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Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...

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Conclusions <strong>and</strong> Significance<br />

CXCR3<br />

Th1<br />

T-bet<br />

IFNγ<br />

CXCR4<br />

X4 HIV<br />

Th2<br />

GATA-3<br />

IL-4<br />

CCR4<br />

R5 HIV<br />

CXCR4<br />

CCR5<br />

CXCR4<br />

CXCR3<br />

CCR6<br />

Th1Th17<br />

T-bet<br />

RORγ<br />

IFNγ, IL-17<br />

CXCR4 CCR5<br />

beta7<br />

X4 HIV<br />

R5 HIV<br />

CCR6<br />

CXCR4<br />

Th17<br />

RORγ<br />

IL-17<br />

CCR4<br />

CCR5<br />

beta7<br />

Infiltration of CCR6+ Th17 <strong>and</strong> Th1Th17 cells into sites of HIV replication in vivo<br />

(e.g., gut, vaginal mucosa, lymph nodes, <strong>and</strong> brain)

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