Jeffrey L. Bennett, MD, PhD - University of Colorado Denver
Jeffrey L. Bennett, MD, PhD - University of Colorado Denver
Jeffrey L. Bennett, MD, PhD - University of Colorado Denver
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NMO Pathogenesis: IL-6 and Interferon<br />
Elevated IL-6 in NMO CSF 4<br />
• Correlation with CSF Anti-AQP4 IgG Titer<br />
Elevated peripheral blood plasma blasts 5<br />
• IL-6 Anti-AQP4 IgG-expressing Cells<br />
Elevated Type 1 interferon Signature 6<br />
• IFN-b Exacerbates Disease Activity 7<br />
Icoz et al., Int J Neurosci, 2010<br />
Control<br />
AQP4<br />
Chihara et al., PNAS, 2011