Untitled

8
AWFI (or Any Water) Supply
If the process requires the addition of product quality water to the process vessel,
for product makeup, or perhaps through the sprays for rinsing following completion
of the transfer,anambient water for injection (AWFI) supply loop (9) may be
connected to the vessel spray supply manifold. Two-ported diaphragm valves
applied as shown in Figure 1will isolate the AWFI loop from CIPS, and provide an
AWFI sample port. The AWFI connection for initial batch makeup may alternatively
be through the transfer panel TP1 to the first vessel (commonly used for mixing),
and via avalve to the spray supply manifold on subsequent vessels in the train.
Operation of the Generic Two-Tank Process Train
Figure 6will serve as the reference for description of the typical process required
in the operation involving two tanks in atrain connected by atransfer line.
Mixing and Transfer
As an example of mixing and transfer operations, consider T1 to be the initial
mixing tank. TP1 would have aU-Bend between ports 1and 2for supply of AWFI
from the facility loop via the isolation and sample valves shown. AU-Bend will also
be required between ports 3and 4for the subsequent transfer and TP2 would
requires aU-Bend between ports 1and 2for transfer to T2. AWFI would be supplied
to fill the tank via path (F) under final control ofvalve T1V1, the quantity being
controlled by ameter,load cells, or aprobe (none shown). The vent filter vent valve
would be open for the fill. The product ingredients (P) would then be added via
the manway or by alternative means, and following agitation, transfer to T2 would
be accomplished by first closing the vent filter vent valve and then applying pressure
to T1 using compressed air (CA) (or other gas) through the vent filter. Valves T1V2
AWFI
CIP
skid
Drain
CA
Vent
T1V3 F
Vent
F
filter P
T1V1
T1
CIP supply
CIP return
T1V2
AWFI
T
TP1
CIPS1 CIPS2
Transfer line
T
T
F
CS CS
CIP return
pump
Vent
filter
CA
Vent
T2
T2V3
T2V2
CIP return
AWFI
T2V4
T2V1
TP2
Seiberling
FIGURE 6 This schematic has been heavy-lined todefine the movement ofgases and the product
during filling with AWFI, the addition of product (P) through the manway, and a top pressure
motivated transfer from T1 to T2 (T). Abbreviation: AWFI, ambient water for injection.
CIPS3
T
Next tank
CIP flush line