- Page 12 and 13: Clean-In-Place for Biopharmaceutica
- Page 14 and 15: Preface Clean-in-Place for Biopharm
- Page 16: Acknowledgments During the final ye
- Page 19 and 20: viii 14. Cleanable Solids Processin
- Page 22 and 23: 1 Introduction and Historical Devel
- Page 24 and 25: Introduction and Historical Develop
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- Page 34 and 35: Introduction and Historical Develop
- Page 36 and 37: Introduction and Historical Develop
- Page 38 and 39: Introduction and Historical Develop
- Page 40: Introduction and Historical Develop
- Page 43 and 44: 22 Roebers and Seiberling example,
- Page 45 and 46: 24 Site selection Feasibility study
- Page 47 and 48: 26 Equipment Buffer tank 1000 Buffe
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32 Roebers and Seiberling Other Con
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34 Return pumps, valve arrays, and
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36 routing and design. Fabrication
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38 Cleaning cycle development may b
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40 & The majority of CIP considerat
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42 treatment) is completely indepen
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44 FIGURE 3 Vapor compression water
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46 Strainer or 25 micron filter (A)
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48 Ankers FIGURE 7 High-capacity so
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50 the water can be used after acyc
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4 The Composition of Cleaning Agent
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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Composition of Cleaning Agents for
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5 Cleaning Cycle Sequences Sally J.
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Cleaning Cycle Sequences 75 Final R
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Cleaning Cycle Sequences 77 TABLE 1
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Cleaning Cycle Sequences 79 CIP Cir
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Cleaning Cycle Sequences 81 Require
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Cleaning Cycle Sequences 83 defined
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Cleaning Cycle Sequences 85 TABLE 3
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Cleaning Cycle Sequences 87 To coun
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Cleaning Cycle Sequences 89 into th
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Cleaning Cycle Sequences 91 CIP Hol
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6 CIP System Components and Configu
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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CIP System Components and Configura
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120 TE/ TT CIP return from process
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122 built in chemical concentration
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124 blow system. The flow control v
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126 Air supply Pressure regulator P
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128 Andersen successfully in return
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130 Andersen Typical performance sp
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132 developed in the PLC system and
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134 Step description Charge recircu
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136 Andersen complications or probl
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138 Andersen causing other unantici
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140 CIP Reports Modern CIP systems
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142 added makeup water to compensat
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8 Cleaning Agent Injection Systems
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Cleaning Agent Injection Systems 14
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Cleaning Agent Injection Systems 14
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Cleaning Agent Injection Systems 15
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Cleaning Agent Injection Systems 15
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Cleaning Agent Injection Systems 15
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Cleaning Agent Injection Systems 15
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9 CIP Spray Device Design and Appli
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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CIP Spray Device Design and Applica
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10 CIP Distribution Piping Systems
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CIP Distribution Piping Systems 177
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CIP Distribution Piping Systems 179
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CIP Distribution Piping Systems 181
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CIP Distribution Piping Systems 183
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CIPR flush valve CIPS To =Tonext op
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CIP Distribution Piping Systems 187
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CIP Distribution Piping Systems 189
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CIP Distribution Piping Systems 191
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CIP Distribution Piping Systems 193
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196 Type 300 austenitic stainless s
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198 Greene Fatigue As stainless ste
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200 durable finish that would meet
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202 cause future rusting and corros
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204 Greene the surface. Although, n
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206 Grinding wheels, sanding materi
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208 be 0.8 m mor30 m in. Ra or less
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210 Greene McWhirter MJ, Bremer PJ,
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212 & P3-A. This entity is asubset
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214 Thus, high-quality, extremely s
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216 FIGURE 1 Hygienic clamp, ferrul
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218 the lining in close contact wit
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220 FIGURE 4 Four-port transfer pan
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222 FIGURE 8 Transfer panel with U-
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224 Clem serves to isolate the stem
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226 FIGURE 10 Double-seat valves in
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228 FIGURE 12 Zero dead-leg diaphra
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230 FIGURE 13 Hygienic impeller ret
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232 Connections for process sensors
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234 Clem 4. ASTM International, 100
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236 Flexible Tubing, Transfer Panel
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238 Seiberling 1. The sprays (Path
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240 Seiberling FIGURE 3 This shop-f
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242 4th floor 2nd floor CIPS CIPR 2
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244 Seiberling FIGURE 7 Asecond low
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246 CIP supply- 2" CIP return- 2" 1
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248 Seiberling CIP and to drain for
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250 Media or buffer prep (typical)
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252 Seiberling FIGURE 16 This tank
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254 To TP Steaming aVessel and Tran
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14 Cleanable Solids Processing Equi
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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Cleanable Solids Processing Equipme
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15 Cleanable API Processing Equipme
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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Cleanable API Processing Equipment
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298 aprogram will make this approac
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300 Rush The manual preparation may
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302 TEMPERATURE CONTROL PROBLEMS Ru
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304 CIP Return Temperature Below Se
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306 CIP SUPPLY FLOW PROBLEMS Rush T
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308 the vessel) and then move the a
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310 it may cause a low-level condit
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312 An effective CIP supply air blo
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314 Rush 2. Troubleshooting is perf
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316 permit requirements from locati
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318 Rauch and Ankers FIGURE 1 CIP s
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320 M M M M Acid caustic Acid caust
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322 pH 14 12 10 8 6 4 2 Change of W
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Biowaste BOD Plant steam 324 Retent
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326 development. Choosing alkali an
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328 WHO SHOULD PLAN COMMISSIONING A
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330 in order to complete the intend
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332 TABLE 1 Normal Device Sequence
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334 Norton Installation Qualificati
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336 Norton Understand the Software
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338 TABLE 2 Phase Parameter Charact
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340 Norton used as the circuit pump
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342 Approval Levels Approval levels
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344 Norton 1. CIPs started to shutd
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19 Cleaning Validation Strategies C
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Cleaning Validation Strategies 349
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Cleaning Validation Strategies 351
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Cleaning Validation Strategies 353
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Cleaning Validation Strategies 355
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Cleaning Validation Strategies 357
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Cleaning Validation Strategies 359
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20 International Regulations INTROD
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International Regulations 363 §211
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International Regulations 365 of th
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International Regulations 367 “
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International Regulations 369 Sanit
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International Regulations 371 guide
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International Regulations 373 The a
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International Regulations 375 TABLE
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International Regulations 377 6. Co
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380 Chemical storage and handling,
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382 [CIPable facility project plann
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384 [Design for cleaning] surface,
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386 International Society for Pharm
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388 Process controls, CIP system in
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390 [Spray cleaning] fixed devices,