Geneeskundige Stichting Koningin Elisabeth verslag - GSKE - FMRE

Thus, each CS from each of the PC types were classified into three types, CS type 1, CS type
2, or CS type3 (Fig. 2B). When the threshold was 0, PC type 1 had equivalent number of CSs in
all CS types, PC type 2 included significantly more CS type 2, and PC type 3 included more CS
type 3 (Fig 2C). As the threshold was increased (see Methods), CS type 1 in PC type 1 reached
the 100 % level faster than CSs in the other PC types (Fig. 2D), while the difference between
CS type2 and CS type 3 was conserved up to threshold 5 (Fig. 2E). Although in PC types there
were all CS types, CS type 2 and CS type 3 in PC type 1 was weaker than those were in PC type
2 and PC type 3.
Interaction between the complex spike and simple spiking before and after
When the mean firing rates of SSs before and after a CS were compared for the classification
of PCs, it was not possible to look at the exact pattern of SS around a CS. In a second study of
the SS firing, three consecutive ISIs between SSs and pauses before and after a CS in each PC
type were measured and compared to a simulated PC spike train constructed from the same
recording to look for deviations from random behavior (see Methods). ISI distribution in total
spike trains of reconstructed SSs and CSs were similar to that from original data (Fig. 3A). The
distribution of three consecutive ISIs between SSs and the pause before and after a CS could
show a shift either to left (+1), right (-1), or no shift (0) (Fig 3B). Pauses after a CS were
significantly longer than that from simulation in all PC types, but pauses before a CS seemed
to be a random. While the ISI after a CS shows the same characteristics for PC type 1, PC type
2 and PC type 3, the ISI before a CS were lengthened compared to the result in simulation (Fig.
3C).
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