CURRICULUM VITAE Associate Professor Hong Zhou, Ph.D., MD ...

Address:
CURRICULUM VITAE
Associate Professor Hong Zhou, Ph.D., MD.
Bone Research Program, ANZAC Research Institute
Hospital Rd, Concord, 2139 NSW,
Telephone/Fax:
(w) 02 9767 9164
Fax 02 9767 9101
E-mail: h.zhou@sydney.eud.au
EDUCATION:
1992 Ph.D. The University Melbourne. “Molecular and cellular studies on
osteoblast differentiation”
1983 MD. Ningxia Medical College, Ningxia, People's Republic of China.
CURRENT POSITION:
8/2009-present Associated Professor, Principal Research Fellow, Bone Research Program,
ANZAC Research Institute, University of Sydney, Australia.
1/2008 – present Head, Molecular Bone Biology Unit, Bone Research Program, ANZAC
Research Institute.
2004-present Visiting Professor, Ningxia Medical University, Ningxia, China
PREVIOUS APPOINTMENTS:
1/2004-7/2009 Senior Research Fellow, Bone Research Program, ANZAC Research
Institute, University of Sydney, Australia.
1/2003-12/2005 Senior Fellow, Department of Medicine, The University of Melbourne, St.
Vincent's Hospital, Australia (three year conjoint position).
1/2003-12/2003 Research Fellow (NH&MRC Senior Research Officer), St. Vincent’s
Institute of Medical Research, Victoria Australia.
4/1996-2002 NH&MRC Senior Research Officer, Department of Medicine, The
University Melbourne, St. Vincent's Hospital, Australia.
4/1992-4/1996 NH&MRC Research Officer, Department of Medicine, The University
Melbourne, St. Vincent's Hospital, Australia.
1985-1986 Specialist training in Renal Medicine and Endocrinology, Affiliated Hospital
of Ningxia Medical College, Ningxia, China.
1983-1984 Resident Medical Officer, Affiliated Hospital of Ningxia Medical College,
Ningxia, China.
HONOURS AND AWARDS:
1. The University of Melbourne Postgraduate Scholarship, for postgraduate research leading to
the degree of Ph.D (1987-1991).
2. Young Investigator Award, from the 15 th Annual Meeting American Society for Bone and
Mineral Research, Tampa, Florida, U.S.A 1993
3. Australian Chinese Achievers’ Award (in the Medicine and Dentistry category) 1995.

4. Outstanding Paper Award, The 2 nd Intl. Conference on Osteoporosis and Bone Research,
Cheng-Du, China, 2005
5. Best Basic Abstract Award, The 17 th Annual Meeting of Australian and New Zealand Bone
and Mineral Society (ANZBMS), Queenstown, New Zealand, 2007
6. Concord Repatriation General Hospital Research travelling Award 2007
7. Best Basic Abstract Award, The 18 th Annual Meeting of Australian and New Zealand Bone
and Mineral Society (ANZBMS), 2008
8. Concord Repatriation General Hospital Research Travel Award 2008
9. Chunhui Plan Award: The Ministry of Education-funded organization, Ministry of
Education, China, 2008
10. Best Basic Abstract Award, The 19 th Annual Meeting of Australian and New Zealand Bone
and Mineral Society (ANZBMS), 2009
PROFESSINAL MEMBERSHIPS:
1993-present Member, American Society for Bone and Mineral Research (ASBMR)
1994-present Member, International Bone and Mineral Society (IBMS)
1995-2010 Member, International Chinese Hard Tissue Society (ICHTS)
2004-present Member, Australian & New Zealand Bone & Mineral Society (ANZBMS)
2000-2004 Board of director, ICHTS
2007-present Board of director, ICHTS
2007-present Member of Concord Repatriation General Hospital Research Committee
2009-present Chair, Women’s Committee, ICHTS
2009-present Member, Program Committee, ICHTS
2009-present Member, Membership Committee, ICHTS
2010-present Life time member, ICHTS
CONFERENCE PARTICIPATION:
Committee member
• Member of Local Organising Committee, International Conference on Animal Models in the
Prevention and Treatment of Osteopenia, Cairns, Australia 1995
• Member of Organising Committee & Scientific Program Committee for 2 nd International
Conference on Osteoporosis and Bone Research (ICOBR), October 19-23, 2005, Cheng-Du,
China
• Member of Scientific Program Committee for 3 rd ICOBR, October 17-20, 2007, Shanghai,
China
Chair Sessions:
• International Conference on Animal Models in the Prevention and Treatment of Osteopenia,
Cairns, Australia, “Session V” 1995.
• 2 nd International Osteoporosis, April 4-5, 1999, Xi’an, China
• 2 nd ICOBR, October 23, 2005, Cheng-Du, China
• Australian & New Zealand Bone & Mineral Society (ANZBMS), September, 2005, Perth,
Australia
• Basic VIII Mechanical regulation of bone and cartilage: mechanism and application. Shanghai
International Congress on Orthopaedics; August 23-26, 2007, Shanghai, China.
• 3 rd ICOBR, October 18, 2007, Shanghai, China
• Osteoporosis and Bone Biology Symposium, Institute of Spine Research Shanghai University of
Traditional Chinese Medicine, October 21, 2007, Shanghai, China
• American Society for Bone and Mineral Research (ASBMR), Concurrent Oral Session:
Osteoporosis Treatment (Preclinical) II, 2009, Denver, USA
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• The International Symposium of Bone and Joint - 1st Joint Symposium of Chinese Speaking
Orthopaedic Society (CSOS) and International Chinese Hard Tissue Society (ICHTS), National
Yang-Ming University, Taiwan November 16, 2010. Taiwan.
• The 140 th Eastern Forum of Science and Technology, ‘Combined traditional Chinese and
Western medicine in prevention and treatment of spine, bone and joint degenerative disease’,
November 20-22. 2010, Shanghai, China
INVITED LECTURES
Invited Presentation at International and national Meetings:
1995 International Conference on Animal Models in the Prevention and Treatment of Osteopenia,
Cairns, Australia. Title: Temporal and spatial distribution of osteoblast gene markers in
bone. Invited Speaker
1999 2 nd International Osteoporosis, April 4-5, Xi’an, China. Title: Cell biology and molecular
biology in bone research. Invited Speaker
2004 4 th Chinese Speaking Orthopaedic Society (CSOS) Scientific Congress, September 22-24,
Beijing, China. Title: Biological mechanisms of bone formation and remodelling. Invited
Speaker
2006 1 st Sydney University Tissue Engineering Network Symposium, November 23, Sydney,
Australia. Invited Speaker
2007 Shanghai International Congress on Orthopaedics, August 25-28, Shanghai, China.
1) Session of Wnt and BMP Signaling in Bone Cells, Title: Glucocorticoid signaling in bone
development. Invited Speaker
2) Session of MSCs and bone regeneration and tumor, Title: Osteoblasts Directly Control
Lineage Commitment Of Mesenchymal Progenitor Cells Through Wnt Signaling. Invited
Speaker
3) Session of Mechanical regulation of bone and cartilage: mechanism and application,
Title: Biological Mechanisms of Bone Remodeling. Invited Speaker
2007 3 rd International Conference on Osteoporosis and Bone Research, October 17-20, Shanghai,
China. Title: How Osteoblasts Control Mesenchymal Progenitors? Invited Plenary
2007 Osteoporosis and Bone Biology Symposium, Institute of Spine Research Shanghai
University of Traditional Chinese Medicine, October 21, Shanghai, China. Title:
Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through
Wnt signaling. Invited Symposium Speaker
2008 Western China Health and Environment Forum, September 4-8, Yinchuan, China Title:
Glucocorticoids Control Lineage Commitment Of Mesenchymal Progenitor Cells Through
Osteoblastic Wnt Signaling. Invited Plenary
2008 118 th Eastern Forum of Science and Technology, ‘Mechanical environment and the exercise
affect the metabolism, repair and regeneration of bone and cartilage’, October 28-29,
Shanghai, China. Title: Glucocorticoid signalling through osteoblasts is essential for
cranial skeletal development. Invited Symposium Speaker
2009 1 st Annual regenerative medicine symposium at Sydney University, October 1, Sydney.
