Neisseria meningitidis - Eurosurveillance

More documents

Recommendations

Info

Figure 3 Detection of mutations in the haemagglutinin gene (HA1) through the course of illness in influenza A(H1N1)pdm09 cases with serial samples, Norway, 2009/10 Case number 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Day of illness Eb Endobronchial brush La Lung autopsy tissue Np Nasopharyngeal sample Pf Pleural fluid Ts Tracheal sample Amino acid substitution – D: aspartic acid; G: glycine; N: asparagine. Genotype changes are shown by arrows. Upper-airway specimen Lower-airway specimen Fatality 66 www.eurosurveillance.org
Of the 13 patients with 222G mutant viruses, we had two or more serial samples available for five (Figure 3). In four of these patients (Cases 2, 5, 6 and 8 in Figure 3), we found only 222D wild type viruses in samples preceding detection of 222G mutant virus. In one patient (Case 1 in Figure 3), both available samples contained 222G mutant virus, but the samples were taken only one day apart, thus reducing the chance of finding differing genotypes. We also had serial samples for three additional non-222G patients (Cases 3, 4 and 7 in Figure 3) who exhibited the same genotype throughout the course of illness (either 222D or 222N). The date of symptom onset was given for 263 cases: 212 mild, 33 severe non-fatal and 18 fatal. Specimens from the mild cases tended to be collected earlier in the course of illness (mean: 4.3 days after symptom onset; 95% CI: 3.7–4.9) than specimens collected from all severe cases, including fatal cases (mean: 6.5 days; 95% CI: 5.2–7.8) (p=0.001, Mann–Whitney U test). The proportion of 222G mutant viruses was higher in specimens collected late (≥8 days after symptom onset) than in those collected early (
Page 2:
Editorial team Editorial advisors B
Page 5 and 6:
genome sequencing technologies, we
Page 7 and 8:
References 1. Struelens MJ, De Ghel
Page 9 and 10:
e procedures in place to check and
Page 11 and 12:
microorganisms [23]. After PCR, amp
Page 13 and 14:
of the based upon repeat patterns (
Page 15 and 16:
two days. Due to a very high accura
Page 17 and 18: eported a clinically meaningful app
Page 19 and 20: 18. Chang HL, Tang CH, Hsu YM, Wan
Page 21 and 22: from: http://www.eurosurveillance.o
Page 23 and 24: Table 1 Online molecular typing dat
Page 25 and 26: Table 2 Currently available softwar
Page 27 and 28: Current concepts and technologies f
Page 29 and 30: References 1. Hesper B, Hogeweg P.
Page 31 and 32: Review articles Automated extractio
Page 33 and 34: diverse organisms, such as the meni
Page 35 and 36: Figure 2 Extracting antigen and ant
Page 37 and 38: Figure 3 Relationships of 139 Neiss
Page 39 and 40: 25. Wirth T, Hildebrand F, Allix-B
Page 41 and 42: Euroroundups Use of multilocus vari
Page 43 and 44: searches were also repeated using G
Page 45 and 46: Table 2 MLVA analysis of Salmonella
Page 47 and 48: anthracis [15], worldwideadopted, b
Page 49 and 50: As MLVA assays rely on the informat
Page 51 and 52: Research articles Current applicati
Page 53 and 54: Table 2 Techniques, time and costs
Page 58 and 59: common C. difficile variants causin
Page 60 and 61: References 1. Bartlett JG. Antibiot
Page 62 and 63: Research articles Within-patient em
Page 64 and 65: Figure 1 Phylogenetic reconstructio
Page 66: Table 2 Prevalence of haemagglutini
Page 71 and 72: of virulence, such a mechanism may
Page 73 and 74: Research articles Molecular epidemi
Page 75 and 76: Table 1 Most frequently observed Ne
Page 78 and 79: G1407 in Denmark, Romania, Slovakia
Page 80 and 81: Treatment failure in patients infec
Page 82 and 83: 31. Buono S, Wu A, Hess DC, Carlson
Page 84 and 85: Irish Mycobacteria Reference Labora
Page 86: Table 2 Clusters of Mycobacterium t
Page 89 and 90: multifunctional database for online
Page 93 and 94: of a laboratory network, which also
Page 95 and 96: References 1. Bean NH, Martin SM. I
Page 97 and 98: Mebendazole was first administered
Page 99 and 100: Figure 4 Neighbour-joining tree bas
Page 101 and 102: Acknowledgments We gratefully thank
Page 103: epidemiologically relevant variants
Page 106 and 107: as possible to be performed with si
Page 108 and 109: Perspectives The need for ethical r
Page 110 and 111: ‘voluntary’, and ‘decisionall
Page 112 and 113: Perspectives Molecular-based survei
Page 114 and 115: Figure 2 Human cases of campylobact
Page 116 and 117: an integrated way [36,37]. This may
Page 118 and 119:
21. Jolley KA, Bliss CM, Bennett JS
Page 120 and 121:
News ECDC starts pilot phase for co
Page 122 and 123:
Poland Meldunki o zachorowaniach na
Page 124 and 125:
122 www.eurosurveillance.org
show all

Neisseria meningitidis - Eurosurveillance

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?