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Summary Report 2012 - Boehringer Ingelheim

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Value through Innovation<br />

<strong>Summary</strong> <strong>Report</strong> <strong>2012</strong>


BOEHRINGER INGELHEIM<br />

GROUP OF COMPANIES<br />

Amounts in millions of EUR,<br />

unless otherwise indicated <strong>2012</strong> 2011 Change<br />

Net sales 14,691 13,171 12%<br />

by region<br />

Europe 29% 31%<br />

Americas 47% 46%<br />

Asia, Australasia, Africa 24% 23%<br />

by business<br />

Human Pharmaceuticals 93% 93%<br />

Animal Health 7% 7%<br />

Research and development 2,795 2,516 11%<br />

Personnel costs 4,024 3,664 10%<br />

Average number of employees 46,228 44,094 5%<br />

Operating income 1,853 2,272 — 18%<br />

Operating income as % of net sales 12.6% 17.3%<br />

Income after taxes 1,237 1,476 — 16%<br />

Income after taxes as % of net sales 8.4% 11.2%<br />

Shareholders’ equity 6,178 7,466 — 17%<br />

Return on shareholders’ equity 16.6% 22.8%<br />

Cash flow 2,225 2,378 — 6%<br />

Investments in tangible assets 562 458 23%<br />

Depreciation of tangible assets 793 535 48%<br />

2<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


usiness year <strong>2012</strong><br />

financial highlights<br />

OUR COMPANY<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> is a research-driven<br />

company dedicated to researching and<br />

developing, manufacturing and marketing<br />

pharmaceuticals that improve health and<br />

quality of life.<br />

Our business areas consist of Human Pharma -<br />

ceuticals and Animal Health. We have more<br />

than 46,000 employees in 140 affi liated companies<br />

worldwide, research and development<br />

(R&D) facilities at six sites worldwide and<br />

20 production plants in 13 countries. R&D<br />

expenditure in Prescription Medicines corresponds<br />

to 22.5% of its net sales.<br />

Our headquarters is at <strong>Ingelheim</strong>, the German<br />

town where the family-owned company was<br />

founded in 1885.<br />

Financial Highlights 3


KEY ASPECTS <strong>2012</strong><br />

andreas barner, wolfram carius, allan hillgrove,<br />

joachim hasenmaier, hubertus von baumbach<br />

(from left to right), the board of managing directors<br />

Dear readers,<br />

Successful long-term, sustainable development of the company,<br />

allied with stable earnings and sound finances, is and<br />

will remain the basis of our independence and is central to<br />

the strategic direction of the <strong>Boehringer</strong> <strong>Ingelheim</strong> group of<br />

companies. Besides independence, the paramount goal is our<br />

most important endeavour to make in equal measure available<br />

a high level of medical progress to patients and physicians<br />

treating them by researching innovative medicines, especially<br />

in indications with urgent medical need.<br />

Growth maintained<br />

In <strong>2012</strong>, <strong>Boehringer</strong> <strong>Ingelheim</strong> was able to build on its successful,<br />

above-market growth from the previous year and<br />

achieved a growth rate of + 11.5%.<br />

4<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


usiness year <strong>2012</strong><br />

key aspects <strong>2012</strong><br />

Both our new products, such as the anticoagulant pradaxa®<br />

and the diabetes medication trajenta®, as well as established<br />

products, such as the respiratory medicines spiriva® and<br />

combivent®, were the main growth drivers – all of these<br />

products from our own research.<br />

Stable earnings and financial position in a difficult market<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> made an operating profit of EUR<br />

1,853 million. This corresponds to an operating margin<br />

of 12.6%.<br />

We are satisfied with this result, as the successful operative<br />

business development overall was negatively impacted by a<br />

multitude of one-off and extraordinary effects. These effects are<br />

the result of decisions which we have taken in order to prepare<br />

the group of companies for a changing business environment.<br />

Our financial management aims to ensure liquidity, limit<br />

financial risks and optimise the cost of capital. It is noteworthy<br />

that it allows the overall financing of the group of<br />

companies to maintain our independent, organic growth.<br />

Outlook<br />

We are convinced, on the basis of our established product<br />

portfolio and the successful launches of new products from<br />

our own research and development expected for 2013 and<br />

beyond will sustainably reinforce and expand our position in<br />

the global human and veterinary pharmaceuticals market.<br />

For 2013, we expect to be able to maintain growth and anticipate<br />

a mid-single digit increase in sales compared to the<br />

fi nancial year <strong>2012</strong>.<br />

Key aspects <strong>2012</strong><br />

5


PERSPECTIVES FOR<br />

MEDICAL INNOVATION<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong>’s commitment to emerging science as a<br />