Title: Osteoblast directly control lineage commitment of mesenchymal progenitor cells
through Wnt signaling. Invited Symposium Speaker
2009 The International Symposium of Bone and Joint - 1st Joint Symposium of Chinese Speaking
Orthopaedic Society (CSOS) and International Chinese Hard Tissue Society (ICHTS),
National Yang-Ming University, Taiwan November 16. Taiwan. Title: Endogenous and
exogenous glucocorticoid signaling in osteoblasts modulate bone development, maintenance
and joint inflammation. Invited Symposium Speaker
2009 140 th Eastern Forum of Science and Technology on ‘Combined traditional Chinese and
Western medicine in prevention and treatment of spine, bone and joint degenerative
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disease’, November 20-22, Shanghai, China. Title: Transgenic disruption of glucocorticoid
signalling in mature osteoblasts attenuated K/BxN serum-induced arthritis in vivo. Invited
Symposium Speaker
2010 6 th Clare Valley Bone Meeting, March 26-29, Clare, South Australia. Title: Glucocorticoids
in bone. Invited Speaker
2010 Eighth International Symposium on Frontiers in Life Sciences New Advances and
Challenges in Multidisciplinary Research August 25-28, Yinchuan, China. Title: The role
of endogenous glucocorticoid in autoimmune arthritis. Invited Speaker.
2010 Australian & New Zealand Bone & Mineral Society (ANZBMS) Annual Scientific Meeting,
September 5-8. Adelaide, Australia. Title: Glucocorticoids and osteoblasts. Invited Speaker
2010 5 th International Conference on Osteoporosis and Bone Research, October 28-31, Shenzhen,
China. Title: Wnt7b plays a unique and essential role in osteoblast differentiation. Invited
Speaker
Invited Seminars at Different Institutions:
International
1993 Division of Endocrinology & Metabolism, Department of Medicine, University of
Connecticut, CT, USA, “Temporal and spatial distribution of osteoblast gene markers in
bone”
1994 Ningxia Medical College, Yinchuan, China, “Novel action of retinoic acid stabilization of
newly synthesized alkaline phosphatase transcripts”.
1994 Affiliated Hospital of Ningxia Medical College, Ningxia, China, “In situ hybridization to
show sequential expression of osteoblast gene markers during bone formation in vivo”.
1995 PERKIN ELMER Foster City, CA, USA, “In Situ RT-PCR and the detection of calcitonin
receptor expression in various tissues”.
1998 International Chinese Hard Tissue Society, “localization of ODF (Osteoclast Differentiation
Factor) mRNA in skeletal and extraskeletal tissues”. San Francisco, USA
2004 Ningxia Medical College, Yinchuan, China.
2004 Affiliated Hospital of Ningxia Medical College, Yinchuan, China.
2005 Shanghai University of Traditional Chinese Medicine, Shanghai, China,
2005 Institutes of Bioscience and Medicine, Tsinghua University, Beijing, China
2005 School of Life Science and Engineering, Tsinghua University, Beijing, China
2006 Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester
School of Medicine, Rochester, New York, USA
2007 The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
2008 Ningxia First People’s Hospital, Ningxia, China
2008 Ningxia Medical University, Yinchuan, China
2008 Shanghai Diabetes Institute, Shanghai Jiao Tong University, Shanghai, China
National
1993 Department of Gastroenterology, St. Vincent’s Hospital (Vic), “The transcriptional and posttranscriptional
action of retinoic acid on the alkaline phosphatase gene expression in
preosteoblast cells” 1993.
1996 Victoria Institute of Animal Research (Vic), “In Situ RT-PCR and its applications” 1995.
Department of Medicine, The University of New South Wales, Prince Henry Hospital
(NSW), “In Situ RT-PCR and the detection of calcitonin receptor expression in various
tissues” 1996.
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1996 Centre for Infectious Diseases and Microbiology, The University of New South
Wales/Westmead Hospital (NSW), “In Situ RT-PCR and the detection of calcitonin receptor
expression in various tissues” 1996.
1996 School of Pathology, The University of New South Wales (NSW), “In Situ RT-PCR and the
detection of calcitonin receptor expression in various tissues” 1996.
1996 Department of Endocrinology, The University of Sydney (NSW), “In Situ RT-PCR and the
detection of calcitonin receptor expression in various tissues” 1996.
1996 Children’s Medical Research Institute (NSW), “In Situ RT-PCR and the detection of
calcitonin receptor expression in various tissues” 1996.
1996 Department of Orthopaedic Surgery, ST. George’s Hospital (NSW), “In Situ RT-PCR and
the detection of calcitonin receptor expression in various tissues” 1996.
1997 Surgical Research Seminars. St. Vincent’s Hospital, (VIC), “Bone formation in vivo” 1997.
2001 St.Vincent's Institute of Medical Research, "Osteoclast inhibitory lectin - a family of new
osteoclast inhibitors" 2001.
2004 Sydney Bone Group, “Osteoclast inhibitory lectins - Insights into a family of new osteoclast
inhibitors”. 2004
2005 School of Pathology, University of New South Wales. "Osteoclast inhibitory lectin - a
family of new osteoclast inhibitors".
2006 Sydney Bone Group, “Glucocorticoid effects on osteoblast.”
2007 Dept of Endocrinology & Metabolism, Concord Repatriation Hospital. “Glucocorticoid
action on osteoblast”
2008 Kolling Institute of Medical Research. “How Osteoblasts Control Mesenchymal
Progenitors”.
2010 Hanson Institute, Adelaide, “Glucocorticoids and osteoblast”.
PEER REVIEW INVOLVEMENT:
Journal reviews for:
Arthritis & Rheum, American J Pathology, Biomaterials, Bone, Journal of Cellular Physiology,
Journal of Orthopaedic Surgery and Research, Biochimica et Biophysica Acta (BBA - Molecular
Cell Research), Cancer Letters, Life Sciences, The Open Arthritis Journal.
Grant reviewing:
Member of NHMRC Grant Review Panel 2008 and 2009
Ad-hoc reviewer, NHMRC Project Grants
Ad-hoc reviewer, Anti-Cancer Council of Victoria
RESEARCH FUNDING:
Current NHMRC Grants & Other Grants:
Current NHMRC Project Grants
621838 H. Zhou, M. Seibel, P. Stewart, F. Buttgereit and M. Cooper “The Role of Endogenous
Glucocorticoids in Autoimmune Arthritis” Period of support: 01/01/2010 to 31/12/2013. Total:
$419,950; by year: 2005 $141,650, 2006 $141,650 2007 $136, 650
621839 M. Seibel, H. Zhou, C. Gundberg and C. Dunstan “The Role of the Osteoblast in
Mediating Glucocorticoid-Induced Metabolic Dysfunction”. Period of support: 01/01/2010 to
31/12/2013. Total: $788,900; by year: 2010: $197,225; 2011: $197,225; 2012: $197,225; 2013:
$197,225
632766 G. Duque, H. Zhou, H. Drissi and W. Li “Role of Lamin A/C in Osteoblastogenesis and
Age-related Bone Loss”. Period of support: 01/01/2010 to 31/12/2012. Total: $458,550; by year:
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2010: $152,850; 2011: $152,850; 2012: $152,850
570946 H. Zhou, M. Seibel, D. Chen and C. Dunstan “How osteoblast control mesenchymal
progenitors”. Period of support: 01/01/2009 to 31/12/2011. Total: $425,875; by year: 2009:
$143,625; 2010: $143,625; 2012: $138,625
Other Grants
Prostate Cancer Foundation of Australia
Seibel, Zheng, Dunstan, Zhou “VitaminD Deficiency and Prostate Cancer Metastasis to Bone”
Funded for 2009-2010. Total $ 284,810 (2009: $147,149; 2010: $137,661)
Past NHMRC Grants & Other Grants:
Past NHMRC Grants
402462 Seibel, Zhou, Dunstan, Krozowski. “Glucocorticoid effects on bone: the role of the
osteoblast” Period of support: 2006-8. Total: $455,250; by year: 2006: $151,750; 2007:
$151,750; 2008: $151,750
352322, Dunstan, Seibel, Zhou, Blair, "Bone Resorption and Breast Cancer Metastasis”, Period of
support: 01/01/2005 to 31/12/2007. Total: $419,950; by year: 2005 $141,650, 2006 $141,650
2007 $136, 650
Program Grant 963211 T.J. Martin, J.A. Danks, M.T. Gillespie, J.M. Moseley, K.W. Ng, H.
Zhou. “Humoral and local regulators of bone resorption and formation”. Period of support:
01/01/96 to 31/12/2000. Total: $3,131,075
Program Grant 003211 T.J. Martin, J.A. Danks, M.T. Gillespie, J.M. Moseley, K.W. Ng, H.
