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<strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> <strong>for</strong><br />

<strong>Cardiovascular</strong> <strong>Health</strong><br />

QUM<br />

Executive Summary<br />

An initiative <strong>of</strong> the <strong>Heart</strong> Foundation Pharmaceutical Roundtable<br />

Rob Wiseman, Anne-Marie Scully, Hayley Caspers red 3 – 2006<br />

QUM


This project was supported by the following members <strong>of</strong> the Pharmaceutical Roundtable:<br />

© 2006 <strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia. All rights reserved.<br />

This is an executive summary <strong>of</strong> the <strong>Quality</strong> use <strong>of</strong> medicines in cardiovascular health report. The<br />

report is available at www.heartfoundation.org.au<br />

This report builds on research reported in: Wiseman R and White S (2005) Views <strong>of</strong> <strong>Quality</strong><br />

<strong>Use</strong> <strong>of</strong> <strong>Medicines</strong>: Stakeholders perceptions <strong>of</strong> their needs, values and responsibilities, and the<br />

opportunities and barriers <strong>for</strong> QUM. Sydney: The Pharmaceutical Alliance.<br />

This is available from: www.pharmalliance.com.au/files/QUM_2005_Report.pdf<br />

<strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia (The <strong>Heart</strong> Foundation Pharmaceutical Roundtable)<br />

The views expressed in this report are those <strong>of</strong> the authors and not necessarily those <strong>of</strong> the <strong>Heart</strong><br />

Foundation Pharmaceutical Roundtable or its partner organisations: the <strong>National</strong> <strong>Heart</strong> Foundation<br />

<strong>of</strong> Australia, Alphapharm, Astrazeneca, Bristol-Myer Squibb, Merck Sharp & Dohme, Pfizer<br />

Australia, Roche, san<strong>of</strong>i-aventis, Solvay Pharmaceuticals and Servier Laboratories.<br />

This work is copyright. No part may be reproduced in any <strong>for</strong>m or language without prior written<br />

permission from the <strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia (national <strong>of</strong>fice). Enquiries concerning<br />

permissions should be directed to copyright@heartfoundation.org.au<br />

Suggested citation: <strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia (Wiseman R, Scully, AM and Caspers<br />

H on behalf <strong>of</strong> the <strong>Heart</strong> Foundation Pharmaceutical Roundtable). <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> in<br />

cardiovascular health (executive summary). West Melbourne, Victoria, 2006.<br />

<strong>National</strong> Library <strong>of</strong> Australia Cataloguing-in-Publication data<br />

Wiseman, Rob, 1969– . <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> Medicine in cardiovascular health (executive summary).<br />

Print: ISBN-10: 1-921226-07-2 ISBN-13: 978-1-921226-07-6<br />

1. <strong>Cardiovascular</strong> agents—Australia. 2. <strong>Cardiovascular</strong> diseases—Australia—Treatment.<br />

3. Pharmaceutical policy—Australia. I. Scully, Anne-Marie. II. Caspers, Hayley. III. Title.<br />

615.71<br />

[ 2 ]


Contents<br />

Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2<br />

The <strong>Heart</strong> Foundation Pharmaceutical Roundtable . . . . . . . . . . . . . . . . . . . . . . . 2<br />

About the project . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2<br />

<strong>Cardiovascular</strong> disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3<br />

<strong>Medicines</strong> and CVD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3<br />

<strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong>. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3<br />

Contents<br />

Stages <strong>of</strong> <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> in <strong>Cardiovascular</strong> <strong>Health</strong>. . . . . . . . . . . . . . . . . . . . . . 4<br />

Be<strong>for</strong>e a cardiovascular event. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Identifying people at risk <strong>of</strong> CVD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Encouraging consumers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Enabling General Practitioners . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Initiating medicines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

Counselling and education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

– Consumer medicine in<strong>for</strong>mation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

Adherence in the longer term . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />

– Home medicine reviews . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />

During a cardiovascular event . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />

Getting people to hospital . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />

Admission to hospital . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />

Engaging specialist physicians . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />

After a cardiovascular event . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />

Discharge: from hospital to home. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />

<strong>Medicines</strong> at discharge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />

Increasing use <strong>of</strong> rehabilitation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />

Supporting environment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

In<strong>for</strong>mation <strong>for</strong> consumers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

Linking health consumer organisations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

Practice nurses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

IT, connectivity and data exchange . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

Tracking medicine use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

Missing in action . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

Hospital administrators and private health insurers . . . . . . . . . . . . . . . . . . . . . . 11<br />

Carers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

[ 1 ]


Background<br />

Background<br />

The <strong>Heart</strong> Foundation Pharmaceutical<br />

Roundtable<br />

The Pharmaceutical Roundtable is made up <strong>of</strong><br />

the <strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia and<br />

11 pharmaceutical manufacturers: Alphapharm,<br />

AstaZeneca, CSL Biotherapies, Gilead, Eli Lilly,<br />

Merck Sharp & Dohme, Pfizer Australia, Roche,<br />

san<strong>of</strong>i-aventis, Solvay Pharmaceuticals and<br />

Servier Laboratories.<br />

About the project<br />

In July 2005, the Pharmaceutical Roundtable<br />

commissioned red 3 to explore <strong>Quality</strong> <strong>Use</strong> <strong>of</strong><br />

