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Jeffrey L. Bennett, MD, PhD - University of Colorado Denver

Jeffrey L. Bennett, MD, PhD - University of Colorado Denver

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NMO Pathogenesis: IL-6 and Interferon<br />

Elevated IL-6 in NMO CSF 4<br />

• Correlation with CSF Anti-AQP4 IgG Titer<br />

Elevated peripheral blood plasma blasts 5<br />

• IL-6 Anti-AQP4 IgG-expressing Cells<br />

Elevated Type 1 interferon Signature 6<br />

• IFN-b Exacerbates Disease Activity 7<br />

Icoz et al., Int J Neurosci, 2010<br />

Control<br />

AQP4<br />

Chihara et al., PNAS, 2011

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