Splenic Infarct, Atrial Fibrillation
Splenic Infarct, Atrial Fibrillation
Splenic Infarct, Atrial Fibrillation
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Warfarin vs<br />
Warfarin:<br />
<br />
<br />
Pros<br />
Tried and true (has been used for >50 years) at reducing risk of stroke<br />
Cheap (but hidden cost of INR monitoring)<br />
Reversible (vit K, FFP)<br />
Can use to kill rats<br />
Cons<br />
Slow onset<br />
Frequent INR monitoring<br />
Multiple drug interactions<br />
DTI’s and Apixiban<br />
<br />
<br />
direct thrombin inhibitors and apixiban<br />
Pros<br />
As effective or more effective at preventing clots<br />
Less bleeding complications<br />
No need for monitoring<br />
Faster onset than warfarin<br />
Cons<br />
Can’t reverse (with anything, even FFP); recent article in Circulation suggests rivaroxaban can be reversed with<br />
“prothrombin complex concentrate”<br />
Expensive (but no cost of INR monitoring)<br />
New (post marketing side effects sure to come)<br />
Utility in rat killing unproven
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