2012 antibiogram - The University of Chicago Department of Medicine
2012 antibiogram - The University of Chicago Department of Medicine
2012 antibiogram - The University of Chicago Department of Medicine
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trimethoprim/<br />
sulfamethoxazole<br />
JANUARY - DECEMBER 2011<br />
SOURCE: TOTAL ISOLATES<br />
[Includes inpatient cultures for blood, urine, wounds,<br />
sputum, etc.]<br />
(% sensitive)<br />
GRAM NEGATIVE ORGANISMS<br />
Acinetobacter baumanni 73 69 19 18 15 26 19 15 14 68 26<br />
Enterobacter cloacae 61 98 95 98 70 85 89 98 84 74 98 67<br />
Escherichia coli 516 99 40 83 90 91 89 60 86 100 60 90 100 72<br />
Klebsiella pneumoniae 258 87 67 71 71 71 69 86 81 69 69 100 66<br />
Proteus mirabilis 207 95 59 71 76 77 76 52 74 97 46 98 55<br />
Providencia stuartii 47 89 96 49 85 11 100 6 83 47<br />
Pseudomonas aeruginosa 216 86 82 88 69 69 83 85<br />
Serratia marcescens 37 97 97 81 89 95 100 97 92 92 97 92<br />
# <strong>of</strong> isolates<br />
tigecycline<br />
piperacillin/<br />
tazobactam<br />
moxifloxacin<br />
imipenem/<br />
cilastatin<br />
gentamicin<br />
cipr<strong>of</strong>loxacin<br />
ceftriaxone<br />
ceftazidime<br />
cefepime<br />
cefazolin<br />
ampicillin<br />
amikacin<br />
vancomycin<br />
trimethoprim/<br />
sulfamethoxazole<br />
tigecycline<br />
tetracycline<br />
rifampin*<br />
penicillin<br />
oxacillin<br />
nitr<strong>of</strong>urantoin<br />
linezolid<br />
erythromycin<br />
clindamycin<br />
ceftriaxone<br />
azithromycin<br />
ampicillin<br />
# <strong>of</strong> isolates<br />
GRAM POSITIVE ORGANISMS<br />
Coagulase negative staphylococcus 149 40 21 99 100 38 5 96 86 100 100<br />
Staphylococcus aureus 464 68 36 100 100 47 7 100 93 100 95 100<br />
Enterococcus faecalis 285 99 14 100 100 98 23 99 91<br />
Enterococcus faecium 98 9 3 100 14 8 20 100 13<br />
Streptococcus agalactiae (Grp B) 57 100 65 100 100 14 100 100<br />
Streptococcus pneumoniae<br />
(inpatient + outpatient specimen) 29 72 100 66 100<br />
* Rifampin should not be used as<br />
monotherapy<br />
RENAL DOSING ADJUSTMENT<br />
Agent Normal Adult 30-50 mL/min 10-30 mL/min < 10 mL/min<br />
HD/PD*<br />
Acyclovir (IV) 5-10 mg/kg/dose 5-10 mg/kg/dose 5-10 mg/kg/dose 50% <strong>of</strong> the dose q24h<br />
q8h<br />
q12h<br />
q24h<br />
Ampicillin (IV) 1-2 g q6h 1-2 g q6h 1-2 g q8h 1-2 g q12h<br />
Ampicillin-Sulbactam (IV) 1.5-3 g q6h 1.5-3 g q6-8h 1.5-3 g q12h 1.5-3 g q24h<br />
Amoxacillin Clavulanate 250-500mg q8h 250-500mg q8h 250-500mg q12h 250-500mg q24h<br />
(PO)<br />
or 875mg q12h<br />
Aztreonam (IV) 1-2 g q8h 1-2 g q8h 1-2 g q12h 1-2 g q24h<br />
Cefazolin (IV) 1-2 g q8h 1-2 g q8h 1-2 g q12h 1-2 g q24h<br />
Cefepime (IV) 1-2 g q8-12h 1-2 g q12h 1-2 g q24h 1-2 g q24h<br />
Cefoxitin (IV) 1-2 g q6-8h 1-2 g q8h 1-2 g q12h 1 g q24h<br />
Ceftazidime (IV) 1-2 g q8-12h 1-2 g q8-12h 1-2 g q24h 500mg q24h<br />
Ceftriaxone (IV) 1 g q24h 1 g q24h 1 g q24h 1 g q24h<br />
Cipr<strong>of</strong>loxacin (IV) 400mg IV q8-12h 400mg q8-12h 400mg q12-24h 400mg q24h<br />
Cipr<strong>of</strong>loxacin (PO) 250mg – 750mg 250mg – 500mg 250mg – 500mg 250mg – 500mg q24h<br />
q12h<br />
q12h<br />
q24h<br />
Colisthemethate (Colistin) 2.5-5 mg/kg/day<br />
divided q12h<br />
Fluconazole (IV/PO) 200-400mg x1 then<br />
200mg q24h<br />
Serum Cr 1.3-1.5<br />
2.5-3.8 mg/kg/day<br />
divided q12h<br />
200-400mg x1<br />
then<br />
100mg q24h<br />
Serum Cr 1.6 – 2.5<br />
2.5 mg/kg q24h<br />
200-400mg x1 then<br />
50-100mg q24h<br />
Serum Cr 2.6 +<br />
1.5 mg/kg q36h<br />
200-400mg x1 then<br />
50-100mg q24h<br />
Imipenem/Cilastatin (IV) 500mg q6h 500mg q8h 250mg q6-8h 250mg q12h<br />
Caution: risk <strong>of</strong><br />
seizures<br />
Metronidazole (IV/PO) 500mg q6-8h 500mg q6-8h 500mg q8h 500mg q8-12h<br />
Moxifloxacin (IV/PO) 400mg q24h 400mg q24h 400mg q24h 400mg q24h<br />
Nafcillin (IV) 1-2 g q4-6h 1-2 g q4-6h 1-2 g q4-6h 1-2 g q4-6h<br />
Piperacillin/Tazobactam<br />
(IV)<br />
3.375 g q6h<br />
4.5 g q6h<br />
(Empiric nosocomial<br />
pneumonia, serious<br />
infection, documented<br />
Pseudomonas)<br />
Trimethoprim/ PO 160mg/800mg<br />
Sulfamethoxazole<br />
(TMP/SMX) Other<br />
(IV/PO)<br />
infxns/<br />
Sepsis<br />
q12h<br />
8-12mg/kg/day<br />
divided q12h<br />
PCP<br />
Tx<br />
PCP<br />
Px<br />
15-20mg/kg/day<br />
divided q6-8h<br />
1 DS tab daily or<br />
three times / week<br />
3.375 g q6h<br />
4.5 g q6h<br />
160mg/800mg<br />
q12h<br />
8-12mg/kg/day<br />
divided q12h<br />
15-20mg/kg/day<br />
divided q6-8h<br />
1 DS tab daily or<br />
three times / week<br />
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