Is there a place for conservative management of CIN2? - National ...

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NCSP independent monitoring report july‐dec 2009
Adverse pregnancy outcomes associated with treatment CIN 3. Adjusted odds ratios (95% CI) <strong>for</strong> the association between cervical procedures and extremely, very, and moderate spontaneous preterm delivery Variable All deliveries (n) a Extremely pretermb (n = 1373) n Odds ratio e (95%) Very pretermc (n = 1665) n Odds ratio e (95%) Moderately pretermd (n = 16,011) n Odds ratio e (95%) LEEP vs no LEEP No LEEP 544,498 1323 1.00 1596 1.00 15,600 1.00 LEEP 8,180 50 3.16 (2.27- 4.40) 69 3.28 (2.56- 4.19) 411 1.89 (1.71- 2.09) Selected procedures vs no procedures No procedure 510,841 1212 1.00 1465 1.00 14,429 1.00 Biopsy 31,630 105 1.28 (1.00- 1.64) 120 Ablation 2,027 6 1.20 (0.44- 3.29) 11 LEEP 8,180 50 3.23 (2.32- 4.50) 69 Noehr. LEEP and spontaneous preterm delivery. Am J Obstet Gynecol 2009. a N = 552,678; 1.32 (1.09- 1.60) 1.91 (1.05- 3.47) 3.37 (2.63- 4.30) 1093 78 411 1.27 (1.19- 1.35) 1.35 (1.08- 1.70) 1.93 (1.74- 2.14) e adjusted <strong>for</strong> calendar time, maternal age at delivery, smoking during pregnancy, and marital status during pregnancy.
Page 1 and 2: Peter Sykes NCSP Colposcopy Symposi
Page 3: Aims /outcome measures Study Aims
Page 7 and 8: • Peter Sykes, Bryony Simcock •
Page 9: How did we get here • Known regre
Page 13 and 14: Very low risk of cancer under the a
Page 15 and 16: Regression of CIN2 authour date Reg
Page 17 and 18: findings • 452 women under 25 wit
Page 19 and 20: Conservative management greater tha
Page 21 and 22: Currently HPV status most predictiv
Page 23 and 24: Biopsy correlates poorly with loop
Page 25: My opinion • Many young women wit

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