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Supplemental Figure 6: S100Z locus synteny. S100Z genes are shown in red. Syntenic
genes found in at least two mammalian genomes are shown in grey. Gene polygons point in
transcriptional orientation. Black lines denote intergenic space where no other genes were
detected, except where blocks of genes inserted below. Dashed arrow highlight a syntenic
gene that has been translocated. Orthologs between species are vertically aligned and
distances are not to scale.
Supplemental Figure 7: Pairwise identity matrix for mammalian S100A7 loci. Number of
predicted amino acid substitutions per site using a Dayhoff matrix based model analyzing 108
positions between 12 sequences. Darker pink in the heatmap indicates greater divergence
between the two sequences.
Supplemental Figure 8: Amino acid alignments for mammalian S100A7 loci. Amino acid
sequences of mammalian S100A7 family members. Dashes indicate gaps inserted for
alignment to other family members. The S100 (pseudo) EF-hand Ca 2+ binding loop is in dark
blue, the C-terminal EF-hand Ca 2+ binding loop in light blue, the linker region connecting the EF-
hands in green, alpha-helices in black, and non-helical regions in gray.
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