Isagel® FM Alginate - FMC Corporation

MATERIAL SAFETY DATA SHEET
Isagel® FM Alginate
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MSDS Ref. No.: 3210101
Date Approved: 07/07/2006
Revision No.: 4
This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication
Standard, 29 CFR 1910.1200; the Canada’s Workplace Hazardous Materials Information System (WHMIS)
and, the EC Directive, 2001/58/EC.
1. PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME: Isagel® FM Alginate
CHEMICAL FAMILY: Polysaccharides
SYNONYMS: Diatomaceous earth (INCI name): amorphous silica; Sodium
alginate: Algin (INCI name), alginic acid, sodium salt; Calcium
sulfate (INCI name): Terra alba, gypsum, native calcium sulfate;
Tetrasodium pyrophosphate (INCI name): TSPP, sodium
pyrophosphate, tetrasodium diphosphate
GENERAL USE: Cosmetics
MANUFACTURER
FMC BioPolymer
1735 Market Street
Philadelphia, PA 19103
(800) 526-3649 (General Information)
FMC Europe NV
Avenue Mounier 83
1200 Brussels, Belgium
+32 2 / 775 8311 (General Information)
2. HAZARDS IDENTIFICATION
EMERGENCY TELEPHONE NUMBERS
+47 / 32 30 3500 (FMC Plant - Drammen, Norway)
(303) 595-9048 (Medical - U.S. - Call Collect)
For leak, fire, spill, or accident emergencies, call:
(800) 424-9300 (CHEMTREC - U.S.A. & Canada)
(703) 527-3887 (CHEMTREC - All Other Countries)
EMERGENCY OVERVIEW:
• White to yellowish, almost odorless, free-flowing powder.
• Powder becomes slippery when wet.
• Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and
dispersed.

Isagel® FM Alginate (3210101) Date: 07/07/2006
POTENTIAL HEALTH EFFECTS: This product may be severely irritating to the eyes. It
may also cause irritation of the skin and respiratory tract. May cause drying and abrasive effects of the skin.
3. COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name CAS# Wt.% EC No. EC Class
Diatomaceous earth (silica,
amorphous)
61790-53-2 None Not classified as hazardous
Sodium alginate 9005-38-3 None Not classified
Calcium Sulfate, dihydrate 10101-41-4 None Not classified
Tetrasodium Pyrophosphate 7722-88-5 231-767-1 Not classified
4. FIRST AID MEASURES
EYES: Immediately flush with water for at least 15 minutes, lifting the upper and lower eyelids
intermittently. See a medical doctor or ophthalmologist immediately.
SKIN: Wash with plenty of soap and water. Get medical attention if irritation occurs and persists.
INGESTION: Drink 1 or 2 glasses of water. Never give anything by mouth to an unconscious
person. If any discomfort persists, obtain medical attention.
INHALATION: Remove to fresh air. If breathing difficulty or discomfort occurs and persists, obtain
medical attention.
NOTES TO MEDICAL DOCTOR: This product is expected to have low oral, dermal and
inhalation toxicity. It may be severely irritating to the eyes (including corneal opacities). It may also be
irritating to the skin and upper respiratory tract. Repeated or prolonged contact with diatomaceous earth
may have a drying and abrasive effect on the skin. Particulates may casue eye irritation due to mechanical
action. Exposure to high inhalation concentrations may cause physical discomfort of the upper respiratory
tract with coughing. Ingestion of large quantities of alginates may cause intestinal obstruction. Aspiration
or inhalation of alginates could cause chemical pneumonitis. Ingestion of TSPP may be associated with
nausea or vomiting, salivation, diarrhea, occasional abdominal discomfort and intestinal distention. Large
doses of phosphates are laxatives. Treatment is symptomatic and supportive.
5. FIRE FIGHTING MEASURES
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Isagel® FM Alginate (3210101) Date: 07/07/2006
EXTINGUISHING MEDIA: Water, foam, dry chemical, CO2
FIRE / EXPLOSION HAZARDS: As with most organic materials, excessive accumulation
of dust on overhead structures may produce explosive concentrations when disturbed and dispersed by a
small explosion that shakes down accumulated dust and causes, momentarily, an ignitable concentration.
Product will burn when in contact with a flame, but self-extinguishes when ignition source is removed.
FIRE FIGHTING PROCEDURES: None. Treat as ''Class A'' fire. Once ignited, the
product tends to smolder.