Zhou. “Humoral and local regulators of bone resorption and formation”. Period of support:
01/01/2000 to 31/12/2004. Total: $3,272,268
Past other Grants
Vice-Chancellor’s Research Award University of Sydney
Zhou, Seibel, Chen, Dunstan Title: “Glucocorticoid effects on bone: the role of the osteoblast”
Period of support: 2008 .$50,000
Vince Agati Memorial Research Award Agency: Anti-Cancer Council of Victoria.
P.F.M. Choong. and H. Zhou. Title: Urokinase plasminogen activator and osteoclast systems
regulate growth and progression in osteosarcoma. Period of Support: 01/01/2002 to 31 12/2004.
Total: $213,125
Pfizer Research Fund Agency: Pfizer Ltd.
KW Ng, H. Zhou, M.T. Gillespie Period of Support: 2000-2001. Total: USD$400,000
Vince Agati Memorial Research Award Agency: Anti-Cancer Council of Victoria.
P.F.M. Choong. J. Fischer, H. Zhou. Title: Roles of urokinase plasminogen activator and
osteoclast resorption in osteosarcoma. Period of Support: 01/01/1999 to 31 12/2001.Total: $141,000
NHMRC Equipment Grants (2004-2010)
Lunar PIXImus II DEXA Scanner Zhou, Seibel, Handelsman, Le Couteur, Nicholson, Clarke,
Robertson, van Zandwijk, Freedman, Kennerson, Allan, Walters, Cogger, Blair, Reid, Simanainen.
2010, $75,000
Stereomicroscope-Imaging Workstation Allan, Seibel, Handelsman, Le Couteur, Kennerson,
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Robertson, Walters, Cogger, Nicholson, Zhou, Blair. 2009, $24,039
Olympus Confocal Microscope Allan, Seibel, Myers, Handelsman, Witting, Kennerson, Freedman
Cogger Robertson, Le Couteur, Nicholson, Zhou, Blair, Clarke. 2008, $63,332
ILLUMINA BEADXPRESS Reader Dunstan, Kennerson, Seibel, Handelsman, Freedman, Le
Couteur, Robertson, Nicholson, Blair, Myers, McLachlan, Zhou, Lowe, McMahon Allan, Muller,
Cogger. 2007, $135,000
Cell culture quarantine and storage facility plus assessories. Dunstan, Allan,Witting, Myers,
Handelsman, Seibel, Nicholson, Zhou, Kennerson, Freedman, Le Couteur, Muller. 2006, $69,000
Bio-Rad iCycler iQ5 Real-Time PCR & Mutation detection system Seibel, Nicholson,
Handelsman, Zhou, Kennerson, Dunstan, Allan, Witting, Kril, Freedman, Le Couteur, Muller.
2005, $74,500
Other Equipment Grants (2004-2009)
Australian Research Council Linage Infrastructure Equipment and Facilities (LIEF) LE0989859
Jones, Darendeliler, Swain, Traini, Young, Richardson, Cairney, Murphy, Ringer, Seibel, Zhou,
Ramsan, Munroe, Archer, Hand, Zhang, Milthorpe, Wang, Masters. “A Multi-Resolution X-ray
Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation” 2009
$1,498,653
Rebecca S Cooper Foundation
Dunstan, Zhou, Seibel. Title: Local Glucocorticoid signalling in inflammatory arthritis.
Image analysis system. 2007, $20,000
Clive and Vera Ramaciotti Foundation Equipment Grant
Seibel, Dunstan, Zhou, Handelsman, Allan, Nicholson, Kennerson, Blair, Myers, Lowe, Witting
“Leica CM3050 S cryostat”. 2006 $25,000
University of Sydney Major Equipment Grant
Seibel, Dunstan, Zhou, Handelsman, Allan, Nicholson, Kennerson, Blair, Myers, Lowe, Witting
“Leica CM3050 S cryostat”. 2006 $26,608
University of Sydney Major Equipment Scheme
Seibel, Zhou, Allan, Nicholson, Witting, LeCouteur, Freedman, Dunstan, Blair, Kennerson,
Robertson, Muller. Kodak Image Station 2000 MM Multi Modal Imager. 2006, $29,872
Rebecca S Cooper Foundation
Dunstan, Seibel, Zhou. Title: Glucocorticoids in inflammatory arthritis. 2005, $9,026
STUDENTS SUPERVISED:
Main Supervisor
PhD students
Vicky. Kartsogiannis 1996-1999 (completed)
Jinwen Tu 2010-
International Exchanging PhD Student From Shanghai Jiaotong University:
Xinyu Shao 2008-2009 (completing)
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International Exchanging Doctoral Students From Humboldt University, Berlin, Germany:
Agnes Weber (international doctoral student) 2007-2008
Holger Henneicke (international doctoral student) 2007-2009
Anastasia Mijuseva (international doctoral student) 2008-2009
Katja Bornert (international doctoral student) 2009-
Uta Heinevetter (international doctoral student) 2009-
Summer Research Scholarship Students:
Jacqueline Hoyola.Echeverria 2005/2006
Ed Fitzgerald 2005/2006
Ed Fitzgerald 2006/2007
Alexander Treble 2007/2008
Giselle Yeo 2007/2008
Julian Pavey 2008/2009
Difei Deng 2009/2010
Co-Supervisor
PhD students:
W.W.Y. Mak 2006 -2010 (thesis submitted)
Li Laine Ooi 2007 -2010 (thesis submitted)
Trupti Trivedi 2009-
Awards to students
• Vicky Kartsogiannis (Ph.D): Roger Melick ANZBMS Young Investigator Award for the
Best Oral presentation at the 6 th Annual Scientific Meeting of ANZBMS, Sydney, NSW,
1996
• Wendy.W.Y. Mak (Ph.D): Concord Clinical Week Research Award, 2005
• Li Laine Ooi (Ph.D.): Endeavour Postgraduate Award 2007-2009
• Holger Henneicke (International doctoral student): Concord Clinical Week Research Award,
2008
• Holger Henneicke: Concord Hospital Research Travel Award, 2009
• Trupti Trivedi (Ph.D): University of Sydney Postgraduate Award 2009-2012
• Li Laine Ooi (Ph.D): Young Investigator Award, 31 st ASBMR Annual Meeting, Denver,
USA, 2009.
• Jinwen Tu (Ph.D): International Postgraduate Award 2010-2012
PATENTS:
Zhou, H., Gillespie, M.T. Hu, Y. Kartsogiannis V. and Ng, K.W. “Inhibitor of osteoclast precursor
formation.” Australian Patent (No. 780470) 2005. International Publication Number WO 01/05964
A1
PUBLICATIONS:
1. Zhou, H., Leaver, D.D., Moseley, J.M., Kemp, B., Ebeling, P.R. and Martin, T.J. Actions of
parathyroid hormone-related protein on the rat kidney in vivo. J.Endocrinology 122: 229-235,
1989. (IF 2.791)
2. Zhou, H., Hammonds, R.G. Jr., Findlay, D.M., Fuller, P.J., Martin, T.J. and Ng, K.W. Retinoic
acid modulation of mRNA levels in malignant, nontransformed, and immortalized osteobalsts.
J. Bone Min. Res. 6: 767-777, 1991. (IF 6.443)
3. Zhou, H., Hammonds, R. J., Findlay, D. M., Martin, T. J., and Ng, K. W. Differential effects of
transforming growth factor-beta 1 and bone morphogenetic protein 4 on gene expression and
differentiated function of preosteoblasts, J Cell Physiol. 155: 112-9, 1993. (IF 4.313)
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4. Choong, P., Zhou, H., and Ng, K. W. Ascorbic acid is a transcriptional regulator of osteoblast
differentiation, Eur J Exp Musculoskel Res. 3: 71-75, 1994.
