2008 - Society for Cardiothoracic Surgery

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Society for Cardiothoracic Surgery • Edinburgh Monday 10th March Session 1 008:30 – 08:40 Ochil Abstract No. 4 The Novel Peroxynitrite Decomp4osition Catalyst FP15 Improves Cardiac & Pulmonary Function after Cardiopulmonary Bypass Authors: G Szabó; T Radovits; C Beller; M Karck Author’s Institution: University of Heidelberg, Heidelberg, Germany Objectives: Peroxynitrite is highly active free radical species which plays a central role in ischaemia/reperfusion injury. We investigated the effects of FP15, a novel peroxynitrite decomposition catalyst on ischaemia/reperfusion injury in an experimental model of cardioplegic arrest and extracorporeal circulation. Methods: Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or FP15 (0.1mg/kg n=6). Left ventricular endsystolic pressure volume relationship (Ees) was measured by a combined pressurevolume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descending coronary blood flow (CBF) and pulmonary blood flow (PBF), endothelium-dependent vasodilatation to acetylcholine (ACH) and endotheliumindependent vasodilatation to sodium nitroprusside (SNP) and alveolo-arterial O 2 gradient were determined. Results: The administration of FP15 led to a significantly better recovery (given as percent of baseline) of Ees 88±7 % vs. 46±6 %, p
Annual Meeting • 2008 • Abstracts Monday 10th March Session 1 08:40 – 08:50 Ochil Abstract No. 5 Effect of Foreign Surface Pacification with Albumin, Aprotinin, Propofol & High Density Lipoprotein Authors: M Poullis Author’s Institution: Cardiothoracic Centre, Liverpool, United Kingdom Objectives: To determine the relative degree of foreign surface pacification with albumin (HSA), aprotinin, propofol and high density lipoprotein (HDL). Methods: A previously validated model involving a parallel plate glass slide technique was utilised. The effects of albumin (HSA), aprotinin, propofol and high density lipoprotein (HDL) were assessed by the ability to inhibit platelet adhesion to the glass slide surface. The experiment was repeated with collagen coated glass slides to reproduce the clinical effect of endothelial denudation. The interventions were then repeated on membrane oxygenators that are utilised for cardiopulmonary bypass. Results: After 60 min 100% of the platelets attached to the glass and aprotinin coated surface, and 88±8%, and 85±3% of the platelets attached to the HSA-coated, and propofol coated glass surfaces respectively. However, at 60 min, only 37±12% of the platelets attached to the HDL coated glass surface with the remaining platelets freely moving, p
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Exhibitor List Annual Meeting • 2
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Thoracic Drainage System Annual Mee
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HEART RESEARCH UK LECTURE Annual Me
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SCTS 2008 Awards Annual Meeting •
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Working Group Chairs Annual Meeting
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Annual Meeting • 2008 • General
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SCTS Annual Meeting’s 10-Year His
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CARDIAC SURGERY Sorin Group is Euro
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2008 - Society for Cardiothoracic Surgery

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