basis for new medicines grows ever stronger. As such, we focus<br />

on studying human disease, the subsets of each disease and<br />

establishing target-disease relationships that enable us to ask<br />

the right questions.<br />

Our aim is to help patients by treating diseases in areas of<br />

high unmet medical need both in our current therapeutic area<br />

focus and in new emerging disease areas. Our R&D activities<br />

include both small molecules and biotherapeutics, thereby<br />

allowing us to choose the most appropriate approach for each<br />

therapeutic concept.<br />

RESEARCH AREAS<br />

[ in focus: six major areas ]<br />

respiratory<br />

diseases<br />

cardiometabolic<br />

diseases<br />

oncology<br />

central nervous<br />

system diseases<br />

immunology<br />

infectious<br />

diseases<br />

6<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


perspectives<br />

for medical innovation<br />

OUR RESEARCH AND DEVELOPMENT SITES<br />

[ 3 major and 3 specialised sites ]<br />

2<br />

1<br />

3<br />

4<br />

5<br />

6<br />

1 ridgefield, usa<br />

2 laval, canada<br />

3 biberach and<br />

ingelheim, germany<br />

4 vienna, austria<br />

5 milan, italy<br />

6 kobe, japan<br />

Status 31.12.<strong>2012</strong><br />

THE BOEHRINGER INGELHEIM PIPELINE<br />

[ compounds in development, total 94 ]<br />

17<br />

respiratory<br />

diseases<br />

9<br />

immunology<br />

10<br />

cns diseases<br />

3<br />

infectious<br />

diseases<br />

24<br />

oncology<br />

31<br />

cardiometabolic<br />

diseases<br />

Research & development<br />

7


RESEARCH WITH PASSION<br />

In <strong>2012</strong>, we employed an average of 7,492 people at our R&D<br />

sites. A total of almost EUR 2.8 billion was invested in the research<br />

and development of new medicines. R&D expenditure<br />

in the business area Prescription Medicines corresponds to<br />

+ 22.5% of its net sales.<br />

Human Pharmaceuticals<br />

In Human Pharmaceuticals we are presented with a wellfilled<br />

pipeline of competitive substances, mainly in oncology,<br />

diabetes, asthma and hepatitis C. We also have a tightly scheduled<br />

series of planned launches of product innovations and<br />

thereby continued growth potential.<br />

After entering the diabetes market in 2011, we expect to enter<br />

the oncology market in 2013 and extend our respiratory portfolio.<br />

The substances from the advanced pipeline, foremost<br />

afatinib in lung cancer and tiotropium or olodaterol in respiratory<br />

diseases, have the potential to be ready for the market<br />

as early as in 2013 as well as in the next few years.<br />

8<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


perspectives<br />

for medical innovation<br />

Our R&D activities include both small molecules<br />

and biotherapeutics, thereby allowing<br />

us to choose the most appropriate approach<br />

for each therapeutic concept.<br />

Animal Health<br />

In Animal Health the focus is on the research and development<br />

of innovative vaccines, primarily for protecting livestock and<br />

companion animals, as well as on pharmaceutical products.<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> invested around EUR 115 million in <strong>2012</strong>,<br />

roughly 11% of total Animal Health sales, in researching and<br />

developing new products and in building up a global network<br />

of new R&D sites. An average 450 employees worked at Animal<br />

Health’s R&D sites in the USA, Germany, Mexico, China and<br />

Japan in <strong>2012</strong>.<br />

Further information:<br />

annualreport.boehringer-ingelheim.com<br />

Research & development<br />

9


OUR BUSINESS AREAS<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> divides its business activities into<br />

the areas Human Pharmaceuticals, Biopharmaceuticals and<br />

Animal Health.<br />

Human Pharmaceuticals<br />

The sales of our Human Pharmaceuticals business were<br />

EUR 13,080 million, thereby showing gratifying growth<br />

of around + 12%.<br />

Prescription Medicines<br />

The business area Prescription Medicines generated sales<br />

growth of + 13%, amounting to EUR 11,405 million. In <strong>2012</strong>,<br />