5. Zhou, H., Manji, S. S., Findlay, D. M., Martin, T. J., Heath, J. K., and Ng, K. W. Novel action
of retinoic acid. Stabilization of newly synthesized alkaline phosphatase transcripts, J Biol
Chem. 269: 22433-9, 1994. (IF 5.8)
6. Zhou, H., Choong, P., McCarthy, R., Chou, S. T., Martin, T. J., and Ng, K. W. In situ
hybridization to show sequential expression of osteoblast gene markers during bone formation
in vivo, J Bone Miner Res. 9: 1489-99, 1994. (IF 6.443)
7. Sleeman, M. W., Zhou, H., Rogers, S., Ng, K. W., and Best, J. D. Retinoic acid stimulates
glucose transporter expression in L6 muscle cells, Mol Cell Endocrinol. 108: 161-7, 1995. (IF
2.97)
8. Ikegame, M., Rakopoulos, M., Zhou, H., Houssami, S., Martin, T. J., Moseley, J. M., and
Findlay, D. M. Calcitonin receptor isoforms in mouse and rat osteoclasts, J Bone Miner Res. 10:
59-65, 1995. (IF 6.443)
9. Manji, S. S., Zhou, H., Findlay, D. M., Martin, T. J., and Ng, K. W. Tumor necrosis factor
alpha facilitates nuclear actions of retinoic acid to regulate expression of the alkaline
phosphatase gene in preosteoblasts, J Biol Chem. 270: 8958-62, 1995. (IF 5.8)
10. Hu, Y., Flanagan, J., Brennan, D. P., Zhou, H., Ng, K. W., Eisman, J. A., and Morrison, N. A.
rHox: a homeobox gene expressed in osteoblastic cells, J Cell Biochem. 59: 486-97, 1995. (IF
3.38)
11. Zhou, H., Choong, P. C., Chou, S. T., Kartsogiannis, V., Martin, T. J., and Ng, K. W.
Transforming growth factor beta 1 stimulates bone formation and resorption in an in-vivo model
in rabbits, Bone. 17: 443S-448S, 1995. (IF 4.145)
12. Zhou, H., Choong, P. F., Henderson, S., Chou, S. T., Aspenberg, P., Martin, T. J., and Ng, K.
W. Marrow development and its relationship to bone formation in vivo: a histological study
using an implantable titanium device in rabbits, Bone. 17: 407-15, 1995. (IF 4.145)
13. Suda, N., Gillespie, M. T., Traianedes, K., Zhou, H., Ho, P. W., Hards, D. K., Allan, E. H.,
Martin, T. J., and Moseley, J. M. Expression of parathyroid hormone-related protein in cells of
osteoblast lineage, J Cell Physiol. 166: 94-104, 1996. (IF 4.313)
14. Romas, E., Udagawa, N., Zhou, H., Tamura, T., Saito, M., Taga, T., Hilton, D. J., Suda, T., Ng,
K. W., and Martin, T. J. The role of gp130-mediated signals in osteoclast development:
regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone
marrow cultures, J Exp Med. 183: 2581-91, 1996. (IF 15.463)
15. Kartsogiannis, V., Moseley, J., McKelvie, B., Chou, S. T., Hards, D. K., Ng, K. W., Martin, T.
J., and Zhou, H. Temporal expression of PTHrP during endochondral bone formation in mouse
and intramembranous bone formation in an in vivo rabbit model, Bone. 21: 385-92, 1997. (IF
4.145)
16. Gillespie, M. T., Thomas, R. J., Pu, Z. Y., Zhou, H., Martin, T. J., and Findlay, D. M.
Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers,
Int J Cancer. 73: 812-5, 1997. (IF 4.56)
17. Schneider, H. G., Kartsogiannis, V., Zhou, H., Chou, S. T., Martin, T. J., and Grill, V.
Parathyroid hormone-related protein mRNA and protein expression in multiple myeloma: a case
report. J Bone Miner Res. 13: 1640-3, 1998. (IF 6.443)
18. Manji, S. S., Ng, K. W., Martin, T. J., and Zhou, H. Transcriptional and posttranscriptional
regulation of osteopontin gene expression in preosteoblasts by retinoic acid, J Cell Physiol. 176:
1-9, 1998. (IF 4.313)
19. Hu, Y. S., Zhou, H., Kartsogiannis, V., Eisman, J. A., Martin, T. J., and Ng, K. W. Expression
of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its
mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormonerelated
protein, Mol Endocrinol. 12: 1721-32, 1998. (IF 5.389)
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20. Zeimer, H. J., Greenaway, T. M., Slavin, J., Hards, D. K., Zhou, H., Doery, J. C., Hunter, A.
N., Duffield, A., Martin, T. J., and Grill, V. Parathyroid-hormone-related protein in sarcoidosis,
Am J Pathol. 152: 17-21, 1998. (IF 5.697)
21. Wojcik, S. F., Schanbacher, F. L., McCauley, L. K., Zhou, H., Kartsogiannis, V., Capen, C. C.,
and Rosol, T. J. Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and
expression of PTHrP mRNA in the bovine mammary gland, J Mol Endocrinol. 20: 271-80,
1998. (IF 3.225)
22. Kartsogiannis, V., Udagawa, N., Ng, K. W., Martin, T. J., Moseley, J. M., and Zhou, H.
Localization of parathyroid hormone-related protein in osteoclasts by in situ hybridization and
immunohistochemistry, Bone. 22: 189-94, 1998. (IF 4.145)
23. Blomme, E. A., Werkmeister, J. R., Zhou, H., Kartsogiannis, V., Capen, C. C., and Rosol, T. J.
Parathyroid hormone-related protein expression and secretion in a skin organotypic culture
system, Endocrine. 8: 143-51, 1998. (IF 1.842)
24. Blomme EAG, Zhou H, Kartsogiannis V, Capen CC, Rosol TJ. Spatial and temporal
expression of parathyroid hormone-related protein during wound healing. The Journal of
Investigative Dermatology 112:788-795, 1999.
25. Kartsogiannis V, Zhou H, Horwood NJ, Thomas RJ, Hards DK, Quinn JMW, Niforas P, Ng
KW, Martin TJ, Gillespie MT. Localization of RANKL (receptor activator of NFkB ligand)
mRNA and protein in skeletal and extraskeletal tissues. Bone 25: 525-534, 1999. (IF 4.145)
26. Fisher JL, Field, CL, Zhou, H., Harris, TL, Henderson, MA, Choong, PFM Urokinase
plasminogen activator system gene expression is increased in human breast carcinoma and tis
bone metastases – A comparison of normal breast tissue, non-invasive and invasive carcinoma
and osseous metastases. Breast Cancer Res. & Treat. 61: 1-12, 2000. (IF 4.453)
27. Zeimer H., Firkin F., Grill V., Slavin, J., Zhou, H., and Martin, TJ. Assessment of cellular
expression of parathyroid-hormone-related protein mRNA and protein in multiple myeloma. J
Pathol. 192: 336-341, 2000. (IF 5.423)
28. Mackie, PS., Fisher, JL., Zhou, H. and Choong, PFM. Bisphosphonates regulate cell growth
and gene expression in the UMR106-01 clonal rat osteosarcoma cell line. British J. Cancer. 84:
951-958, 2001. (IF 4.635)
