Wolfgang Kreyling - NanoImpactNet

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Outline of of pressing issues from my point of of view • Routes of Nanoparticle intake • Exposure and dosimetry • Long-term NP dose estimates • Controlled NP administration • NP trafficking back + forth across lung membrane • Long-term NP translocation • Mechanisms of NP accumulation in 2 nd target organs (role NP- protein-complex formation from our biokinetic point of view) • Toxicological testing in primary vs. secondary target organs HelmholtzZentrum münchen German Research Center for EnvironmentalHealth Institute of Lung Biology & Disease Focus Network Nanoparticles and Health
NP in human lungs Gehr,1988 1 mm Alveolar wall HelmholtzZentrum münchen German Research Center for EnvironmentalHealth Nanoparticles (NP): Routes of of Intake 140 m², m , erythrocyte, erythrocyte, 7 µm Institute for Inhalation Biology Focus Network Nanoparticles and Health ~2 m² 400 m²
Page 1: NanoImpactNet: Workshop on on Proto
Page 5 and 6: Lomer et al. J. Nutr., 2004 Helmhol
Page 7 and 8: HelmholtzZentrum münchen German Re
Page 9 and 10: NP Trafficking across Lung Epitheli
Page 11 and 12: Nanoparticle (NP) translocation int
Page 13 and 14: Systemic translocation of nanoparti
Page 15 and 16: HelmholtzZentrum münchen German Re

Wolfgang Kreyling - NanoImpactNet

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