FLAMMABLE LIMITS: Not applicable
6. ACCIDENTAL RELEASE MEASURES
RELEASE NOTES: Powder becomes slippery when wet. Maintain good housekeeping practices
to minimize accumulation of settled dust, especially on overhead surfaces. Sweep up the spilled material
and dispose of in accordance with the waste disposal method outlined in Section 13, "Disposal
Considerations" below. Refer to Section 8 "Exposure Controls / Personal Protection" for appropriate
personal protective equipment.
7. HANDLING AND STORAGE
HANDLING AND STORAGE: Use local exhaust or general dilution ventilation to control
exposure to dust. Always use safe lifting techniques when manually moving containers, especially when
handling containers weighing more than 50 pounds (22.7 kg). To protect quality, store in a tight container
in a dry place. Avoid exposure to excessive heat. Keep material out of lakes, streams, ponds and sewer
drains.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE LIMITS
Chemical Name ACGIH OSHA Supplier
Diatomaceous earth
(silica, amorphous)
3 mg/m 3 (TWA)
(respirable fraction)
10 mg/m 3 (STEL)
(inhalable fraction)
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80 mg/m 3 (PEL)

Isagel® FM Alginate (3210101) Date: 07/07/2006
Chemical Name ACGIH OSHA Supplier
Calcium Sulfate,
dihydrate
Tetrasodium
Pyrophosphate
10 mg/m 3 (TWA)
(inhalable dust)
5 mg/m 3 (TWA)
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15 mg/m 3 (PEL)
(inhalable dust)
5 mg/m 3 (PEL)
(respirable dust)
5 mg/m 3 (PEL)
ENGINEERING CONTROLS: Use local exhaust, which is sufficient enough to remove
airborne dust.
PERSONAL PROTECTIVE EQUIPMENT
EYES AND FACE: Whenever airborne dust concentrations are high, appropriate
protective eyewear, such as mono-goggles, should be worn to prevent eye contact.
RESPIRATORY: Whenever dust in the worker's breathing zone cannot be controlled with
ventilation or other engineering means, workers should wear respirators or dust masks approved by
NIOSH/MSHA, EU CEN or comparable certification organization to protect them against airborne
dust.
PROTECTIVE CLOTHING: No special clothing is required; however, all work
clothing should be laundered before reuse.
GLOVES: No special gloves are required; however, if gloves are worn, the outside of the
gloves should be washed thoroughly with soap and water after use.
COMMENTS:
ADDITIONAL EXPOSURE LIMITS:
Diatomaceous earth:
Australia (TWA) 10 mg/m³
Australia MAK: 4 mg/m 3
China (STEL): 10 mg/m³ (total dust)
Germany MAK: 4 mg/m 3
Hong Kong (TWA): 10 mg/m³
Korea (TWA): 10 mg/m³
Singapore (PEL): 10 mg/m³
Switzerland MAK: 4 mg/m 3
United Kingdom TWA: 1.2 mg/m 3 (total respirable dust)
Calcium sulfate:
China (STEL): 10 mg/m³ (total dust)
China (TWA): 8 mg/m³ (respirable dust)
France (TWA) 10 mg/m³
United Kingdom (OES): 10 mg/m³ (total inhalable dust); 4 mg/m³ (respirable dust)

Isagel® FM Alginate (3210101) Date: 07/07/2006
Tetrasodium pyrophosphate:
Australia (TWA) 10 mg/m³
Belgium (TWA) 10 mg/m³
France (TWA): 5 mg/m³
Germany (TWA): 5 mg/m³
Singapore (PEL): 5 mg/m³
Switzerland (TWA): 5 mg/m³
United Kingdom (TWA): 5 mg/m³
9. PHYSICAL AND CHEMICAL PROPERTIES
ODOR: Almost odorless
APPEARANCE: White to yellowish, free-flowing powder
AUTOIGNITION TEMPERATURE: > 200 °C (> 392 °F)
BOILING POINT: None volatile
EVAPORATION RATE: (Butyl acetate = 1) Not applicable
FLASH POINT: Not applicable
MELTING POINT: Not available
PERCENT VOLATILE: Not available
pH: 8.0 - 10.0 (1% solution)
SOLUBILITY IN WATER: Slowly soluble, forming a viscous, colloidal solution
VAPOR DENSITY: Not available
VAPOR PRESSURE: Not available
COMMENTS:
EXPLOSIVE PROPERTIES: Not applicable
10. STABILITY AND REACTIVITY
CONDITIONS TO AVOID: Strong oxidizing agents, high temperatures and
high humidity levels.