29. Zhou, H., Kartsogiannis, V., Hu, YS., Elliott, J., Quinn, JMW., Mckinstry, WJ., Gillespie, MT.
and Ng, KW. A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol
Chem. 276: 14916-14923, 2001. (IF 5.8)
30. Fisher JL., Mackie, PS., Howard, ML., Zhou, H. and Choong, PFM. The expression of the
urokinase plasminogen activator system in metastatic murine osteosarcoma: an in vivo mouse
model. Clinical Cancer Research 7: 1654-1600, 2001. (IF 6.25)
31. Zhou, H., Kartsogiannis, V., Quinn, JMW., Ly, C., Gange, C., Elliott, J., Ng, KW. and
Gillespie, MT. Osteoclast inhibitory lectin - a family of new osteoclast inhibitors. J Biol
Chem. 277: 48808-48815, 2002. (IF 5.8)
32. Quan, GMY., Ojaimi, J., Nadesapillai, APW., Zhou, H and Choong, PFM. Resistance of
epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of
antiangiogenic factors. Pathobiology. 70: 361-367, 2002 (IF 1.818)
33. Hu, YS, Zhou, H., Myers, D., Quinn, JMW., Gerald GJ., Chi, L., Christine, G., Kartsogiannis,
V., Elliott, J., Kostakis, P., Zannettino, ACW., Cromer, B., Mckinstry, WJ., David M Findlay,
DM., Gillespie, MT. and Ng, KW. Isolation of a human homolog of osteoclast inhibitory lectin
that inhibits the formation and function of osteoclasts. J Bone Miner Res. 19: 89-99, 2004. (IF
6.443)
34. Gange CT, Quinn JM, Zhou H, Kartsogiannis V, Gillespie MT, Ng KW Characterization of
sugar binding by osteoclast inhibitory lectin. J Biol Chem. 279: 29043-29049, 2004 (IF 5.8)
35. Quan, GMY, Ojaimi J, Li Y, Zhou H, Karsogiannis V, Choong, PFM. Localization of pigment
epithelium-derived factor in growing mouse bone. Calcif Tissue Int, 76:146-153, 2005. (IF
2.737)
10

36. Dass CR, Nadesapillai APW, Robin D, Howard ML, Fisher JL, Zhou H, Choong PFM
Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma. Clin Exp
Metastasis 22:643-652, 2006. (IF 2.51)
37. Trivett MK, Potter IC, Power G, Zhou H, Macmillan DL, Martin TJ, Danks JA Parathyroid
hormone-related protein production in the lamprey geotria australis: developmental and
evolutionary perspectives. Dev Genes Evol. 215:553-563, 2005. (IF 2.068)
38. Seibel MJ, Dunstan C, Zhou H, Allan CM, Handelsman DJ Sex steroids, not FSH, influence
bone mass. Cell 127: 1079, 2006. (IF 29.194)
39. Zheng Y, Zhou H, Brennan K, Blair JM, Modzelewski JRK, Seibel MJ, Dunstan CR. Inhibition
of Bone Resorption, Rather than Direct Cytotoxicity, Mediates the Anti-Tumour Actions of
Ibandronate and Osteoprotegerin in a Murine Model of Breast Cancer Bone Metastasis. Bone
40: 471-478, 2007. (IF 4.145)
40. Nakamura A, Ly C, Cipetic M, Sims NA, Vieusseux J, Kartsogiannis V, Bouralexis S, Saleh H,
Zhou H, Price JT, Martin TJ, Ng KW, Gillespie MT, Quinn JM. Osteoclast inhibitory lectin
(OCIL) inhibits osteoblast differentiation and function in vitro. Bone 40: 305-315, 2007. (IF
4.145)
41. Zheng Y, Zhou H, Modzelewski JRK, Kalak R, Blair JM, Seibel MJ, Dunstan CR Accelerated
Bone Resorption, Due to Dietary Calcium Deficiency, Promotes Tumour Growth in a Murine
Model of Breast Cancer Bone Metastasis. Cancer Research 67: 9542-9548, 2007 (IF 7.672)
42. Zhou H, Mak W, Zheng Y, Dunstan CR, Seibel MJ Osteoblasts directly control lineage
commitment of mesenchymal progenitor cells through Wnt signaling. J Biol Chem. 283: 1936-
1945, 2008 (IF 5.8)
43. Ramaswamy, Y., Wu, C., Zhou, H. Zreiqat, H. Biological response of human bone cells to
zinc-modified Ca-Si-based ceramics. Acta Biomater 4: 1487-1497, 2008. (IF 3.11)
44. Zheng, Y., Zhou H, Fong-Yee, C, Modzelewski JRK, Seibel MJ, Dunstan CR Bone resorption
increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clin Exp
Metastasis 25:559-567, 2008. (IF 2.51)
45. Kartsogiannis V, Sims NA, Quinn JMW, Ly C, Cipetić M, Poulton IJ, Walker EC, Saleh H,
McGregor NE, Wallace ME, Smyth MJ, Martin TJ, Zhou H, Ng KW and Gillespie MT. OCIL
(osteoclast inhibitory lectin) deficiency causes osteopenia. J Biol Chem. 283: 30850-30860,
2008. (IF 5.8)
46. Herrmann M, Henneicke H, Street J, Modzelewski J, Kalak R, Buttgereit F, Dunstan CR, Zhou
H, Seibel MJ. The challenge of continuous exogenous glucocorticoid administration in mice.
Steroids. 74:245-9, 2009. (IF 2.588)
47. Zhou H, Mak W, Kalak R, Street J, Fong-Yee C, Zheng Y, Dunstan CR and Seibel MJ.
Glucocorticoid signalling through osteoblasts is essential for cranial skeletal development.
Development 136: 427-436, 2009. (IF 7.76)
48. Buttgereit F*, Zhou H* Kalak R, Gaber T, Spies C, Straub RH, Modzelewski J, Dunstan CR,
Seibel MJ. Transgenic disruption of glucocortocoid signaling in mature osteoblasts and
osteocytes attenuates K/BxN serum-induced arthritis in vivo. Arthritis & Rheum 60:1998-2007,
2009 (*equal first authors). (IF 7.751)
49. Kalak R, Zhou H, Dunstan C, Street J, Day R, Modzelewski J, Liu P, Li G, Seibel MJ.
Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone
structure in mice. Bone 45: 61-67, 2009 (IF 4.145)
51. Mak W, Shao X, Dunstan CR, Seibel MJ, Zhou H. Biphasic glucocorticoid-dependent
regulation of Wnt expression and its inhibitors in mature osteoblastic cells. Calcif Tissue Int.
85: 538-545, 2009 (IF 2.737)
52. Ooi Li, Zhou H, Kalak R, Zheng Y, Conigrace A, Seibel MJ, Dunstan CR Vitamin D
Deficiency Promotes Human Breast Cancer Growth in a Murine Model of Bone Metastasis.
Cancer Research (In press, accepted on 21.12.2009) (IF 7.672)
11

53. Weber AJ, Li G, Kalak R, Street J, Buttgereit F, Dunstan CR, Seibel MJ and Zhou H
Osteoblast-targeted Disruption of Glucocorticoid Signalling does not delay intramembranous
bone healing. Steroids 75: 282-286, 2010 (IF 2.588).
54. Liu PY, Kalak R, Lue YH, Jia Y, Erkkila K, Zhou H, Seibel MJ, Wang C, Swerdloff RS,
Dunstan CR. Genetic and Hormonal Control of Bone Volume, Architecture and Remodelling in
XXY Mice. J Bone Miner Res. (In press, accepted on 1.4.10) (IF 6.443)
REVIEWS
55. Ng, K. W., Zhou, H., Manji, S., and Martin, T. J. Regulation and regulatory role of the
retinoids, Crit Rev Eukaryot Gene Expr. 5: 219-53, 1995.
56. Dunstan CR, Zhou H, Seibel MJ. FGF23: A phosphatonin regulating phosphate homeostasis?
Endocrinology, 145(7):3084-6, 2004
57. Blair J, Zhou H, Seibel MJ, Dunstan CR Mechanisms of disease: roles of OPG, RANKL and
RANK in the pathophysiology of skeletal metastasis. Nature Clin Oncology 3:41-49. 2006
58. Buttgereit F, Zhou H, Seibel MJ. Arthritis and endogenous glucocorticoids: the emerging role of
the 11 beta HSD-enzymes. Editorial. Ann Rheum Dis. 67:1201-1203, 2008.
BOOK CHAPTERS
1. Howlett, C.R., Chen, N., Zhang, X., Akin, F.A., Haynes, D., Hanley, L., Revell, P., Evans, P.,
Zhou, H. and Zreiqat, H. Effects of biomaterial chemistries on the osteoblastic molecular
phenotype and osteogenesis: in vitro and in vivo studies. In, "Bone Engineering." Ed. J.E.
Davies. Toronto, Canada. 240-254. 1999.
2. Feng X and Zhou H Osteoclast Biology. In: Current Topics in Bone Biology. Deng HW and
Liu YZ (Eds), World Scientific Publishing Co., Singapore, p71-93, 2005
3. Chen N, Lichorish DO, O’Dell R, Zhou H, Howlett CR. The importance of cellular recruitment
and differentiation in establishing in vivo bone biomaterial interfaces and repairing osseous
voids. In, “Ceramics, Cells and Tissues. Materials for scaffolding of biological engineered
systems” Ravaglioli A and krajewski A (Eds), Publisher: Consiglio Nazionale delle Ricerche.
Volume 10, p25-32, 2006
4. Dunstan CR, Blair JM, Zhou H, Seibel MJ, Metabolic Bone Diseases. In M. Williams (Ed.),
Comprehensive Medicinal Chemistry Volume 6, Edition 2. 2007 (in press).
5. Zhou H, Chen D, Dunstan CR, Seibel MJ, Bone Metabolism. In Encyclopedia of Molecular
Pharmacology, Offermanns S and Rosenthal W (eds.) Springer, Berlin pp 276-283, 2008
Oral Presentations at National/International Meetings
1. Zhou, H., Findlay, D.M., Martin, T.J., Heath, J.K., and Ng, K.W. 1993. Novel Action of
Retinoic Acid - Stabilization of Newly-Synthesized Alkaline-Phosphatase and Osteopontin
Transcripts. Journal of Bone and Mineral Research 8:S119-S119 (Plenary OR 12).
