Ketamine in Chronic Pain - McMaster University
Ketamine in Chronic Pain - McMaster University
Ketamine in Chronic Pain - McMaster University
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Crowley KL, Flores JA, Hughes CN, Iacono RP. Cl<strong>in</strong>ical application of ketam<strong>in</strong>e o<strong>in</strong>tment <strong>in</strong> the treatment of<br />
significant allodynia and hyperalgesia associated with chronic neuropathic pa<strong>in</strong>. J Pharm Comp 1998;2:123<br />
27.<br />
The study <strong>in</strong>volved 5 patients rang<strong>in</strong>g from 25 to 70 years of age. The dose used ranged from 0.093 mg/kg<br />
to 9.33 mg/kg. All reported significant relief of pa<strong>in</strong> and wished to cont<strong>in</strong>ue the therapy. The average<br />
(NAS) score pre-application was 8.8. and post 1.6.<br />
The authors proposed that part of the effect of topical ketam<strong>in</strong>e might lie <strong>in</strong> <strong>in</strong>terruption of<br />
afferent transmission via <strong>in</strong>teractions with local Na+-K+ channels that may reduce centrally<br />
mediated hyperexcitability.<br />
Topical <strong>Ketam<strong>in</strong>e</strong> Gel: Possible Role <strong>in</strong> Treat<strong>in</strong>g Neuropathic Pa<strong>in</strong><br />
1.Arnold Gammaitoni PharmD 1,2 ,<br />
2.Roll<strong>in</strong> M. Gallagher MD, MPH 1,3 ,<br />
3.Maripat Welz-Bosna RN 1,3<br />
Pa<strong>in</strong> Medic<strong>in</strong>e<br />
Volume 1, Issue 1, pages 97–100, March 2000
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