STABILITY: Stable
POLYMERIZATION: Will not occur
INCOMPATIBLE MATERIALS: Diatomaceous earth: bases, halogens, acids, metal
salts, oxidizing materials, combustible materials.
HAZARDOUS DECOMPOSITION PRODUCTS: None known
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Isagel® FM Alginate (3210101) Date: 07/07/2006
11. TOXICOLOGICAL INFORMATION
EYE EFFECTS: No data available for the formulation.
Diatomaceous earth (silica, amorphous): May cause irritation (species unknown)
Sodium alginate: Non-irritating (rabbit)
TSPP: Extremely irritating (unwashed eyes) (rabbit) Minimally irritating (washed eyes, rabbits)
SKIN EFFECTS: No data available for the formulation.
Sodium alginate: Non-irritating (rabbit)
TSPP: Non-irritating (rabbit)
DERMAL LD50: No data available for the formulation.
TSPP: > 2,000 mg/kg (rabbit)
ORAL LD50: No data available for the formulation.
Diatomaceous earth (silica, amorphous): 3,160 mg/kg (rat)
Sodium alginate: > 5,000 mg/kg (rat)
TSPP: 4,000 mg/kg (rat)
INHALATION LC50: No data available for the formulation.
Sodium alginate: 4.72 mg/l (1 h) (rat)
SENSITIZATION: No data available for the formulation.
Sodium alginate: (Skin) Non-sensitizing (guinea pig)
ACUTE EFFECTS FROM OVEREXPOSURE: This product is expected to have low
oral, dermal and inhalation toxicity. It may be severely irritating to the eyes (including corneal opacities).
It may also be irritating to the skin and upper respiratory tract. Repeated or prolonged contact with
diatomaceous earth may have a drying and abrasive effect on the skin. Particulates may casue eye irritation
due to mechanical action. Exposure to high inhalation concentrations may cause physical discomfort of the
upper respiratory tract with coughing. Ingestion of large quantities of alginates may cause intestinal
obstruction. Aspiration or inhalation of alginates could cause chemical pneumonitis. Ingestion of TSPP
may be associated with nausea or vomiting, salivation, diarrhea, occasional abdominal discomfort and
intestinal distention. Large doses of phosphates are laxatives.
CHRONIC EFFECTS FROM OVEREXPOSURE: No data available for the
formulation. A study of workers exposed for more than five years to diatomaceous earth revealed no
significant pulmonary X-ray changes. Silicosis, in one case characterized as mild, was reported to be found
in two groups of crude diatomite workers. The International Agency for Research on Cancer (IARC) has
classified amorphous silica as having inadequate evidence for carcinogenicity to humans and experimental
animals. Sodium alginate showed no adverse effects in chronic studies when administered in the diet (5 -
15%). The Joint WHO/FAO Expert Committee on Food Additives (JECFA) has granted an Acceptable
Daily Intake (ADI) of "not specified" (no upper limit), the best possible classification for food additives
(JECFA, 39th session of 23/12 February 1992). No further data are available. Calcium sulfate was not
mutagenic in the Ames assay. TSPP was negative in the Ames assay. Excessive, sub-chronic, exposures to
high levels of TSPP have been shown to cause kidney damage in laboratory animals.
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Isagel® FM Alginate (3210101) Date: 07/07/2006
CARCINOGENICITY:
Chemical Name IARC NTP OSHA Other
Diatomaceous earth (silica, See "Chronic Not listed Not listed (ACGIH) Not listed
amorphous)
Effects"
above
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL DATA: No data available for the formulation. Inorganic compounds in
contact with the soil, sub-surface or surface waters may be taken up by plants and utilized as essential
nutrients. Phosphates may also form precipitates, usually with calcium or magnesium. The resultant
compounds are insoluble in water and become a part of the soil or sediment. The term biodegradability, as
such, is not applicable to inorganic compounds.
ECOTOXICOLOGICAL INFORMATION: No data available for the formulation.
Sodium alginate is biodegradable.
TSPP:
96-hour LC50 > 100 mg/L (non-toxic) (rainbow trout, inland silversides, mysid shrimp) (low toxicity)
48-hour EC50 > 100 mg/L (non-toxic) (daphnia magna) (low toxicity)
13. DISPOSAL CONSIDERATIONS
DISPOSAL METHOD: No special disposal methods are suggested. It is the user's responsibility
to comply with all applicable local, state, and federal laws, rules, regulations and standards.