our anticoagulant pradaxa®, with sales of EUR 1.1 billion,<br />

exceeded the EUR 1 billion sales mark for the first time.<br />

The products spiriva® (EUR 3.6 billion), already established<br />

for 10 years, micardis® (EUR 1.6 billion) and combivent®<br />

(EUR 883 million) continued to record growth in sales.<br />

In addition, trajenta®, for the treatment of type 2 diabetes,<br />

has significant sales potential. We consider it very disappointing<br />

that trajenta®, a medication developed and manufactured in<br />

Germany, is precisely not available in Germany for patients<br />

with type 2 diabetes. We remain convinced that trajenta®<br />

[ spiriva® ]<br />

[ micardis® ]<br />

10<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


kapitelname<br />

perspectives<br />

kapitelname<br />

for better health<br />

has a distinct, patient-relevant, added benefit and we consider<br />

our position confirmed by positive therapeutic experiences in<br />

some 40 countries around the world.<br />

Consumer Health Care<br />

The business area Consumer Health Care expanded again,<br />

mainly in emerging markets and achieved worldwide sales<br />

of EUR 1,505 million, corresponding to growth of + 7.8%<br />

compared to the previous year.<br />

Biopharmaceuticals<br />

The business area Biopharmaceuticals focuses on the development<br />

and production of new, innovative biopharmaceuticals.<br />

It is comprised of the contract manufacturing business,<br />

biosimilars and the research and development of new biological<br />

active ingredients. Here, <strong>Boehringer</strong> <strong>Ingelheim</strong> achieved<br />

