Bioisosteres & Validation
Bioisosteres & Validation
Bioisosteres & Validation
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Goal of exercise<br />
• Show that this strategy for bioisostere<br />
identification can help in compound<br />
optimization.<br />
• Validate<br />
– <strong>Bioisosteres</strong><br />
– Similarity method<br />
– Database<br />
• Concept<br />
• Robust<br />
• Limitations<br />
CUP VIII, Santa Fe, Feb 2007