Intensiteitsgemoduleerde Radiotherapie (IMRT) - KCE
Intensiteitsgemoduleerde Radiotherapie (IMRT) - KCE
Intensiteitsgemoduleerde Radiotherapie (IMRT) - KCE
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8 Intensity-modulated radiotherapy <strong>KCE</strong> reports 62<br />
3 CLINICAL DATA<br />
3.1 CLINICAL EFFECTIVENESS<br />
3.1.1 Literature search<br />
3.1.1.1 Methods<br />
A literature search was conducted in January and February 2007 using the following<br />
databases: Medline (Pubmed), Embase, Cochrane. In addition, manufacturers and<br />
distributors of <strong>IMRT</strong> systems were requested to provide any clinical evaluations of their<br />
equipment.<br />
Inclusion criteria<br />
Type of publication: systematic review, meta-analysis, controlled clinical trial. Only<br />
patient efficacy or safety studies comparing <strong>IMRT</strong> with another type of external<br />
radiotherapy for the same target were included. Comparative studies without use of<br />
randomisation, e.g. comparisons with a historical control group, are included with the<br />
limitation that the resulting evidence can be considered supportive at most. Clinical<br />
reports without control group, dosimetric studies, planning studies, animal studies or<br />
studies concerning only technical aspects or phantoms were excluded. The type of<br />
pathology studied did not constitute an exclusion criterion.<br />
Language: reports in English.<br />
Method: full articles were searched only if the title or abstract suggested the report<br />
could be included.<br />
Medline/Pubmed search<br />
"Radiotherapy, Intensity-Modulated"[MeSH] has been included as MESH term only<br />
recently (2006), so the term “Radiotherapy, Conformal”, introduced in 1999, was used.<br />
This MESH term was used in Pubmed Clinical Queries. “Therapy” was used as Clinical<br />
Study Category and the scope was set to broad and sensitive. Only reports published in<br />
2004 and later were considered, as a systematic search had been conducted up to<br />
March 2004 and reported in a HTA report by the Gallician Agency for Health<br />
Technology Assessment. 7 The 4 study reports retained in this HTA report have been<br />
added to our search results.<br />
Pubmed search: (Radiotherapy, Conformal[MeSH]) AND ((clinical[Title/Abstract] AND<br />
trial[Title/Abstract]) OR clinical trials[MeSH Terms] OR clinical trial[Publication Type]<br />
OR random*[Title/Abstract] OR random allocation[MeSH Terms] OR therapeutic<br />
use[MeSH Subheading])<br />
Limits: added to PubMed in the last 3 years. The PubMed search was done on January 4,<br />
2007 and repeated February 8, 2007 for the 2006 period.<br />
Titles and abstracts were scanned and full articles retrieved where clinical outcome<br />
measures were used, at least one treatment arm used <strong>IMRT</strong> and was compared with a<br />
control group.<br />
Embase search (13 februari 2007): ('intensity modulated radiation<br />
therapy'/exp OR 'intensity modulated radiation therapy' OR<br />
'intensity modulated radiotherapy' OR 'imrt') AND (('clinical<br />
trial'/exp OR 'clinical trial') OR (random*) OR ('clinical trial':it))<br />
AND [2004-2007]/py