Docteur de l'université Automatic Segmentation and Shape Analysis ...

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viii with AD. We identify the regions affected by the atrophy in AD by assessing the spatial difference between the control and AD groups at each corresponding landmark. Localized shape analysis is performed on the regions exhibiting significant inter-group difference, which is shown to improve the discrimination ability of the principal component analysis (PCA) based SSM. The principal components describing the localized shape variability among the population are also shown to display stronger correlation with the decline of episodic memory scores linked to the pathology of hippocampus in AD. Keywords : Medical Imaging, Image Analysis, Image Segmentation, multiatlas based segmentation, Shape Analysis, Statistical Shape Model, Hippocampus, Alzheimer’s Disease
TABLE DES MATIÈRES Acknowledgements iii Résumé v Abstract vii 1 Introduction 1 1.1 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.1 Alzheimer’s disease . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.2 Hippocampus and its role in AD . . . . . . . . . . . . . . . 6 1.1.3 MRI in AD studies . . . . . . . . . . . . . . . . . . . . . . . 9 1.1.3.1 MRI . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1.1.3.2 Structural MR in AD . . . . . . . . . . . . . . . . 12 1.2 Plan of the thesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2 Literature Review 17 2.1 Segmentation of hippocampus in MR images . . . . . . . . . . . . . 17 2.1.1 Hippocampal atlases and segmentation protocols . . . . . . 19 2.1.2 Survey of segmentation algorithms . . . . . . . . . . . . . . 23 2.1.2.1 Region growing and deformable models . . . . . . 23 2.1.2.2 Shape and appearance based methods . . . . . . . 24 2.1.2.3 Atlas based methods . . . . . . . . . . . . . . . . . 25 2.1.3 Evaluation of segmentation . . . . . . . . . . . . . . . . . . 29 2.2 Quantitative analysis of shapes . . . . . . . . . . . . . . . . . . . . 30 2.2.1 Representation of shapes . . . . . . . . . . . . . . . . . . . . 32 2.2.2 Alignment of point sets . . . . . . . . . . . . . . . . . . . . 33 2.2.3 Establishment of correspondence . . . . . . . . . . . . . . . 35 2.2.4 Dimension reduction . . . . . . . . . . . . . . . . . . . . . . 37 2.3 Measuring the hippocampal atrophy . . . . . . . . . . . . . . . . . 37 2.3.1 Volume measurement . . . . . . . . . . . . . . . . . . . . . . 38 2.3.2 Shape analysis . . . . . . . . . . . . . . . . . . . . . . . . . 39 2.4 Approach adopted in this thesis . . . . . . . . . . . . . . . . . . . . 40 ix
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144 LIST OF PUBLICATIONS using dive
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146 BIBLIOGRAPHY Alzheimer, A. (191
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148 BIBLIOGRAPHY Baillard, C., Hell
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150 BIBLIOGRAPHY of post mortem mag
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152 BIBLIOGRAPHY B. (2008). Three-d
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154 BIBLIOGRAPHY Cootes, T. F., Tay
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156 BIBLIOGRAPHY head in MR images
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158 BIBLIOGRAPHY Evans, A. C., Coll
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BIBLIOGRAPHY 161 Ghanei, A., Soltan
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BIBLIOGRAPHY 163 Heckemann, R. A.,
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BIBLIOGRAPHY 165 R. C. (2003). MRI
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BIBLIOGRAPHY 167 Konrad, C., Ukas,
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BIBLIOGRAPHY 169 Mahony, R. and Man
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BIBLIOGRAPHY 171 disease, mild cogn
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BIBLIOGRAPHY 173 Petersen, R. C., S
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BIBLIOGRAPHY 175 Rorden, C. and Bre
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BIBLIOGRAPHY 177 Shen, K., Bourgeat
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BIBLIOGRAPHY 179 Barillot, C., Hayn
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BIBLIOGRAPHY 181 Tzourio-Mazoyer, N
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BIBLIOGRAPHY 183 Vos, F. M., de Bru
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BIBLIOGRAPHY 185 Woolrich, M. W., J
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