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A61K - Cooperative Patent Classification

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CPC - <strong>A61K</strong> - 2013.07 - page 75<br />

NOTE<br />

-<br />

Porphyrins used as simple heterocyclic carriers containing a<br />

radioactive nucleus (e.g. 11C) or substituted with a radioactive nucleus<br />

(e.g. 18F), are classified in <strong>A61K</strong> 51/0451<br />

<strong>A61K</strong> 51/0487 . . . . { Metallocenes, i.e. complexes based on a radioactive metal complexed by<br />

two cyclopentadienyl anions }<br />

<strong>A61K</strong> 51/0489 . . . { Phosphates or phosphonates, e.g. bone-seeking phosphonates; (<br />

phospholipids: <strong>A61K</strong> 51/0408 ; nucleotides or nucleic acids: <strong>A61K</strong> 51/0491 ) }<br />

<strong>A61K</strong> 51/0491 . . . { Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA,<br />

RNA, nucleic acid aptamers }<br />

<strong>A61K</strong> 51/0493 . . . { Steroids, e.g. cholesterol, testosterone }<br />

<strong>A61K</strong> 51/0495 . . . { Pretargeting }<br />

NOTE<br />

-<br />

Pretargeting is the administration of an agent X bearing the radioisotope or<br />

radioactive nucleus and of an agent Y capable of binding X and a cell Y in<br />

several steps, e.g. the radiolabelled agent is a radiolabelled biotin and the<br />

agent Y is a (strept)avidin molecule targeting specific cells. <strong>Classification</strong><br />

is also made according to the nature of the carrier bearing/linked to the<br />

radioactive nucleus, e.g. an antibody<br />

<strong>A61K</strong> 51/0497 . . . { conjugates with a carrier being an organic compounds }<br />

NOTE<br />

-<br />

The compound which bears, complexes or chelates the radioactive<br />

nucleus, is covalently linked or complexed to the carrier being another<br />

(small) organic molecule, i.e. not oligomeric, polymeric, dendrimeric.<br />

<strong>Classification</strong> is also made according to the nature of this small organic<br />

molecule. In case of a conjugate comprising a complex-forming compound<br />

(chelating group) complexing a radioactive metal linked to the carrier<br />

(organic compound in <strong>A61K</strong> 49/04Z ), the nature of this complex-forming<br />

compound is not classified except if the complexing/chelating group is the<br />

subject of the invention and is uncommon, e.g. 111In-DTPA-glucose is<br />

classified in <strong>A61K</strong> 51/0497 (not in <strong>A61K</strong> 51/048 ) and in <strong>A61K</strong> 51/0491<br />

<strong>A61K</strong> 51/06 . . . Macromolecular compounds, { carriers being organic macromolecular<br />

compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules (<br />

peptides, proteins, polyamino acids <strong>A61K</strong> 51/08 ; antibodies <strong>A61K</strong> 51/10 ) }<br />

<strong>A61K</strong> 51/065 . . . . { conjugates with carriers being macromolecules }<br />

NOTE<br />

-<br />

The compound which bears, complexes or chelates the radioactive<br />

nucleus, is covalently linked or complexed to the carrier being a<br />

macromolecule (not being a peptide, polyamino acid, protein,<br />

antibody). In case of a conjugate comprising a complex-forming<br />

compound (chelating group) complexing a radioactive metal linked to<br />

the carrier (organic macromolecular compound in <strong>A61K</strong> 49/06Z ), the<br />

nature of this complex-forming compound is not classified except if it is<br />

the real contribution of the claimed invention and it is an uncommon<br />

complexing/chelating group, e.g. 111In-DTPA-PEG is classified in

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