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Morning Report

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Premature Ovarian Failure<br />

• AKA Primary Ovarian Insufficiency<br />

• Mean age of menopause is 50±4yo<br />

– ‘Premature’ if less than 40yo, amenorrhea ≥ 4 mths &<br />

menopausal-range FSH<br />

• Biopsy not helpful<br />

Turner syndrome<br />

Fragile X syndrome<br />

Chemotherapy<br />

Radiation<br />

Cigarette smoke<br />

Follicle Depletion Follicle Dysfunction<br />

FSH, LH<br />

receptor<br />

mutations<br />

Autoimmunity

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