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eNEoNATAL REviEw poDcAST TRANScRipT<br />

MR. BoB BUSKER: Welcome to this eNeonatal<br />

Review Podcast.<br />

eNeonatal Review is presented by the Johns <strong>Hopkins</strong><br />

University School of Medicine, and the Institute for<br />

Johns <strong>Hopkins</strong> Nursing. This program is supported by<br />

educational grants from Abbott Nutrition, Cornerstone<br />

Pharmaceuticals, Ikaria, and Mead Johnson Nutrition.<br />

Today’s program is a companion piece to our<br />

eNeonatal Review newsletter issue: Optimizing<br />

Nutritional Support with Protein and Energy for<br />

Very Low Birth Weight Infants.<br />

Our guest today is one of that issue’s authors, Dr.<br />

David Adamkin, from the University of Louisville.<br />

This activity has been developed for neonatologists,<br />

respiratory therapists, nurse practitioners, neonatal<br />

nurses, and others who work in the NICU. There are<br />

no fees or prerequisites for this activity.<br />

The Accreditation and Credit Designation Statements<br />

can be found at the end of this podcast. For additional<br />

information about accreditation, <strong>Hopkins</strong> policies, and<br />

expiration dates and to take the posttest to receive<br />

credit online, please go to our website newsletter<br />

archive, www.eneonatalreview.org, and click the<br />

Volume 9, Issue 14 podcast link.<br />

Learning objectives for this audio program are, that<br />

after completing this activity, the participant will<br />

demonstrate the ability to:<br />

n Describe the importance of starting parenteral<br />

nutrition in the first hours of life, even in the face<br />

of critical illness in VLBW infants;<br />

n Evaluate the role of parenteral amino acids in<br />

glycemic control, as well as lipids in relation to lung<br />

dysfunction, in VLBW infants; and,<br />

n Discuss the role of donor-fortified milk in VLBW<br />

infants.<br />

I’m Bob Busker, managing editor of eNeonatal<br />

Review. On the line we have with us Dr. David H.<br />

Adamkin, Professor of Pediatrics, Director of the<br />

Division of Neonatal Medicine, and Rounsavall<br />

Endowed Chair of Neonatology, at the University<br />

of Louisville.<br />

Dr. Adamkin has indicated that he has no financial<br />

interests or relationships with any commercial entity<br />

whose products or services are relevant to the content<br />

of this presentation, and his discussion today will not<br />

reference the unlabeled or unapproved uses of any<br />

drugs or products.<br />

Dr. Adamkin, welcome to this eNeonatal Review<br />

podcast.<br />

DR. DAviD ADAMKiN: Thank you very much, Bob.<br />

MR. BUSKER: In your newsletter issue, Doctor, you<br />

reviewed studies describing the importance of<br />

enhancing nutrition in very low birth weight infants —<br />

that would be babies weighing less than 1500gm— to<br />

decrease morbidities and promote improved<br />

neurodevelopmental outcomes. What I’d like to do<br />

today is expand on that information, and discuss how<br />

it can actually be applied in the NICU. So if you<br />

would, doctor — start us out with patient scenario.<br />

DR. ADAMKiN: The case that we’re discussing is<br />

a 610 gm, small for gestational age, 26-week infant,<br />

delivered by emergency C-section because of placental<br />

abruption and fetal distress. Baby’s Apgar scores were<br />

2, 4, 6, and 8, at 1, 5, 10, and 15 minutes, respectively.<br />

Infant received positive pressure ventilation in the<br />

delivery room and was intubated and given surfactant.<br />

The cord blood pH is 7 with a base excess of -10. The<br />

infant is started on intravenous fluids of D10W<br />

through a UVC and D5W in the UAC for total fluids of<br />

80 cc/kg/daycc/kg/day.<br />

So this is a tiny baby that’s growth-restricted with a<br />

difficult initial course, including fetal acidosis, and is<br />

started on D10 and D5 through the UVC and the UAC.<br />

At 12 hours of age the morning labs include a plasma<br />

glucose of 180mg/dLmg/dL after two ACCU-CHEKs<br />

revealed 140 and 160, and the potassium is 7.3<br />

mEq/L. The infant’s urine output has been 1.5<br />

cc/kg/hr, the BUN is 15, and the creatinine is 0.7.<br />

MR. BUSKER: Why wasn’t this baby started on<br />

early TPN?<br />

DR. ADAMKiN: It’s possible, because of the baby’s<br />

condition at birth, the fetal hypoxia acidosis, that the<br />

clinicians were concerned about the baby’s ability to<br />

metabolize TPN and that may have been why the<br />

clinicians chose not to start TPN. Let’s delve into<br />

eNeonatal Review Podcast <strong>Transcript</strong>, Volume 9: Issue 14<br />

1

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