경희대학교 동서의학대학원 의 학 영 양 학 과 김 선 아

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Table of Contents Table of Contents ················································································································ ⅰ List of Tables ························································································································ ⅲ List of Figures ······················································································································· ⅳ Abbreviations ························································································································· ⅴ Chapter 1. LITERATURE REVIEW ··············································································· 1 Ⅰ. Collagen ······························································································································ 2 Collagen and skin ············································································································· 2 Molecular structure·········································································································· 4 Collagen types ················································································································· 6 Fibrillar Collagens···································································································· 8 Nonfibrillar Collagens···························································································· 10 Basement membrane collagens································································ 11 Short chain collagens·················································································· 12 Fibril-associated collagens······································································· 12 Type I Collagen······································································································ 13 Type III Collagen ···································································································· 15 Collagen synthesis ········································································································· 16 Collagen degradation ····································································································· 23 MMPs·························································································································· 25 Biological properties of collagen ·············································································· 32 - i -
Ⅱ. Collagen and ascorbic acid ························································································ 33 Ascorbic acid ··················································································································· 33 Effect of ascorbic acid on collagen production ·················································· 36 Ⅲ. Collagen and silicon ····································································································· 39 Ⅳ. Prolyl hydroxylase ········································································································ 42 Gene regulation of proly 4-hydroxylase ······························································· 43 Ⅴ. Lyslyl hydroxylase ········································································································ 45 Chapter 2. Human dermal fibroblast cell에서 ascorbic acid, silicon lysine 및 proline이 collagen 합성에 미치는 <strong>영</strong>향 ···················································· 52 ABSTRACT ························································································································· 53 1. 서론 ······································································································································· 55 2. 재료 및 방법 ······················································································································· 57 3. 결<strong>과</strong> 및 고찰 ······················································································································· 62 4. 요약 및 결론 ······················································································································· 75 5. 참고 문헌 ····························································································································· 77 Appendix ·································································································································· 80 Acknowledgements ··············································································································· 82 - ii -
Page 1 and 2: 석 사 학 위 논 문 Human derma
Page 3: 김선아의 의학영양학 석사
Page 7 and 8: List of Figures Figure Page 1. The
Page 9 and 10: Chapter I. LITERATURE REVIEW - 1 -
Page 11 and 12: kinetic energy is constantly in mot
Page 13 and 14: Figure 1. Triple-stranded helical m
Page 15 and 16: Table 1. Collagen types α Chains T
Page 17 and 18: is contains three identical α chai
Page 19 and 20: incluede in this category because o
Page 21 and 22: Type IX collagen is expressed in ca
Page 23 and 24: most immunogenic regions of type I
Page 25 and 26: Figure 2. Formation of collagen A p
Page 27 and 28: Fig 3. Collagen synthesis - 19 -
Page 29 and 30: the extension peptides are removed.
Page 31 and 32: synthesis and remolding continue at
Page 33 and 34: into collagenases, gelatinases, str
Page 35 and 36: 2003). While plasmin is a potent ac
Page 37 and 38: Baker et al. 2002). Although TIMPs
Page 39 and 40: produce clealvage under physiologic
Page 41 and 42: dietary ascorbic acid, scurvy devel
Page 43 and 44: than those cultured in the absence
Page 45 and 46: triple helices into the fivers and
Page 47 and 48: which were restored upon the additi
Page 49 and 50: Ⅳ. Prolyl hydroxylase Collagen pr
Page 51 and 52: mechanism leading to this retention
Page 53 and 54: esulting hydroxylysine residues hav
Page 55 and 56:
1988 Burgeson RE. The collagens of
Page 57 and 58:
egeneration. Matrix 11:63-8, 1991 M
Page 59 and 60:
1985 Wood G. The heterogeneity of c
Page 61 and 62:
Human dermal fibroblast cell에서
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1. 서론 피부는 탄력성을
Page 65 and 66:
1. 세포배양 2. 재료 및 방
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3. 세포의 증식측정 Human fib
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4.2 Polymerase Chain Reaction (PCR)
Page 71 and 72:
Table 3.1. Proliferation of HS27 ce
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3.2. HS27 cell에서 ascorbic acid,
Page 75 and 76:
ascorbic acid silicon lysine prolin
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ascorbic acid silicon lysine prolin
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3.3. HS27 cell에서 ascorbic acid,
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- 73 - 2) The signal intensity from
Page 83 and 84:
4. 요약 및 결론 피부 진피
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참고문헌 1. Ishikawa T, Ishikaw
Page 87 and 88:
19. Katsuhiro Uzawa, Heather N. Yeo
Page 89 and 90:
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경희대학교 동서의학대학원 의 학 영 양 학 과 김 선 아

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