Sodium alginate:
NOTE: Handle as a non-hazardous material
BOD(5) : approximately 4000 - 5000 mgO/l
COD : approximately 6000 - 7000 mgO/l
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION (DOT)
MARINE POLLUTANT: None
ADDITIONAL INFORMATION: Not listed in Title 49 of the U.S. Code of
Federal Regulations as a hazardous
material.
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Isagel® FM Alginate (3210101) Date: 07/07/2006
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Stabilizer / emulsifier; water soluble, dry
INTERNATIONAL MARITIME DANGEROUS GOODS (IMDG)
ADDITIONAL INFORMATION: Not regulated
ADR - EUROPEAN AGREEMENT CONCERNING THE
INTERNATIONAL CARRIAGE OF DANGEROUS GOODS BY ROAD
ADDITIONAL INFORMATION: Not regulated
INTERNATIONAL CIVIL AVIATION ORGANIZATION (ICAO) /
INTERNATIONAL AIR TRANSPORT ASSOCIATION (IATA)
ADDITIONAL INFORMATION: Not regulated
OTHER INFORMATION:
Canada (TDG) : Not applicable
15. REGULATORY INFORMATION
UNITED STATES
SARA TITLE III (SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT)
SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355, APPENDIX A):
Not listed
SECTION 311 HAZARD CATEGORIES (40 CFR 370):
Not applicable
SECTION 312 THRESHOLD PLANNING QUANTITY (40 CFR 370):
The Threshold Planning Quantity (TPQ) for this product, if treated as a mixture, is 10,000 lbs;
however, this product contains the following ingredients with a TPQ of less than 10,000 lbs.:
None
SECTION 313 REPORTABLE INGREDIENTS (40 CFR 372):
This product does not contain any toxic chemicals subject to the reporting requirements of
Section 313, Title III of the SARA (Superfund Amendments and Reauthorization Act) of
1986.

Isagel® FM Alginate (3210101) Date: 07/07/2006
CERCLA (COMPREHENSIVE ENVIRONMENTAL RESPONSE COMPENSATION AND
LIABILITY ACT)
CERCLA DESIGNATION & REPORTABLE QUANTITIES (RQ) (40 CFR 302.4):
Not listed
TSCA (TOXIC SUBSTANCE CONTROL ACT)
TSCA INVENTORY STATUS (40 CFR 710):
Listed (all components, plus anhydrous calcium sulfate)
U.S. STATES
CANADA
U.S. State Regulation:
States with Right-to-Know Statutes:
Tetrasodium pyrophosphate: CA, MA, MN, NJ, NC, PA, RI
WHMIS (WORKPLACE HAZARDOUS MATERIALS INFORMATION SYSTEM):
Chemical Name: TSPP
Product Identification Number: 2811
Hazard Classification / Division: Class D, Div. 2, Subdiv. B. (Toxic)
Ingredient Disclosure List: Listed
Domestic Substance List: Listed (all components, plus anhydrous calcium sulfate)
E NUMBERS:
E 401 (sodium alginate)
E 516 (calcium sulfate)
E 450(iii) (tetrasodium pyrophosphate)
INTERNATIONAL LISTINGS
Diatomaceous earth
Australia (AICS): Listed
China: Listed
Korea: KE-21794
Philippines (PICCS): Listed
Sodium alginate
Australia (AICS): Listed
China: Listed
Japan (ENCS): (8)-237
Korea: KE-00492
Philippines (PICCS): Listed
Calcium sulfate, dihydrate
Australia (AICS): Listed
China: Listed
Philippines (PICCS): Listed
TSPP
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Isagel® FM Alginate (3210101) Date: 07/07/2006
Australia (AICS): Listed
China: Listed
Japan (ENCS): (1)-497
Korea: KE-33702
Philippines (PICCS): Listed
16. OTHER INFORMATION
NFPA
Health 2
Flammability 1
Reactivity 0
Special None
No special requirements
NFPA = National Fire Protection Association
Degree of Hazard Code:
4 = Extreme
3 = High
2 = Moderate
1 = Slight
0 = Insignificant
REVISION SUMMARY:
This MSDS replaces Revision #3, dated October 01, 2004.
Changes in information are as follows:
Section 1 (Product and Company Identification)
Section 15 (Regulatory Information)
Section 16 (Other Information)
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