Creutzfeldt-Jakob's disease or Prion Disease or Mad Cow ... - iSites

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Spongiform (intracellular vacuolation) change in the cortical gray matter of the brain, characteristic of TSEs and prions aggregates Walker et al.,
*Neuronal death *Neuronal apoptosis Features of TSEs and CJD *Astrogliosis (as a cause or a consequence of inflammation) *Protein misfolding and aggregation *Precipitation of aggregates (proteinaceous material) both at an intracellular and extracellular level (amyloid plaques)
Page 1 and 2: Creutzfeldt-Jakob’s disease or Pr
Page 3 and 4: Severe Brain Atrophy in CDJ’s pat
Page 5 and 6: Models for conformational conversio
Page 7 and 8: Symptoms in Creutzfeldt-Jakob’s D
Page 9 and 10: Cow affected by Bovine Spongiform E
Page 11: Absence of Protease-K-digested PrP
Page 15 and 16: Epidemiology of Creutzfeldt-Jakob
Page 17 and 18: Incidence of vCJD reported worldwid
Page 19 and 20: Functional domains of the prion pro
Page 21 and 22: Amyloid plaques in TSE Kuru disease
Page 23 and 24: Physiologic role of PrP c Caughey
Page 25 and 26: Infarcts are larger in PrP c KO mic
Page 27 and 28: PrP c protects against oxidative st
Page 29 and 30: PrP c maintains synaptic architectu
Page 31 and 32: PrP c physiological functions
Page 33 and 34: Mechanism of replication of PrP Sc
Page 35 and 36: The “unfortunate” goal of CDJ d
Page 37 and 38: Different biochemical and structura
Page 39 and 40: Fibrils of prion protein: self prop
Page 41 and 42: PMCA: protein misfolding cyclic amp
Page 43 and 44: Inoculation of synthetic strains of
Page 45 and 46: PrP c localizes at the plasma membr
Page 47 and 48: Where does the conversion from PrP
Page 49 and 50: Prion protein scrapie accumulation
Page 51 and 52: Post-translational modifications on
Page 53 and 54: Inhibition of GPI-anchor could redu
Page 55 and 56: PrP aggregates can be found at an i
Page 57 and 58: Induced intracellular aggregates ca
Page 59 and 60: Direct transfer of prion cytosolic
Page 61 and 62: PrP c KO mice are viable, develop n
Page 63 and 64:
Accumulation of degenerating lysoso
Page 65 and 66:
Autophagic vacuoles form at the syn
Page 67 and 68:
Autophagy-inducing drugs can regula
Page 69 and 70:
Autophagy as an approach to reduce
Page 71:
Approaches for the treatment of CJD
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