NIHR HTA PROGRAMME - NIHR Health Technology Assessment ...
NIHR HTA PROGRAMME - NIHR Health Technology Assessment ...
NIHR HTA PROGRAMME - NIHR Health Technology Assessment ...
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Date<br />
Place<br />
Present Members<br />
NETSCC Secretariat<br />
Observers<br />
Apologies<br />
<strong>NIHR</strong> <strong>HTA</strong> <strong>PROGRAMME</strong><br />
<strong>HTA</strong> Surgery Themed Call Board<br />
Minutes of Full Proposal Meeting<br />
Tuesday 12 and Wednesday 13 March 2013<br />
Danubius Hotel Regents Park, London<br />
Professor Steve Goodacre (Chair)<br />
Professor Hywel Williams (Deputy Chair)<br />
Professor Amanda Farrin<br />
Professor Gordon Murray<br />
Professor Simon Dixon<br />
Professor Jane Blazeby<br />
Professor Matthew Costa<br />
Professor Paula Ghaneh<br />
Professor Hisham Mehanna<br />
Professor Thanos Athanasiou<br />
Professor Rod Taylor<br />
Professor Freddie Hamdy<br />
Professor James Mason<br />
Professor Dion Morton<br />
Professor Ceri Phillips<br />
Professor Andrew Bradbury<br />
Professor Sam Eljamel<br />
Ms Lynda Wyld<br />
Professor Ken Stein<br />
Professor John Scholefield<br />
Professor Tom Walley (Director, <strong>HTA</strong> Programme)<br />
Dr Peter Davidson (Director, NETSCC <strong>HTA</strong>)<br />
Dr Nick Hicks (Consultant Advisor)<br />
Dr Sarah Puddicombe (Assistant Director)<br />
Mrs Fay Habens (Programme Manager)<br />
Mrs Andrea Ingram (Assistant Programme Manager)<br />
N/A<br />
Professor John Scholefield (Day 2 Only)<br />
Professor Simon Dixon (Day 2 Only)<br />
Professor Jane Blazeby (Day 2 Only)<br />
<strong>HTA</strong> Surgery Themed Call<br />
1
Discussion of Surgery Full Proposals<br />
<strong>HTA</strong> Surgery Themed Call<br />
Hutchinson (12/35/57): Randomised Evaluation of Surgery with Craniectomy for<br />
patients Undergoing Evacuation of Acute Subdural Haematoma (RESCUE-ASDH)<br />
Professor Goodacre chaired. Professor Morton and Professor Murray left the room.<br />
The board discussed the proposal and wished to see a resubmission.<br />
Goldberg (12/35/27): Total Ankle Replacement Versus Ankle Arthrodesis (TARVA)<br />
trial: A pragmatic, randomised controlled trial to assess clinical and cost<br />
effectiveness, with an internal feasibility phase.<br />
Professor Goodacre chaired.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Theologis (12/35/36): A Pragmatic Randomised Controlled Multi-Centre Trial of<br />
Minimally-Invasive versus Conventional Multi-level Surgery in Children with Cerebral<br />
Palsy<br />
Professor Goodacre chaired. Professor Hamdy left the room<br />
The board discussed the proposal and declined it.<br />
Young (12/35/01): Scaldcare: Does surgical management using biosynthetic skin<br />
substitutes for small scalds in young children decrease the rate of skin grafting<br />
compared to traditional non-surgical treatment and is it cost effective?<br />
Dr Davidson chaired. Professor Goodacre, Professor Williams, Professor Scholefield,<br />
Professor Blazeby, Professor Morton, Professor Mehanna and Ms Wyld left the room.<br />
The board discussed the proposal and declined it.<br />
Goyal (12/35/17): POSNOC - POsitive Sentinel NOde: adjuvant therapy alone versus<br />
adjuvant therapy plus Clearance or axillary radiotherapy: A randomised controlled<br />
trial of axillary treatment in women with early stage breast cancer who have<br />
metastases in one or two sentinel nodes.<br />
Dr Davidson chaired. Professor Williams, Professor Scholefield and Ms Wyld left the room.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Hamdy (12/35/54): A randomised controlled trial of Partial prostate Ablation versus<br />
Radical prosTatectomy (PART) in intermediate risk unilateral clinically localised<br />
prostate cancer.<br />
Professor Williams chaired. Professor Blazeby, Professor Hamdy and Ms Wyld left the<br />
room.<br />
The board discussed the proposal and wished to see a resubmission.<br />
Bradbury (12/35/45): Multicentre randomised controlled trial to compare the clinical<br />
and cost-effectiveness of a ‘vein bypass first’ with an ‘best endovascular first’<br />
revascularisation strategy for severe limb ischaemia due to infrageniculate arterial<br />
disease (Bypass v Angioplasty in Severe Ischaemia of the Leg,BASIL-2)<br />
Professor Williams chaired. Professor Bradbury, Professor Morton and Professor Mehanna<br />
2
left the room.<br />
<strong>HTA</strong> Surgery Themed Call<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Tucker (12/35/44): Transabdominal versus Conventional Transthoracic Pleural Drain<br />
Insertion at Oesophagectomy for Resectable Oesophageal and Gastrooesophageal<br />
Junctional Cancer (TATT)<br />
