IR Acute Hepatitis B
IR Acute Hepatitis B
IR Acute Hepatitis B
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Serologic Markers (cont)<br />
• HBeAg‐ protein marker indicating HBV replication and infectivity<br />
– Associated with high levels of HBV DNA in serum and high rates of<br />
transmission from carrier mothers to babies<br />
– HBeAg seroconversion to anti‐Hbe occurs early in acute HBV, typically<br />
before HBsAg seroconversion to anti anti‐ HBs<br />
– Seroconversion may take months to years in pt with chronic HBV but<br />
indicates decrease of serum HBV DNA and remission<br />
• HBV DNA<br />
– Most assays use real time PCR, reporting in IU/mL<br />
– Recovery from acute hepatitis accompanied by disappearance of HBV<br />
DNA in i serum<br />
– Low levels HBV DNA detectable in the blood for many years
Change language