<strong>Cardiovascular</strong> <strong>Medicines</strong>. Specific goals <strong>of</strong> the<br />

project were to:<br />

• identify barriers to <strong>Quality</strong> <strong>Use</strong> <strong>of</strong><br />

<strong>Cardiovascular</strong> <strong>Medicines</strong><br />

• help the Roundtable develop strategies to<br />

overcome these barriers<br />

• prioritise actions to help the Roundtable<br />

achieve <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Cardiovascular</strong><br />

<strong>Medicines</strong>.<br />

red 3 conducted the research in three stages:<br />

1 Interviewing nearly fifty key stakeholders<br />

in cardiovascular health and <strong>Quality</strong> <strong>Use</strong><br />

<strong>of</strong> <strong>Medicines</strong>.<br />

2 Collating the contributions <strong>of</strong> these<br />

stakeholders and presenting the results to<br />

a <strong>National</strong> Stakeholder Workshop, held<br />

in Canberra on 25 November 2005. The<br />

event was structured to fill gaps in the<br />

work to date, correct misunderstandings<br />

and mistakes, and to add further detail. It<br />

also sought suggestions <strong>for</strong> practical action<br />

to achieve <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> in<br />

<strong>Cardiovascular</strong> <strong>Health</strong>.<br />

3 Combining the workshop’s outcomes with<br />

findings reported in the research literature.<br />

This project built on previous research by red 3<br />

<strong>for</strong> the <strong>National</strong> <strong>Medicines</strong> Policy and The<br />

Pharmaceutical Alliance.<br />

[ 2 ]


<strong>Cardiovascular</strong> disease<br />

<strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong><br />

<strong>Cardiovascular</strong> disease (CVD) is the cause <strong>of</strong><br />

more deaths in Australia than any other group<br />

<strong>of</strong> diseases. CVD accounted <strong>for</strong> 37.6 per cent <strong>of</strong><br />

all deaths in Australia during 2002. The burden<br />

<strong>of</strong> CVD continues to grow, as more and more<br />

Australians are living with the disease as a<br />

chronic condition.<br />

CVD is also a leading cause <strong>of</strong> long-term<br />

disability. In 1998, over 1.1 million Australians<br />

were affected —nearly one third <strong>of</strong> all people<br />

with a disability. Of concern is evidence that<br />

the burden <strong>of</strong> CVD is growing: in the 1990s,<br />

the prevalence <strong>of</strong> heart, stroke and vascular<br />

conditions rose by 18.2 per cent.<br />

The burden <strong>of</strong> cardiovascular disease is not<br />

spread evenly in the Australian community.<br />

CVD is more common among people in lower<br />

socio¬economic groups, and they are at a higher<br />

risk <strong>of</strong> developing the disease. People living in<br />

rural and remote areas are also more likely to die<br />

<strong>of</strong> CVD, as are Indigenous Australians.<br />

Co-morbidities with CVD are common—<br />

diabetes, renal failure and depression in<br />

particular. Over 80 per cent <strong>of</strong> elderly<br />

Australians have at least one chronic illness,<br />

and many have two or more.<br />

There is strong evidence that the burden<br />

<strong>of</strong> CVD on Australia’s health care system<br />

is growing. <strong>Cardiovascular</strong> conditions<br />

account <strong>for</strong> about 11 per cent <strong>of</strong> all problems<br />

managed by GPs in 2002–2003. CVD was the<br />

principal diagnosis <strong>of</strong> 7 per cent <strong>of</strong> all people<br />

hospitalised in 2001–2002.<br />

<strong>Medicines</strong> and CVD<br />

<strong>Medicines</strong> are one part <strong>of</strong> treating CVD.<br />

The main strategy <strong>for</strong> managing CVD is risk<br />

reduction, through lifestyle changes. Ways that<br />

medicines are used to treat CVD include:<br />

• reducing the risk <strong>of</strong> CVD—<strong>for</strong> example by<br />