Professor Goodacre chaired. Professor Morton, Professor Bradbury, Professor Blazeby<br />
and Professor Mehanna left the room. Professor Walley joined the meeting.<br />
The board discussed the proposal and declined it.<br />
Philpott (12/35/49): A systematic review, economic evaluation and value of<br />
information analysis of medical and surgical treatments for chronic rhinosinusitis<br />
Professor Goodacre chaired. Professor Scholefield left the meeting.<br />
The board discussed the proposal and declined it.<br />
<strong>HTA</strong> Surgery Themed Call Board<br />
Day 2<br />
Discussion of Surgery Full Proposals<br />
King (12/35/38): Treatment of Advanced Glaucoma Study (TAGS): A multicentre<br />
randomised controlled trial comparing primary medical treatment with primary<br />
trabeculectomy for people with newly diagnosed advanced glaucoma<br />
Professor Goodacre chaired. Professor Williams left the room.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Charteris (12/35/64): A randomised controlled trial of adjunctive intraocular and<br />
periocular steroid (triamcinolone acetonide) versus standard treatment in eyes<br />
undergoing vitreoretinal surgery for open globe trauma<br />
Professor Goodacre chaired.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Francis (12/35/58): No Surgery Trial: Can early breast cancer patients safely avoid<br />
surgery following a pCR (pathological Complete Response) resulting from neoadjuvant<br />
anti-HER2 therapy with chemotherapy, confirmed by multiple ultrasound<br />
directed biopsies?<br />
Professor Williams chaired. Professor Morton, Ms Wyld, Professor Bradbury, Professor<br />
Murray and Professor Mehanna left the room.<br />
The board discussed the proposal and declined it.<br />
Powell (12/35/22): STAT: Small Thoracic Aneurysm Trial<br />
3
Professor Williams chaired. Professor Athanasiou left the room.<br />
The board discussed the proposal and declined it.<br />
<strong>HTA</strong> Surgery Themed Call<br />
Jayne (12/35/07): A randomised comparison of the Fenix® magnetic anal sphincter<br />
versus sacral nerve stimulation for adult faecal incontinence.<br />
Professor Williams chaired. Professor Farrin and Ms Wyld left the room.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Hashim (12/35/15): A randomised controlled trial to determine the clinical and cost<br />
effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP)<br />
versus transurethral resection of the prostate (TURP) in the National <strong>Health</strong> Service<br />
(NHS).<br />
Professor Williams chaired.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Bundred (12/35/50): A randomised controlled trial testing the effect of primary<br />
endocrine therapy on re-excision and reoperation rates amongst women treated for<br />
postmenopausal hormone receptor positive ductal carcinoma in situ (DCIS)<br />
Professor Williams chaired. Professor Murray and Professor Walley left the room.<br />
The board discussed the proposal and declined it.<br />
Bhattacharya (12/35/23): A multicentre randomised controlled trial comparing<br />
laparoscopic supra-cervical hysterectomy with second generation endometrial<br />
ablation for the treatment of heavy menstrual bleeding (HEAT)<br />
Professor Goodacre chaired.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Luyt (12/35/61): Surgical drainage, irrigation, and fibrinolytic therapy (DRIFT) in<br />
premature infants with post-haemorrhagic ventricular dilatation: Brain function and<br />
structure at school age<br />
Professor Goodacre chaired.<br />
The board discussed the proposal and declined it.<br />
Post meeting note: Following a post board review a resubmission was invited.<br />
Torkington (12/35/29): Hughes Abdominal Repair Trial - abdominal wall closure<br />
technique to reduce incidence of incisional hernias: multi-centre pragmatic<br />
randomised trial<br />
Professor Goodacre chaired. Professor Phillips left the room.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
Paleri (12/35/32): A feasibility randomised controlled trial of pre-treatment<br />
gastrostomy tube versus oral feeding plus as-needed nasogastric tube feeding in<br />
4
<strong>HTA</strong> Surgery Themed Call<br />
patients undergoing chemoradiation for head and neck cancer (TUBE trial)<br />
Professor Goodacre chaired.<br />
The board discussed the proposal and recommended it for funding, subject to certain<br />
conditions.<br />
McDaid (12/35/02): Primary shoulder replacement surgery for people with arthritis: a<br />
systematic review and decision model<br />
Professor Goodacre chaired. Professor Mason left the room.<br />
The board discussed the proposal and declined it.<br />
Close of meeting.<br />
5
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