2. Manji, S., Findlay, D.M., Zhou, H., Martin, T.J., and Ng, K.W. 1993. Tumor-Necrosis-Factor-
Alpha Facilitates Nuclear Actions of Retinoic Acid to Promote Differentiation of Preosteoblasts.
Journal of Bone and Mineral Research 8:S143-S143 (OR 105)
3. Zhou, H., Kartsogiannis, V., Quinn, J.M.W., Elliott, J., Ly, C., Ng, K.W., and Gillespie, M.T.
2001. Osteoclast Inhibitory Lectin - A family of new osteoclast inhibitors. Journal of Bone and
Mineral Research 16:S138-S138 (Plenary OR 1006).
12

4. H. Zhou, K. Brennan, Y. Zheng, C.R. Dunstan, M.J. Seibel Inhibition of Glucocorticoid
Signaling by Overexpression of 11beta HSD2 in Mature Osteoblasts Inhibits Nodule Formation
and Increases Adipogenesis In Vitro. 15th ANZMBS annual Scientific Meeting 2005.
5. C.R. Dunstan, H. Zhou, K. Brennan, M.J. Seibel. Osteoblasts Targeted Overexpression of
Hydroxysteroid Dehydrogenase Type 2 Induces Delayed Calvarial Development in Transgenic
Mice. 15th ANZMBS annual Scientific Meeting 2005
6. H. Zhou, K. Brennan, W.W.Y. Mak, Y. Zheng, C.R. Dunstan, M.J. Seibel. Inhibition of
glucocorticoid signaling by overexpression of 11beta hsd2 in mature osteoblasts inhibits nodule
formation and increases adipogenesis in vitro. 2 nd International Conference on Osteoporosis
and Bone Research (ICOBR), Cheng-Du, China. October 19-23, 2005. *The presentation won
the Outstanding Paper Award for this international meeting.
7. Zhou H, Mak WM, Kalajzic I, Dunstan CR, Seibel MJ (2006) A novel function of mature
osteoblasts: Regulation of differentiation of early precursors through a glucocorticoid
dependent pathway. Journal of Bone and Mineral Research 21:S58-S58.
8. Zhou, H., Mak, W., Zheng, Y., Dunstan, C.R., and Seibel, M.J. 2007. Osteoblast-targeted
disruption of glucocorticoid signalling delays intramembranous bone development in vivo. 17th
ANZMBS annual Scientific Meeting Queenstown, New Zealand 2007. This abstract won the
Best Abstract Award.
9. Zhou, H., Mak, W., Zheng, Y., Dunstan, C.R., and Seibel, M.J. 2007. Osteoblast-targeted
disruption of glucocorticoid signalling delays intramembranous bone development in vivo.
Journal of Bone and Mineral Research 22:S275-S275.
10. Liu, P.Y., Kalak, R., Lue, Y., Erkkila, K., Simanainen, U., Zhou, H., Hikim, A., Handelsman,
D., Seibel, M., Wang, C., et al. XXY mice have an osteoporotic phenotype. Journal of Bone
and Mineral Research 22:S6-S6. 28 th Annual Meeting of the ASBMR, 2007
11. Zhou, H., Buttgereit, F., Gaber, T., Kalak, R., Huschcr, D., Modzelewski, J., Dunstan, C.R.,
and Seibel, M.J. 2007. Transgenic disruption of glucocorticoid signalling in mature osteoblasts
attenuates KRN serum-induced arthritis in vivo. Calcified Tissue International 80:S27-S27.
34 th European Symposium on Calcified Tissues, 2007.
12. Kalak R, Allan CM, McTavish KJ, Dunstan CR, Zhou H, Seibel MJ, Handelsman DJ (2008)
Transgenic Expression of Human FSH in Female Mice Has an Anabolic Effect on Bone.
Journal of Bone and Mineral Research 23:S63-S63. 29 th Annual Meeting of the ASBMR, 2008
13. Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zhen, Y., Dunstan, C. R. and Seibel,
M. J. Glucocorticoid Signalling Through Osteoblasts Is Essential for Cranial Skeletal
Development. 18th ANZMBS annual Scientific Meeting Melbourne, Australia 2008
14. Kalak R, Allan CM, McTavish KJ, Dunstan CR, Zhou H, Handelsman DJ and Seibel MJ
Transgenic Expression of Human FSH in Female Mice Has an Anabolic Effect on Bone. 18th
ANZMBS annual Scientific Meeting Melbourne, Australia 2008. *This abstract won the
Best Abstract Award
15. Herrmann M, Henneicke H, Street J, Modzelewski J, Kalak R, Buttgereit F, Dunstan CR, Zhou
H, Seibel MJ Mature Osteoblasts Mediate Glucocorticoid-induced cortical bone loss is
13

mediated by osteoblast-controlled activation of bone resorption. 2 nd Joint Meeting International
Bone & Mineral Society (IBMS) and ANZMBS, 2009.
16. Kartsogiannis V, Sims NA, Quinn JMW, Ly C, Cipetić M, Poulton IJ, Walker EC, Saleh H,
McGregor NE, Wallace ME, Smyth MJ, Martin TJ, Zhou H, Ng KW and Gillespie MT.
Osteoclast inhibitory lectin (OCIL), an immune cell product that is required for normal bone
physiology in vivo. 2 nd Joint Meeting International Bone & Mineral Society (IBMS) and
ANZMBS, 2009. *This abstract won the Best Abstract Award for this international
meeting.
17. Ooi L, Zhou H, Conigrave AD, Seibel MJ and Dunstan CR. 1,25-Dihydroxy-Vitamin D3
protects against breast cancer-induced bone resorption. VIII International Meeting on Cancer
Induced Bone Disease 2009.
18. Zheng Y, Zhou H, Seibel MJ, and Dunstan CR. RANKL induces tumour-derived IL-6
expression in breast cancer metastasis to bone. VIII International Meeting on Cancer Induced
Bone Disease 2009.
19. Henneicke H, Herrmann M, Street J, Modzelewski J, Buttgereit F, Zhou H, Seibel MJ
Glucocorticoid-induced fat accrual is mediated by the osteoblast. 30 th Annual Meeting of the
ASBMR, 2009
20. Herrmann M, Henneicke H, Street J, Modzelewski J, Kalak R, Day R, Buttgereit F, Dunstan CR,
Zhou H, Seibel MJ The role of osteoblasts and osteocytes in glucocorticoid-induced cortical
bone loss. 30 th Annual Meeting of the ASBMR, 2009
21. Ooi, L, Zhou, H., Kalak R, Zheng Y, Conigrave, AD, Seibel, MJ. and Dunstan, CR. Vitamin D
deficiency enhances breast cancer-induced osteolysis and increases breast cancer growth in
bone. 30 th Annual Meeting of the ASBMR, 2009
22. Zheng, Y., Zhou, H., Fong-Yee C, Mikuscheval A, Buttgereit F, Seibel, MJ and Dunstan, CR.
RANKL enhances tumour-derived IL-6 expression in breast cancer metastasis in bone. 30 th
Annual Meeting of the ASBMR, 2009
23. Henneicke H, Herrmann M, Street J, Modzelewski J, Buttgereit F, Zhou H, Seibel MJ
Glucocorticoid-induced fat accrual is mediated by the osteoblast. 73 rd Annual Scientific
Meeting of the American College of Rheumatology, October 17-21, 2009 Philadelphia, USA
Posters Exhibits at National/international Meetings:
1. Zhou, H., Choong, P., McCarthy, R., Chou, S.T., Martin, T.J., and Ng, K.W. 1993. In-Situ
Hybridization to Show Sequence of Gene-Expression During Bone-Formation in-Vivo. Journal
of Bone and Mineral Research 8:S177-S177.
2. Zhou, H., Findlay, D.M., Martin, T.J., Heath, J.K., and Ng, K.W. 1993. Novel Action of
Retinoic Acid - Stabilization of Newly-Synthesized Alkaline-Phosphatase and Osteopontin
Transcripts. Journal of Bone and Mineral Research 8:S119-S119.
3. Anderson, G.I., Allan, E.H., Zhou, H., Heersche, J.N.M., and Martin, T.J. 1995. Osteoclasts
Activated by Lowered Ph Express Urokinase Receptor Message and Induce Greater
Plasminogen Activation. Journal of Bone and Mineral Research 10:S222-S222.
14

4. Suda, N., Kuroda, T., Gillespie, M.T., Zhou, H., Ho, P.W.M., Hards, D.K., Martin, T.J., and
Moseley, J.M. 1995. Differential Expression of Parathyroid Hormone-Related Protein and Its
Receptor in Rat Calvariae. Journal of Bone and Mineral Research 10:S172-S172.