lowering blood pressure, modifying lipid<br />

levels, and preventing blood clots<br />

• helping to open blocked arteries after a heart<br />

attack or stroke<br />

• helping to prevent the body rejecting<br />

implants and tissue grafts<br />

In the 1990s, Australia developed a <strong>National</strong><br />

<strong>Medicines</strong> Policy. It has four central objectives:<br />

• timely access to medicines that Australians<br />

need at a cost individuals and the<br />

community can af<strong>for</strong>d<br />

• medicines meeting appropriate standards <strong>of</strong><br />

quality, safety and efficacy<br />

• quality use <strong>of</strong> medicines<br />

• maintaining a responsible and viable<br />

medicines industry.<br />

The <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> involves:<br />

1 Selecting management options wisely by:<br />

• considering the place <strong>of</strong> medicines in<br />

treating illness and maintaining health<br />

• recognising that there may be better ways<br />

than medicine to manage many disorders.<br />

2 Choosing suitable medicines if a medicine<br />

is considered necessary, so that the best<br />

available option is selected by taking into<br />

account:<br />

• the individual<br />

• the clinical condition<br />

• risks and benefits<br />

• dosage and length <strong>of</strong> treatment<br />

• any co-existing conditions<br />

• other therapies<br />

• monitoring considerations<br />

• costs <strong>for</strong> the individual, the community<br />

and the health system as a whole.<br />

3 Using medicines safely and effectively to get<br />

the best possible results by:<br />

• monitoring outcomes<br />

• minimising misuse, over-use and<br />

under-use<br />

• improving people’s ability to solve<br />

problems related to medication,<br />

such as negative effects or managing<br />

multiple medications.<br />

CVD / QUM<br />

• aiding recovery after surgery.<br />

[ 3 ]


Stages <strong>of</strong> <strong>Quality</strong> <strong>of</strong> <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Use</strong> <strong>Medicines</strong> <strong>of</strong> <strong>Medicines</strong> in <strong>Cardiovascular</strong> in <strong>Cardiovascular</strong> <strong>Health</strong> <strong>Health</strong><br />

Stages <strong>of</strong> QUM in CV <strong>Health</strong><br />

This summary presents the issues <strong>of</strong><br />

This summary presents the issues <strong>of</strong> greatest importance to those consulted. It has been organised<br />

greatest importance to those consulted. It<br />

around the patient’s journey through cardiovascular disease, summarised in the following diagram.<br />

has been organised around the patient’s<br />

journey through cardiovascular disease,<br />

summarised in the following diagram.<br />

be<strong>for</strong>e an event<br />

identifying<br />

people at risk<br />

1A<br />

diagnosing<br />

disease<br />

1B<br />

during an event<br />

cardiovascular<br />

event<br />

2<br />

lifestyle advice and<br />

prescribing medicine<br />

1<br />

getting<br />

people to<br />

hospital<br />

lifestyle<br />

changes<br />

3A<br />

3B<br />

dispensing<br />

medicine<br />

2<br />

admission<br />

4<br />

counselling and<br />

education<br />

3<br />

intervention<br />

5<br />

taking<br />

medicine<br />

4<br />

recovery<br />

6<br />

monitoring use<br />

and effects<br />

5<br />

discharge<br />

7<br />

adhering<br />

after an event<br />

1A<br />

2A<br />

3 4<br />

1B<br />

GP<br />

1C<br />

rehab<br />

2B<br />

carers<br />

support<br />

groups<br />

specialist<br />

physician<br />

community<br />

pharmacist<br />

nurses and<br />

allied health<br />

4<br />

[ 4 ]


Be<strong>for</strong>e a cardiovascular event<br />

Identifying people at risk <strong>of</strong> CVD<br />

Early identification <strong>of</strong> people at risk <strong>of</strong> CVD<br />

helps prevent the disease developing. Many<br />

people do not realise they are at risk until it is<br />

too late.<br />

There is strong support <strong>for</strong> a national risk<br />

assessment program to identify Australians at<br />

a higher risk <strong>of</strong> CVD. Those consulted stressed<br />

that such a program should cover other chronic<br />

illnesses, not just cardiovascular disease.<br />

Benefits <strong>of</strong> a national risk assessment program<br />

could include:<br />

• earlier identification <strong>of</strong> cardiovascular risk<br />

and cardiovascular disease<br />

• early targeting <strong>of</strong> specific risk factors<br />

• reducing mortality from CVD, improving<br />

quality <strong>of</strong> life, and potentially reducing the<br />

severity <strong>of</strong> cardiovascular events<br />

• lowering the financial burden <strong>of</strong><br />

CVD on consumers, families and the<br />

Australian community<br />

• creating greater predictability in health<br />

budgets and resource use by improved<br />

cost effectiveness.<br />

The main barriers to comprehensive risk<br />

assessment identified in this project were:<br />

• motivating Australians—particularly men—to<br />

go to a health pr<strong>of</strong>essional <strong>for</strong> an assessment<br />

• generating enough time <strong>for</strong> health<br />

pr<strong>of</strong>essionals to carry out a comprehensive<br />

risk assessment<br />

• funding.<br />

Encouraging consumers<br />

A barrier to improving treatment outcomes is<br />

that many Australians believe ‘doctor knows<br />

best’, and leave important decisions to their<br />

health pr<strong>of</strong>essionals. There is good evidence<br />

that consumers can achieve better health<br />

outcomes and quality <strong>of</strong> life if they actively take<br />

part in treatment decisions.<br />

Consumers should be encouraged to:<br />

• discuss their health, medical history and<br />

illnesses with their health pr<strong>of</strong>essionals<br />

• discuss their willingness to try various<br />

management options (such as better<br />

nutrition, physical activity, smoking<br />

cessation, and use <strong>of</strong> medicines)<br />

• provide health pr<strong>of</strong>essionals with accurate<br />

in<strong>for</strong>mation about all their medicines—<br />

including prescription, over-the-counter and<br />

complementary medicines<br />

• discuss costs and other constraints be<strong>for</strong>e<br />

selecting treatment options.<br />

Enabling General Practitioners<br />

There is already a great deal <strong>of</strong> in<strong>for</strong>mation<br />

