AN INTRODUCTION TO RECOMBINATION AND LINKAGE ANALYSIS

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Multilocus Linkage Analysis(4) Under the NI assumption, reduced to to a pairwise analysis of recombination between adjacent markers. Estimate order by maximize the appropriate likelihood under each of the candidate orders Problems – Humans cannot be experimentally crossed – Maternal and paternal alleles may be identical at some loci – Ancestors may not be available for the analysis

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Page 1 and 2: AN INTRODUCTION TO RECOMBINATION AN
Page 3 and 4: Mendel’s First Law Mendel’s Law
Page 5 and 6: Mendel’s Mendel s Experiment 2
Page 9 and 10: Linkage Analysis What is Linkage An
Page 11 and 12: Genetic Distance between two loci D
Page 13 and 14: Derivation of Mather’s Formula Un
Page 15 and 16: Multilocus Linkage Analysis(1) Look
Page 17: Multilocus Linkage Analysis(3) The

AN INTRODUCTION TO RECOMBINATION AND LINKAGE ANALYSIS

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