strehlitz et al 2008, Toress-
Chavolla and Alocilja 2009, Wang Y. Et al. 2012, Weng et al. 2012).
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