and training materials on cardiovascular health<br />

<strong>for</strong> consumers and health pr<strong>of</strong>essionals. But,<br />

while these resources exist, they can be hard<br />

to find. Many documents, training courses,<br />

and educational resources are not available in<br />

an electronic <strong>for</strong>mat and there<strong>for</strong>e cannot be<br />

accessed online. Working out whether medical<br />

in<strong>for</strong>mation is evidence-based, up¬to-date and<br />

accurate can also be difficult <strong>for</strong> consumers and<br />

health care pr<strong>of</strong>essionals alike.<br />

One way to improve access to in<strong>for</strong>mation<br />

is to develop a portal <strong>for</strong> all cardiovascular<br />

in<strong>for</strong>mation, which brings together:<br />

Be<strong>for</strong>e a cardiovascular event<br />

• educational materials<br />

• clinical evidence<br />

• clinical practice guidelines<br />

• research<br />

• projects underway and completed<br />

• health services<br />

• support groups.<br />

[ 5 ]


Be<strong>for</strong>e a cardiovascular event (cont.)<br />

Be<strong>for</strong>e a cardiovascular event<br />

The bulk <strong>of</strong> cardiovascular risk assessment<br />

and prescribing is done in general practice.<br />

However, general practice is under significant<br />

pressure. A particular problem <strong>for</strong> GPs is the<br />

growing volume <strong>of</strong> clinical evidence and<br />

guidelines they are expected to know. The<br />

amount is far greater than they have to time<br />

read, and the volume too large to remember.<br />

GPs find keeping up to date difficult, especially<br />

when their patients have several conditions or<br />

are taking several medicines. The in<strong>for</strong>mation<br />

available to guide GPs is very fragmented<br />

and difficult to access as a whole. There is<br />

growing evidence that guidelines are not being<br />

translated into clinical practice.<br />

More effective ways need to be found to<br />

provide GPs with in<strong>for</strong>mation in ways that are<br />

manageable and memorable. Where effective<br />

methods have been found, they need to be<br />

more widely used.<br />

Counselling and education<br />

Some patients do not understand what their<br />

doctor tells them about cardiovascular disease or<br />

their treatment. Research has shown that patient<br />

confusion is responsible <strong>for</strong> nearly two-thirds<br />

<strong>of</strong> medicine-related problems after discharge<br />

from hospital. Research has also found that,<br />

while consumers are generally satisfied with<br />

their doctor’s technical knowledge, they felt that<br />

GPs’ greatest weakness is in communicating.<br />

The problem is not just a matter <strong>of</strong> doctors’<br />

skill, but also a lack <strong>of</strong> time to counsel patients,<br />

particularly when managing chronic diseases.<br />

Possible solutions include:<br />

• providing doctors with training on how to<br />

communicate with their patients<br />

• making greater use <strong>of</strong> nurses in general<br />

practice and hospitals to ‘interpret’ doctors’<br />

directions <strong>for</strong> patients and carers<br />

[ 6 ]<br />

Initiating medicines<br />

There is evidence that some doctors are underprescribing<br />

medicines which have been shown<br />

to be effective in reducing the risk <strong>of</strong> CVD.<br />

These include ACE inhibitors, beta-blockers and<br />

lipid-modifying drugs. Doctors would benefit<br />

from advice and training on:<br />

• the degree <strong>of</strong> current under-prescribing<br />

• risks posed by under-use <strong>of</strong> these medicines<br />

• appropriate use <strong>of</strong> these medicines<br />

• appropriate target doses<br />

Some <strong>of</strong> the common medicines used to reduce<br />

risk <strong>of</strong> cardiovascular disease can have side<br />

effects initially, and it may take doctors some<br />

time to find a <strong>for</strong>mulation or combination<br />

<strong>of</strong> medicines that is well-tolerated by the<br />

patient. This might involve switching between<br />

medicines, as well as titrating doses up and<br />

down. Many patients do not understand the<br />

reasons <strong>for</strong> these changes. Because <strong>of</strong> this, and<br />