5. Zhou, H., Manji, S., Findlay, D.M., Martin, T.J., and Ng, K.W. 1995. Nuclear Processing Is
Important to the Action of Retinoic Acid in the Regulation of Osteopontin Gene-Expression.
Journal of Bone and Mineral Research 10:S207-S207.
6. Kartsogiannis, V., Moseley, J., McKelvie, B., Chou, S.T., Hards, D.K., Ng, K.W., Martin, T.J.,
and Zhou, H. 1996. Temporal expression of PTHrP during both endochondral and
intramembranous bone formation by in situ hybridisation and immunohistochemistry. Journal
of Bone and Mineral Research 11:S438-S438.
7. Zhou, H., Findlay, D.M., Hards, D., Kartsogiannis, V., McKelvie, B., Chou, S.T., Martin, T.J.,
and Ng, K.W. 1996. Detection of calcitonin receptor mRNA in paraffin-embedded tissue using
in situ reverse transcriptase polymerase chain reaction. Journal of Bone and Mineral Research
11:S458-S458.
8. Hu, Y.S., Zhou, H., Kartsogiannis, V., Eisman, J.A., Martin, T.J., and Ng, K.W. 1997.
Expression of rat homeobox gene, rHox, in developing and adult tissues in mice and regulation
of its mRNA expression in osteoblasts by BMP2 and PTHrP. Journal of Bone and Mineral
Research 12:47-47.
9. Kartsogiannis, V., Udagawa, N., Ng, K.W., Martin, T.J., Moseley, J., and Zhou, H. 1997.
Localization of PTHrP in osteoclasts by in situ hybridization and immunohistochemistry.
Journal of Bone and Mineral Research 12:S271-S271.
10. Thomas, R., Pu, Z.Y., Zhou, H., Martin, T.J., Findlay, D.M., and Gillespie, M.T. 1997.
Calcitonin receptors and osteopontin expression are markers in primary breast cancers. Journal
of Bone and Mineral Research 12:F394-F394.
11. Zeimer, H.J., Hards, D.K., Zhou, H., Slavin, J.L., Martin, T.J., and Grill, V. 1997. Parathyroid
hormone related-protein in sarcoidosis. Journal of Bone and Mineral Research 12:T448-T448.
12. Blomme, E., Zhou, H., Kartsogiannis, V., Capen, C.C., and Rosol, T.J. 1997. Spatial and
temporal expression of parathyroid hormone-related protein in the skin during the process of
wound healing. Journal of Bone and Mineral Research 12:T437-T437.
13. Blomme, E., Zhou, H., Kartsogiannis, V., Capen, C.C., and Rosol, T.J. 1998. Temporal and
spatial expression of parathyroid hormone-related protein (PTHrP) during the healing of skin
wounds. Modern Pathology 11:55A-55A.
14. Yenson-Chu, E., Zhou, H., Ng, K.W., Martin, T.J., and Romas, E. 1999. Pro-inflammatory
cytokines and PGE2 regulate synovial fibroblast-like cell PTHrP production. Arthritis and
Rheumatism 42:S95-S95.
15. Zhou, H., Hu, Y.S., Kartsogiannis, V., Elliott, J., Quinn, J., Gillespie, M.T., Martin, T.J., and
Ng, K.W. 1999. A novel osteoblast-derived molecule that inhibits the early phase of osteoclast
formation. Journal of Bone and Mineral Research 14:S198-S198 (Plenary Post).
15

16. Zhou, H., Hu, Y.S., Wong, S.Y., Gillespie, M.T., Martin, T.J., and Ng, K.W. 1999. Regulatory
studies on a novel protein, OCIL, that inhibits the early phase of osteoclast formation. Journal
of Bone and Mineral Research 14:S361-S361.
17. Hu, Y.S., Myers, D., Zhou, H., Quinn, J.M.W., Kartsogiannis, V., Elliott, J., Gange, C.,
McKinstry, W.J., Gillespie, M.T., and Ng, K.W. 2001. Isolation of a human homolog of
osteoclast inhibitory lectin that inhibits osteoclastogenesis. Journal of Bone and Mineral
Research 16:S268-S268.
18. Zhou, H., Kartsogiannis, V., Hu, Y.S., Elliott, J., Quinn, J.M.W., McKinstry, W.J., Gillespie,
M.T., and Ng, K.W. 2001. A novel osteoblast-derived molecule that inhibits osteoclast
formation. Bone 28:S70-S70.
19. Sims, N.A., Zhou, H., Martin, T.J., Gillespie, M.T., Ng, K.W., and Romas, E. 2001. Osteoclast
inhibitory lectin (OCIL), RANKL and OPG expression at sites of inflammation and joint
destruction in rheumatoid and collagen-induced arthritis. Journal of Bone and Mineral Research
16:S305-S305.
20. Gange, C., Kartsogiannis, V., Zhou, H., Quinn, J.M.W., Gillespie, M.T., and Ng, K.W. 2002.
Carbohydrate binding specificity of osteoclast inhibitory lectin. Journal of Bone and Mineral
Research 17:S254-S254.
21. Quinn, J.M.W., Hausler, K.D., Gange, C., Zhou, H., Rubin, J.S., Martin, T.J., and Gillespie,
M.T. 2002. Osteoclast progenitors stimulated by TGF-beta or by RANKL differ in their
sensitivity to osteoclastogenesis inhibitors. Journal of Bone and Mineral Research 17:S346-
S346.
22. Brennan, K.J., Zhou, H., de Winter, J., Dunstan, C.R., and Seibel, M.J. 2004. Transgenic mice
over-expressing 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) under the
Col1alpha(I) promoter provide a model to test direct effects of exogenous corticosteroids on
osteoblasts. Journal of Bone and Mineral Research 19:S200-S200.
23. Kartsogiannis, V., Zhou, H., Quinn, J.M.W., Gange, C., Elliott, J., Ly, C., Martin, T.J., Ng,
K.W., and Gillespie, M.T. 2004. Osteoclast inhibitory lectins-insights into a family of new
osteoclast inhibitors. Bone 34:S24-S24.
24. Nakamura, A., Quinn, J.M.W., Sims, N.A., Gange, C.T., Zhou, H., Kartsogiannis, V., Allan,
E.H., Martin, T.J., Ng, K.W., and Gillespie, M.T. 2004. Osteoclast inhibitory lectin (OCIL) is
required for normal bone remodelling in vivo and inhibits osteoblast function in vitro. Journal
of Bone and Mineral Research 19:S8-S8.
25. Quinn, J.M.W., Gange, C.T., Zhou, H., Jenkins, B.J., Nakamura, A., Cromer, B.A., Purton,
L.E., Ly, C., Myers, D.E., Martin, T.J., et al. 2004. CD69 and osteoclast inhibitory lectin have
similar effects on osteoclasts and their progenitors. Journal of Bone and Mineral Research
19:S280-S280.
26. Brennan, K., DeWinter, J., Zhou, H., Dunstan, C.R., and Seibel, M.J. 2005. Corticosterone
treatment produces rapid and profound reductions in circulating osteocalcin levels in mice. Bone
36:S369-S370.
27. Dunstan, C.R., Zhou, H., Brennan, K., Zheng, Y., and Seibel, M.J. 2005. Osteoblast targeted
overexpression of hydroxysteroid dehydrogenase type 2 induces delayed calvarial development
in transgenic mice. Journal of Bone and Mineral Research 20:S311-S311.
16

28. Kartsogiannis, V., Ly, C., Zhou, H., Gallagher, O., Buckle, C., De Leenheer, E., Vanderkerken,
K., Ng, K.N., Martin, T.J., Gillespie, M.T., et al. 2005. Expression of RANKL, OPG, PTHrP
and OCIL in multiple myeloma are influenced by the tumor cells' proximity to bone. Journal of
Bone and Mineral Research 20:S211-S211.
29. Kartsogiannis, V., Ly, C., Zhou, H., Gallagher, O., De Leenhey, E., Buckle, C., Ng, K.W.,
Martin, T.J., Gillespie, M.T., and Croucher, P. 2005. Expression of PTHrP, RANK, OPG and
OCIL in multiple myeloma are influenced by the tumor cells' proximity to bone. Cancer
Treatment Reviews 31:S25-S25.