net sales amounting to EUR 549 million (+ 5.8%).<br />

Animal Health<br />

The products in our Animal Health business developed<br />

equally favourably, with total sales of EUR 1,062 million<br />

(+ 8.8%) led by ingelvac circoflex®, a swine vaccine, with<br />

sales of EUR 279 million (+ 8.6%).<br />

[ pradaxa® ] [ ingelvac circoflex® ]<br />

Our businesses<br />

11


BOEHRINGER INGELHEIM<br />

CORPORATION<br />

Net sales by businesses<br />

(in millions of EUR) <strong>2012</strong> 2011 Change<br />

Prescription Medicines 11,405 10,096 13.0%<br />

Consumer Health Care 1,505 1,396 7.8%<br />

Pharma Chemicals and<br />

Pharmaceuticals Production 162 178 — 9.0%<br />

Biopharmaceuticals 549 519 5.8%<br />

Animal Health 1,062 976 8.8%<br />

Net sales by region (in millions of EUR) <strong>2012</strong> 2011 Change<br />

Americas 6,905 6,087 13.4%<br />

Europe 4,194 4,037 3.9%<br />

Asia, Australasia, Africa (AAA) 3,592 3,047 17.9%<br />

Key figures (in millions of EUR) <strong>2012</strong> 2011 Change<br />

Net sales 14,691 13,171 11.5%<br />

Operating income 1,853 2,272 — 18.4%<br />

Return on net sales 12.6% 17.3%<br />

RESEARCH AND DEVELOPMENT<br />

R&D Key figures <strong>2012</strong> 2011 2010 2009 2008<br />

Expenditure in millions of EUR 2,795 2,516 2,453 2,215 2,109<br />

– as % of net sales 19.0 19.1 19.5 17.4 18.2<br />

Prescription Medicines<br />

expenditure in millions<br />

of EUR 2,563 2,372 2,306 2,100 2,016<br />

– as % of Prescription<br />

Medicines net sales 22.5 23.5 23.8 20.9 22.1<br />

Average number of employees 7,492 7,159 7,093 6,934 6,788<br />

Investments in tangible assets<br />

(without investments in infrastructure)<br />

in millions of EUR 139 112 83 125 145<br />

12<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


usiness year <strong>2012</strong><br />

at a glance<br />

PRESCRIPTION MEDICINES<br />

Net sales (in millions of EUR) <strong>2012</strong> 2011 Change<br />

spiriva® 3,562 3,153 13.0%<br />

micardis® 1,623 1,593 1.9%<br />

pradaxa® 1,108 629 76.2%<br />

combivent® 883 766 15.3%<br />

CONSUMER HEALTH CARE<br />

Net sales (in millions of EUR) <strong>2012</strong> 2011 Change<br />

buscopan® 212 180 17.8%<br />

dulcolax® 193 171 12.9%<br />

mucosolvan® 166 160 3.8%<br />

pharmaton® 136 137 — 0.7%<br />

ANIMAL HEALTH<br />

Net sales (in millions of EUR) <strong>2012</strong> 2011 Change<br />

ingelvac circoflex® 279 257 8.6%<br />

metacam® 99 96 3.1%<br />

ingelvac® prrs 68 57 19.3%<br />

vetmedin® 49 46 6.5%<br />

EMPLOYEES<br />

Average number of employees<br />

by region <strong>2012</strong> 2011<br />

Americas 15,208 14,300<br />

Europe 22,106 21,380<br />

Asia, Australasia, Africa (AAA) 8,914 8,414<br />

46,228 44,094<br />

At a glance<br />

13


CORPORATE BODIES<br />

Shareholders’ Committee<br />

christian boehringer<br />

Chairman of the Shareholders’ Committee<br />

christoph boehringer<br />

erich von baumbach jr.<br />

ferdinand von baumbach<br />

isabel boehringer<br />

dr mathias boehringer<br />

Advisory Board<br />

prof. dr michael hoffmann-becking<br />

Attorney at Law, Düsseldorf, Chairman of the Advisory Board<br />

egbert appel<br />

Trustee, Martin Hilti Family Trust<br />

Member of the Board and Managing Director, Hilti Foundation<br />

dr andreas kreimeyer<br />

Member of the Board of Executive Directors and<br />

Research Executive Director, BASF SE<br />

prof. dr fredmund malik (until 31.12.<strong>2012</strong>)<br />

Chairman of the Board, Malik Management Zentrum St. Gallen AG<br />

jan rinnert<br />

Vice Chairman of the Board of Management, Heraeus Holding GmbH<br />

Board of Managing Directors*<br />

prof.** dr dr andreas barner<br />

Chairman of the Board, Corporate Board Divisions Human Resources and<br />

Research, Development and Medicine<br />

hubertus von baumbach<br />

Corporate Board Division Finance<br />

prof. h.c. dr wolfram carius<br />

Corporate Board Divisions Biopharmaceuticals and Operations<br />

dr joachim hasenmaier (from 01.10.<strong>2012</strong>)<br />

Corporate Board Divisions Animal Health and Consumer Health Care<br />

allan hillgrove (from 01.01.2013)<br />

Corporate Board Division Pharma Marketing and Sales<br />

engelbert tjeenk willink (until 31.12.<strong>2012</strong>)<br />

Corporate Board Division Pharma Marketing and Sales<br />

* Change of structure of Corporate Board Divisions from 01.10.<strong>2012</strong><br />

** Republic of Austria<br />

14<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> summary report <strong>2012</strong>


corporate bodies<br />

imprint<br />

If you have any queries or comments,<br />

please contact us.<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> GmbH<br />

Binger Strasse 173<br />

55216 <strong>Ingelheim</strong><br />

Germany<br />

Telephone + 49 6132 77-0<br />

Fax + 49 6132 72-3000<br />

Contact<br />

Corporate Division Communications<br />

E-mail webmaster@boehringer-ingelheim.com<br />

Internet www.boehringer-ingelheim.com<br />

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<strong>Boehringer</strong> <strong>Ingelheim</strong> GmbH<br />

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Printed by<br />

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Copyright<br />

©<br />

<strong>Boehringer</strong> <strong>Ingelheim</strong> GmbH, 2013<br />

All rights reserved. No part of this Annual <strong>Report</strong> <strong>2012</strong> may be reproduced<br />

or transmitted in any form or by any means, electronic or photocopy,<br />

without permission in writing from <strong>Boehringer</strong> <strong>Ingelheim</strong> GmbH.<br />

Figures from third parties used in the annual report are based on data<br />

available at the time the financial statement was drawn up.<br />

With the CO 2<br />

emission reduction certificates we support a project that distributes water<br />

treatment units to households in rural districts in Kenya. The project improves public<br />

health significantly, inasmuch as it guarantees access to clean drinking water.<br />

Imprint<br />

15


www.boehringer-ingelheim.com<br />

annualreport.boehringer-ingelheim.com

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