the side effects, some patients refuse treatment.<br />

Some doctors need help explaining to<br />

consumers —be<strong>for</strong>e commencing a new<br />

medicine—why switching and changing doses<br />

is <strong>of</strong>ten necessary initially, and how long it may<br />

take to find a suitable medicine or combination<br />

<strong>of</strong> medicines.<br />

• greater counselling by pharmacists when<br />

dispensing medicines.<br />

Consumer medicine in<strong>for</strong>mation<br />

An important tool <strong>for</strong> educating consumers<br />

about their medicines is the Consumer<br />

Medicine In<strong>for</strong>mation (CMI) sheet. By law, all<br />

prescription and pharmacist-only medicines<br />

must have CMI. Topics that CMIs cover include:<br />

– the purpose <strong>of</strong> the medicine<br />

– issues to consider be<strong>for</strong>e taking the medicine<br />

– how to take the medicine correctly<br />

– what to do while taking the medicine<br />

– side effects<br />

– a description <strong>of</strong> the medicine.<br />

CMI is the only standardised consumer<br />

in<strong>for</strong>mation prepared <strong>for</strong> each individual<br />

medicine. They are normally provided<br />

by pharmacists at the time the medicine<br />

is dispensed.<br />

A 2004 review <strong>of</strong> pharmacies found that only<br />

12 per cent <strong>of</strong> consumers received a CMI when<br />

dispensed a prescription medicine. Also, many<br />

health pr<strong>of</strong>essionals, including nurses and<br />

specialist doctors, do not know that CMI exist.<br />

There is a widespread belief that consumers do<br />

not know to ask <strong>for</strong> CMI.


Consumers and health pr<strong>of</strong>essionals need to<br />

be further educated about CMI. Consumers<br />

should be encouraged to ask <strong>for</strong> CMI when<br />

collecting medicines.<br />

Adherence in the longer term<br />

There is evidence that once a person has started<br />

taking medicines, their adherence is likely to be<br />

poor—particularly to long-term management <strong>of</strong><br />

chronic disease.<br />

Adherence to preventative treatments is<br />

particularly low among patients without<br />

symptoms. Since many <strong>of</strong> the medicines<br />

prescribed <strong>for</strong> cardiovascular disease require<br />

minimum concentration levels to have any<br />

effect, low adherence means the medicine has<br />

either limited or no effect.<br />

Strategies shown to improve adherence include:<br />

• prescribing fewer daily doses (the more<br />

doses a person has to take, the more likely<br />

they are to miss one)<br />

• helping patients develop a schedule <strong>for</strong> their<br />

medicines<br />

• helping patients select reminders and<br />

• cues to take their medicines.<br />

Research shows that, while these strategies<br />

might work in the short term, few have been<br />

proved effective <strong>for</strong> long-term treatment. This is<br />

important <strong>for</strong> CVD, where the condition <strong>of</strong>ten<br />

requires long-term medicine use. Further work<br />

to promote long-term adherence to medication<br />

is needed.<br />

Home Medicine Reviews<br />

One tool to improve the use, effectiveness<br />

and safety <strong>of</strong> medicines is the Home Medicine<br />

Review (HMR). During an HMR, a pharmacist<br />

visits a patient’s home, to:<br />

– check that medicines are being used<br />

appropriately<br />

– identify problems with use<br />

– track medicine use<br />

– identify potential interactions<br />

– check <strong>for</strong> expired medicines<br />

Once completed, the pharmacist reports the<br />

results <strong>of</strong> the HMR to the referring doctor.<br />

HMRs are seen as particularly valuable after<br />

discharge from hospital, when they can help<br />

increase patient adherence and improve<br />

medication management.<br />

More pharmacists need to be trained to carry<br />

out HMRs, and doctors encouraged to request<br />

them when appropriate. Giving specialist<br />

doctors authority to order HMRs may also<br />

be helpful.<br />

Be<strong>for</strong>e a cardiovascular event<br />

[ 7 ]


During a cardiovascular event<br />

During a cardiovascular event<br />

Getting people to hospital<br />

When a cardiovascular event occurs, it is<br />

crucial to get treatment as soon as possible. A<br />

quarter <strong>of</strong> Australians die within an hour <strong>of</strong> their<br />

first symptoms, and the risk is greater <strong>for</strong> people<br />

who have already experienced a heart attack.<br />

Un<strong>for</strong>tunately, many people do not seek<br />

help early enough. They either die or sustain<br />

permanent damage. Currently, half <strong>of</strong> all<br />

heart attack deaths occur be<strong>for</strong>e the person<br />

reaches hospital.<br />

People at risk <strong>of</strong> CVD and their families need to<br />

be educated about:<br />

• recognising the symptoms <strong>of</strong> acute<br />

cardiovascular events<br />

• what to do if a cardiovascular event occurs<br />

—and how quickly action is required.<br />

Admission to hospital<br />

A major barrier to QUM in hospitals is<br />

inaccuracies in the medicine records developed<br />

at admission. Developing this record is <strong>of</strong>ten<br />

difficult because:<br />

• many patients cannot accurately remember<br />

what medicines they are using<br />

• the patient may be unable to speak<br />

• most patients do not keep a medicines list<br />

with them<br />

• patients or family members may not think to<br />

bring medicines when they come to hospital,<br />

and <strong>of</strong>ten do not bring packages with them,<br />

making identification difficult<br />

Further complications result from differences<br />

between hospitals. Each hospital has different<br />

processes <strong>for</strong> developing medicine lists.<br />

Hospitals also vary in how they record<br />

in<strong>for</strong>mation <strong>for</strong> future reference—especially<br />

