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Biochemical and laboratory aspects of purine and ... - ERNDIM

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Uric acid: Gout / Stones / Hyperuricaemia:<br />

Ranges are critical!<br />

Urate fractional excretion on a creatinine basis (FEur)<br />

is both age <strong>and</strong> sex dependant.<br />

Diagnosis: Normal age+sex vs:<br />

-primary (age-onset) gout<br />

-familial juvenile hyperuricemic nephropathy<br />

(under-diagnosed!)<br />

-iatrogenic gout (drug induced,<br />

including vitamin C)<br />

-associated with other metabolic<br />

disease, e.g., MMA<br />

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