Lipid Profile in Chronic Renal Failure Patients on Dialysis

LIPIDS | ORIGINAL RESEARCH
<strong>Lipid</strong> <strong>Profile</strong> <strong>in</strong> <strong>Chronic</strong> <strong>Renal</strong> <strong>Failure</strong> <strong>Patients</strong> on Dialysis
Nzere Nwamaka Chijioke 1 , Bartimaeus E.A.S 1 , Okeke C.U. 2
Received: 16/4/12, Reviewed: 24/6/12, Accepted: 5/7/12
Key words: <strong>Chronic</strong> renal failure, lipid profile, cardiovascular disease.
DOI: 10.5083/ejcm.20424884.81
ABSTRACT
The <strong>in</strong>cidence of chronic renal failure (CRF) is on the <strong>in</strong>crease <strong>in</strong> Nigeria. This study on the effect of
CRF on lipid profile is carried out <strong>in</strong> CRF patients on dialysis treatment. A total of 100 subjects (both
male and female) were used for the study. 50 of them were apparently healthy, while the rema<strong>in</strong><strong>in</strong>g
50 were CRF patients on dialysis. The levels of triglyceride (TG), total cholesterol (TC), high density
lipoprote<strong>in</strong> – cholesterol (HDL-C), low density lipoprote<strong>in</strong>- cholesterol (LDL-C) and very low density
lipoprote<strong>in</strong> –cholesterol (VLDL-L) were estimated us<strong>in</strong>g enzymatic methods. Their cardiovascular
risk <strong>in</strong>dices (TC/HDL-C and LDL-C/HDL-C) were also determ<strong>in</strong>ed.
The results <strong>in</strong>dicated that all the parameters were significantly (p

HAEMORRHAGE WITH TICLOPIDINE AND CLOPIDOGREL
MATERIALS AND METHODS
A total of 100 adult subjects were used for this study. Fifty of them
(30 males and 20 females) who were apparently healthy were used
as control while the rema<strong>in</strong><strong>in</strong>g 50 (30 males and 20 females) were
patients with chronic renal failure on dialysis treatment. 5ml of
blood sample collected from each subject at fast<strong>in</strong>g state (<strong>in</strong> the
morn<strong>in</strong>g) was used to estimate the level of serum total cholesterol,
triglyceride, HDL-C, LDL-C, and VLDL-C us<strong>in</strong>g enzymatic method
with Human Diagnostic test kit. 18
The subjects were grouped <strong>in</strong>to 4, thus; Group 1- healthy males.
Group 2- healthy females. Group 3 –males with chronic renal failure.
Group 4 – females with chronic renal failure.
STATISTICAL ANALYSIS
The data collated after biochemical analysis were subjected to statistical
calculation us<strong>in</strong>g statistical software (Megastat). The mean,
standard deviation/ standard error of mean (s.e), F-distribution test
were obta<strong>in</strong>ed. Critical value or test of probability less than 0.05 (p<
0.05) was regarded significant.
RESULTS
The results obta<strong>in</strong>ed are presented <strong>in</strong> the tables below.
Table 1: The means ± s.e TC, TG, HDL-C, LDL-C, and VLDL-C of the male subjects.
GROUPS TC mmol/l TG mmol/l HDL-C mmol/l LDL-C mmol/l VLDL-C mmol/l
GROUP 1 4.22±0.6 1.15± 0.2 1.82± 0.3 1.95±0.5 0.52± 0.1
GROUP 3 5.96±0.79 1.55±0.09 1.34±0.04 3.93±0.19 0.70±0.2
P-Value p

HEALTHCARE BULLETIN | LIPIDS
Table 4: TThe ratios of TC/HDL-C and LDL-C/HDL-C of the female subjects
GROUPS TC/HDL-C LDL-C/HDL-C
GROUP 2 2.40 1.09
GROUP 4 4.07 2.50
DISCUSSION
REFERENCES
The results show that TC, TG, HDL-C, LDL-C, and VLDL levels of the
CRF patients were significantly (p

LIPID PROFILE IN CHRONIC RENAL FAILURE PATIENTS ON DIALYSIS
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