<strong>for</strong> discharge.<br />

Possible solutions include:<br />

• creating a transferable or centralised<br />

electronic medicine record<br />

• developing a standard procedure <strong>for</strong><br />

recording patients’ medicine details<br />

at admission<br />

• asking people—particularly those at risk <strong>of</strong><br />

an acute cardiovascular event—to keep an<br />

up-to-date record <strong>of</strong> their medicines with<br />

them at all times.<br />

Engaging specialist physicians<br />

In the community, general practitioners make<br />

most decisions about the management <strong>of</strong> CVD,<br />

including use <strong>of</strong> medicines. In the last decade,<br />

there have been many programs to help GPs<br />

achieve <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong>.<br />

In hospitals, the key decisions about prescribing<br />

cardiovascular medicines are made by<br />

cardiologists. Compared with GPs, there have<br />

been few QUM programs designed specifically<br />

<strong>for</strong> specialists. New programs are needed <strong>for</strong><br />

specialist doctors, including cardiologists—<br />

especially as they are reported to be a major<br />

influence on GPs’ prescribing behaviour.<br />

• many patients do not mention overthe¬counter<br />

or complementary medicines.<br />

[ 8 ]


After a cardiovascular event<br />

Discharge: from hospital to home<br />

A major source <strong>of</strong> problems in the use <strong>of</strong><br />

cardiovascular medicines—and <strong>for</strong> the<br />

ongoing management <strong>of</strong> cardiovascular<br />

disease generally —is in the transition from<br />

hospital to home or residential care. Less than<br />

a third <strong>of</strong> GPs are told that their patients have<br />

been to hospital, or receive in<strong>for</strong>mation from<br />

the hospital.<br />

A particular object <strong>of</strong> criticism is the hospital<br />

discharge letter. Problems include:<br />

• many patients are not given a letter<br />

• many patients do not have a doctor to give<br />

the letter to<br />

• each hospital has its own discharge letter,<br />

leading to inconsistencies and omissions<br />

• many letters do not explain which medicines<br />

are to be reduced after discharge<br />

• many letters do not supply contact details in<br />

case <strong>of</strong> questions<br />

• letters frequently contain errors.<br />

One potential solution to this problem is to<br />

better align the PBS and hospital <strong>for</strong>mularies.<br />

Hospital pharmacists can also help by advising<br />

specialists on the availability and cost <strong>of</strong><br />

medicines <strong>for</strong> consumers after discharge.<br />

Increasing use <strong>of</strong> rehabilitation<br />

<strong>Medicines</strong> are only one part <strong>of</strong> management<br />

after a cardiovascular event. There is also a<br />

range <strong>of</strong> services to help people recover from a<br />

cardiovascular event, including rehabilitation,<br />

physiotherapy, specialised gymnasium<br />

programs, and community health centres. These<br />

are <strong>of</strong>ten poorly coordinated and in<strong>for</strong>mation<br />

about such programs can be difficult <strong>for</strong> both<br />

consumers and health pr<strong>of</strong>essionals to obtain.<br />

There is evidence <strong>of</strong> under-referral <strong>of</strong> patients to<br />

cardiac rehabilitation programs. This is because:<br />

• referral to rehabilitation is <strong>of</strong>ten not<br />

standard practice<br />

• rehabilitation is not accessible <strong>for</strong> all<br />

Australians, especially those in rural and<br />

remote areas<br />

After a cardiovascular event<br />

There is broad agreement that electronic<br />

or transferable health records would be the<br />

best way to reduce the loss <strong>of</strong> in<strong>for</strong>mation at<br />

discharge. In the absence <strong>of</strong> electronic records,<br />

an alternative is to improve and standardise<br />

discharge communication processes.<br />

<strong>Medicines</strong> at discharge<br />

Hospital pharmacies are funded separately<br />

from the PBS, and each hospital has its own<br />

<strong>for</strong>mulary. As a consequence:<br />

• hospitals may use medicines not listed on<br />

the PBS<br />

• hospitals and specialists may use medicines<br />

that are difficult or expensive <strong>for</strong> consumers<br />

to obtain after discharge.<br />

As a result, after a patient is discharged, their<br />

GP may need to change medicines prescribed<br />

in hospital. Some patients, however, can<br />

be unwilling to change from the medicines<br />

prescribed by their specialist. This can lead to<br />

unnecessarily high costs, patients not filling<br />

scripts, double-dosing, and lower adherence.<br />

• rehabilitation is not sufficiently attractive<br />

<strong>for</strong> Indigenous Australians, older women,<br />

people who do not speak English, and other<br />

disadvantaged groups.<br />

Ways to improve use <strong>of</strong> rehabilitation services,<br />

and there<strong>for</strong>e improve health outcomes <strong>for</strong><br />

those recovering from a cardiovascular event,<br />

include:<br />

• updating and promoting the <strong>Heart</strong><br />

Foundation’s register <strong>of</strong> cardiac rehabilitation<br />

centres and their services<br />

• developing and publicising a directory <strong>of</strong><br />

service providers, including physiotherapists,<br />

certified gymnasium instructors, and<br />

community health centres<br />

• encouraging GPs and cardiologists to<br />

make greater use <strong>of</strong> rehabilitation services<br />

where appropriate<br />

• encouraging patients to attend and complete<br />

rehabilitation courses.<br />

[ 9 ]