30. Zhou, H., Brennan, K., Zheng, Y., Dunstan, C.R., and Seibel, M.J. 2005. Inhibition of
glucocorticoid signaling by overexpression of 11beta HSD2 in mature osteoblasts inhibits
nodule formation and increases adipogenesis in vitro. Journal of Bone and Mineral Research
20:S104-S104, (Plenary Poster).
31. Zheng, Y., Zhou, H., Modzelewski, J.R.K., Blair, J.M., Seibel, M.J., and Dunstan, C.R. 2006.
Accelerated bone resorption promotes tumour establishment and growth in a murine model of
breast cancer bone metastasis. Cancer Treatment Reviews 32:S37-S38.
32. Mak, W., Zhou, H., Dunstan, C.R., and Seibel, M.J. 2007. Glucocorticoids stimulate Wnt
expression in mature osteoblasts. Journal of Bone and Mineral Research 22:S247-S247.
33. Zheng, Y., Zhou, H., Modzelewski, J.R.K., Kalak, R., Blair, J.M., Seibel, M.J., and Dunstan,
C.R. 2007. Accelerated bone resorption, due to dietary calcium deficiency, promotes tumor
growth in a Murine model of breast cancer bone metastasis. Journal of Bone and Mineral
Research 22:S3-S3.
34. Zheng, Y., Zhou, H., Modzelewski, J.R.K., Kalak, R., Blair, J.M., Seibel, M.J., and Dunstan,
C.R. 2007. Accelerated bone resorption promotes tumour growth in a murine model of breast
cancer bone metastasis. Calcified Tissue International 80:S39-S40.
35. Zhou, H., Buttgereit, E., Gaber, T., Kalak, R., Dragovic, R., Huscher, D., Straub, R.H.,
Modzelewski, J., Dunstan, C.R., and Seibel, M.J. 2007. Transgenic disruption of glucocorticoid
signalling in mature osteoblasts attenuates KRN serum-induced arthritis in vivo. Journal of
Bone and Mineral Research 22:S275-S275.
36. Zhou, H., Buttgereit, F., Gaber, T., Kalak, R., Huschcr, D., Modzelewski, J., Dunstan, C.R., and
Seibel, M.J. 2007. Transgenic disruption of glucocorticoid signalling in mature osteoblasts
attenuates KRN serum-induced arthritis in vivo. Calcified Tissue International 80:S27-S27.
37. H. Zhou, F. Buttgereit, T. Gaber, R. Kalak, R. Dragovic, D. Huscher, R.H. Straub, J.
Modzelewski, C.R. Dunstan, M.J. Seibel Transgenic disruption of glucocorticoid signalling in
mature osteoblasts attenuates krn serum-induced arthritis in vivo. 17th ANZBMS annual
scientific meeting Queenstown, New Zealand 2007.
38. W. Mak, H. Zhou, C. R. Dunstan, M. J. Seibel. Glucocorticoids stimulate Wnt expression in
mature osteoblasts. 17th ANZBMS annual scientific meeting queenstown, New Zealand 2007.
39. Zhou H, Mak W, Zheng Y, Dunstan CR, Seibel MJ Osteoblasts directly control lineage
commitment of mesenchymal progenitor cells through Wnt signaling. Shanghai International
Congress on Orthopaedics, August 23-26, 2007, Shanghai, China
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40. Zhou H, Mak W, Kalak R, Street J, Fong-Yee C, Zheng Y, Dunstan CR and Seibel MJ.
Glucocorticoid signalling through osteoblasts is essential for cranial skeletal development.
Shanghai International Congress on Orthopaedics, August 23-26, 2007 Shanghai, China
41. H. Zhou, F. Buttgereit, T. Gaber, R. Kalak, R. Dragovic, D. Huscher, R.H. Straub, J.
Modzelewski, C.R. Dunstan, M.J. Seibel Transgenic disruption of glucocorticoid signalling in
mature osteoblasts attenuates KRN serum-induced arthritis in vivo. Shanghai International
Congress on Orthopaedics, August 23-26, 2007, Shanghai, China
42. Zhou H, Mak W, Zheng Y, Dunstan CR, Seibel MJ Osteoblasts directly control lineage
commitment of mesenchymal progenitor cells through Wnt signaling. International Conference
on Osteoporosis and Bone Research (ICOBR), October 17-20, 2007, Shanghai, China
43. Zhou H, Mak W, Kalak R, Street J, Fong-Yee C, Zheng Y, Dunstan CR and Seibel MJ.
Glucocorticoid signalling through osteoblasts is essential for cranial skeletal development.
International Conference on Osteoporosis and Bone Research (ICOBR), October 17-20, 2007,
Shanghai, China
44. H. Zhou, F. Buttgereit, T. Gaber, R. Kalak, R. Dragovic, D. Huscher, R.H. Straub, J.
Modzelewski, C.R. Dunstan, M.J. Seibel Transgenic disruption of glucocorticoid signalling in
mature osteoblasts attenuates KRN serum-induced arthritis in vivo. International Conference on
Osteoporosis and Bone Research (ICOBR), October 17-20, 2007, Shanghai, China
45. Herrmann M, Henneicke H, Street J, Modzelewski J, Buttgereit F, Dunstan CR, Zhou H, Seibel
MJ (2008) The Challenge of Continuous Exogenous Glucocorticoid Administration in Mice.
Journal of Bone and Mineral Research 23:S398-S398
46. Kalak R, Street J, Day RE, Modzelewski JRK, Liu PY, Li G, Dunstan CR, Zhou H, Seibel MJ
(2008) Glucocorticoid Signaling in Osteoblasts Maintains Normal Bone Structure in Mice.
Journal of Bone and Mineral Research 23:S104-S104 (Plenary Poster).
47. Weber AJ, Li G, Kalak R, Street J, Dunstan CR, Buttgereit F, Zhou H, Seibel MJ (2008)
Normal Intramembranous Fracture Healing in Mice with Transgenic Osteoblast-targeted
Disruption of Glucocorticoid Signalling: Analysis by Microcomputed Tomography. Journal of
Bone and Mineral Research 23:S178-S178
48. Weber AJ, Li G, Kalak R, Street J, Dunstan CR, Buttgereit F, Zhou H, Seibel MJ Normal
Intramembranous Fracture Healing in Mice with Transgenic Osteoblast-targeted Disruption of
Glucocorticoid Signalling: Analysis by Microcomputed Tomography. 18th ANZMBS annual
Scientific Meeting Melbourne, Australia 2008.
49. Kartsogiannis V, Sims NA, Quinn JMW, Ly C, Cipetić M, Poulton IJ, Walker EC, Saleh H,
McGregor NE, Wallace ME, Smyth MJ, Martin TJ, Zhou H, Ng KW and Gillespie MT OCIL
(osteoclast inhibitory lectin) deficiency causes osteopenia. 18th ANZMBS annual Scientific
Meeting Melbourne, Australia 2008.
50. Herrmann, M., H. Henneicke, J. Street, J. Modzelewski, R. Kalak, F. Buttgereit, C.R. Dunstan,
H. Zhou, and M.J. Seibel. 2009. Glucocorticoid-induced cortical bone loss is mediated by
osteoblast-controlled activation of bone resorption. Bone 44:009.
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51. Kartsogiannis, V., N.A. Sims, J.M.W. Quinn, C. Ly, M. Cipetic, I.J. Poulton, E.C. Walker, H.
Saleh, N.E. McGregor, M.E. Wallace, M.J. Smyth, T.J. Martin, H. Zhou, K.W. Ng, and M.T.
Gillespie. 2009. Osteoclast Inhibitory Lectin (OCIL), an immune cell product that is required
for normal bone physiology in vivo. Bone 44:379
52. Shao X, Fong-Yee C, Dunstan CR, Jia W, Chen D, Seibel MJ and Zhou H Differential
regulation of osteoblast differentiation by Wnt7b and Wnt10b. 30 th Annual Meeting of the
ASBMR, 2009
53. Ooi, L., H. Zhou, A.D. Conigrave, M.J. Seibel, and C.R. Dunstan. 2009. Vitamin D deficiency
is associated with enhanced tumour growth in a mouse model of breast cancer growth in bone.
Bone 44:463.
54. Weber AJ, Li G, Kalak R, Street J, Buttgereit F, Dunstan CR, Seibel MJ and Zhou H
Osteoblast-targeted Disruption of Glucocorticoid Signalling does not delay intramembranous
bone healing. 73 rd Annual Scientific Meeting of the American College of Rheumatology,
October 17-21, 2009 Philadelphia, USA
19