2008 - Society for Cardiothoracic Surgery

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Society for Cardiothoracic Surgery • Edinburgh Monday 10th March Session 1 08:10 – 08:20 Ochil Abstract No. 2 NAPDH Oxidase-derived Superoxide Generation Contributes to Venous Endothelial Dysfunction in Human Heart Failure. Authors: A Momin 1 ; R Dworakowski 1 ; S Walker 1 ; M Kearney 1 ; A Shah 1 Author’s Institution: 1 GKT School of Medicine King’s College, London, United Kingdom Objectives: Venous endothelial dysfunction contributes to the pathophysiology of human heart-failure, by altering venous capacitance, vascular volume and ventricular preload. The aim of this study was to compare venous endothelial function in human subjects with and without heart-failure and to investigate potential underlying mechanisms. Methods: Segments of saphenous vein harvested from consecutive CABG patients, 18 had heart failure diagnosed by conventional criteria and 34 had preserved LV (Control). Vascular function assessed in organ-baths from vasomotor dose-response curves to acetylcholine and sodium nitroprusside (endothelium-dependent and independent agonists). The mRNA-expression of NADPH-oxidase components (Nox1, Nox2, Nox4, p47, p67) and eNOS in venous segments was quantified by real-time PCR using the SYBR- Green and standard-curve method. Superoxide production in venous homogenates measured by lucigenin-enhanced chemiluminescence. All patients had measurement of lipids, glucose, CRP, interleukin-1 and TNF-alpha levels. Results: Patients with heart failure had greater endothelial dysfunction than controls (16±3 vs 40±8%; p
Annual Meeting • 2008 • Abstracts Monday 10th March Session 1 008:20 – 08:30 Ochil Abstract No. 3 Peri-adventitial Application of Slow Release Rapamycin-eluting Microbeads Inhibits Vein Graft Disease in a Large Animal Model Authors: T Rajathurai; S Rizvi; A Newby; G Murphy Author’s Institution: Bristol Heart Institute, Bristol, United Kingdom Objectives: To evaluate the effects of sustained release of the anti-proliferative agent rapamycin in porcine vein grafts in vivo. Methods: Rapamycin eluting polyvinyl alcohol (PVA) microbeads suspended in vehicle (pluronic gel) were applied to the adventitial surface of porcine saphenous vein to carotid artery interposition grafts. Contralateral vein grafts (vehicle alone) served as controls. A low dose, 180μg rapamycin/cm 2 , and a high dose, 380μg rapamycin/cm 2 , were evaluated. Morphometric and immunocytochemical analyses were performed at 1 and 4 weeks post-grafting. Values are expressed as mean ± standard error. Serum and tissue rapamycin levels were assessed using high performance liquid chromatography. Results: Neointimal thickness (102±15 rapamycin vs 210 ±29 μm control, n=8, p=0.005), medial thickness (231±18 vs 308±38 μm, p=0.09) and overall wall thickness (334±27 vs 518±65 μm, p=0.02) were reduced by low dose rapamycin-eluting microbead application in 4-week vein grafts. There was no difference between treated and control groups at the higher dose, possibly as a result of a systemic effect of rapamycin release. Immunocytochemical staining for DBA Lectin demonstrated no loss of endothelium in the microbead treated grafts at any dose when compared with controls. Conclusions: Rapamycin-eluting microbeads, when applied in vivo, reduced neointima formation in porcine vein grafts at 28 days without significant endothelial denudation. These results demonstrate that microbeads may be used as a delivery vehicle for antiproliferative agents at the time of aorto-coronary bypass grafting. Ultimately this may help in reducing the incidence of vein graft failure in cardiac surgery patients. 37
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Thoracic Drainage System Annual Mee
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HEART RESEARCH UK LECTURE Annual Me
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SCTS 2008 Awards Annual Meeting •
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Working Group Chairs Annual Meeting
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Annual Meeting • 2008 • General
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SCTS Annual Meeting’s 10-Year His
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CARDIAC SURGERY Sorin Group is Euro
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2008 - Society for Cardiothoracic Surgery

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