Supporting environment<br />

Supporting environment<br />

In<strong>for</strong>mation <strong>for</strong> consumers<br />

There is a substantial amount <strong>of</strong> in<strong>for</strong>mation<br />

available on topics such as healthy eating and<br />

physical activity <strong>for</strong> consumers and health<br />

pr<strong>of</strong>essionals. However, it is highly fragmented<br />

and <strong>of</strong>ten inconsistent. This can confuse<br />

consumers and discourage them from making<br />

positive changes to their lifestyle.<br />

Much existing lifestyle advice does not take into<br />

account the differing dietary requirements <strong>of</strong><br />

people with chronic diseases (such as limiting<br />

fluids or reducing salt intake). Some in<strong>for</strong>mation<br />

fails to explain how to balance competing<br />

demands <strong>for</strong> people with co-morbidities.<br />

Likewise, physical activity programs tend to<br />

focus on the impact <strong>of</strong> activity on individual<br />

diseases, but ignore the contributions <strong>of</strong> exercise<br />

to general well-being and mental health.<br />

There is a need <strong>for</strong> groups providing health<br />

advice to work together in order to develop<br />

consistent advice on nutrition and physical<br />

activity <strong>for</strong> people with CVD.<br />

Linking health consumer organisations<br />

Different health consumer organisations have<br />

much to learn from one another and to gain by<br />

pooling their skills. Greater collaboration could<br />

lead to:<br />

• better advocacy<br />

• better coordination<br />

• development and dissemination <strong>of</strong> consistent<br />

health messages<br />

• better services <strong>for</strong> rural and remote areas,<br />

where resources are scarce.<br />

Practice nurses<br />

To date, the health pr<strong>of</strong>essionals who have<br />

received the most attention in QUM programs<br />

have been doctors and pharmacists.<br />

Nurses also have an important role to play, but<br />

many are unaware <strong>of</strong> the basic QUM principles<br />

and lack access to key resources (such as<br />

CMI). Areas where nurses might play a greater<br />

role include:<br />

• undertaking cardiovascular risk assessments<br />

• follow-up after hospital discharge<br />

• checking adherence and medicine use<br />

• managing medical records<br />

• providing counselling and in<strong>for</strong>mation to<br />

consumers and families<br />

• translating medical advice <strong>for</strong> consumers<br />

and carers.<br />

IT, connectivity and data exchange<br />

Treating cardiovascular diseases involves<br />

long-term treatment, <strong>of</strong>ten by many health<br />

pr<strong>of</strong>essions in several health settings. Treatments<br />

frequently evolve over the patient’s lifetime.<br />

Management <strong>of</strong> many chronic diseases would<br />

be easier with electronic health records.<br />

There is strong support <strong>for</strong> electronic health<br />

records, either as a portable medical record<br />

or in a centrally-maintained database. It is<br />

believed that this will:<br />

• reduce error rates<br />

• reduce uncertainty when transferring patients<br />

between health care settings<br />

• reduce duplication <strong>of</strong> ef<strong>for</strong>t<br />

• allow tracking <strong>of</strong> medicine use.<br />

Ultimately, all <strong>of</strong> these things will help improve<br />

health outcomes.<br />

Greater use <strong>of</strong> IT connectivity may also improve<br />

communication between health pr<strong>of</strong>essionals<br />

and aid their decision-making.<br />

Tracking medicine use<br />

It is very difficult to track the use <strong>of</strong> medicines.<br />

This affects all levels <strong>of</strong> the health system. For<br />

example, at the practice level, it may be difficult<br />

<strong>for</strong> a doctor to know whether patients are filling<br />

their scripts and using their medicines. At the<br />

national level, there is currently little linkage<br />

between medication use and health outcomes,<br />

so it is difficult to assess the efficacy, safety and<br />

cost-effectiveness <strong>of</strong> treatment in everyday life.<br />

Identifying interactions and reasons <strong>for</strong> nonadherence<br />

is also difficult. More coordinated<br />

tracking <strong>of</strong> medicine use could help develop<br />

better policies and programs.<br />

[ 10 ]<br />

• giving advice to patients on nutrition and<br />

physical activity


Missing in action<br />

Hospital administrators and private<br />

health insurers<br />

Private health insurers fund a large part <strong>of</strong><br />

health spending. They are well placed to<br />

influence the uptake <strong>of</strong> QUM, particular by<br />

hospital health pr<strong>of</strong>essionals. They are in a<br />

position to encourage health service providers<br />

to adopt methods that provide QUM—such<br />

