HIV associated CNS disease in the era of HAART - Virology Education

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Recent cohort studies • 15-60% cognitive impairment Presented at the 5th INTEREST workshop – 10 – 13 May 2010, Dar-es-Salaam, Tanzania
Neuropathology • Leuko-encephalopathy • HIV-encephalitis • Microglial cels, perivascular macrophages, multinucleated giant cells • Infected astrocytes Presented at the 5th INTEREST workshop – 10 – 13 May 2010, Dar-es-Salaam, Tanzania
Page 1 and 2: HIV associated CNS disease in the e
Page 3 and 4: HAND HIV-associated neurocognitive
Page 5: • Complaints of: - Memory problem
Page 9 and 10: Cognitive domains • Speed of info
Page 11 and 12: Category Mini-mental state examinat
Page 13 and 14: HIV dementia Scale • Memory - reg
Page 15 and 16: CSF markers of HIV CNS infection
Page 17 and 18: Neuro-pathogenesis • Ongoing HIV-
Page 19 and 20: How important is CNS penetration? -
Page 21 and 22: CNS penetration-effectiveness (CPE)
Page 23 and 24: N3 Regimen CPE rank and detectable
Page 25 and 26: CNS penetration effectiveness (CPE)
Page 27 and 28: Antiretroviral Treatment CNS Penetr
Page 29 and 30: Efavirenz CSF concentrations Efavir
Page 31 and 32: Abacavir CSF concentrations Abacavi
Page 33 and 34: ATZ/(r) CSF concentrations 100-fold
Page 35 and 36: CPE Ranks 2010 4 3 2 1 NRTIs Zidovu
Page 37 and 38: Cornelissen M et al. Antiviral Ther
Page 39: Discussion Questions • In your ex

HIV associated CNS disease in the era of HAART - Virology Education

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