as early risk assessment and continuity <strong>of</strong> care<br />

plans. They also have the potential to link<br />

funding across different health settings in order<br />

to support ongoing care.<br />

Hospital administrators have not been drawn<br />

into QUM. Without their involvement, changes<br />

in hospital practice are unlikely.<br />

Carers<br />

Carers have proved difficult to draw into<br />

QUM. Other stakeholders recognise that they<br />

have a large role to play in helping patients<br />

make decisions about medicines and adhere<br />

to treatment. Lack <strong>of</strong> engagement is a barrier<br />

to QUM.<br />

Carers have needs <strong>of</strong> their own, which can<br />

be quite unlike those <strong>of</strong> patients. In particular<br />

they can need help to deal with the stress,<br />

social isolation, depression and anxiety that<br />

<strong>of</strong>ten results from supporting a person who<br />

is living with chronic CVD or has suffered an<br />

acute event.<br />

Carers’ needs include:<br />

Missing in action<br />

• in<strong>for</strong>mation on the cardiovascular disease<br />

affecting the person they are caring <strong>for</strong><br />

• knowledge about the treatments—<br />

particularly how to help people adhere to<br />

their medicines and lifestyle changes<br />

• psychological, social and emotional support.<br />

[ 11 ]


Notes<br />

Notes<br />

[ 12 ]


Australian Capital<br />

Territory<br />

Canberra<br />

15 Denison Street<br />

Deakin ACT 2600<br />

T: (02) 6282 5744<br />

New South Wales<br />

Sydney<br />

Level 3, 80 William Street<br />

Sydney NSW 2011<br />

T: (02) 9219 2444<br />

Northern Territory<br />

Darwin<br />

Darwin Central Offices<br />

3rd Floor, 21 Knuckey Street<br />

Darwin NT 0800<br />

T: (08) 8981 1966<br />

Queensland<br />

Brisbane<br />

557 Gregory Terrace<br />

Fortitude Valley QLD 4006<br />

T: (07) 3872 2500<br />

Tasmania<br />

Hobart<br />

86 Hampden Road<br />

Battery Point TAS 7004<br />

T: (03) 6224 2722<br />

Northern Tasmania<br />

Kings Meadows Community<br />

<strong>Health</strong> Centre, McHugh Street<br />

Kings Meadows TAS w7249<br />

T: (03) 6336 5116<br />

Victoria<br />

<strong>Heart</strong> Foundation Offices<br />

Newcastle<br />

Suite 5, OTP House<br />

Brad<strong>for</strong>d Close<br />

Kotara NSW 2289<br />

T: (02) 4952 4699<br />

Illawarra<br />

Kiama Hospital and<br />

Community <strong>Health</strong> Service<br />

Bonaira Street<br />

Kiama NSW 2533<br />

T: (02) 4232 0122<br />

Townsville<br />

Suite 7B, 95 Denham Street<br />

Townsville QLD 4810<br />

T: (07) 4721 4686<br />

South Australia<br />

Adelaide<br />

155-159 Hutt Street<br />

Adelaide SA 5000<br />

T: (08) 8224 2888<br />

Melbourne<br />

Level 12, 500 Collins Street<br />

Melbourne VIC 3000<br />

T: (03) 9329 8511<br />

Western Australia<br />

Perth<br />

334 Rokeby Road<br />

Subiaco WA 6008<br />

T: (08) 9388 3343<br />

[ 13 ]


<strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong> <strong>for</strong> <strong>Cardiovascular</strong> <strong>Health</strong><br />

An initiative <strong>of</strong> the <strong>Heart</strong> Foundation Pharmacies Rountable<br />

Executive Summary<br />

<strong>Cardiovascular</strong> diseases are the greatest cause<br />

<strong>of</strong> death and disability in Australia, and they are<br />

becoming more common.<br />

Along with healthy lifestyle changes, medications<br />

are the main treatment <strong>for</strong> cardiovascular<br />

diseases. The Australian community spends over<br />

$1.5 billion a year on cardiovascular medicines.<br />

There is agreement that many are not being used<br />

to their best effect. Some are under prescribed.<br />

Many patients do not remain on long-term<br />

treatments. There are great losses <strong>of</strong> medicine<br />

in<strong>for</strong>mation when patients move between<br />

health care settings particularly into and out<br />

<strong>of</strong> hospitals. Providing consumers, carers and<br />

health pr<strong>of</strong>essionals with medicine in<strong>for</strong>mation is<br />

a continuing problem.<br />

In 2005, stakeholders were asked what was<br />

needed to achieve <strong>Quality</strong> <strong>Use</strong> <strong>of</strong> <strong>Medicines</strong><br />

(QUM) in cardiovascular health. Consumers,<br />

policy-makers, health pr<strong>of</strong>essionals and<br />

manufacturers all contributed.<br />

The result, presented in this report, was 128<br />

practical suggestions <strong>for</strong> action, along with a rich<br />

description <strong>of</strong> the problems and goals <strong>of</strong> those<br />

concerned with cardiovascular disease, and an<br />

outline <strong>of</strong> groups still to be engaged in QUM.<br />

The <strong>Heart</strong> Foundation Parmaceutical Roundtable members:<br />

HFN0490 JUL10<br />

©2010 <strong>National</strong> <strong>Heart</strong> Foundation <strong>of</strong> Australia ACN 008 419 761

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